Last update
10/7/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Blend of Probiotic Bacteria:Lactobacillus acidophilus (La-14),Bifidobacterium lactis (Bl-04),Bifidobacterium longum (Bl-05)
8 Billion CFU
*
Top Medical Research Studies
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
We studied the effects of BD400 in a collagen-induced arthritis rat model, aiming to understand if it could delay rheumatoid arthritis (RA). Through monitoring arthritis signs, measuring gut health, and assessing immune responses, we found that BD400 significantly reduced swelling and clinical scores in the rats.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Read More
Most Useful Reviews
9
Restored digestion
8 people found this helpful
After suffering from an autoimmune disorder, my mother experienced severe dysbiosis post-covid. Pharmaceuticals failed to help, but these capsules significantly restored her digestive health from the first days of use.
Read More
9
Improved environment
After childbirth, I used advanced ferrochel to improve my ferritin levels, along with these probiotics. They effectively improved my intestinal environment and have shown excellent results for my autoimmune disorder.
Read More
9
Balanced flora
Probiotics are essential for maintaining my oral and intestinal flora balance, crucial for managing my autoimmune disorder. When I run out, I can certainly tell the difference.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8
- All Researches
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Read More
9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
Our study investigated how Bifidobacterium longum, paired with methimazole, affects thyroid function in Graves' disease patients. Over six months, we divided participants into distinct treatment groups.
While methimazole alone improved thyroid health markers, it didn’t significantly lower the thyrotropin receptor antibody, an important indicator of potential disease recurrence. On the other hand, those receiving Bifidobacterium longum along with methimazole showed notable improvements, with TRAb levels returning to normal.
This suggests that probiotics might positively influence thyroid function by altering gut microbiota and metabolites, linking the gut and thyroid effectively.
While methimazole alone improved thyroid health markers, it didn’t significantly lower the thyrotropin receptor antibody, an important indicator of potential disease recurrence. On the other hand, those receiving Bifidobacterium longum along with methimazole showed notable improvements, with TRAb levels returning to normal.
This suggests that probiotics might positively influence thyroid function by altering gut microbiota and metabolites, linking the gut and thyroid effectively.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restored digestion
8 people found this helpful
After suffering from an autoimmune disorder, my mother experienced severe dysbiosis post-covid. Pharmaceuticals failed to help, but these capsules significantly restored her digestive health from the first days of use.
Read More
9
Improved environment
After childbirth, I used advanced ferrochel to improve my ferritin levels, along with these probiotics. They effectively improved my intestinal environment and have shown excellent results for my autoimmune disorder.
Read More
9
Balanced flora
Probiotics are essential for maintaining my oral and intestinal flora balance, crucial for managing my autoimmune disorder. When I run out, I can certainly tell the difference.
Read More
7.5
Works well
6 people found this helpful
I ordered it in the cold weather and found it effective. While it may not be the strongest, it certainly aids in tackling intestinal viruses, which is beneficial for autoimmune disorders.
Read More
8
Copes with imbalances
5 people found this helpful
In cases of intestinal dysfunction related to my autoimmune disorder, I take one capsule daily. It helps alleviate imbalances like bloating and flatulence, making a significant difference in my wellbeing.
Read More
Frequently Asked Questions
9
Restored digestion
8 people found this helpful
After suffering from an autoimmune disorder, my mother experienced severe dysbiosis post-covid. Pharmaceuticals failed to help, but these capsules significantly restored her digestive health from the first days of use.
9
Improved environment
After childbirth, I used advanced ferrochel to improve my ferritin levels, along with these probiotics. They effectively improved my intestinal environment and have shown excellent results for my autoimmune disorder.
2
No improvement noted
1 people found this helpful
The order arrived promptly and well-packaged, but I did not notice any effect. I previously experienced bloating and flatulence, but these vitamins did not help alleviate my symptoms, nor did I observe any progress regarding my autoimmune disorder.
8
Copes with imbalances
5 people found this helpful
In cases of intestinal dysfunction related to my autoimmune disorder, I take one capsule daily. It helps alleviate imbalances like bloating and flatulence, making a significant difference in my wellbeing.
