' 
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
8
Niacin may lower osteoarthritis risk
Association between niacin intake and osteoarthritis in the US population based on NHANES 1999-2018.
Focused niacin and arthritis impact
We aimed to understand the relationship between niacin intake and osteoarthritis (OA) by analyzing data from the National Health and Nutrition Examination Survey spanning from 1999 to 2018. With over 30,000 participants in the study and almost 2,000 diagnosed with osteoarthritis, we found some interesting results.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
Read More
8
Dietary niacin linked to RA
Association Between Dietary Niacin Intake and Rheumatoid Arthritis in American Women: A Study Based on National Health and Nutrition Examination Survey Database.
Study shows niacin's isolated impact
We explored the relationship between dietary niacin intake and rheumatoid arthritis (RA) in American women using data from the National Health and Nutrition Examination Survey. By analyzing data collected from 2003 to 2016, we aimed to understand whether higher levels of niacin could lead to a decrease in the prevalence of RA.
Our findings revealed that women with RA had lower dietary niacin intakes compared to those without the condition. Specifically, we observed a significant negative correlation between niacin intake and the likelihood of having RA. This means that as dietary niacin intake increased, the odds of having RA decreased.
Notably, we found that the association was particularly strong among women aged 40 and above, those with a poverty income ratio greater than 3.5, women with at least a college education, and individuals who were obese or non-smokers. These insights suggest that dietary niacin could be an important dietary consideration for reducing the risk of RA in specific groups of women.
Our findings revealed that women with RA had lower dietary niacin intakes compared to those without the condition. Specifically, we observed a significant negative correlation between niacin intake and the likelihood of having RA. This means that as dietary niacin intake increased, the odds of having RA decreased.
Notably, we found that the association was particularly strong among women aged 40 and above, those with a poverty income ratio greater than 3.5, women with at least a college education, and individuals who were obese or non-smokers. These insights suggest that dietary niacin could be an important dietary consideration for reducing the risk of RA in specific groups of women.
Read More
9
SHIP1 inhibition may relieve RA
Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.
Limited relevance to inositol treatment
We explored how inhibiting a specific lipid phosphatase known as SHIP1 could potentially help in treating rheumatoid arthritis (RA). This study primarily investigated the impact of using a SHIP1 inhibitor on the expansion of myeloid-derived suppressor cells (MDSCs) in a mouse model that mimics the symptoms of RA. By employing a small molecule called 3α-aminocholestane (3AC), we observed a significant increase in MDSCs within the treated mice. This increase seemed to correlate with a noticeable reduction in both the severity and incidence of arthritis symptoms.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Read More
Most Useful Reviews
9.5
Provides arthritis relief
Great for arthritis! The flush variety of niacin aids circulation and may reduce allergies. However, I appreciate the non-flush variant as it provides relief from arthritis without the discomfort. I find it essential for my mobility; I can hardly walk without it. It works brilliantly!
Read More
8.8
Helps with arthritis
Very good! No flushing. This water-soluble vitamin plays an important role in metabolism, the nervous system, and digestion, while lowering LDL cholesterol, increasing HDL cholesterol, and reducing triglycerides. Niacin may also help treat arthritis symptoms. The typical dose is 500mg at bedtime, and your doctor might increase it every four weeks, maintaining a maximum of 2000mg per day. Taking niacin also addresses deficiencies but should be paired with a balanced diet.
Read More
9.5
Pain relief achieved
Good quality niacin! I only wish larger packages were available since I consume them quickly. Niacin and Vitamin C taken multiple times daily have made my rheumatoid arthritis pain-free and placed me in remission. Although I've read that the non-flush free pill might be more effective, I prefer the flush-free option as the flushes are uncomfortable.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
SHIP1 inhibition may relieve RA
Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.
Limited relevance to inositol treatment
We explored how inhibiting a specific lipid phosphatase known as SHIP1 could potentially help in treating rheumatoid arthritis (RA). This study primarily investigated the impact of using a SHIP1 inhibitor on the expansion of myeloid-derived suppressor cells (MDSCs) in a mouse model that mimics the symptoms of RA. By employing a small molecule called 3α-aminocholestane (3AC), we observed a significant increase in MDSCs within the treated mice. This increase seemed to correlate with a noticeable reduction in both the severity and incidence of arthritis symptoms.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Read More
8
Niacin may lower osteoarthritis risk
Association between niacin intake and osteoarthritis in the US population based on NHANES 1999-2018.
Focused niacin and arthritis impact
We aimed to understand the relationship between niacin intake and osteoarthritis (OA) by analyzing data from the National Health and Nutrition Examination Survey spanning from 1999 to 2018. With over 30,000 participants in the study and almost 2,000 diagnosed with osteoarthritis, we found some interesting results.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
Read More
8
Dietary niacin linked to RA
Association Between Dietary Niacin Intake and Rheumatoid Arthritis in American Women: A Study Based on National Health and Nutrition Examination Survey Database.
Study shows niacin's isolated impact
We explored the relationship between dietary niacin intake and rheumatoid arthritis (RA) in American women using data from the National Health and Nutrition Examination Survey. By analyzing data collected from 2003 to 2016, we aimed to understand whether higher levels of niacin could lead to a decrease in the prevalence of RA.
Our findings revealed that women with RA had lower dietary niacin intakes compared to those without the condition. Specifically, we observed a significant negative correlation between niacin intake and the likelihood of having RA. This means that as dietary niacin intake increased, the odds of having RA decreased.
Notably, we found that the association was particularly strong among women aged 40 and above, those with a poverty income ratio greater than 3.5, women with at least a college education, and individuals who were obese or non-smokers. These insights suggest that dietary niacin could be an important dietary consideration for reducing the risk of RA in specific groups of women.
Our findings revealed that women with RA had lower dietary niacin intakes compared to those without the condition. Specifically, we observed a significant negative correlation between niacin intake and the likelihood of having RA. This means that as dietary niacin intake increased, the odds of having RA decreased.
Notably, we found that the association was particularly strong among women aged 40 and above, those with a poverty income ratio greater than 3.5, women with at least a college education, and individuals who were obese or non-smokers. These insights suggest that dietary niacin could be an important dietary consideration for reducing the risk of RA in specific groups of women.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Provides arthritis relief
Great for arthritis! The flush variety of niacin aids circulation and may reduce allergies. However, I appreciate the non-flush variant as it provides relief from arthritis without the discomfort. I find it essential for my mobility; I can hardly walk without it. It works brilliantly!
8.8
Helps with arthritis
Very good! No flushing. This water-soluble vitamin plays an important role in metabolism, the nervous system, and digestion, while lowering LDL cholesterol, increasing HDL cholesterol, and reducing triglycerides. Niacin may also help treat arthritis symptoms. The typical dose is 500mg at bedtime, and your doctor might increase it every four weeks, maintaining a maximum of 2000mg per day. Taking niacin also addresses deficiencies but should be paired with a balanced diet.
Read More
9.5
Pain relief achieved
Good quality niacin! I only wish larger packages were available since I consume them quickly. Niacin and Vitamin C taken multiple times daily have made my rheumatoid arthritis pain-free and placed me in remission. Although I've read that the non-flush free pill might be more effective, I prefer the flush-free option as the flushes are uncomfortable.
Read More
8.8
Significant improvement
Niacin combined with apple pectin has considerably improved several types of rheumatoid arthritis over six years. I recommend it for anyone struggling with similar conditions.
8.8
Helpful for arthritis
I started taking niacin for rheumatoid arthritis, and its flash-free formula has been really beneficial for me.
