NOW Supplements Alpha GPC

Supplement Facts

Serving Size: 2 Veg Capsules

Amount Per Serving

%DV

Alpha GPC (L-alpha-glycerylphosphorylcholine)

600 mg

The product is found useful for the following medical conditions

We investigated the potential benefits of alpha-glyceryl-phosphoryl-choline (α-GPC) in tackling the complex challenges of Alzheimer's disease (AD). Using a triple transgenic mouse model known as 3xTg-AD, mice were treated with α-GPC for eight months starting at four months of age. This approach allowed us to assess its impact on both neuroinflammation and memory over a significant timeframe.

Our findings revealed that chronic treatment with α-GPC led to a notable reduction in amyloid deposits, which are often associated with AD. We observed improvements in the balance of the immune response within the brain, especially among important cells like astrocytes and microglia. These changes reflected not just a decrease in inflammation but also an increase in protective, anti-inflammatory molecules.

Furthermore, the treatment positively influenced synaptic function, crucial for memory and learning. Behaviorally, the α-GPC-treated mice demonstrated enhanced cognitive abilities, as evidenced by longer exploration times of new objects—a key indicator of memory function—compared to their untreated counterparts.

In summary, our research supports α-GPC as a promising candidate for therapeutic intervention in the early stages of Alzheimer's. Its ability to reduce inflammation and support brain health could provide new avenues for aiding memory and cognitive function as we age.

7.5

Enhances memory clarity

Most Useful Review

42 people found this helpful

Alpha GPC greatly enhances my nootropic regimen, particularly in improving short-term memory. I incorporate it with a group of B vitamins, DMAE capsules, and magnesium. Memory issues, even in young individuals, can sometimes stem from forgetfulness due to stress. I encourage anyone facing these challenges, including those concerned about Alzheimer’s, to consider it as it has greatly benefitted me.

Updated: Apr 2025

Food Poisoning details

1 people found this helpful

Great product for brain support! The quality is excellent, just like all NOW Foods products! The ingredients are natural, without unnecessary additives, and the alpha-GPC is in a well-absorbed form. The capsules are a convenient size and easy to swallow. The dosage of 300 mg is ideal, especially when taken 1-2 times daily. After just a couple of weeks, I noticed an improvement in my concentration and clarity of thought. An excellent supplement for cognitive support!

Updated: Apr 2025

Blurred Vision details

40 people found this helpful

Improved vision and mood! I have no idea how this supplement works, but it does! I have been taking it for just two weeks, only one capsule a day instead of the recommended two. My vision has become noticeably clearer. Two weeks ago, I thought the house opposite was far enough away, and people couldn't see what was happening in my apartment. Now, I am not so sure! The clarity of my vision has greatly improved. I am delighted; I have more energy, and my mood has brightened. I feel inspired to create and learn new things, all from just one capsule a day! I do take it alongside cod liver oil and sunflower lecithin as well.

Updated: Apr 2025

Dizziness details

Alpha GPC from Now is an exceptionally effective brain supplement that saved me from severe dizziness, which doctors could not diagnose. Now, I take GPC, vitamins, bacopa, magnesium, and other supplements to boost brain function. My condition has improved significantly, and after completing the GPC course, I will begin taking GABA. The capsules are of medium size, and the recommendation for adults is to take two per day. I'm very satisfied with the quality and ingredients.

Updated: Apr 2025

Heart Attack details

1 people found this helpful

For memory, focus, calm, and POTS, read more in my review. Originally, I bought Alpha GPC because I heard it helps with Huperzine A for POTS, increasing choline, which slows the heart rate and calms an overactive nervous system, a significant issue for those with POTS. I’ve tried various types of choline, but this one works best. It also assists with focus, memory, and sleep. I highly recommend it.

Updated: Apr 2025

Tinnitus details

Quick improvement noted

Most Useful Review

2 people found this helpful

I read reviews about this product, ordered it, and have been taking it for just a few days. I feel the effects quickly, particularly regarding my brain memory health and the tinnitus sounds in my head. Thank you. I intend to purchase it again in the future.

