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Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
The product is found useful for the following medical conditions
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8.9
9.5
No flushing side effects
Most Useful Review
Truly is flush-free! I was prescribed Niacin for cholesterol and this brand is the only one that doesn’t produce the flushing symptoms. Others claimed to be flush-free but weren't. This supplement has helped lower my cholesterol without side effects, and I don’t need prescription meds anymore.
Back Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.8
9.5
No back pain
Most Useful Review
Very effective! Since I started taking niacin, my long-term back pain has vanished. I can now lie on my back without discomfort throughout the night. My husband, who has also started taking it, experienced significant benefits as well. He was advised to check for potential collagen disease, and since we began this regimen, his symptoms have improved dramatically. We're both committed to using it daily.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8.8
9.5
Cured back pain
Most Useful Review
Very great! After I started taking niacin for better sleep, my long-standing bone pain disappeared. I often struggled to lie on my back and woke frequently, but now I sleep soundly without discomfort. Notably, my husband began taking it too, and it has significantly aided him in battling his potential collagen disease. I was initially sceptical, but I found the pain eased almost immediately after starting niacin – it’s now essential for both of us.
Eczema details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.8
9.5
Improved symptoms
Most Useful Review
Niacin flush-free has significantly improved my atopic dermatitis, which I've struggled with for many years. Despite using steroids and moisturisers, I endured itching, redness, and eczema. After discovering Niacin Flash Free, which is said to help break down histamine, I started taking one tablet twice daily. Within a month, I noticed a clear reduction in itching and redness, and my eczema has gradually lessened. Other supplements may have also contributed positively, but my symptoms have improved markedly, allowing me to wear black clothing without anxiety. I find Niacin Flash Free truly effective for treating my eczema.
Allergies details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.7
9.5
Diminished food allergies
Most Useful Review
A niacin deficiency apparently hindered my serotonin production. After supplementation, I noticed improved mental stability and posture. Surprisingly, my food allergies have also improved significantly, and the scratches I used to have on my skin while sleeping have nearly disappeared.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 5 Reviews
8.7
8
Niacin may lower osteoarthritis risk
Association between niacin intake and osteoarthritis in the US population based on NHANES 1999-2018.
Most Relevant Research
We aimed to understand the relationship between niacin intake and osteoarthritis (OA) by analyzing data from the National Health and Nutrition Examination Survey spanning from 1999 to 2018. With over 30,000 participants in the study and almost 2,000 diagnosed with osteoarthritis, we found some interesting results.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
9.5
Provides arthritis relief
Most Useful Review
Great for arthritis! The flush variety of niacin aids circulation and may reduce allergies. However, I appreciate the non-flush variant as it provides relief from arthritis without the discomfort. I find it essential for my mobility; I can hardly walk without it. It works brilliantly!
Chest Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.7
8.8
Chest pain gone
Most Useful Review
Very effective! There’s no flushing at all, and my chest pain during physical exertion has disappeared. However, I do wonder if 500mg might be too strong for my liver.
Dizziness details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Significant dizziness relief
Most Useful Review
When I gave my family member with hay fever regular niacin (500 mg) for the first time, I experienced stinging in my eyes and face, followed by severe dizziness and nausea. My neighbour also had stinging eyes. I even collapsed at the mall, prompting an ambulance ride to the hospital. Once there, I vomited significantly, which I rarely do, but afterwards, I felt revitalised and all my symptoms vanished. Surprisingly, this has worked quite effectively for them. Now, I’m giving a different formulation that doesn’t cause adverse reactions, and it seems to be fine.
High Cholesterol details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 71 Reviews
8.7
9
Inositol boosts growth and health
Inositol Inclusion Affects Growth, Body Composition, Antioxidant Performance, and Lipid Metabolism of Largemouth Bass ().
