5/28/2025
Last update
5/28/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Biotin
1 mg (1,000 mcg)
3333%
Top Medical Research Studies
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
8
Biotin treatment mitigates rash symptoms
This study looked at children with partial biotinidase deficiency to understand its effects and inheritance. While many were healthy at diagnosis, we found that one child developed skin rash, hair loss, and muscle weakness—symptoms that improved following biotin treatment.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Most Useful Reviews
9
No rashes noted
6 people found this helpful
Good biotin with an appropriate dosage; it did not cause any rashes. I consumed it with zinc picolinate (22 mg from Solgar), which also helped raise my iron levels. Now, my hair has stopped shedding.
0
Severe rashes experienced
2 people found this helpful
Caution! Causes rashes! I had read numerous praises and purchased it, but a week later, I developed deep, painful, subcutaneous acne on my face and back. Despite hoping my body would adjust, the situation worsened. I stopped taking it, and my skin eventually recovered. After a month and a half, I tried it again, but the same thing happened! I wouldn't recommend it since the rashes take a long time to heal and leave marks behind. I bought two cans but must discard them.
0
Daily rashes observed
1 people found this helpful
I experienced rashes from taking a large dose daily.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
9.5
We reviewed the clinical and biochemical characteristics of 28 Chinese patients with holocarboxylase synthetase (HLCS) deficiency. Through this retrospective analysis, we observed that most patients exhibited symptoms like rash, seizures, and vomiting. However, after timely biotin supplementation, almost all showed remarkable improvement in their symptoms and overall health.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
9.5
We explored a fascinating case involving a 6-year-old Vietnamese boy diagnosed with holocarboxylase synthetase deficiency, which is linked to biotin metabolism issues. The boy had a significant skin rash and metabolic acidosis, raising suspicion of multiple carboxylase deficiency. After confirming the diagnosis through urine and genetic tests, he began treatment with biotin.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
9.5
We explored a case involving a 2-month-old boy who presented with severe symptoms, including seizures and rash, and was quickly suspected of having biotinidase deficiency. After starting him on biotin supplements, we observed remarkable improvement within just 48 hours. His skin conditions, including perioral and perianal rashes, as well as overall health, significantly improved after regular biotin intake. At 10 months, the child is thriving and seizure-free, showcasing how effective timely biotin treatment can be in alleviating symptoms and resolving rash in such cases.
9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
No rashes noted
6 people found this helpful
Good biotin with an appropriate dosage; it did not cause any rashes. I consumed it with zinc picolinate (22 mg from Solgar), which also helped raise my iron levels. Now, my hair has stopped shedding.
0
Severe rashes experienced
2 people found this helpful
Caution! Causes rashes! I had read numerous praises and purchased it, but a week later, I developed deep, painful, subcutaneous acne on my face and back. Despite hoping my body would adjust, the situation worsened. I stopped taking it, and my skin eventually recovered. After a month and a half, I tried it again, but the same thing happened! I wouldn't recommend it since the rashes take a long time to heal and leave marks behind. I bought two cans but must discard them.
0
Daily rashes observed
1 people found this helpful
I experienced rashes from taking a large dose daily.
0
Rashes intensified
Biotin caused rashes for me. If you have acne-prone skin, its supplementation can exacerbate the issue. I read that biotin deficiency is rare and that excess intake from supplements isn't necessary, as it's readily absorbed from food. I no longer take it.
0
Rash of sores
I disliked this product as it caused large rashes and sores. It also made me feel nauseous. The packaging was convenient, with no taste or smell, but it did not improve my skin.
Frequently Asked Questions
7.5
Reduced rashes
2 people found this helpful
My skin has improved significantly after drinking biotin for a month. Rashes have decreased, and my face feels nourished. My hair, which was overly dry, has become more moisturised.
2
Rashes during treatment
Excellent quality! I followed the scheme for 30 days, followed by 14 days off. My hair has noticeably grown, but rashes appeared on my face. My nutritionist suggested taking one capsule every other day. After a second course, my hair looks healthy, skin is clear, and I'm satisfied. The capsules are small and neutral in taste, with enough quantity for multiple courses.
0
Severe rashes experienced
2 people found this helpful
Caution! Causes rashes! I had read numerous praises and purchased it, but a week later, I developed deep, painful, subcutaneous acne on my face and back. Despite hoping my body would adjust, the situation worsened. I stopped taking it, and my skin eventually recovered. After a month and a half, I tried it again, but the same thing happened! I wouldn't recommend it since the rashes take a long time to heal and leave marks behind. I bought two cans but must discard them.
7.5
Fewer rashes
My skin condition has improved remarkably, resulting in fewer rashes.
9
No rashes noted
6 people found this helpful
Good biotin with an appropriate dosage; it did not cause any rashes. I consumed it with zinc picolinate (22 mg from Solgar), which also helped raise my iron levels. Now, my hair has stopped shedding.
7.5
Suitable for my son
1 people found this helpful
My son is taking biotin with Vitamin C. Although summer typically worsens his sweating rash, this year it looks much better. I don't need dermatological treatments or steroids. It seems to be a good fit for him, so I intend to continue.
