We explored a new targeted agent designed to treat atherosclerosis by focusing on macrophage-mannose receptors. This study tested the effectiveness and safety of a specially formulated nanoagent in a mouse model of atherosclerosis.
The agent showed a notable reduction in inflammation within the arterial plaques while being well-tolerated in terms of toxicity. We found it had good imaging capabilities, allowing for better visualization of macrophages linked to atherosclerosis.
Overall, this promising approach may improve both the diagnosis and treatment of cardiovascular diseases linked to atherosclerosis.
Read More
7
Mannose linked to heart risks
High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors.
We explored how mannose levels relate to insulin resistance and cardiovascular health in a large group of participants. By analyzing data from 1,403 individuals, including those who suffered a heart attack, we found that high mannose was linked to increased risks of adverse cardiac events, regardless of glucose levels and traditional risk factors.
This suggests that mannose could serve as a novel marker to detect harmful changes in metabolic health that could lead to cardiovascular issues down the line. However, it is essential to note that this study highlights association rather than a direct cause-and-effect relationship.
Read More
Most Useful Reviews
9
Reduced exacerbations
171 people found this helpful
WON CHRONIC CYSTITIS! I had cystitis since university, and it took a toll on my life. I regret not starting antibiotics sooner. Eventually, a gynecologist prescribed Nolicin, but after some time, E. coli returned. I tried every antibiotic available without long-term relief. Finally, I was tested for hormones and discovered low progesterone levels. Treatment with hormones was effective, leading to fewer exacerbations. I started using D-mannose from NOW Foods about nine months ago, and I haven't had a single exacerbation since! For me, this product is a miracle!
Read More
9
Highly effective solution
25 people found this helpful
Goodbye cystitis! I discovered D-mannose based on reviews. It works just as well as antibiotics against Escherichia coli. Unlike antibiotics, D-mannose prevents harmful bacteria from adhering to the bladder walls. Combining this with cranberries and other supplements has been a powerful way to combat this disease. I advocate using it for at least a month, as results can be seen earlier. Highly recommend!
Read More
9
Stable remission achieved
21 people found this helpful
I faced cystitis from an early age and often needed antibiotics, but the problem persisted. However, this supplement, combined with cranberry juice, has allowed me to achieve stable remission from cystitis. I recommend it wholeheartedly and believe every woman should have it in her medicine cabinet. The capsules are also easy to swallow!
We explored a new targeted agent designed to treat atherosclerosis by focusing on macrophage-mannose receptors. This study tested the effectiveness and safety of a specially formulated nanoagent in a mouse model of atherosclerosis.
The agent showed a notable reduction in inflammation within the arterial plaques while being well-tolerated in terms of toxicity. We found it had good imaging capabilities, allowing for better visualization of macrophages linked to atherosclerosis.
Overall, this promising approach may improve both the diagnosis and treatment of cardiovascular diseases linked to atherosclerosis.
Read More
7
Mannose linked to heart risks
High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors.
We explored how mannose levels relate to insulin resistance and cardiovascular health in a large group of participants. By analyzing data from 1,403 individuals, including those who suffered a heart attack, we found that high mannose was linked to increased risks of adverse cardiac events, regardless of glucose levels and traditional risk factors.
This suggests that mannose could serve as a novel marker to detect harmful changes in metabolic health that could lead to cardiovascular issues down the line. However, it is essential to note that this study highlights association rather than a direct cause-and-effect relationship.
Read More
User Reviews
USERS' SCORE
Good
Based on 27 Reviews
8.4
All Reviews
Positive Reviews
Negative Reviews
9
Reduced exacerbations
171 people found this helpful
WON CHRONIC CYSTITIS! I had cystitis since university, and it took a toll on my life. I regret not starting antibiotics sooner. Eventually, a gynecologist prescribed Nolicin, but after some time, E. coli returned. I tried every antibiotic available without long-term relief. Finally, I was tested for hormones and discovered low progesterone levels. Treatment with hormones was effective, leading to fewer exacerbations. I started using D-mannose from NOW Foods about nine months ago, and I haven't had a single exacerbation since! For me, this product is a miracle!
Read More
9
Highly effective solution
25 people found this helpful
Goodbye cystitis! I discovered D-mannose based on reviews. It works just as well as antibiotics against Escherichia coli. Unlike antibiotics, D-mannose prevents harmful bacteria from adhering to the bladder walls. Combining this with cranberries and other supplements has been a powerful way to combat this disease. I advocate using it for at least a month, as results can be seen earlier. Highly recommend!
Read More
9
Stable remission achieved
21 people found this helpful
I faced cystitis from an early age and often needed antibiotics, but the problem persisted. However, this supplement, combined with cranberry juice, has allowed me to achieve stable remission from cystitis. I recommend it wholeheartedly and believe every woman should have it in her medicine cabinet. The capsules are also easy to swallow!