Most Relevant Research
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
9.5
Reduces back pain
Most Useful Review
This product has been fantastic! Since I began taking niacin for better sleep, my chronic back pain has vanished. I now sleep soundly through the night. My husband, who started taking it too, received alarming news about his potential collagen disease but has shown improvement since we began. Niacin has significantly alleviated our pains.
Knee Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Knee injury recovery
Most Useful Review
My knee is numb due to an injury, and I'm taking 6g of Niacin daily. I find it greatly helps with recovery and alleviating knee pain. I haven't experienced any side effects, and I intend to continue using it.
Acne details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
Myo-inositol improves acne symptoms
Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome.
Most Relevant Research
We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
9.5
Reduced pimples
Most Useful Review
I purchased this on my cosmetologist's recommendation! Niacinamide helps regulate sebum production, and its antimicrobial and anti-inflammatory properties lessen the activity of acne-causing bacteria. It diminishes redness, reduces the number of spots, and aids in healing acne scars. After taking it for a month, I noticed significantly fewer spots on my face; it could be my new skincare routine or these vitamins.
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 18 Reviews
8.6
9
Inositol protects against cardiac damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Most Relevant Research
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
9.5
Back pain relief
Most Useful Review
Very good! Since I started taking niacin for better sleep, my long-standing back pain has vanished. Initially, I had trouble lying on my back and woke frequently at night, but now I sleep soundly. My husband, who began taking it too, was informed by his doctor about a potential collagen disease. After extensive research, we decided to supplement with niacin, and the pain nearly disappeared the next day. It’s now essential for both of us.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 18 Reviews
8.6
8
Myo-inositol: Depression treatment potential
Cyclitols: From Basic Understanding to Their Association with Neurodegeneration.
Most Relevant Research
We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
8.8
Effective treatment
Most Useful Review
It's great for managing depression, and being flush-free makes it even more comfortable to take.
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 26 Reviews
8.6
8
Inositol boosts heart protective adiponectin
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
Most Relevant Research
Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
9.5
Helps with circulation
Most Useful Review
Niacin is effective for high cholesterol and aids in circulation issues, migraines, and digestive problems. It also assists those seeking to pass drug tests. Niacinamide treats diabetes and skin conditions. It's beneficial for schizophrenia, memory issues, and heart disease, making it a versatile and valuable supplement.
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.5
8.8
No niacin flush
Most Useful Review
Having used niacin for some time, I would experience a flush, leading me to take it at night, but it disrupted my sleep. I tried this flash-free version, and it worked well without causing any flush, allowing me to drink it at any time. It’s ideal for those who suffer from flush.
Headache details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.5
9.5
No more headaches
Most Useful Review
Taking normal niacin gave me headaches, but this variant does not cause that issue at all. I highly recommend it to anyone who experiences similar headaches.
Hives details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.5
8.8
Skin problems resolved
Most Useful Review
I no longer get hives! I experienced flushes when taking niacin, so I bought Flash Free. After a year of use, the frequent hives have vanished! It's recommended for those with skin issues!
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
Supplement improves IBS symptoms
Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome.
Most Relevant Research
We explored how a mixture of beta-glucan, inositol, and digestive enzymes could alleviate gastrointestinal symptoms in patients with inflammatory bowel disease (IBD) and concurrent irritable bowel syndrome (IBS).
The study involved 43 patients who were already in clinical remission and treated only with mesalamine. They were divided into two groups: one received the usual treatment plus the supplement, while the other only received the standard care.
After four weeks, we observed notable improvements in symptoms such as bloating, flatulence, and abdominal pain in the group taking the supplement. Our findings suggest that this combination may significantly enhance the overall well-being of IBD-IBS patients, making their daily lives a bit easier.
The study involved 43 patients who were already in clinical remission and treated only with mesalamine. They were divided into two groups: one received the usual treatment plus the supplement, while the other only received the standard care.