9.5
We explored a case involving a 2-month-old boy who presented with severe symptoms, including seizures and rash, and was quickly suspected of having biotinidase deficiency. After starting him on biotin supplements, we observed remarkable improvement within just 48 hours. His skin conditions, including perioral and perianal rashes, as well as overall health, significantly improved after regular biotin intake. At 10 months, the child is thriving and seizure-free, showcasing how effective timely biotin treatment can be in alleviating symptoms and resolving rash in such cases.
We evaluated two premature twin infants who experienced serious health issues due to riboflavin and biotin deficiencies. They presented with skin rash and other severe complications while receiving prolonged parenteral nutrition.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
9.5
We explored the effects of biotin treatment on a young boy diagnosed with biotinidase deficiency, which presented with neurological issues and a skin rash. Upon administration of 20 mg of biotin daily, we observed a significant and rapid improvement in both his clinical condition and biochemical markers, leading to the cessation of antiseizure medications. Importantly, despite the presence of a rash, biotin showed clear efficacy in improving the patient's overall health without developmental delays by 18 months.
8
Biotin shows variable rash improvement
We investigated the effects of biotin therapy on patients suffering from a rare condition affecting holocarboxylase formation. Among the five patients, four showed a significant improvement in their rashes with doses ranging from 10 to 20 mg daily.
However, one patient required a much higher dose of 100 mg daily for her skin rash to improve. While biotin was effective in alleviating some symptoms, it did not completely resolve all clinical issues for everyone involved in the study. We concluded that biotin can help with rashes in certain cases, but the benefits vary greatly among individuals.
However, one patient required a much higher dose of 100 mg daily for her skin rash to improve. While biotin was effective in alleviating some symptoms, it did not completely resolve all clinical issues for everyone involved in the study. We concluded that biotin can help with rashes in certain cases, but the benefits vary greatly among individuals.
References
- Zou H, Yang L, Zhang R, Qin Y. Case report: A case of holocarboxylase synthetase deficiency with respiratory tract as the initial symptom. Front Genet. 2024;15:1439343. 10.3389/fgene.2024.1439343
- Kim SW, Lee HJ, Choi N, Kim EK, Ko JM. Dramatic Clinical Improvement With Biotin Mega-Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency. Mol Genet Genomic Med. 2024;12:e70002. 10.1002/mgg3.70002
- Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. 10.1177/23247096231168111
- Ling S, Qiu W, Zhang H, Liang L, Lu D, et al. Clinical, biochemical, and genetic analysis of 28 Chinese patients with holocarboxylase synthetase deficiency. Orphanet J Rare Dis. 2023;18:48. 10.1186/s13023-023-02656-y
- Shoaib M, Faraz A, Ahmed SA, Jamil M, Aijaz Z. Diagnostic Dilemma Of Biotinidase Deficiency: Case Of A Child From Pakistan. J Ayub Med Coll Abbottabad. 2016;28:821.
- Ogawa Y, Kiba T, Nakano K, Fujiwara K, Taniguchi H, et al. [Prospective study of biotin treatment in patients with erythema due to gefitinib or erlotinib]. Gan To Kagaku Ryoho. 2014;41:517.
- Hui J, Law E, Chung C, Fung S, Yuen P, et al. The first reported HLCS gene mutation causing holocarboxylase synthetase deficiency in a Vietnamese patient. World J Pediatr. 2012;8:278. 10.1007/s12519-011-0301-9
- Rajendiran A, Sampath S. Biotinidase deficiency--clinching the diagnosis rapidly can make all the difference!. BMJ Case Rep. 2011;2011. 10.1136/bcr.07.2011.4494
- Chou IC, Wang CS, Lin WD, Lin HC, Tsai CH, et al. Holocarboxylase synthetase deficiency: report of one case. Acta Paediatr Taiwan. 2006;47:309.
- Kimura M, Fukui T, Tagami Y, Fujiwaki T, Yokoyama M, et al. Normalization of low biotinidase activity in a child with biotin deficiency after biotin supplementation. J Inherit Metab Dis. 2003;26:715.
- Schulpis KH, Karikas GA, Tjamouranis J, Regoutas S, Tsakiris S. Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 2001;42:1359.
- Gulati S, Passi GR, Kumar A, Kabra M, Kalra V, et al. Biotinidase deficiency--a treatable entity. Indian J Pediatr. 2000;67:464.
- Suormala T, Fowler B, Duran M, Burtscher A, Fuchshuber A, et al. Five patients with a biotin-responsive defect in holocarboxylase formation: evaluation of responsiveness to biotin therapy in vivo and comparative biochemical studies in vitro. Pediatr Res. 1997;41:666.
- Livne M, Gibson KM, Amir N, Eshel G, Elpeleg ON. Holocarboxylase synthetase deficiency: a treatable metabolic disorder masquerading as cerebral palsy. J Child Neurol. 1994;9:170.
- Héron B, Gautier A, Dulac O, Ponsot G. [Biotinidase deficiency. Progressive encephalopathy curable with biotin]. Arch Fr Pediatr. 1993;50:875.
- McVoy JR, Levy HL, Lawler M, Schmidt MA, Ebers DD, et al. Partial biotinidase deficiency: clinical and biochemical features. J Pediatr. 1990;116:78.
