Last update
3/25/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Moderately Good
Based on 46 Reviews
7.8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Total Carbohydrate
< 1 g
< 1%**
Stinging Nettle Extract (Urtica dioica) (Root)
500 mg
†
Top Medical Research Studies
8
We evaluated how Urtica dioica, commonly known as nettle, affects prostate cancer cells, specifically the PC3 line. Utilizing various assays, we observed that the dichloromethanolic extract significantly inhibited cell growth and induced cell death, specifically through apoptosis.
Our tests showed increased expression of caspase-3 and caspase-9 genes while lowering Bcl-2 levels, indicating a powerful apoptotic response. We also noted that the treatment led to cell cycle arrest at the G2 phase, suggesting Urtica dioica could be a promising candidate for developing new prostate cancer therapies.
Our tests showed increased expression of caspase-3 and caspase-9 genes while lowering Bcl-2 levels, indicating a powerful apoptotic response. We also noted that the treatment led to cell cycle arrest at the G2 phase, suggesting Urtica dioica could be a promising candidate for developing new prostate cancer therapies.
Read More
8
We explored how Urtica dioica agglutinin (UDA), a lectin from stinging nettle, affects prostate cancer cells in the lab. The study found that UDA can block the binding of a key growth factor to its receptor on skin cancer cells.
Although UDA showed significant inhibition, other lectins were less effective. The findings suggest that UDA could play a role as a potential treatment for prostate issues by hindering growth signals in prostate tissue. However, it’s important to note that the study was conducted in controlled lab conditions, and further research is needed.
Although UDA showed significant inhibition, other lectins were less effective. The findings suggest that UDA could play a role as a potential treatment for prostate issues by hindering growth signals in prostate tissue. However, it’s important to note that the study was conducted in controlled lab conditions, and further research is needed.
Read More
7
We evaluated how a 20% methanolic extract from stinging nettle roots affects human prostate cancer cells, specifically LNCaP and hPCPs. The results revealed a significant antiproliferative effect on LNCaP cells over seven days, peaking at a 30% reduction in growth at a concentration of 1.0E-6 mg/ml. Notably, this effect was time-dependent and did not exhibit any cytotoxicity. However, the stromal cells showed no changes. Overall, we observed encouraging evidence of stinging nettle's potential against prostate cancer cells, though only for specific cells.
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Most Useful Reviews
9
Effective choice
19 people found this helpful
This product supports prostate cancer health well. My husband finds it beneficial and it has improved his condition.
Read More
9
Prostate health
7 people found this helpful
This product is excellent for prostate cancer health at any age. I highly recommend it for those seeking support with prostate issues, as I have noticed significant benefits since using it.
Read More
9
Prostate health benefit
5 people found this helpful
This product features great quality and natural ingredients, suitable for adults. It effectively protects prostate health. The taste is acceptable, and it's essential to take it regularly for the most benefit. It’s an excellent herbal solution.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
- All Researches
8
We evaluated how Urtica dioica, commonly known as nettle, affects prostate cancer cells, specifically the PC3 line. Utilizing various assays, we observed that the dichloromethanolic extract significantly inhibited cell growth and induced cell death, specifically through apoptosis.
Our tests showed increased expression of caspase-3 and caspase-9 genes while lowering Bcl-2 levels, indicating a powerful apoptotic response. We also noted that the treatment led to cell cycle arrest at the G2 phase, suggesting Urtica dioica could be a promising candidate for developing new prostate cancer therapies.
Our tests showed increased expression of caspase-3 and caspase-9 genes while lowering Bcl-2 levels, indicating a powerful apoptotic response. We also noted that the treatment led to cell cycle arrest at the G2 phase, suggesting Urtica dioica could be a promising candidate for developing new prostate cancer therapies.
Read More
8
We explored how Urtica dioica agglutinin (UDA), a lectin from stinging nettle, affects prostate cancer cells in the lab. The study found that UDA can block the binding of a key growth factor to its receptor on skin cancer cells.
Although UDA showed significant inhibition, other lectins were less effective. The findings suggest that UDA could play a role as a potential treatment for prostate issues by hindering growth signals in prostate tissue. However, it’s important to note that the study was conducted in controlled lab conditions, and further research is needed.
Although UDA showed significant inhibition, other lectins were less effective. The findings suggest that UDA could play a role as a potential treatment for prostate issues by hindering growth signals in prostate tissue. However, it’s important to note that the study was conducted in controlled lab conditions, and further research is needed.
Read More
7
We explored how 3,4-divanillyltetrahydrofuran (DTH), derived from Urtica dioica roots, affects prostate cancer cells with varying androgen sensitivity. Using advanced techniques, we radiolabeled DTH to understand its uptake in two types of prostate cancer cells: LNCaP, which is androgen-sensitive, and PC3, which is not.