After four weeks, we observed notable improvements in symptoms such as bloating, flatulence, and abdominal pain in the group taking the supplement. Our findings suggest that this combination may significantly enhance the overall well-being of IBD-IBS patients, making their daily lives a bit easier.
8.8
Calms anxiety
Most Useful Review
B3 plays a crucial role in metabolising carbohydrates, lipids, and proteins while assisting oxidation in the body. It supports normal nervous system function, calms nerves, alleviates irritability and anxiety, and improves insomnia linked to depression. B3 also aids intestinal digestion and promotes oral, skin, and tongue health, while contributing to hormone synthesis and lowering cholesterol.
Kidney Stones details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
Inositol shows promise for nephropathies
Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies.
Most Relevant Research
We explored the potential of inositol hexakisphosphate (IP6) and its analogues as a treatment for calcium oxalate (CaOx) nephropathies, conditions often linked to kidney stones. Our study utilized a new machine learning approach that helped screen various chemical modifications of IP6 to find a particularly effective compound.
This innovative method led us to identify a divalent inositol phosphate that demonstrated remarkable activity. In our findings, this molecule completely inhibited the crystallization of CaOx crystals at very low concentrations. Additionally, it significantly reduced the interaction between crystals and kidney cells, preventing harmful changes in gene expression related to kidney damage.
We observed that, in a mouse model experiencing increased levels of oxalate, the IP6 analogue reduced crystal formation and subsequent kidney injury. With these promising results, we believe that these inositol analogues may offer a new therapeutic option for those suffering from calcium oxalate-related kidney issues.
This innovative method led us to identify a divalent inositol phosphate that demonstrated remarkable activity. In our findings, this molecule completely inhibited the crystallization of CaOx crystals at very low concentrations. Additionally, it significantly reduced the interaction between crystals and kidney cells, preventing harmful changes in gene expression related to kidney damage.
We observed that, in a mouse model experiencing increased levels of oxalate, the IP6 analogue reduced crystal formation and subsequent kidney injury. With these promising results, we believe that these inositol analogues may offer a new therapeutic option for those suffering from calcium oxalate-related kidney issues.
8.8
Kidney health improved
Most Useful Review
The quality and ingredients are excellent. It helps improve low-density lipoprotein, protects kidney health, and maintains normal metabolism. With 180 capsules in a bottle, it's more than sufficient. My mother has been taking it for a few months and has responded positively. I would definitely consider purchasing it again.
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.5
7
Myo-Inositol Support in Menopause
Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle.
Most Relevant Research
We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
9.5
Symptoms relieved
Most Useful Review
Excellent high-quality niacin improves conditions during menopause. It alleviates hot flashes and enhances overall well-being while normalising the nervous system's functioning. With its natural composition and high dosage, it compensates for any deficiencies. The taste is neutral, and the size is easy to swallow; plus, the packaging is sizeable.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
7
Niacin may reduce migraine risk
Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey.
Most Relevant Research
We examined the link between dietary niacin intake and migraine occurrences by analyzing data from the National Health and Nutrition Examination Survey. This study focused on adults over 20 years old, looking specifically at their reported experiences with severe headaches and the amount of niacin they consume daily.
Among the 10,246 participants, we found that 20.1% reported having migraines. Those who had a higher intake of niacin showed a lower likelihood of experiencing migraines. For instance, compared to individuals with the lowest niacin intake, those in higher intake categories (Q2, Q3, and Q4) had significantly reduced odds of suffering from migraines. The results indicated that increasing dietary niacin had a favorable effect, suggesting an L-shaped curve relationship where the optimal intake appears to be around 21 mg per day.
This study highlighted a possible connection between niacin consumption and migraine prevention, indicating that moderate levels might play a protective role. However, it’s important to approach these findings cautiously, as they don’t establish cause and effect directly. Further research could illuminate how dietary choices might influence migraine frequency and severity.