Updated: Apr 2025

Autism details

2 people found this helpful

Blessings to those who created this supplement for my daughter with autism! It was recommended to us, and we are witnessing significant changes, despite it being accompanied by other treatments. Thank you, iHerb!

Updated: Apr 2025

Sleep Apnea details

Sleep quality enhancement

Most Useful Review

1 people found this helpful

The quality of my sleep has improved. Initially bought for my child, when I tried it, I noticed an improvement in my own sleep quality. Although it can be tough to consume due to its size and gritty texture, I mix a small amount into yoghurt for my child. I’m hopeful for continued positive effects.

Updated: Apr 2025

Brain Tumor details

Improved thinking speed

Most Useful Review

21 people found this helpful

This is a powerful brain stimulant! After taking it, I felt a significant increase in cognitive function, remembering material was easier, and I experienced a 30% boost in thinking speed. It also gave me a sense of being superhuman. Just remember to adhere to the dosage and use only one capsule. I wholeheartedly recommend it!

Updated: Mar 2026

High Cholesterol details

Enhances memory function

Most Useful Review

4 people found this helpful

Excellent! Many face memory issues at any age. I often forget things like whether I turned off the iron. This memory supplement has outperformed pills. I take it once a year, and my memory does improve, although stress can worsen our mental faculties. Therefore, I highly recommend it, as it can be beneficial in various situations, from stroke to Alzheimer's disease.

Updated: Apr 2025

Blood Clot details

Good. This product crosses the blood-brain barrier and may aid memory and mental clarity, which is significant for me as an older person. However, I didn't notice any difference after using just one bottle, so I won't reorder yet. It might require more than 30 days to see effects. If I choose to order again, I will purchase multiple bottles. I believe it's worth a try due to the benefits shown in clinical trials regarding blood clots.

Updated: Apr 2025

Insomnia details

Potential insomnia risk

Most Useful Review

I really like this supplement; it works as expected. However, I believe it could lead to insomnia if taken after midday.

Updated: Apr 2025

Mild Cognitive Impairment details

4 people found this helpful

I take 1200 mg daily, which has significantly reversed my dementia. The cloudy fog lifted quickly, but it took three years for clarity and memory recall to improve. A French study showed that 300 mg yielded little effect, yet with prolonged use in Alzheimer’s patients, recall increased by around 30%.

Updated: Apr 2025

Autoimmune Disorder details

Cognitive improvement

Most Useful Review

1 people found this helpful

It's effective; my thoughts have cleared significantly and my memory has markedly improved. Overall, my cognitive abilities are notably better!

Updated: Mar 2026

Stroke details

SCIENTIFIC SCORE

Possibly Effective

Based on 4 Researches

alpha-GPC enhances stroke recovery

Barbagallo Sangiorgi G, Barbagallo M, Giordano M, Meli M, Panzarasa R. alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial. Ann N Y Acad Sci. 1994;717:253.

We investigated how alpha-glycerophosphocholine (alpha-GPC) can aid in recovery for individuals who have recently suffered strokes or transient ischemic attacks. In this multicenter clinical trial involving 2044 patients, alpha-GPC was given after the event—first through injections for 28 days and then as a daily oral supplement for five months.

Throughout the treatment, we measured cognitive recovery using various scales, including the Mathew Scale, Mini Mental State Test, Crichton Rating Scale, and Global Deterioration Scale. Over the course of just 28 days, patients showed significant improvements in their mental recovery, with the Mathew Scale score increasing by an impressive 15.9 points. By the end of the five-month study, we noticed that many participants achieved near-normal cognitive scores, with 71% experiencing no cognitive decline.

While some patients did report mild adverse effects like heartburn and nausea, the overall tolerability was excellent, with only 2.14% needing to discontinue treatment due to side effects. We learned that alpha-GPC has a promising role in supporting cognitive recovery following strokes and transient ischemic attacks, highlighting its potential benefits in rehabilitation settings.

Improved condition

Most Useful Review

2 people found this helpful

I combined this with citicoline for my mother’s stroke recovery. It's excellent — her foggy memory is clearing, and she’s more active. I experienced significant effects too, feeling more energetic and calm without drowsiness.