Our findings revealed that DTH exhibited a higher toxicity towards LNCaP cells compared to PC3 cells. While the study uncovers potential roles of DTH in treating certain prostate cancer types, it emphasizes the need for further research to fully understand its effectiveness.
Our findings revealed that DTH exhibited a higher toxicity towards LNCaP cells compared to PC3 cells. While the study uncovers potential roles of DTH in treating certain prostate cancer types, it emphasizes the need for further research to fully understand its effectiveness.
Read More
7
We investigated the effectiveness of various Iranian medicinal plants, focusing on their potential to inhibit prostate cancer cell growth. Using a method called maceration, extracts from these plants were tested against different prostate cancer cell lines.
Notably, we found that Urtica dioica, along with Euphorbia szovitsii and Medicago sativa, showed significant anti-proliferative effects. This suggests that these plants could be vital in developing new treatments for prostate cancer.
However, it's crucial to approach these findings with caution, as the testing mainly occurred in cell lines, and further research is needed to determine their real-world efficacy.
Notably, we found that Urtica dioica, along with Euphorbia szovitsii and Medicago sativa, showed significant anti-proliferative effects. This suggests that these plants could be vital in developing new treatments for prostate cancer.
However, it's crucial to approach these findings with caution, as the testing mainly occurred in cell lines, and further research is needed to determine their real-world efficacy.
Read More
7
We analyzed the safety and effects of a combination therapy including Urtica dioica for treating lower urinary tract symptoms (LUTS) in 320 patients. Over 30 days to a year, patients received a mix of Urtica dioica, Serenoa repens, and Pinus pinaster.
While the treatment significantly alleviated LUTS for 85% of individuals, especially pain and irritative symptoms, it did not demonstrate any changes in prostate volume or flow rate. Most importantly, there's no conclusive evidence that this combination can prevent prostate cancer, suggesting the need for further research.
While the treatment significantly alleviated LUTS for 85% of individuals, especially pain and irritative symptoms, it did not demonstrate any changes in prostate volume or flow rate. Most importantly, there's no conclusive evidence that this combination can prevent prostate cancer, suggesting the need for further research.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 46 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective choice
19 people found this helpful
This product supports prostate cancer health well. My husband finds it beneficial and it has improved his condition.
Read More
9
Prostate health
7 people found this helpful
This product is excellent for prostate cancer health at any age. I highly recommend it for those seeking support with prostate issues, as I have noticed significant benefits since using it.
Read More
9
Prostate health benefit
5 people found this helpful
This product features great quality and natural ingredients, suitable for adults. It effectively protects prostate health. The taste is acceptable, and it's essential to take it regularly for the most benefit. It’s an excellent herbal solution.
Read More
7.5
Hormonal balance support
5 people found this helpful
This supplement effectively helps men by reducing aromatase production, which converts testosterone into oestrogen, thus positively impacting prostate health and overall hormonal balance. I recommend it for men over 30.
Read More
9
Reduces urination frequency
4 people found this helpful
I confirmed that stinging nettle root extract effectively decreases urination frequency. It serves as a dihydrotestosterone blocker, potentially benefiting both hair loss and prostate cancer.
Read More
Frequently Asked Questions
7.5
Significant improvement
4 people found this helpful
Excellent for the prostate. It’s necessary to take two pills twice daily for three months, but I felt a significant improvement within a month or less.
9
Eases prostate symptoms
2 people found this helpful
I bought it for my husband, who had prostate troubles. After a course of this supplement, the symptoms disappeared.
9
Reduces prostate medication
2 people found this helpful
This is great for enlarged prostates. I take it daily with Saw Palmetto and have stopped all prescribed medications. There have been no side effects, only benefits.
7
We explored how 3,4-divanillyltetrahydrofuran (DTH), derived from Urtica dioica roots, affects prostate cancer cells with varying androgen sensitivity. Using advanced techniques, we radiolabeled DTH to understand its uptake in two types of prostate cancer cells: LNCaP, which is androgen-sensitive, and PC3, which is not.
Our findings revealed that DTH exhibited a higher toxicity towards LNCaP cells compared to PC3 cells. While the study uncovers potential roles of DTH in treating certain prostate cancer types, it emphasizes the need for further research to fully understand its effectiveness.
Our findings revealed that DTH exhibited a higher toxicity towards LNCaP cells compared to PC3 cells. While the study uncovers potential roles of DTH in treating certain prostate cancer types, it emphasizes the need for further research to fully understand its effectiveness.
7
We investigated how the aqueous extract of Urtica dioica affects adenosine deaminase (ADA) activity in prostate cancer tissues.
