' 
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.9
USERS' SCORE
Good
Based on 13 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
250 mg
278%
Vitamin E (as d-alpha Tocopheryl Succinate)
20 mg
133%
Alpha Lipoic Acid
100 mg
†
Top Medical Research Studies
9
Vitamin E shows promise for MASH
Vitamin E (300 mg) in the treatment of MASH: A multi-center, randomized, double-blind, placebo-controlled study.
High relevance to liver disease
We investigated the effects of a daily dose of 300 mg vitamin E for treating metabolic dysfunction-associated steatohepatitis (MASH). In our study, 124 non-diabetic individuals were randomly assigned to either vitamin E or a placebo.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
Read More
9
Vitamin E improves liver markers
Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
Relevant for liver disease research
We analyzed multiple clinical trials to understand how vitamin E impacts liver disease, specifically metabolic dysfunction-associated steatotic liver disease (MASLD).
Our findings reveal that vitamin E significantly improves key liver markers like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting it may help reduce liver inflammation.
Additionally, vitamin E enhances liver histology by decreasing fat accumulation and inflammation. However, it does not appear to affect liver fibrosis.
Overall, vitamin E could be a valuable option for managing liver health in MASLD patients.
Our findings reveal that vitamin E significantly improves key liver markers like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting it may help reduce liver inflammation.
Additionally, vitamin E enhances liver histology by decreasing fat accumulation and inflammation. However, it does not appear to affect liver fibrosis.
Overall, vitamin E could be a valuable option for managing liver health in MASLD patients.
Read More
9
Vitamin C reduces liver injury
The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.
Highly relevant protective effects
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Read More
Most Useful Reviews
9.5
Liver function improved
Taking lipoic acid greatly supported my mother's liver health. Although her tests showed normal results, the doctor recommended it for additional care. After discontinuing the injections, my mother felt relief as her liver "calmed down". The capsules are fairly large, but not difficult to swallow. Overall, a highly effective option!
Read More
8.8
Improves liver function
Lipic acid, being an essential coenzyme, regulates lipid and carbohydrate metabolism while positively impacting liver function. It effectively detoxifies against heavy metal poisoning and could benefit those with type 2 diabetes, thus promoting overall health and vitality.
Read More
9.5
Enhances liver function
This product effectively serves as an antioxidant, supporting liver function and lowering insulin levels significantly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.9
- All Researches
9.5
Vitamin C enhances liver cancer treatment
Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC.
Combination therapy shows promise.
We observed an intriguing case involving a 68-year-old male patient diagnosed with unresectable hepatocellular carcinoma (HCC). This case focused on the potential benefits of incorporating high-dose intravenous vitamin C into the treatment regimen alongside atezolizumab and bevacizumab.
Initially, the patient underwent the combination therapy, but while the imaging showed stable disease, there was only a modest decline in alpha-fetoprotein (AFP) levels. Unfortunately, the patient's condition further declined. In response, a dose of 30 grams of intravenous vitamin C was added to the treatment plan.
Remarkably, this adjustment led to a swift and noteworthy reduction in AFP levels, normalization of liver function tests, and substantial improvement in overall symptoms. Four months later, imaging indicated significant tumor shrinkage and necrosis.
As of 30 months post-diagnosis, the patient benefits from the combined regimen, showing normal liver function and a dramatically reduced AFP level, all while maintaining an active lifestyle. This case demonstrates the potential synergistic effects of high-dose vitamin C in treating unresectable HCC alongside standard therapies, warranting further investigation into such combination approaches.
Initially, the patient underwent the combination therapy, but while the imaging showed stable disease, there was only a modest decline in alpha-fetoprotein (AFP) levels. Unfortunately, the patient's condition further declined. In response, a dose of 30 grams of intravenous vitamin C was added to the treatment plan.
Remarkably, this adjustment led to a swift and noteworthy reduction in AFP levels, normalization of liver function tests, and substantial improvement in overall symptoms. Four months later, imaging indicated significant tumor shrinkage and necrosis.
As of 30 months post-diagnosis, the patient benefits from the combined regimen, showing normal liver function and a dramatically reduced AFP level, all while maintaining an active lifestyle. This case demonstrates the potential synergistic effects of high-dose vitamin C in treating unresectable HCC alongside standard therapies, warranting further investigation into such combination approaches.
Read More
9
Vitamin C reduces liver injury
The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.
Highly relevant protective effects
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Read More
9
L-AP mitigates liver injury
L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways.
Highly relevant to liver injury
This study investigated how L-ascorbic acid 6-palmitate (L-AP), a derivative of vitamin C, could affect liver injury during sepsis. We focused on understanding its potential to alleviate liver damage caused by an overactive immune response. Through a series of experiments, including the cecal ligation and puncture method in mice, we observed that L-AP significantly increased the survival rates of these animals.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
Read More
9
Vitamin E shows promise for MASH
Vitamin E (300 mg) in the treatment of MASH: A multi-center, randomized, double-blind, placebo-controlled study.
High relevance to liver disease
We investigated the effects of a daily dose of 300 mg vitamin E for treating metabolic dysfunction-associated steatohepatitis (MASH). In our study, 124 non-diabetic individuals were randomly assigned to either vitamin E or a placebo.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
Read More
9
Vitamin E improves liver health
A 6-month randomized controlled trial for vitamin E supplementation in pediatric patients with Gaucher disease: Effect on oxidative stress, disease severity and hepatic complications.
Highly relevant study findings
We examined how vitamin E supplementation affects liver disease in children with Gaucher disease. In this clinical trial, 40 pediatric patients receiving enzyme replacement therapy were divided into two groups: one received vitamin E for six months and the other did not.
The results showed that vitamin E significantly reduced oxidative stress markers and improved liver health, as indicated by decreases in liver and spleen volumes and stiffness. This suggests that vitamin E can enhance treatment efficacy for Gaucher disease, making it a safe and beneficial addition to existing therapies.
The results showed that vitamin E significantly reduced oxidative stress markers and improved liver health, as indicated by decreases in liver and spleen volumes and stiffness. This suggests that vitamin E can enhance treatment efficacy for Gaucher disease, making it a safe and beneficial addition to existing therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Liver function improved
Taking lipoic acid greatly supported my mother's liver health. Although her tests showed normal results, the doctor recommended it for additional care. After discontinuing the injections, my mother felt relief as her liver "calmed down". The capsules are fairly large, but not difficult to swallow. Overall, a highly effective option!
Read More
8.8
Improves liver function
Lipic acid, being an essential coenzyme, regulates lipid and carbohydrate metabolism while positively impacting liver function. It effectively detoxifies against heavy metal poisoning and could benefit those with type 2 diabetes, thus promoting overall health and vitality.
9.5
Enhances liver function
This product effectively serves as an antioxidant, supporting liver function and lowering insulin levels significantly.
8.8
Enhances liver function
Alpha-lipoic acid possesses antioxidant properties and aids in carbohydrate and lipid metabolism. It assists in transforming glucose into energy and improves vascular function, all while fostering liver cell recovery and promoting the elimination of toxins from the body.
9.5
Effective liver care
An excellent drug for liver care.
