Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 15 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Coenzyme Q10 (CoQ10)
100 mg
*
Hawthorn Berry (Crataegus laevigata and/or monogyna) (Fruit)
400 mg
*
Top Medical Research Studies
8
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
Read More
8
We examined the effects of coenzyme Q10 (CoQ10) on chronic fatigue syndrome (CFS) to understand its potential benefits for individuals suffering from this condition. Our investigation highlighted how CoQ10 could possibly alleviate some symptoms related to CFS, such as fatigue and exercise intolerance, which many patients experience.
CoQ10 acts as a powerful antioxidant, playing an essential role in how our cells generate energy. By supplementing with CoQ10, studies suggest that patients may see improvements in overall quality of life, including reduced feelings of tiredness and enhanced performance during physical activities.
The evidence indicates a positive relationship between CoQ10 supplementation and decreased fatigue levels in those with chronic fatigue syndrome. By helping to minimize oxidative stress and protect mitochondrial function, CoQ10 might provide significant relief to sufferers of CFS, making it a promising candidate for future therapeutic strategies.
Overall, our findings suggest that coenzyme Q10 could offer a valuable option for managing chronic fatigue syndrome, providing hope for those looking for effective treatment approaches.
CoQ10 acts as a powerful antioxidant, playing an essential role in how our cells generate energy. By supplementing with CoQ10, studies suggest that patients may see improvements in overall quality of life, including reduced feelings of tiredness and enhanced performance during physical activities.
The evidence indicates a positive relationship between CoQ10 supplementation and decreased fatigue levels in those with chronic fatigue syndrome. By helping to minimize oxidative stress and protect mitochondrial function, CoQ10 might provide significant relief to sufferers of CFS, making it a promising candidate for future therapeutic strategies.
Overall, our findings suggest that coenzyme Q10 could offer a valuable option for managing chronic fatigue syndrome, providing hope for those looking for effective treatment approaches.
Read More
8
CoQ10 Shows Heart Function Improvement
We investigated the effects of coenzyme Q10 (CoQ10) treatment on patients experiencing chronic fatigue syndrome and related symptoms. In a comprehensive study, 115 patients presented with fatigue, precordial pain, and arrhythmias, which are often precursors to heart failure. Among these individuals, those with chronic fatigue syndrome were evaluated alongside groups with hypertensive cardiovascular disease and mitral valve prolapse syndrome.
We recorded key health metrics, including blood pressure, CoQ10 blood levels, and echocardiographic measurements that assess both diastolic and systolic heart function. The participants were then given CoQ10 supplements, and we conducted follow-up evaluations to measure any changes.
The treatment resulted in promising enhancements across the board—eighty percent of hypertensive patients experienced lowered blood pressure, while all participants showed improved diastolic functioning. Moreover, more than half of the hypertensive group saw a reduction in myocardial thickness. However, while the results were favorable for various heart-related conditions, we noted that the information does not isolate the effects specifically for chronic fatigue syndrome, limiting our understanding of CoQ10’s isolated efficacy for this group.
Overall, the initial trial indicates that CoQ10 could potentially benefit heart function, which may help alleviate some symptoms associated with chronic fatigue syndrome, although more focused studies are needed to draw definitive conclusions for this specific condition.
We recorded key health metrics, including blood pressure, CoQ10 blood levels, and echocardiographic measurements that assess both diastolic and systolic heart function. The participants were then given CoQ10 supplements, and we conducted follow-up evaluations to measure any changes.
The treatment resulted in promising enhancements across the board—eighty percent of hypertensive patients experienced lowered blood pressure, while all participants showed improved diastolic functioning. Moreover, more than half of the hypertensive group saw a reduction in myocardial thickness. However, while the results were favorable for various heart-related conditions, we noted that the information does not isolate the effects specifically for chronic fatigue syndrome, limiting our understanding of CoQ10’s isolated efficacy for this group.
Overall, the initial trial indicates that CoQ10 could potentially benefit heart function, which may help alleviate some symptoms associated with chronic fatigue syndrome, although more focused studies are needed to draw definitive conclusions for this specific condition.