Using samples from ten patients with localized prostate cancer, we found that the extract significantly inhibited ADA activity.
This inhibition could be a key reason behind the potential benefits of Urtica dioica in managing prostate cancer. However, more comprehensive studies are needed to fully understand its effects and mechanisms.
Using samples from ten patients with localized prostate cancer, we found that the extract significantly inhibited ADA activity.
This inhibition could be a key reason behind the potential benefits of Urtica dioica in managing prostate cancer. However, more comprehensive studies are needed to fully understand its effects and mechanisms.
8
We evaluated how Urtica dioica, commonly known as nettle, affects prostate cancer cells, specifically the PC3 line. Utilizing various assays, we observed that the dichloromethanolic extract significantly inhibited cell growth and induced cell death, specifically through apoptosis.
Our tests showed increased expression of caspase-3 and caspase-9 genes while lowering Bcl-2 levels, indicating a powerful apoptotic response. We also noted that the treatment led to cell cycle arrest at the G2 phase, suggesting Urtica dioica could be a promising candidate for developing new prostate cancer therapies.
Our tests showed increased expression of caspase-3 and caspase-9 genes while lowering Bcl-2 levels, indicating a powerful apoptotic response. We also noted that the treatment led to cell cycle arrest at the G2 phase, suggesting Urtica dioica could be a promising candidate for developing new prostate cancer therapies.
7
We investigated the effectiveness of various Iranian medicinal plants, focusing on their potential to inhibit prostate cancer cell growth. Using a method called maceration, extracts from these plants were tested against different prostate cancer cell lines.
Notably, we found that Urtica dioica, along with Euphorbia szovitsii and Medicago sativa, showed significant anti-proliferative effects. This suggests that these plants could be vital in developing new treatments for prostate cancer.
However, it's crucial to approach these findings with caution, as the testing mainly occurred in cell lines, and further research is needed to determine their real-world efficacy.
Notably, we found that Urtica dioica, along with Euphorbia szovitsii and Medicago sativa, showed significant anti-proliferative effects. This suggests that these plants could be vital in developing new treatments for prostate cancer.
However, it's crucial to approach these findings with caution, as the testing mainly occurred in cell lines, and further research is needed to determine their real-world efficacy.
7
We analyzed the safety and effects of a combination therapy including Urtica dioica for treating lower urinary tract symptoms (LUTS) in 320 patients. Over 30 days to a year, patients received a mix of Urtica dioica, Serenoa repens, and Pinus pinaster.
While the treatment significantly alleviated LUTS for 85% of individuals, especially pain and irritative symptoms, it did not demonstrate any changes in prostate volume or flow rate. Most importantly, there's no conclusive evidence that this combination can prevent prostate cancer, suggesting the need for further research.
While the treatment significantly alleviated LUTS for 85% of individuals, especially pain and irritative symptoms, it did not demonstrate any changes in prostate volume or flow rate. Most importantly, there's no conclusive evidence that this combination can prevent prostate cancer, suggesting the need for further research.
References
- Tekin V, Kozgus Guldu O, Medine EI, Biber Muftuler FZ. Examination of the Association Between 3,4-Divanillyltetrahydrofuran Lignan ( Origin) and Prostate Cancer Cells by I Radiolabeling. Cancer Biother Radiopharm. 2021;36:326. 10.1089/cbr.2020.3602
- Asadi-Samani M, Rafieian-Kopaei M, Lorigooini Z, Shirzad H. A screening of growth inhibitory activity of Iranian medicinal plants on prostate cancer cell lines. Biomedicine (Taipei). 2018;8:8. 10.1051/bmdcn/2018080208
- Mohammadi A, Mansoori B, Aghapour M, Baradaran B. Urtica dioica dichloromethane extract induce apoptosis from intrinsic pathway on human prostate cancer cells (PC3). Cell Mol Biol (Noisy-le-grand). 2016;62:78. PubMed
- Pavone C, Abbadessa D, Tarantino ML, Oxenius I, Laganà A, et al. [Associating Serenoa repens, Urtica dioica and Pinus pinaster. Safety and efficacy in the treatment of lower urinary tract symptoms. Prospective study on 320 patients]. Urologia. 2010;77:43. PubMed
- Durak I, Biri H, Devrim E, Sözen S, Avci A. Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biol Ther. 2004;3:855. PubMed
- Konrad L, Müller HH, Lenz C, Laubinger H, Aumüller G, et al. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med. 2000;66:44. PubMed
- Wagner H, Geiger WN, Boos G, Samtleben R. Studies on the binding of Urtica dioica agglutinin (UDA) and other lectins in an in vitro epidermal growth factor receptor test. Phytomedicine. 1995;1:287. 10.1016/S0944-7113(11)80004-8
Data last updated:
