Last update
5/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1.5 g
<1%**
Total Sugars
1.5 g
†
D-Mannose
1.5 g (1,500 mg)
†
Top Medical Research Studies
8
Mannose shows potential against prostate cancer
We investigated how mannose, a sugar related to glucose, affects prostate cancer cells. Our study found that mannose inhibits cancer cell growth and encourages their programmed death, or apoptosis, in laboratory settings. It also showed promising anticancer effects in mice, all while maintaining their health.
However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.
However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.
Read More
8
Mannogalactofucans show potential benefits
We explored the effects of low molecular weight mannogalactofucans (LMMGFs) on human prostate cancer cells. LMMGFs show promise in slowing cell growth and inducing cell death, particularly by disrupting critical cellular pathways. In lab tests, they led to significant changes in cell behavior, including cell cycle arrest and increased expression of certain death signals. Additionally, in a mouse model, LMMGFs effectively reduced tumor size. Overall, these findings suggest that LMMGFs could be valuable as part of health foods or therapeutic treatments for prostate cancer.
Read More
8
We investigated the role of Endo180, a lectin receptor, in early prostate cancer and its interaction with CD147. Our analysis revealed that the Endo180-CD147 partnership helps maintain cell adhesion and inhibits a process called epithelial-to-mesenchymal transition (EMT), which is crucial for tumor progression.
The study results suggest that bolstering this interaction could be a promising new strategy to enhance survival rates for men with prostate cancer. Overall, this interaction offers a potential therapeutic avenue we could explore further to improve outcomes.
The study results suggest that bolstering this interaction could be a promising new strategy to enhance survival rates for men with prostate cancer. Overall, this interaction offers a potential therapeutic avenue we could explore further to improve outcomes.
Read More
Most Useful Reviews
7.5
Effective for UTI
5 people found this helpful
I highly recommend this product for relieving prostate cancer symptoms. I have an enlarged prostate and frequently experience UTIs, making it difficult to urinate. After starting D-Mannose, my symptoms improved significantly, much like antibiotics. I found the powder more effective than the capsules, but the capsules are convenient for travel.
Read More
7.5
No noticeable benefit
I took D-Mannose for urinary tract inflammation related to my prostate cancer, but sadly, I didn’t experience any benefits. It only seemed to enhance urination without alleviating other symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
- All Researches
9
We evaluated the effectiveness of mannose-modified chitosan nanoparticles in delivering a preventative vaccine against prostate cancer in mice. By administering these nanoparticles intranasally, we observed stronger immune responses and a notable reduction in tumor growth compared to standard methods. The anti-GRP IgG levels remained elevated for 11 weeks, showcasing better delivery efficiency. Additionally, tumors in the group treated with our modified nanoparticles weighed significantly less than those in other groups. This suggests that our approach could be a promising direction in anti-tumor immunotherapy.
Read More
8
We explored how polysaccharides extracted from Yunnan Tratt fruits affect prostate cancer DU145 cells. Our study investigated their ability to inhibit cell proliferation, migration, and invasion, along with their role in inducing apoptosis.
We utilized various methods, including assays for cell viability and migration, as well as flow cytometry to assess the effects on the cell cycle. The results revealed that Tratt polysaccharides can indeed suppress the growth of DU145 cells while promoting cell death through changes in important proteins and genes.
We utilized various methods, including assays for cell viability and migration, as well as flow cytometry to assess the effects on the cell cycle. The results revealed that Tratt polysaccharides can indeed suppress the growth of DU145 cells while promoting cell death through changes in important proteins and genes.
Read More
8
Mannose shows potential against prostate cancer
We investigated how mannose, a sugar related to glucose, affects prostate cancer cells. Our study found that mannose inhibits cancer cell growth and encourages their programmed death, or apoptosis, in laboratory settings. It also showed promising anticancer effects in mice, all while maintaining their health.
However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.
However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.
Read More
8
Mannogalactofucans show potential benefits
We explored the effects of low molecular weight mannogalactofucans (LMMGFs) on human prostate cancer cells. LMMGFs show promise in slowing cell growth and inducing cell death, particularly by disrupting critical cellular pathways. In lab tests, they led to significant changes in cell behavior, including cell cycle arrest and increased expression of certain death signals. Additionally, in a mouse model, LMMGFs effectively reduced tumor size. Overall, these findings suggest that LMMGFs could be valuable as part of health foods or therapeutic treatments for prostate cancer.
Read More
8
We investigated the role of Endo180, a lectin receptor, in early prostate cancer and its interaction with CD147. Our analysis revealed that the Endo180-CD147 partnership helps maintain cell adhesion and inhibits a process called epithelial-to-mesenchymal transition (EMT), which is crucial for tumor progression.
The study results suggest that bolstering this interaction could be a promising new strategy to enhance survival rates for men with prostate cancer. Overall, this interaction offers a potential therapeutic avenue we could explore further to improve outcomes.
The study results suggest that bolstering this interaction could be a promising new strategy to enhance survival rates for men with prostate cancer. Overall, this interaction offers a potential therapeutic avenue we could explore further to improve outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for UTI
5 people found this helpful
I highly recommend this product for relieving prostate cancer symptoms. I have an enlarged prostate and frequently experience UTIs, making it difficult to urinate. After starting D-Mannose, my symptoms improved significantly, much like antibiotics. I found the powder more effective than the capsules, but the capsules are convenient for travel.
Read More
7.5
No noticeable benefit
I took D-Mannose for urinary tract inflammation related to my prostate cancer, but sadly, I didn’t experience any benefits. It only seemed to enhance urination without alleviating other symptoms.
Read More
Frequently Asked Questions
7.5
Effective for UTI
5 people found this helpful
I highly recommend this product for relieving prostate cancer symptoms. I have an enlarged prostate and frequently experience UTIs, making it difficult to urinate. After starting D-Mannose, my symptoms improved significantly, much like antibiotics. I found the powder more effective than the capsules, but the capsules are convenient for travel.
7.5
No noticeable benefit
I took D-Mannose for urinary tract inflammation related to my prostate cancer, but sadly, I didn’t experience any benefits. It only seemed to enhance urination without alleviating other symptoms.
8
We explored how polysaccharides extracted from Yunnan Tratt fruits affect prostate cancer DU145 cells. Our study investigated their ability to inhibit cell proliferation, migration, and invasion, along with their role in inducing apoptosis.
We utilized various methods, including assays for cell viability and migration, as well as flow cytometry to assess the effects on the cell cycle. The results revealed that Tratt polysaccharides can indeed suppress the growth of DU145 cells while promoting cell death through changes in important proteins and genes.
We utilized various methods, including assays for cell viability and migration, as well as flow cytometry to assess the effects on the cell cycle. The results revealed that Tratt polysaccharides can indeed suppress the growth of DU145 cells while promoting cell death through changes in important proteins and genes.
7
We investigated the effects of polysaccharides extracted from endophytic fungi on prostate cancer cells. Our analysis revealed that these polysaccharides, particularly IPS-2, displayed strong antioxidant properties and could inhibit the growth of prostate cancer cells, promoting cell death through apoptosis. Interestingly, this treatment did not harm non-cancerous cells, suggesting a targeted approach. Overall, we found that these polysaccharides could be a promising avenue for cancer treatment, potentially increasing the effectiveness of existing therapies.
8
Mannose shows potential against prostate cancer
We investigated how mannose, a sugar related to glucose, affects prostate cancer cells. Our study found that mannose inhibits cancer cell growth and encourages their programmed death, or apoptosis, in laboratory settings. It also showed promising anticancer effects in mice, all while maintaining their health.
However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.
However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.
8
Mannogalactofucans show potential benefits
We explored the effects of low molecular weight mannogalactofucans (LMMGFs) on human prostate cancer cells. LMMGFs show promise in slowing cell growth and inducing cell death, particularly by disrupting critical cellular pathways. In lab tests, they led to significant changes in cell behavior, including cell cycle arrest and increased expression of certain death signals. Additionally, in a mouse model, LMMGFs effectively reduced tumor size. Overall, these findings suggest that LMMGFs could be valuable as part of health foods or therapeutic treatments for prostate cancer.
References
- Yang Z, Chen G. Inhibition of Proliferation and Induction of Apoptosis in Prostatic Carcinoma DU145 Cells by Polysaccharides from Yunnan Tratt. Molecules. 2024;29. 10.3390/molecules29071575
- Naveen KV, Sathiyaseelan A, Mandal S, Han K, Wang MH. Unveiling the Structural Characteristics and Bioactivities of the Polysaccharides Extracted from Endophytic sp. Molecules. 2023;28. 10.3390/molecules28155788
- Deng YL, Liu R, Cai ZD, Han ZD, Feng YF, et al. Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism. Asian J Androl. 2022;24:540. 10.4103/aja2021104
- Chen F, Ran L, Mi J, Yan Y, Lu L, et al. Isolation, Characterization and Antitumor Effect on DU145 Cells of a Main Polysaccharide in Pollen of Chinese Wolfberry. Molecules. 2018;23. 10.3390/molecules23102430
- Lee J, Lee S, Synytsya A, Capek P, Lee CW, et al. Low Molecular Weight Mannogalactofucans Derived from Undaria pinnatifida Induce Apoptotic Death of Human Prostate Cancer Cells In Vitro and In Vivo. Mar Biotechnol (NY). 2018;20:813. 10.1007/s10126-018-9851-3
- Rodriguez-Teja M, Gronau JH, Minamidate A, Darby S, Gaughan L, et al. Survival Outcome and EMT Suppression Mediated by a Lectin Domain Interaction of Endo180 and CD147. Mol Cancer Res. 2015;13:538. 10.1158/1541-7786.MCR-14-0344-T
- Yao W, Peng Y, Du M, Luo J, Zong L. Preventative vaccine-loaded mannosylated chitosan nanoparticles intended for nasal mucosal delivery enhance immune responses and potent tumor immunity. Mol Pharm. 2013;10:2904. 10.1021/mp4000053