Read More
Most Useful Reviews
9
ATP production
1 people found this helpful
Coenzyme Q10 is essential for ATP production in the mitochondria, crucial for exercise and tackling chronic fatigue syndrome. It diminishes oxidative stress, enhancing muscle function and reducing fatigue.
Read More
9
Effective daily use
I've noticed a remarkable improvement with daily coenzyme Q10. My energy has increased, and chronic fatigue syndrome symptoms have diminished. I plan to continue taking it.
Read More
7.5
Rejuvenating effects
33 people found this helpful
Coenzyme Q10 provides natural energy, particularly beneficial for those with cardiovascular diseases or chronic fatigue syndrome. While it offers a mild effect for others, consistent use (3-6 capsules daily) proves effective. It’s essential to consume it with fatty foods. For those over 35-40 years, regular intake is advisable, and be cautious with combinations containing Hawthorn, as it may lower blood pressure.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
- All Researches
9
We examined the impact of coenzyme Q10, combined with alpha lipoic acid, on individuals suffering from chronic COVID syndrome, which features symptoms similar to chronic fatigue syndrome. The study involved 174 patients, who were divided into two groups.
One group received the combined treatment, while the other group did not receive any treatment at all. Our focus was primarily on how well the treatment reduced fatigue, measured using the Fatigue Severity Scale (FSS).
The results were quite striking: a majority of those who received the treatment showed a significant reduction in fatigue compared to those who did not. In fact, over 53% of patients in the treatment group reported a complete response, whereas only a small fraction in the control group achieved similar results.
Overall, our findings indicate a positive effect of coenzyme Q10 and alpha lipoic acid on reducing chronic fatigue symptoms associated with chronic COVID. However, to validate these results further, we believe that a double-blind, placebo-controlled trial would be essential for confirming the effectiveness of this treatment approach.
One group received the combined treatment, while the other group did not receive any treatment at all. Our focus was primarily on how well the treatment reduced fatigue, measured using the Fatigue Severity Scale (FSS).
The results were quite striking: a majority of those who received the treatment showed a significant reduction in fatigue compared to those who did not. In fact, over 53% of patients in the treatment group reported a complete response, whereas only a small fraction in the control group achieved similar results.
Overall, our findings indicate a positive effect of coenzyme Q10 and alpha lipoic acid on reducing chronic fatigue symptoms associated with chronic COVID. However, to validate these results further, we believe that a double-blind, placebo-controlled trial would be essential for confirming the effectiveness of this treatment approach.
Read More
We conducted a thorough study to explore how coenzyme Q10, combined with NADH, can alleviate symptoms of chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS). In a well-structured, 12-week randomized, double-blind, placebo-controlled trial, we enrolled 207 patients suffering from ME/CFS. Participants were split into two groups, with one receiving a daily dose of 200 mg CoQ10 and 20 mg NADH, while the other took a matching placebo.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
Read More
8
We observed intriguing effects of micronutrient supplementation, including coenzyme Q10, on chronic fatigue syndrome. The studies analyzed provided a comprehensive look at how these supplements might enhance energy levels and promote overall wellbeing.
In several well-conducted trials, participants receiving a combination of multiple micronutrients with coenzyme Q10 showed reduced oxidative stress. This was particularly noted in those experiencing chronic fatigue syndrome. Additionally, healthy individuals demonstrated increased cerebral blood flow, enhanced energy expenditure, and improved fat oxidation when supplemented.
Participants also reported less mental and physical fatigue and found improvements in their cognitive performance during demanding tasks. The collective findings suggest that bolstering our diets with these supplements can offer significant benefits, especially in regions where micronutrient deficiencies are prevalent, even among those who generally eat well.
Overall, this evidence underscores the potential of coenzyme Q10 when used alongside other micronutrients to help improve nutritional status, energy metabolism, and subjective wellbeing in individuals facing chronic fatigue syndrome.
In several well-conducted trials, participants receiving a combination of multiple micronutrients with coenzyme Q10 showed reduced oxidative stress. This was particularly noted in those experiencing chronic fatigue syndrome. Additionally, healthy individuals demonstrated increased cerebral blood flow, enhanced energy expenditure, and improved fat oxidation when supplemented.
