Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Biotin
1 mg (1,000 mcg)
3333%
Top Medical Research Studies
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
7
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Most Useful Reviews
9
Reduced hair fall
24 people found this helpful
My hair stopped falling out just two days after starting biotin; previously, it was shedding in "packs", leaving me worried. Eventually, I noticed undercoat hairs started to grow. I was surprised that this vitamin is produced by gut bacteria, which explains why hair falls out more under stress. I did not find specific guidelines for daily use, but I take 5000 mg in three capsules. It's become essential in my routine, and I’m recommending it to others.
9
Stopped hair loss
13 people found this helpful
Biotin has been a lifeline for my hair! Suffering from hair loss due to anaemia and genetics, I was devastated. Since I started using Biotin, I have experienced considerable hair growth and no further loss. I'm excited and ordering more today!
9
Dermatitis alleviated
7 people found this helpful
My mother and I took just one course of Biotin, and the results have been impressive. My hair has stopped falling out, and I've seen significant improvement in its condition. The Biotin also helped alleviate my seborrheic dermatitis, which is a major relief. I'm ordering additional jars to continue this positive trend.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
- All Researches
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
9
We observed a fascinating case of a four-year-old girl diagnosed with Thiamine Metabolism Dysfunction Syndrome 5 and acute disseminated encephalomyelitis, who exhibited marked improvement after treatment with biotin and thiamine. Initially presenting with fever and agitation post-vaccination, genetic tests later revealed a pathogenic variant in the TPK1 gene. The girl's clinical status improved significantly, with resolution of autism spectrum disorder symptoms, supporting the role of early intervention. This case strengthens the evidence for biotin and thiamine in treating metabolic deficiencies related to TPK1.
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
8
We explored two intriguing cases of biotinidase deficiency, a rare genetic disorder that can mimic conditions like Neuromyelitis Optica Spectrum Disorder. Initially, both patients received treatments for immune-mediated disorders, but when their symptoms worsened, further testing revealed biotinidase deficiency.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
7
We set out to examine the effects of high-dose pharmaceutical-grade biotin on patients with different types of demyelinating neuropathies.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
User Reviews
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced hair fall
24 people found this helpful
My hair stopped falling out just two days after starting biotin; previously, it was shedding in "packs", leaving me worried. Eventually, I noticed undercoat hairs started to grow. I was surprised that this vitamin is produced by gut bacteria, which explains why hair falls out more under stress. I did not find specific guidelines for daily use, but I take 5000 mg in three capsules. It's become essential in my routine, and I’m recommending it to others.
9
Stopped hair loss
13 people found this helpful
Biotin has been a lifeline for my hair! Suffering from hair loss due to anaemia and genetics, I was devastated. Since I started using Biotin, I have experienced considerable hair growth and no further loss. I'm excited and ordering more today!
9
Dermatitis alleviated
7 people found this helpful
My mother and I took just one course of Biotin, and the results have been impressive. My hair has stopped falling out, and I've seen significant improvement in its condition. The Biotin also helped alleviate my seborrheic dermatitis, which is a major relief. I'm ordering additional jars to continue this positive trend.
9
No side effects
3 people found this helpful
This supplement effectively helped my hair grow, and I've noticed no side effects! I'm planning to order again for sure.
9
Hair regrowth observed
2 people found this helpful
After giving birth, I noticed excessive hair loss after three months. I decided to take biotin to improve my hair and skin. I’ve never had thick eyebrows or eyelashes, but I hoped for growth. With 1000 mcg daily, I realised that hair began to grow back within a week, and hair loss stopped after two weeks. My eyelashes seem more resilient, as do my eyebrows. I will continue taking it for health and beauty!
Frequently Asked Questions
7.5
Reduced hair fall
3 people found this helpful
My first order was for 12 cans, and after ten days of use, my hair is no longer shedding like before. I've been combining this with iron and other vitamins, which I believe has also contributed to reducing hair fall.
7.5
Thicker hair
2 people found this helpful
Biotin has been excellent for my hair; I encountered issues this winter, but after three weeks of taking it, my hair has become thicker and stronger. I plan to order a higher dosage next time.
10
Strengthened immune system
1 people found this helpful
After two months of taking Biotin, I've noticed fantastic results. My hair has gained volume and stopped falling out, while small wounds heal more quickly. Most importantly, it has strengthened my immune system; I had outbreaks of herpes that didn't develop into sores, thanks to Biotin. I'm highly satisfied and plan to order more.
