Last update
5/6/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
9
ITPP enhances heart attack recovery
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Read More
Most Useful Reviews
7.5
Boosts good cholesterol
33 people found this helpful
To fight heart disease, I manage my cholesterol with Crestor, diet, and exercise. Despite achieving weight loss, my HDL levels were still inadequate until my doctor suggested Niacin. After a year of using this brand, my cholesterol profile has improved significantly without any side effects.
Read More
9
Promotes heart health
3 people found this helpful
Flush-Free Niacin is effective for heart health!
Read More
9
Heart health improvement
2 people found this helpful
I found niacin to be excellent for heart health. After trying it myself and buying some for my mother, I was pleasantly surprised. There were no side effects of heat or redness, and it was gentle on the heart. I definitely want to get some for myself now.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
ITPP enhances heart attack recovery
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Boosts good cholesterol
33 people found this helpful
To fight heart disease, I manage my cholesterol with Crestor, diet, and exercise. Despite achieving weight loss, my HDL levels were still inadequate until my doctor suggested Niacin. After a year of using this brand, my cholesterol profile has improved significantly without any side effects.
Read More
9
Promotes heart health
3 people found this helpful
Flush-Free Niacin is effective for heart health!
Read More
9
Heart health improvement
2 people found this helpful
I found niacin to be excellent for heart health. After trying it myself and buying some for my mother, I was pleasantly surprised. There were no side effects of heat or redness, and it was gentle on the heart. I definitely want to get some for myself now.
Read More
7.5
Heart attack prevention
10 people found this helpful
Niacin, particularly Nicotinic acid, aids in lowering cholesterol and dilates blood vessels. It enhances blood flow, increases hemoglobin, and improves heart function, thereby preventing heart attacks. This vitamin also stimulates digestion and hormone synthesis, contributing to overall well-being.
Read More
7.5
Supports heart health
Niacin, or vitamin B3, is essential for many body functions, including lowering cholesterol and triglycerides, which can help reduce heart disease risk. Its antioxidant properties further protect against free radical damage, making it a crucial vitamin found in various foods and supplements.
Read More
Frequently Asked Questions
9
Heart health improvement
2 people found this helpful
I found niacin to be excellent for heart health. After trying it myself and buying some for my mother, I was pleasantly surprised. There were no side effects of heat or redness, and it was gentle on the heart. I definitely want to get some for myself now.
7.5
Heart attack prevention
10 people found this helpful
Niacin, particularly Nicotinic acid, aids in lowering cholesterol and dilates blood vessels. It enhances blood flow, increases hemoglobin, and improves heart function, thereby preventing heart attacks. This vitamin also stimulates digestion and hormone synthesis, contributing to overall well-being.
9
ITPP enhances heart attack recovery
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
References
- Oknińska M, El-Hafny-Rahbi B, Paterek A, Mackiewicz U, Crola-Da Silva C, et al. Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells. J Cell Mol Med. 2020;24:2272. 10.1111/jcmm.14909