9
Balanced flora
Probiotics are essential for maintaining my oral and intestinal flora balance, crucial for managing my autoimmune disorder. When I run out, I can certainly tell the difference.
7.5
Powerful results
1 people found this helpful
I have ordered these probiotics several times. Initially, I took them daily, but found them too potent for my autoimmune disorder, so now I take them every other day, which is effective.
7.5
Consistent results
I appreciate this company, ordering both vitamin D3 and bifidobacteria. There's a noticeable difference in my autoimmune disorder symptoms when I take them regularly.
8
Lactic acid bacteria combat autoimmune symptoms
We investigated the potential of Lactobacillus and Bifidobacterium in alleviating symptoms of multiple sclerosis using a rat model. The study involved 48 male rats, which were divided into groups to evaluate the effects of these bacteria on demyelination caused by cuprizone.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
8
This randomized, double-blind trial sought to see how synbiotics, including Lactobacillus acidophilus, could help patients with systemic lupus erythematosus (SLE). Fifty patients were divided into two groups: one received synbiotics alongside their standard therapy, while the other got standard therapy alone over two months.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
8
We explored the combination of Lactobacillus acidophilus (LA) and tacrolimus (Tac) for treating systemic lupus erythematosus (SLE) in mice.
By administering both treatments over eight weeks, we saw improvement in T cell balance—the key regulators of the immune response.
The combination therapy not only reduced harmful autoantibodies but also significantly boosted Treg cells while lowering Th17 cells.
These findings suggest that LA can enhance Tac's effectiveness and may offer a promising avenue for better management of autoimmune disorders like SLE.
By administering both treatments over eight weeks, we saw improvement in T cell balance—the key regulators of the immune response.
The combination therapy not only reduced harmful autoantibodies but also significantly boosted Treg cells while lowering Th17 cells.
These findings suggest that LA can enhance Tac's effectiveness and may offer a promising avenue for better management of autoimmune disorders like SLE.
8
We explored how Bifidobacterium lactis 420 (B420) affects autoimmune hepatitis (AIH) by targeting the gut-liver connection. Our findings reveal that B420 reduced markers of liver inflammation in mice with experimental autoimmune hepatitis. It enhanced gut health by raising levels of beneficial short-chain fatty acids and strengthening the intestinal barrier. However, while it showed promise in improving liver immune function, its effects on a key signaling pathway were less impactful than expected. Overall, B420 suggests exciting new approaches for managing autoimmune hepatitis through gut health.
References
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. 10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. 10.3389/fimmu.2021.696074
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. 10.1016/j.nut.2021.111282
- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. 10.3389/fimmu.2020.01832
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. 10.1007/s00296-020-04558-9
- Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. 10.3390/nu9111166
- Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. 10.1080/07315724.2017.1347074
- Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. 10.1017/S000711451700085X
- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. 10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
- Piva F, Gervois P, Karrout Y, Sané F, Romond MB. Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development. Nutrients. 2023;15. 10.3390/nu15234861
- Huo D, Cen C, Chang H, Ou Q, Jiang S, et al. Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis. Commun Biol. 2021;4:1046. 10.1038/s42003-021-02587-z
- Li D, Cheng J, Zhu Z, Catalfamo M, Goerlitz D, et al. Treg-inducing capacity of genomic DNA of subsp. . Allergy Asthma Proc. 2020;41:372. 10.2500/aap.2020.41.200064
