NOW Supplements Niacin

Myo-inositol improves acne symptoms

Based on 10 Researches

Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome.

Most Relevant Research

We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.

At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.

Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.

This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.

Improved skin texture

Most Useful Review

Niacin is vital for mental well-being, and as I experience flashes, I opted for niacinamide. Initially, I began taking it for cognitive benefits, yet I noticed a significant reduction in my acne and sebum production, resulting in more beautiful skin.

Cardiovascular Disease details

Inositol protects against cardiac damage

Based on 2 Researches

Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.

Most Relevant Research

We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.

The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.

Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.

9.5

Cholesterol maintenance

Most Useful Review

No flushing is essential! Flushing-free MP3 is particularly beneficial for cardiovascular health and cholesterol management.

Chronic Fatigue Syndrome details

I bought it for my girlfriend, but after trying it, I wake up feeling different in the morning! I need to purchase it again. I believe it's the best for relieving fatigue and has great effect and quality.

Cold details

Inositol enhances rapeseed cold tolerance

Based on 6 Researches

Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.).

Most Relevant Research

We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.

Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.

Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.

9.5

No more cold

Most Useful Review

I take a tablet daily, along with lysine pure powder and a vitamin for bone health. Thanks to this regimen, my joints are quite responsive, and my hands and feet no longer feel cold in winter. With a small amount of GABA and B6, my prior depression and anxiety have improved significantly.

The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.

Most Relevant Research

We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.

Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.

The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.

8.8

Indispensable for head

Most Useful Review

I find this supplement essential for those who work mentally and care for their liver. There's no facial flushing after taking it, and the effects are gentle and long-lasting. It's remarkably good value for money; thank you, NOW Foods!

Blood Clot details

SCI offers safe anticoagulant potential

Likely Very Effective

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.

Most Relevant Research

We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.

In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.

Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.

9.5

Increased strength

Most Useful Review

I've been taking this product daily for two months, and I feel great! My blood circulation has improved significantly, and my body feels pleasantly warm. Despite long work hours, I've managed to maintain my stamina. My skin and hair have also become noticeably healthier, especially when taken with vitamin C. Overall, it's been a positive addition to my routine as I’m over 40.

Brain Tumor details

INPP5E's impact on medulloblastoma

Based on 2 Researches

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.

Most Relevant Research

We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.

Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.

Boosted brain function

Most Useful Review

Helps keep the nervous system, digestive system, and skin in good condition. It reduced my cholesterol and provided a boost to my brain function.

Depression details

Myo-inositol: Depression treatment potential

Based on 4 Researches

Cyclitols: From Basic Understanding to Their Association with Neurodegeneration.

Most Relevant Research

We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.

While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.

However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.

8.8

Improved sleep quality

Most Useful Review

It's working! I'm taking one after dinner. I previously had terrible flushing with niacin, which is why I opted for this one. I'm sleeping better than before, and I'm less depressed. I've been on medication for over 20 years due to recurrent depression, yet I'm told I'm fine. Since megavitamin therapy is a lengthy process and encompasses various supplements aside from niacin, I plan to stick with this for the time being.

Food Poisoning details

Improved cholesterol levels

I began using this product after my cholesterol check, discovering that while my overall cholesterol was low, my good cholesterol (HDL) was also quite low. My doctor recommended Niacin among other things. At my subsequent cholesterol check, I noted a 5-point increase in my HDL levels. I nearly exclusively use Now Foods.

High Cholesterol details

IP6 improves cholesterol levels

Based on 10 Researches

Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane.

Most Relevant Research

We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.

Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.

9.5

Cholesterol significantly lowered

Most Useful Review

This product effectively lowered my cholesterol without causing redness. After four months, my total cholesterol dropped from 6.3 to 3.7, and the harmful cholesterol decreased from 4.27 to 2.3. I believe the benefits stem from using it alongside other remedies like silymarin and omega.

