Last update
6/14/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
USERS' SCORE
Good
Based on 56 Reviews
8
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1.5 g
<1%**
Total Sugars
1.5 g
†
D-Mannose
1.5 g (1,500 mg)
†
Top Medical Research Studies
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
Read More
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
Read More
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Read More
Most Useful Reviews
9
Immediate relief
8 people found this helpful
Following laparoscopy, I frequently experienced cystitis due to my autoimmune disorder. After taking d-mannose, I noticed relief almost immediately; the burning sensations and urgency subsided after the initial dose. I'm now taking it regularly and feeling great. Highly recommend!
Read More
9
Family use
7 people found this helpful
This product is fantastic! I absolutely love it and have ordered more for my family.
Read More
9
Symptoms alleviated
5 people found this helpful
First order with iHerb and I'm now a permanent customer! After researching, I discovered D-mannose and its beneficial effects on cystitis caused by an autoimmune disorder. I ordered it together with Cranberry Concentrate and after just three days of taking them, all symptoms disappeared! Now I take this combination twice a year for prevention.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
- All Researches
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
Read More
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Read More
9
We explored how engineered antibodies using mannose 6-phosphate analogs can enhance treatment for autoimmune and inflammatory disorders. Through a clever design, these antibodies target both harmful proteins and specific receptors on cells, which allows for greater internalization and degradation of these proteins.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
Read More
9
We explored an innovative approach to treating rheumatoid arthritis (RA) using mannose-targeted methotrexate delivery systems. This strategy involved creating chimaeric polymersomes that deliver higher amounts of methotrexate directly to macrophages.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
Read More
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
Read More
User Reviews
USERS' SCORE
Good
Based on 56 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immediate relief
8 people found this helpful
Following laparoscopy, I frequently experienced cystitis due to my autoimmune disorder. After taking d-mannose, I noticed relief almost immediately; the burning sensations and urgency subsided after the initial dose. I'm now taking it regularly and feeling great. Highly recommend!
Read More
9
Family use
7 people found this helpful
This product is fantastic! I absolutely love it and have ordered more for my family.
Read More
9
Symptoms alleviated
5 people found this helpful
First order with iHerb and I'm now a permanent customer! After researching, I discovered D-mannose and its beneficial effects on cystitis caused by an autoimmune disorder. I ordered it together with Cranberry Concentrate and after just three days of taking them, all symptoms disappeared! Now I take this combination twice a year for prevention.
Read More
9
Cystitis relief
5 people found this helpful
This remedy has been my salvation from cystitis caused by E. coli! I've been taking it with cranberries for over two years after each encounter, and I haven’t had a relapse. My doctors couldn't help, but this product has allowed me to live without the routine discomfort associated with my autoimmune disorder.
Read More
8
Bacterial reduction
5 people found this helpful
I ordered D-mannose for a friend with cystitis caused by Escherichia coli. After one can, her tests showed a significant reduction in bacteria. She plans to continue using it and may combine it with cranberries.
Read More
Frequently Asked Questions
9
Rapid results
4 people found this helpful
After much thought, I ordered D-mannose and was relieved to find that it alleviated my acute inflammation in just 2-3 days! I didn’t expect such swift results, and it truly works wonders for my autoimmune disorder.
9
Cystitis relief
5 people found this helpful
This remedy has been my salvation from cystitis caused by E. coli! I've been taking it with cranberries for over two years after each encounter, and I haven’t had a relapse. My doctors couldn't help, but this product has allowed me to live without the routine discomfort associated with my autoimmune disorder.
9
Symptoms alleviated
5 people found this helpful
First order with iHerb and I'm now a permanent customer! After researching, I discovered D-mannose and its beneficial effects on cystitis caused by an autoimmune disorder. I ordered it together with Cranberry Concentrate and after just three days of taking them, all symptoms disappeared! Now I take this combination twice a year for prevention.
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
9
We explored an innovative approach to treating rheumatoid arthritis (RA) using mannose-targeted methotrexate delivery systems. This strategy involved creating chimaeric polymersomes that deliver higher amounts of methotrexate directly to macrophages.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
References
- Lu Y, Xiong Y, Zhang S, Wang B, Feng Y, et al. D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis. Front Pharmacol. 2024;15:1454713. 10.3389/fphar.2024.1454713
- Zhao YL, Li ZX. [Therapeutic potential of EAE mice with sodium oligomannate and effects of intestinal flora and microglia polarization]. Zhonghua Yi Xue Za Zhi. 2024;104:1521. 10.3760/cma.j.cn112137-20231114-01087
- Daurat M, Gauthier C, El Cheikh K, Ali LMA, Morère E, et al. Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins. Front Immunol. 2024;15:1273280. 10.3389/fimmu.2024.1273280
- Jiang Q, Wei B, You M, Zhou X. d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice. Int Immunopharmacol. 2023;118:110087. 10.1016/j.intimp.2023.110087
- Yang L, Sha Y, Wei Y, Fang H, Jiang J, et al. Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy. Biomater Sci. 2023;11:2211. 10.1039/d2bm02072f