Read More
9
Hygiene maintained
10 people found this helpful
This has been my experience with D-Mannose. My last UTI was severe, and I was put on a course of antibiotics. I quickly began taking D-Mannose capsules and powder, alongside drinking plenty of water. Since then, I’ve had no infections and feel this product is a godsend. I am relieved to avoid further antibiotics for this condition!
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9
Relieves chronic symptoms
5 people found this helpful
D-mannose is exceptional for treating genitourinary infections caused by E. coli! I've dealt with chronic cystitis, urethritis, and pyelonephritis for over three years, experiencing relapses every couple of months. I consistently test my urine for E. coli, and when found, I turn to D-mannose. It works every time. Previously, I relied on various antibiotics that upset my stomach and led to thrush. Now, I tackle E. coli without harm to my body, and I take one capsule thrice daily for prevention after swimming or when I'm at risk of overcooling.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
D-mannose is a type of simple sugar that is closely related to glucose. It is naturally found in various fruits and plants, including cranberries, apples, and peaches. D-mannose has garnered attention primarily for its potential benefits in supporting urinary tract health. Research suggests that it may help prevent urinary tract infections (UTIs) by inhibiting the adhesion of bacteria, such as E. coli, to the walls of the urinary tract.
Many people consider D-mannose as a natural supplement to support urinary tract function, particularly for those who experience recurrent UTIs. Available in powder or capsule form, it is often taken for preventative purposes or during an active infection, thanks to its ability to promote urinary health. While more research is needed to fully establish its efficacy, D-mannose is generally regarded as safe for most individuals, albeit it’s always a good practice to consult with a healthcare professional before beginning any new supplement regimen.
Based on user reviews, many people report experiencing relief from symptoms related to their urinary conditions after using D-mannose for a period ranging from a few days to several weeks. Some users mention feeling significant improvements within just a few days of starting their regimen, particularly during acute episodes of cystitis, where relief is noted almost immediately after administration Read Review. Others suggest that for the best results, a consistent intake over a month or more may be most effective for chronic issues, emphasizing the importance of preventive measures alongside immediate treatment Read Review.
Additionally, reviews indicated that users who combine D-mannose with other supplements, like cranberry, often experience enhanced results and fewer recurrences of their urinary conditions. For sustained improvement and management of symptoms, many recommend incorporating it into a longer-term health strategy, stressing that individual responses may vary based on personal health circumstances Read Review. As with any supplement, users are advised to monitor their response and consult with a healthcare provider for tailored dosing and management strategies.
The scientific research surrounding mannose and cardiovascular disease presents intriguing insights, particularly in the realm of atherosclerosis. A study identified a targeted nanoagent that, while designed for imaging, showed effectiveness in reducing inflammation within arterial plaques in a mouse model of atherosclerosis [1]. This suggests a potential avenue for enhancing both the diagnostic and therapeutic landscape for cardiovascular diseases associated with artery plaque buildup.
Additionally, another study found a correlation between elevated mannose levels and increased cardiovascular risks, indicating that mannose might serve as a novel biomarker for impending cardiac issues [2]. However, it’s important to approach these findings with caution as they primarily highlight associations rather than confirmed cause-and-effect relationships. Therefore, while there is scientific support suggesting mannose has implications for cardiovascular health, further research is needed to solidify its role in prevention and treatment.
Based on user reviews, many individuals report significant improvements in their cystitis symptoms after incorporating D-mannose into their routines. For example, one user shared that after starting D-mannose nine months ago, they have not experienced a single exacerbation of chronic cystitis, considering it a miracle product Read Review. Others note rapid alleviation of pain and discomfort associated with urination, indicating that symptoms can diminish quickly—often within days or even hours after taking the supplement Read Review. Additionally, a user highlighted that D-mannose, when combined with cranberry juice, has helped achieve stable remission from their recurrent cystitis Read Review.
Users also emphasize the importance of timely administration; many advocate taking D-mannose at the onset of symptoms for the best results. For instance, one reviewer describes taking D-mannose immediately when they sense symptoms starting, claiming that it effectively eliminates the bacterial infection associated with their urinary condition while avoiding disruption to their beneficial gut bacteria Read Review. Overall, while individual experiences can vary widely, the general consensus among users points to D-mannose as a promising option for managing and preventing urinary tract issues.
Users report positively on combining D-mannose with other supplements, particularly cranberry, for managing urinary conditions linked to cardiovascular disease. Many indicate that this combination enhances efficacy, often noting improved prevention against recurrence of symptoms and better overall outcomes. For instance, one user emphasized that mixing D-mannose with cranberries created a “powerful way” to combat cystitis, advocating for extended use for maximum benefit Read Review. Another user echoed this, stating that the combination allowed them to maintain stable remission from chronic cystitis Read Review.