Participants also reported less mental and physical fatigue and found improvements in their cognitive performance during demanding tasks. The collective findings suggest that bolstering our diets with these supplements can offer significant benefits, especially in regions where micronutrient deficiencies are prevalent, even among those who generally eat well.
Overall, this evidence underscores the potential of coenzyme Q10 when used alongside other micronutrients to help improve nutritional status, energy metabolism, and subjective wellbeing in individuals facing chronic fatigue syndrome.
Read More
8
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
Read More
We conducted a thorough evaluation of how coenzyme Q10 (CoQ10) combined with nicotinamide adenine dinucleotide (NADH) affects individuals with Chronic Fatigue Syndrome (CFS). A proof-of-concept trial ran for eight weeks with 80 CFS patients, who were randomly assigned to receive either the CoQ10 and NADH supplement or a placebo. This method ensured that our results were reliable, as both patients and researchers were unaware of which group received the supplement or the placebo, making it a double-blind study.
Our primary focus was to measure the effect on age-predicted maximum heart rate (max HR) during exercise tests. Alongside this, we also looked at secondary factors including levels of fatigue, pain, and sleep quality. After the eight-week period, we found that individuals who took the CoQ10 and NADH combination showed a reduction in max HR during the cycle ergometer test. Additionally, they reported improvements in fatigue levels.
These results are promising as they suggest that this combination could be safe and potentially effective for reducing both heart rate responses to exertion and overall fatigue in CFS patients. However, we recognize the need for larger controlled trials to further validate these findings before drawing definitive conclusions.
Our primary focus was to measure the effect on age-predicted maximum heart rate (max HR) during exercise tests. Alongside this, we also looked at secondary factors including levels of fatigue, pain, and sleep quality. After the eight-week period, we found that individuals who took the CoQ10 and NADH combination showed a reduction in max HR during the cycle ergometer test. Additionally, they reported improvements in fatigue levels.
These results are promising as they suggest that this combination could be safe and potentially effective for reducing both heart rate responses to exertion and overall fatigue in CFS patients. However, we recognize the need for larger controlled trials to further validate these findings before drawing definitive conclusions.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
ATP production
1 people found this helpful
Coenzyme Q10 is essential for ATP production in the mitochondria, crucial for exercise and tackling chronic fatigue syndrome. It diminishes oxidative stress, enhancing muscle function and reducing fatigue.
Read More
9
Effective daily use
I've noticed a remarkable improvement with daily coenzyme Q10. My energy has increased, and chronic fatigue syndrome symptoms have diminished. I plan to continue taking it.
Read More
7.5
Rejuvenating effects
33 people found this helpful
Coenzyme Q10 provides natural energy, particularly beneficial for those with cardiovascular diseases or chronic fatigue syndrome. While it offers a mild effect for others, consistent use (3-6 capsules daily) proves effective. It’s essential to consume it with fatty foods. For those over 35-40 years, regular intake is advisable, and be cautious with combinations containing Hawthorn, as it may lower blood pressure.
Read More
7.5
Mental health improvement
22 people found this helpful
Coenzyme Q10 is well-known for its cardiovascular benefits, but it positively affects mental health too. Studies show that doses of 200-800 mg can alleviate depression symptoms, including fatigue and concentration issues. The supplement supports mitochondrial function, which is crucial for those with chronic fatigue syndrome, reducing stress hormone levels and enhancing overall mood.
Read More
9
Dependable supplement
4 people found this helpful
After starting CoQ10, I noticed I no longer caught every cold. I switched to a cheaper brand but fell ill, so I reverted to NOW brand, which I trust. Initially, I took 30 mg, now 100 mg daily due to chronic fatigue syndrome. When I got sick, I doubled my dosage and have since remained well.
Read More
Frequently Asked Questions
9
Effective daily use
I've noticed a remarkable improvement with daily coenzyme Q10. My energy has increased, and chronic fatigue syndrome symptoms have diminished. I plan to continue taking it.