- Shi P, Qu H, Nian D, Chen Y, Liu X, et al. Treatment of Guillain-Barré syndrome with Bifidobacterium infantis through regulation of T helper cells subsets. Int Immunopharmacol. 2018;61:290. 10.1016/j.intimp.2018.06.015
- Laparra JM, Olivares M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 ameliorates gliadin-induced alterations in liver iron mobilisation. Br J Nutr. 2013;110:1828. 10.1017/S0007114513001098
- Laparra JM, Olivares M, Gallina O, Sanz Y. Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model. PLoS One. 2012;7:e30744. 10.1371/journal.pone.0030744
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. 10.3389/fimmu.2025.1518181
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. 10.3389/fendo.2022.754401
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. 10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. 10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. 10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. 10.1111/j.1365-2249.2008.03788.x
- Qian S, Zhang X, Zheng X, Li R, Hao X, et al. Development of interleukin-27 recombinant Lactococcus lactis and its efficacy in treating psoriasis and colitis in mice. Int J Biol Macromol. 2024;282:137113. 10.1016/j.ijbiomac.2024.137113
- Akgul A, Freguia CF, Maddaloni M, Hoffman C, Voigt A, et al. Treatment with a Lactococcus lactis that chromosomally express E. coli cfaI mitigates salivary flow loss in a Sjögren's syndrome-like disease. Sci Rep. 2023;13:19489. 10.1038/s41598-023-46557-3
- Mathieu C, Wiedeman A, Cerosaletti K, Long SA, Serti E, et al. A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab. Diabetologia. 2024;67:27. 10.1007/s00125-023-06014-2
- Sassi G, Licata G, Ventriglia G, Wouters A, Lemaitre P, et al. A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis-Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes. Diabetes. 2023;72:1470. 10.2337/db22-0852
- Guimaraes MAF, Pinheiro-Rosa N, Oliveira RP, Aguiar SLF, Miranda MCG, et al. Hsp65-producing Lactococcus lactis inhibits experimental autoimmune encephalomyelitis by preventing cell migration into spinal cord. Cell Immunol. 2023;384:104661. 10.1016/j.cellimm.2022.104661
- Nelson AS, Akgul A, Maddaloni M, Bhagyaraj E, Hoffman C, et al. Oral probiotic promotes indoleamine 2,3-dioxygenase- and TGF-β-Producing plasmacytoid dendritic cells to initiate protection against type 1 diabetes. Immunol Lett. 2021;239:12. 10.1016/j.imlet.2021.07.009
- Akgul A, Maddaloni M, Jun SM, Nelson AS, Odreman VA, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99. 10.1186/s13075-021-02475-1
- Preisser TM, da Cunha VP, Santana MP, Pereira VB, Cara DC, et al. Recombinant Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model. J Diabetes Res. 2021;2021:6697319. 10.1155/2021/6697319
- Gusmao-Silva G, Aguiar SLF, Miranda MCG, Guimarães MA, Alves JL, et al. Hsp65-Producing Prevents Antigen-Induced Arthritis in Mice. Front Immunol. 2020;11:562905. 10.3389/fimmu.2020.562905
- Cook DP, Cunha JPMCM, Martens PJ, Sassi G, Mancarella F, et al. Intestinal Delivery of Proinsulin and IL-10 via Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis. Front Immunol. 2020;11:1103. 10.3389/fimmu.2020.01103
- Nelson AS, Maddaloni M, Abbott JR, Hoffman C, Akgul A, et al. Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice. Sci Rep. 2020;10:6156. 10.1038/s41598-020-62881-4
- Maddaloni M, Kochetkova I, Hoffman C, Pascual DW. Delivery of IL-35 by Ameliorates Collagen-Induced Arthritis in Mice. Front Immunol. 2018;9:2691. 10.3389/fimmu.2018.02691
- Lang J, Wang X, Liu K, He D, Niu P, et al. Oral delivery of staphylococcal nuclease by Lactococcus lactis prevents type 1 diabetes mellitus in NOD mice. Appl Microbiol Biotechnol. 2017;101:7653. 10.1007/s00253-017-8480-5
- Kasarełło K, Szczepankowska A, Kwiatkowska-Patzer B, Lipkowski AW, Gadamski R, et al. Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis. Folia Neuropathol. 2016;54:249.
- Liu KF, Liu XR, Li GL, Lu SP, Jin L, et al. Oral administration of Lactococcus lactis-expressing heat shock protein 65 and tandemly repeated IA2P2 prevents type 1 diabetes in NOD mice. Immunol Lett. 2016;174:28. 10.1016/j.imlet.2016.04.008