Leg Cramps details

I use this product for blood circulation, and now I experience fewer leg cramps, with my feet feeling warm.

Menopause details

Myo-Inositol Support in Menopause

Based on 9 Researches

Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle.

Most Relevant Research

We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.

To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.

Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.

8.8

Increased well-being

Most Useful Review

I take one tablet in the morning and another at night. I used to feel irritated and depressed during menopause, but now I have more good days.

Rash details

Improved skin condition

It contains niacin, which doesn't cause redness, and proved perfect for my skin. Even after a short time, I noticed an improvement in my skin tone, and there were no side effects such as redness or rash. I was particularly pleased as it improved my skin's condition and made my tone more even.

Migraine details

Niacin may reduce migraine risk

Based on 2 Researches

Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey.

Most Relevant Research

We examined the link between dietary niacin intake and migraine occurrences by analyzing data from the National Health and Nutrition Examination Survey. This study focused on adults over 20 years old, looking specifically at their reported experiences with severe headaches and the amount of niacin they consume daily.

Among the 10,246 participants, we found that 20.1% reported having migraines. Those who had a higher intake of niacin showed a lower likelihood of experiencing migraines. For instance, compared to individuals with the lowest niacin intake, those in higher intake categories (Q2, Q3, and Q4) had significantly reduced odds of suffering from migraines. The results indicated that increasing dietary niacin had a favorable effect, suggesting an L-shaped curve relationship where the optimal intake appears to be around 21 mg per day.

This study highlighted a possible connection between niacin consumption and migraine prevention, indicating that moderate levels might play a protective role. However, it’s important to approach these findings cautiously, as they don’t establish cause and effect directly. Further research could illuminate how dietary choices might influence migraine frequency and severity.

8.8

Long-term migraine help

Most Useful Review

I have taken this daily for eight years initially to cure and then to prevent migraine cluster headaches. Flush-free niacin was recommended by my M.D. I have also suggested this remedy to my daughter, who has experienced the same satisfying results. I prefer NOW products for their quality and reasonable prices.

Anxiety details

Inositol reduces anxiety in hens

Questionable

Based on 8 Researches

Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.

Most Relevant Research

We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.

Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.

Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.

Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.

Helpful for anxiety

Most Useful Review

Great product! I found this niacin very helpful for anxiety. Thank you.

Autoimmune Disorder details

Myo-inositol enhances vitamin D effects

Questionable

Based on 5 Researches

The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study.

Most Relevant Research

Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.

We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.

Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.

8.8

Mindful progress

Most Useful Review

For the transition to niacin, we are gradually using niacinamide and niacin 100mg. As I increase the dosage, the total will rise, making it challenging to consume large capsules and grains consistently. I perceive this as a transitional period and try not to fret too much. Previously, I became quite impatient, and after beginning with protein and megavitamins, I suddenly became unwell and lost my health. However, it’s been three months without giving up. I view this as a mental practice, adjusting my approach carefully and listening to my body daily. The first two months were tough, but during the third month, I have felt considerable effects. If you struggle, take things slowly and start with a small amount.

Common Cold details

Effective against stress

My husband and I take Niacin daily, as it helps us manage stress and improves circulation, especially in cold weather. Most importantly, it aids us in overcoming allergic reactions if we consume something that upsets our digestion. Our doctor recommended it to us.

Sleep Apnea details

I bought it for my child who cannot take niacinamide due to its bitterness. Incorporating it into breakfast, her mood and sleep have improved significantly without any fuss.

Allergies details

Nutrition impact noted

I began taking it to manage impulsivity from ADHD symptoms. After a year of adjusting the dosage, I found that 500mg x 2 capsules and an additional 250mg worked well for me (though the ideal amount varies for each individual). I was pleased to find that my anger in frustrating situations has reduced. I have allergies and can only take flash-free supplements, as the regular ones cause significant itching. For ADHD children, I found 250mg less effective, while 500mg daily showed greater results.

Cancer details