7.5
Rejuvenating effects
33 people found this helpful
Coenzyme Q10 provides natural energy, particularly beneficial for those with cardiovascular diseases or chronic fatigue syndrome. While it offers a mild effect for others, consistent use (3-6 capsules daily) proves effective. It’s essential to consume it with fatty foods. For those over 35-40 years, regular intake is advisable, and be cautious with combinations containing Hawthorn, as it may lower blood pressure.
7.5
Mental health improvement
22 people found this helpful
Coenzyme Q10 is well-known for its cardiovascular benefits, but it positively affects mental health too. Studies show that doses of 200-800 mg can alleviate depression symptoms, including fatigue and concentration issues. The supplement supports mitochondrial function, which is crucial for those with chronic fatigue syndrome, reducing stress hormone levels and enhancing overall mood.
9
Chronic fatigue relief
Coenzyme Q-10 promotes cellular energy, enhances efficiency, and helps combat chronic fatigue syndrome. I take it daily alongside other supplements and recommend its use.
9
Arrhythmia relief
1 people found this helpful
Since taking coenzyme Q10 for my tachycardia and chronic fatigue syndrome, my symptoms have significantly improved. It activates mitochondria in cells, aiding fatigue recovery, and the added Hawthorn fruit benefits heart health. I consume one tablet each morning after my meal, hoping it helps my skin too.
9
Dependable supplement
4 people found this helpful
After starting CoQ10, I noticed I no longer caught every cold. I switched to a cheaper brand but fell ill, so I reverted to NOW brand, which I trust. Initially, I took 30 mg, now 100 mg daily due to chronic fatigue syndrome. When I got sick, I doubled my dosage and have since remained well.
6
Heart support
8 people found this helpful
Taking coenzyme is crucial for heart health, especially with pressure issues or chronic fatigue syndrome. I recommend combining it with omega-3. I've been taking it regularly post-50, having experienced noticeable improvements in heart function and energy levels. I take one capsule twice daily, which suffices for me.
7.5
Energy boost
3 people found this helpful
Coenzyme Q10 enhances cellular energy production, efficiency, and physical endurance, pivotal for combating chronic fatigue syndrome. The safe daily dosage ranges from 100-300 mg, with medical consultation recommended for personalised amounts. Spinach is the finest plant source of CoQ10.
9
ATP production
1 people found this helpful
Coenzyme Q10 is essential for ATP production in the mitochondria, crucial for exercise and tackling chronic fatigue syndrome. It diminishes oxidative stress, enhancing muscle function and reducing fatigue.
We conducted a thorough study to explore how coenzyme Q10, combined with NADH, can alleviate symptoms of chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS). In a well-structured, 12-week randomized, double-blind, placebo-controlled trial, we enrolled 207 patients suffering from ME/CFS. Participants were split into two groups, with one receiving a daily dose of 200 mg CoQ10 and 20 mg NADH, while the other took a matching placebo.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
8
We conducted an enlightening study to explore the potential benefits of Coenzyme Q10 in managing chronic fatigue syndrome (CFS). Our research involved an 8-week, randomized, double-blind, placebo-controlled trial with 73 participants from Spain. This rigorous approach allowed us to carefully evaluate the effects of CoQ10 combined with NADH on patients suffering from this debilitating condition.
Participants who received the treatment experienced significant improvements in their fatigue levels, as indicated by a reduction in the fatigue impact scale total score. The results showed that their biochemical parameters, including key indicators like NAD+/NADH levels, CoQ10, ATP, and citrate synthase, were markedly better when compared to those on the placebo. Additionally, we noted that levels of harmful lipoperoxides decreased, which is a positive sign for overall health.
These findings suggest that the combination of CoQ10 and NADH could offer promising therapeutic benefits for those grappling with the challenges of CFS. However, it’s important to recognize the need for larger studies to validate and deepen our understanding of these initial results.