Among the 10,246 participants, we found that 20.1% reported having migraines. Those who had a higher intake of niacin showed a lower likelihood of experiencing migraines. For instance, compared to individuals with the lowest niacin intake, those in higher intake categories (Q2, Q3, and Q4) had significantly reduced odds of suffering from migraines. The results indicated that increasing dietary niacin had a favorable effect, suggesting an L-shaped curve relationship where the optimal intake appears to be around 21 mg per day.
This study highlighted a possible connection between niacin consumption and migraine prevention, indicating that moderate levels might play a protective role. However, it’s important to approach these findings cautiously, as they don’t establish cause and effect directly. Further research could illuminate how dietary choices might influence migraine frequency and severity.
9.5
Improved health
Most Useful Review
Niacin has been excellent; I no longer experience hot flashes like I did with the usual form, which left me red and overheated. My overall health has improved, and I have noticed a decrease in migraines.
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Good
Based on 27 Reviews
8.4
8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Most Relevant Research
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
9.5
Decreased anxiety
Most Useful Review
I purchased this for a teenager with anxiety. Initially, I was on medication, but I tried niacinamide to reduce my dosage. After three months, I started taking 100mg of niacin, two tablets after meals. I’ve adapted to it, and my anxiety has significantly decreased, allowing me to stop my hospital medication. The niacin seems to work well; I’ll soon try niacin 500mg for future prevention. I’m smiling more and feeling brighter, all without side effects, so I’ll keep using it.
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Most Relevant Research
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
7.5
Assists cancer treatment
Most Useful Review
Cornsine is beneficial in the battle against cancer; I genuinely hope to assist my friends!
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
8.8
Fatigue alleviated
Most Useful Review
After hearing that niacin is effective for fatigue, I started taking it two weeks ago. It seems to help – I find it less difficult to manage my fatigue than before. The no-flush formula avoids the unwanted redness effect, making it a comfortable choice. I recommend it for those suffering from fatigue.
Nausea details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 10 Reviews
8.3
9
Niacin alleviates nausea-like symptoms
Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra.
Most Relevant Research
We investigated how niacin affects nausea in mice suffering from a condition similar to pellagra. To mimic this condition, we fed the mice a low-niacin diet and administered isoniazid, a drug known to induce symptoms characteristic of niacin deficiency.
In our study, we observed that mice on a low-niacin diet displayed signs of nausea through pica behavior—a common way to assess nausea in rodents. Importantly, this behavior was not present in mice that continued to receive a normal diet.
After administering niacin as a treatment, we found that it effectively prevented the pica behavior and helped restore normal levels of certain metabolites affected by isoniazid. These findings suggest that niacin supplementation can significantly alleviate nausea-like symptoms associated with pellagra in our mouse model.
Overall, we’re excited that our newly established method for measuring pica could be an essential tool for understanding nausea associated with dietary deficiencies.
In our study, we observed that mice on a low-niacin diet displayed signs of nausea through pica behavior—a common way to assess nausea in rodents. Importantly, this behavior was not present in mice that continued to receive a normal diet.
After administering niacin as a treatment, we found that it effectively prevented the pica behavior and helped restore normal levels of certain metabolites affected by isoniazid. These findings suggest that niacin supplementation can significantly alleviate nausea-like symptoms associated with pellagra in our mouse model.
Overall, we’re excited that our newly established method for measuring pica could be an essential tool for understanding nausea associated with dietary deficiencies.
9.5
No more nausea
Most Useful Review
I had stomach pain and nausea previously when taking niacinamide, so I opted for this flash-free option. I take one tablet after each meal and haven't encountered any issues thus far. After consuming it, my hands and feet felt slightly warm, which was quite pleasant.
Gout details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.2
8
Rebixiao granules reduced gout symptoms
Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis.
Most Relevant Research
We observed the effectiveness of Rebixiao granules, which include niacin, in treating patients with repeatedly attacking acute gouty arthritis. In the study, 90 patients were split into two groups. The first group received Rebixiao granule treatment, while the second group was given traditional anti-inflammatory tablets. Both groups also followed standard treatments like dietary changes and hydration.
