We explored the effects of Lactobacillus acidophilus in a breast cancer model. By administering a specific dose over 15 days, we observed a notable reduction in tumor growth in treated mice. The study revealed changes in key immune markers, suggesting L. acidophilus can shift immune responses toward a more protective state against tumors. However, the research suggests that while promising, further investigation is needed to fully understand these mechanisms of action.
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Bifidobacterium treatment shows efficacyAnti-tumor effect of a recombinant Bifidobacterium strain secreting a claudin-targeting molecule in a mouse breast cancer model.
High relevance for breast cancer
We explored the use of a special strain of Bifidobacterium longum that produces a targeted protein against breast cancer. This strain, known as B. longum-C-CPE-PE23, was tested in mice with breast tumors. It effectively limited tumor growth without harmful side effects, making it a noteworthy option for treatment.
The research indicates that this bacteria can localize in tumors and deliver therapeutic agents specifically. Overall, B. longum-C-CPE-PE23 shows great promise as a safe and effective treatment strategy for breast cancer.
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We explored the potential of nisin, a natural antimicrobial peptide, to combat breast cancer cells, specifically the MCF-7 cell line. By evaluating its effects under optimal production conditions, we found that nisin has strong anticancer properties, showing significant cytotoxicity with an IC50 of 5 μM against MCF-7 cells.
Additionally, when combined with doxorubicin, nisin enhanced the drug's effectiveness. However, our results suggest that while promising, further research is needed to fully establish nisin's role in breast cancer therapy.
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Lactobacillus with Dox shows promiseCoadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects.
Relevant study on cancer treatment
We explored how adding Lactobacillus acidophilus and vitamin D3 to doxorubicin treatment could help alleviate its side effects and improve effectiveness in breast cancer. In a study using mice, several groups were given different combinations of treatments.
The groups that received probiotics and vitamin D3 alongside doxorubicin saw reduced tumor volume and weight compared to the control group. Gene expression analysis also indicated that these combinations improved gene activity related to cancer cell death while lowering harmful gene expressions.
Overall, this suggests that coadministering doxorubicin with probiotics and vitamin D3 might be a promising approach to enhance breast cancer therapy.
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Lactobacillus and propolis show promiseInvestigation of the supportive therapy potential of propolis extract and Lactobacillus acidophilus LA-5 milk combination against breast cancer in mice.
Potential supportive therapy insights
We investigated how Lactobacillus acidophilus milk and propolis extract might help combat breast cancer in a mouse model. Using various assays, we found that the combination of these treatments led to a significant reduction in tumor sizes and stimulated immune responses.
While propolis showed promising cytotoxic effects on cancer cells, it was the combination with acidophilus milk that demonstrated the most impressive anti-tumor impact. However, it's important to note that the efficacy seen in mice may not directly translate to human treatment.
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