Participants who received the treatment experienced significant improvements in their fatigue levels, as indicated by a reduction in the fatigue impact scale total score. The results showed that their biochemical parameters, including key indicators like NAD+/NADH levels, CoQ10, ATP, and citrate synthase, were markedly better when compared to those on the placebo. Additionally, we noted that levels of harmful lipoperoxides decreased, which is a positive sign for overall health.
These findings suggest that the combination of CoQ10 and NADH could offer promising therapeutic benefits for those grappling with the challenges of CFS. However, it’s important to recognize the need for larger studies to validate and deepen our understanding of these initial results.
7
We explored the potential impact of coenzyme Q10 on chronic fatigue syndrome (CFS) through a systematic review of existing studies. The aim was to find out if this popular supplement could help improve symptoms such as fatigue and overall quality of life for those affected by CFS.
Seventeen studies met our criteria for inclusion, each investigating various dietary modifications and nutritional supplements. Among them, coenzyme Q10 was evaluated in conjunction with another supplement, nicotinamide adenine dinucleotide hydride (NADH). While some improvements in fatigue were noted with this combined approach, we need to be clear that the evidence did not strongly support the isolated effectiveness of coenzyme Q10 alone for CFS symptoms.
Overall, we found insufficient evidence to confirm that coenzyme Q10, on its own or in combination, offers significant therapeutic benefits for patients with chronic fatigue syndrome. Hence, more targeted research focusing on CFS populations is needed to paint a clearer picture of how coenzyme Q10 and other nutritional interventions might fit into treatment strategies.
Seventeen studies met our criteria for inclusion, each investigating various dietary modifications and nutritional supplements. Among them, coenzyme Q10 was evaluated in conjunction with another supplement, nicotinamide adenine dinucleotide hydride (NADH). While some improvements in fatigue were noted with this combined approach, we need to be clear that the evidence did not strongly support the isolated effectiveness of coenzyme Q10 alone for CFS symptoms.
Overall, we found insufficient evidence to confirm that coenzyme Q10, on its own or in combination, offers significant therapeutic benefits for patients with chronic fatigue syndrome. Hence, more targeted research focusing on CFS populations is needed to paint a clearer picture of how coenzyme Q10 and other nutritional interventions might fit into treatment strategies.
References
- Dorczok MC, Mittmann G, Mossaheb N, Schrank B, Bartova L, et al. Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review. Nutrients. 2025;17. 10.3390/nu17030475
- Barletta MA, Marino G, Spagnolo B, Bianchi FP, Falappone PCF, et al. Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome. Clin Exp Med. 2023;23:667. 10.1007/s10238-022-00871-8
- Castro-Marrero J, Domingo JC, Cordobilla B, Ferrer R, Giralt M, et al. Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?. Antioxid Redox Signal. 2022;36:729. 10.1089/ars.2022.0018
- Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, et al. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13. 10.3390/nu13082658
- Maggini S, Óvári V, Ferreres Giménez I, Pueyo Alamán MG. Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing. Nutr Hosp. 2021;38:3. 10.20960/nh.03788
- Campagnolo N, Johnston S, Collatz A, Staines D, Marshall-Gradisnik S. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. J Hum Nutr Diet. 2017;30:247. 10.1111/jhn.12435
- Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016;42:431. 10.1002/biof.1293
- Castro-Marrero J, Sáez-Francàs N, Segundo MJ, Calvo N, Faro M, et al. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial. Clin Nutr. 2016;35:826. 10.1016/j.clnu.2015.07.010
- Castro-Marrero J, Cordero MD, Segundo MJ, Sáez-Francàs N, Calvo N, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?. Antioxid Redox Signal. 2015;22:679. 10.1089/ars.2014.6181
- Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Altern Ther Health Med. 2014;20 Suppl 1:18.
- Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, et al. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal. 2014;20:1169. 10.1089/ars.2013.5198
- Morris G, Anderson G, Berk M, Maes M. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. Mol Neurobiol. 2013;48:883. 10.1007/s12035-013-8477-8
- Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, et al. Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett. 2009;30:470.
- Bentler SE, Hartz AJ, Kuhn EM. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005;66:625.
- Langsjoen PH, Langsjoen PH, Folkers K. Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment. Clin Investig. 1993;71:S140.