One interesting aspect was the animal study that involved administering hypoxanthine and niacin to mice. This helped establish a model to see how these treatments affected uric acid levels in the blood. The results showed that Rebixiao granules were effective at reducing blood uric acid and had quicker results than just anti-inflammatory treatments alone. However, while niacin was part of the treatment, the study does not clarify its isolated impact on gout as it was combined with other ingredients.
Overall, we found that Rebixiao granules, possibly aided by niacin, were beneficial for gout patients without significant side effects. This indicates a promising option for managing gout symptoms and preventing future attacks.
One interesting aspect was the animal study that involved administering hypoxanthine and niacin to mice. This helped establish a model to see how these treatments affected uric acid levels in the blood. The results showed that Rebixiao granules were effective at reducing blood uric acid and had quicker results than just anti-inflammatory treatments alone. However, while niacin was part of the treatment, the study does not clarify its isolated impact on gout as it was combined with other ingredients.
Overall, we found that Rebixiao granules, possibly aided by niacin, were beneficial for gout patients without significant side effects. This indicates a promising option for managing gout symptoms and preventing future attacks.
8.8
Helps with hormones
Most Useful Review
Niacin, also known as vitamin B3, is a remarkable supplement. I take it during menopause, as it doesn't trigger hot flashes like regular vitamin B3. It aids those with hormone issues, helps with gout, and improves blood microcirculation. I wish you all good health.
Insomnia details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.2
7.5
Improved sleep quality
Most Useful Review
Niacin for insomnia. I initially took niacinamide, but when I switched to this non-flush type niacin, I could stop using sleeping pills smoothly. I began with 500mg and increased it to 3000mg. Along with it, I also take two-pardy, magnesium, vitamin B12, etc.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
9.5
Pain relief observed
Most Useful Review
Since using this product, I’ve noticed less pain in my legs, and the spider veins are starting to decrease. I’m very satisfied!
Autoimmune Disorder details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
USERS' SCORE
Good
Based on 18 Reviews
8.1
8
Myo-inositol enhances vitamin D effects
The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study.
Most Relevant Research
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
9.5
Lameness improvement
Most Useful Review
I started taking Niacin Flush for preventive purposes under Dr. Tokumi Fujikawa's approach. I noticed an improvement in blood flow in my right leg; my lameness has improved significantly. Niacin's vasodilatory effects are evident; while results may vary, I believe it is worthwhile.
Heart Attack details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.1
9
ITPP enhances heart attack recovery
Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells.
Most Relevant Research
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
8.8
Clears blood vessels
Most Useful Review
Due to coronary heart disease, I have significant blockages in my blood vessels. I know niacin aids in clearing these, and I've experienced minimal flushes. I trust its quality, and it hasn’t affected my allergies.
Blood Clot details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 4 Reviews
8
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Most Relevant Research
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
9
Lowers cholesterol
Most Useful Review
No flushing issues; the effect is decent, so I’ll keep taking it. Niacin is known for reducing blood lipids and enhancing good cholesterol while lowering bad cholesterol. My family, who has diabetes, is keen on controlling blood lipids without prescriptions. This product doesn’t cause flushing, and my family feels well after a while, with test results improving. I’ll continue observing the effects!
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.9
9.5
Reduced stress
Most Useful Review
I started taking this for stress-induced sleeplessness. I'm pleased to say it has helped alleviate my heart palpitations and shortness of breath, allowing me to sleep better at night. My overall sense of relief has improved significantly.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.6
8
Myo-inositol improves insulin resistance
The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.
Most Relevant Research
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
8.3
Helpful symptoms improvement
Most Useful Review
Helpful for my disease symptoms. There is no flushing or itching, and as my doctor says, it significantly aids in alleviating my liver disease symptoms.