Moreover, users who took D-mannose alongside other maintenance supplements reported fewer relapses and less reliance on antibiotics, highlighting its preventive capabilities. Those taking D-mannose as a part of a broader health strategy, including cranberry products, noted a marked decrease in the frequency of their urinary tract infections over time. While individual results can vary, the consensus reflects a recommendation for integrating D-mannose with complementary supplements to optimize urinary health and potentially support cardiovascular stability Read Review.
9
Remarkable relief
6 people found this helpful
D-mannose has been my solace since childhood—cystitis has plagued me for ages, and at times I felt utterly hopeless! I tried antibiotics, monural, and various remedies, yet they proved ineffective. Recently, I turned to D-mannose, initially sceptical, but it has become my salvation! When I sense cystitis onset, I grasp it and take three capsules, and the discomfort fades within 15 minutes! After taking it for three months, I feel compelled to share—it genuinely works without causing addiction!
9
Highly effective solution
25 people found this helpful
Goodbye cystitis! I discovered D-mannose based on reviews. It works just as well as antibiotics against Escherichia coli. Unlike antibiotics, D-mannose prevents harmful bacteria from adhering to the bladder walls. Combining this with cranberries and other supplements has been a powerful way to combat this disease. I advocate using it for at least a month, as results can be seen earlier. Highly recommend!
7.5
Prevents relapses effectively
1 people found this helpful
Excellent! Mannose is essential for those with urinary tract and prostate gland issues. It works well as a daily preventative for chronic cases, or temporarily for acute situations. It effectively prevents relapses with daily use. Adding more cranberry extract could enhance results, but remember, dietary supplements alone won’t solve everything. A healthy lifestyle and nutrition are crucial; without these changes, the disease won't go away.
9
Reduced exacerbations
171 people found this helpful
WON CHRONIC CYSTITIS! I had cystitis since university, and it took a toll on my life. I regret not starting antibiotics sooner. Eventually, a gynecologist prescribed Nolicin, but after some time, E. coli returned. I tried every antibiotic available without long-term relief. Finally, I was tested for hormones and discovered low progesterone levels. Treatment with hormones was effective, leading to fewer exacerbations. I started using D-mannose from NOW Foods about nine months ago, and I haven't had a single exacerbation since! For me, this product is a miracle!
9
Fast relief
2 people found this helpful
This supplement is fantastic for acute cystitis as it stops Escherichia coli from adhering to the urinary tract endothelium. Pain and discomfort during urination quickly vanish. It's useful both as an emergency solution and for regular preventative use.
9
Stable remission achieved
21 people found this helpful
I faced cystitis from an early age and often needed antibiotics, but the problem persisted. However, this supplement, combined with cranberry juice, has allowed me to achieve stable remission from cystitis. I recommend it wholeheartedly and believe every woman should have it in her medicine cabinet. The capsules are also easy to swallow!
7.5
Effective for prevention
31 people found this helpful
D-mannose is a lifesaver for cystitis. When I sense that cystitis is about to strike, I take D-mannose right away. It’s crucial to act before inflammation starts. My routine involves taking three capsules daily while drinking plenty of water to expel bacteria. D-mannose eliminates the bacterial infection linked to urinary tract disease without disrupting beneficial gut bacteria, and it has no side effects. I recommend taking one capsule daily as a preventative measure for urinary health.
9
Targeted therapy shows promise
Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis.
We explored a new targeted agent designed to treat atherosclerosis by focusing on macrophage-mannose receptors. This study tested the effectiveness and safety of a specially formulated nanoagent in a mouse model of atherosclerosis.
The agent showed a notable reduction in inflammation within the arterial plaques while being well-tolerated in terms of toxicity. We found it had good imaging capabilities, allowing for better visualization of macrophages linked to atherosclerosis.
Overall, this promising approach may improve both the diagnosis and treatment of cardiovascular diseases linked to atherosclerosis.
7
Mannose linked to heart risks
High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors.
We explored how mannose levels relate to insulin resistance and cardiovascular health in a large group of participants. By analyzing data from 1,403 individuals, including those who suffered a heart attack, we found that high mannose was linked to increased risks of adverse cardiac events, regardless of glucose levels and traditional risk factors.
This suggests that mannose could serve as a novel marker to detect harmful changes in metabolic health that could lead to cardiovascular issues down the line. However, it is essential to note that this study highlights association rather than a direct cause-and-effect relationship.
References
Lee SY, Kim JH, Song JW, Min JS, Kim HJ, et al. Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis. Int J Pharm. 2024;654:123951. doi:10.1016/j.ijpharm.2024.123951
Fortin E, Campi B, Ferrannini E, Mari A, Mellbin LG, et al. High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors. Diabetes Care. 2024;47:246. doi:10.2337/dc23-0870