9
Reduced hair fall
24 people found this helpful
My hair stopped falling out just two days after starting biotin; previously, it was shedding in "packs", leaving me worried. Eventually, I noticed undercoat hairs started to grow. I was surprised that this vitamin is produced by gut bacteria, which explains why hair falls out more under stress. I did not find specific guidelines for daily use, but I take 5000 mg in three capsules. It's become essential in my routine, and I’m recommending it to others.
9
Surprising results achieved
5 people found this helpful
I ordered biotin for the first time and was pleasantly surprised within a week! After giving birth, my hair was falling out wildly, but within a week of taking biotin, these issues disappeared. I highly recommend this wonderful product! If my feedback was helpful, please click YES!
9
Improved overall health
1 people found this helpful
This wonderful tool is ordered to strengthen hair, though it didn't achieve that purpose. However, my hair began to grow rapidly. Moreover, my appetite returned, and my stomach issues miraculously disappeared from these capsules. Additionally, my facial skin became clearer. I liked it and plan to continue this course.
7.5
Thicker hair growth
3 people found this helpful
To restore my thinning hair, I used a range of supplements, including Biotin, for three months. I've noticed increased volume and thickness, while my nails have also become stronger and skin much healthier, particularly on my face, which is well-hydrated now.
7
Less hair fall
1 people found this helpful
I liked it! I ordered this after a break from another brand with lower dosage. I appreciate this one—new hairs sprouted and the thinning at my temples has improved. I experienced less hair loss while taking it alongside Omega-3 and using strengthening masks to achieve long hair. Overall, it has helped my hair grow.
6
Skin and hair improved
28 people found this helpful
I consulted with a Kinesiology teacher who recommended biotin due to my autoimmune disorder. Previously, I struggled with various allergies, but I felt a direct effect from biotin. A significant number of water bubbles emerged, which improved during summer. I believe diet and lifestyle also played roles, but my hair and skin improved significantly.
7
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
8
We explored two intriguing cases of biotinidase deficiency, a rare genetic disorder that can mimic conditions like Neuromyelitis Optica Spectrum Disorder. Initially, both patients received treatments for immune-mediated disorders, but when their symptoms worsened, further testing revealed biotinidase deficiency.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
4
We set out to investigate whether high-dose biotin (HDB) therapy might heighten the risk of relapses in patients with progressive multiple sclerosis (PMS). Our study, involving 2,628 patients receiving HDB and a matched control group, showed no significant increase in relapse rates.
Analyses indicated similar annualized relapse rates for both groups, meaning HDB doesn't appear to elevate relapse risks in PMS. Notably, previous relapses seemed to predict future ones, regardless of HDB treatment. Overall, our findings suggest that HDB may not contribute to an increased risk of relapse for PMS patients.
Analyses indicated similar annualized relapse rates for both groups, meaning HDB doesn't appear to elevate relapse risks in PMS. Notably, previous relapses seemed to predict future ones, regardless of HDB treatment. Overall, our findings suggest that HDB may not contribute to an increased risk of relapse for PMS patients.
References
- Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2023-258703
- Créange A, Hutin E, Sedel F, Le Vigouroux L, Lefaucheur JP. High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study. BMC Neurol. 2023;23:389. doi:10.1186/s12883-023-03440-y
- Thompson ZE, Boyd NK, Khoshnood MM, Santoro JD. Thiamine metabolism dysfunction syndrome 5 (THMD5) mimicking acute disseminated encephalomyelitis. Am J Med Genet A. 2023;191:2868. doi:10.1002/ajmg.a.63376
- Ongaro A, Violatto MB, Casarin E, Pellerani I, Marchini G, et al. The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence. Nanomedicine. 2022;40:102497. doi:10.1016/j.nano.2021.102497
- Espiritu AI, Remalante-Rayco PPM. High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials. Mult Scler Relat Disord. 2021;55:103159. doi:10.1016/j.msard.2021.103159
- Collongues N, Kuhle J, Tsagkas C, Lamy J, Meyer N, et al. Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high-dose pharmaceutical-grade biotin (MD1003). Brain Behav. 2021;11:e01998. doi:10.1002/brb3.1998
- Mathais S, Moisset X, Pereira B, Taithe F, Ciron J, et al. Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis. Neurotherapeutics. 2021;18:378. doi:10.1007/s13311-020-00926-2
- Shah S, Khan N, Lakshmanan R, Lewis B, Nagarajan L. Biotinidase deficiency presenting as Neuromyelitis Optica Spectrum Disorder. Brain Dev. 2020;42:762. doi:10.1016/j.braindev.2020.07.007
