Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
8
Myo-inositol enhances vitamin D effects
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
Read More
4
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Read More
4
Inositol's impact on autoimmune thyroid
We set out to explore the effects of a combination of selenium and inositol on thyroid function and autoimmune characteristics in people with thyroid disorders. Through our systematic search spanning numerous databases, we reviewed studies published from 2007 to 2022, focusing on how these supplements influence thyroid health.
The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.
Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.
Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
Read More
Most Useful Reviews
9
Lameness improvement
1 people found this helpful
I started taking Niacin Flush for preventive purposes under Dr. Tokumi Fujikawa's approach. I noticed an improvement in blood flow in my right leg; my lameness has improved significantly. Niacin's vasodilatory effects are evident; while results may vary, I believe it is worthwhile.
Read More
9
Good quality price
This affordable niacin suits me well; the price matches the quality, and I'll definitely order it again.
Read More
9
Panic disorder improvement
9 people found this helpful
This supplement effectively improved my panic disorder. I take one tablet each morning, noon, and evening along with vitamin C. By following Fujikawa's blog and practices, I have managed to stop almost all my medications after ten years of struggle with panic.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
- All Researches
8
Our exploration focused on how Myoinositol, often known as Myo, impacts autoimmune disorders, particularly autoimmune thyroiditis. We learned that Myo plays a crucial role in the body's thyroid function by aiding in the production of thyroid hormones and regulating iodine, which is essential in this process.
Interestingly, when Myo was combined with Selenium in treatment, patients with subclinical hypothyroidism showed significant decreases in thyroid-stimulating hormone (TSH) levels. Additionally, levels of antithyroid autoantibodies also dropped, which is promising for those battling autoimmune thyroid issues.
However, it is important to note that the study did not exclusively isolate the effect of Myoinositol, as the results were observed in conjunction with Selenium. Therefore, while the findings are encouraging, we cannot definitively claim that Myo alone yields the same benefits in managing autoimmune disorders.
Interestingly, when Myo was combined with Selenium in treatment, patients with subclinical hypothyroidism showed significant decreases in thyroid-stimulating hormone (TSH) levels. Additionally, levels of antithyroid autoantibodies also dropped, which is promising for those battling autoimmune thyroid issues.
However, it is important to note that the study did not exclusively isolate the effect of Myoinositol, as the results were observed in conjunction with Selenium. Therefore, while the findings are encouraging, we cannot definitively claim that Myo alone yields the same benefits in managing autoimmune disorders.
Read More
8
Myo-inositol enhances vitamin D effects
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
Read More
4
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Read More
4
Inositol's impact on autoimmune thyroid
We set out to explore the effects of a combination of selenium and inositol on thyroid function and autoimmune characteristics in people with thyroid disorders. Through our systematic search spanning numerous databases, we reviewed studies published from 2007 to 2022, focusing on how these supplements influence thyroid health.
The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.
Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.
Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
Read More
4
We explored the effects of myo-inositol as part of a treatment regimen for young women with Hashimoto's thyroiditis—an autoimmune disorder. This study primarily compared the sexual functioning and depressive symptoms of women who were untreated versus those receiving various supplements including vitamin D and selenomethionine alongside myo-inositol.
While all treatment groups showed improved sexual functioning and well-being compared to the untreated women, we observed that the greatest benefits came from those receiving vitamin D. Additionally, there were no significant differences in sexual functioning and depressive symptoms between the myo-inositol and selenomethionine treatment groups.
As a result, we must note that myo-inositol's isolated effect was not clearly determined in this study due to its combination with other treatments. Therefore, while myo-inositol is seen as part of a broader therapy, its specific influence on autoimmune disorders warrants further investigation.
While all treatment groups showed improved sexual functioning and well-being compared to the untreated women, we observed that the greatest benefits came from those receiving vitamin D. Additionally, there were no significant differences in sexual functioning and depressive symptoms between the myo-inositol and selenomethionine treatment groups.
As a result, we must note that myo-inositol's isolated effect was not clearly determined in this study due to its combination with other treatments. Therefore, while myo-inositol is seen as part of a broader therapy, its specific influence on autoimmune disorders warrants further investigation.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lameness improvement
1 people found this helpful
I started taking Niacin Flush for preventive purposes under Dr. Tokumi Fujikawa's approach. I noticed an improvement in blood flow in my right leg; my lameness has improved significantly. Niacin's vasodilatory effects are evident; while results may vary, I believe it is worthwhile.
Read More
9
Good quality price
This affordable niacin suits me well; the price matches the quality, and I'll definitely order it again.
Read More
9
Panic disorder improvement
9 people found this helpful
This supplement effectively improved my panic disorder. I take one tablet each morning, noon, and evening along with vitamin C. By following Fujikawa's blog and practices, I have managed to stop almost all my medications after ten years of struggle with panic.
Read More
7.5
Sleep disorder aid
8 people found this helpful
I’ve struggled with a sleep disorder for nearly 20 years, often finding it hard to fall asleep. After starting niacin, my sleep has gradually improved. I previously tried higher doses but experienced uncomfortable flashes, which led me to this flash-free option. My sleep quality has significantly enhanced, reducing my irritability and anxiety levels.
Read More
7.5
Bipolar disorder support
7 people found this helpful
I recommend this for mental stability in conditions like frustration and anxiety. As someone with bipolar disorder who practices megavitamin therapy, I've noted differences in effects among niacin's various forms. Although I am sensitive, and do experience some flashes, this supplement alongside others has helped me achieve a more stable mental state.
Read More
Frequently Asked Questions
7.5
Panic disorder recovery
2 people found this helpful
I’ve been practising the Fujikawa method to recover from panic disorder. Six months ago, I discovered this supplement through my doctor's molecular nutrition approach. After starting with Niacinamide, I’ve now switched to Niacin Flash Free and have noticed significant stability in my mental state over the previous months.
7.5
Bipolar disorder support
7 people found this helpful
I recommend this for mental stability in conditions like frustration and anxiety. As someone with bipolar disorder who practices megavitamin therapy, I've noted differences in effects among niacin's various forms. Although I am sensitive, and do experience some flashes, this supplement alongside others has helped me achieve a more stable mental state.
2
No effect noticed
I bought this to help with my sleep disorder but haven't noticed any particular benefits yet. One bottle may not be sufficient for effects.
7.5
Tic disorder alleviation
4 people found this helpful
Since my son began taking this supplement for his tic disorder, his symptoms have noticeably decreased. Although he’s yet to establish a consistent routine with supplements, any lapse results in symptom recurrence, indicating their positive effect.
9
Panic disorder improvement
9 people found this helpful
This supplement effectively improved my panic disorder. I take one tablet each morning, noon, and evening along with vitamin C. By following Fujikawa's blog and practices, I have managed to stop almost all my medications after ten years of struggle with panic.
7.5
Sleep disorder aid
8 people found this helpful
I’ve struggled with a sleep disorder for nearly 20 years, often finding it hard to fall asleep. After starting niacin, my sleep has gradually improved. I previously tried higher doses but experienced uncomfortable flashes, which led me to this flash-free option. My sleep quality has significantly enhanced, reducing my irritability and anxiety levels.
7.5
Blood vessel health
1 people found this helpful
I used this as prescribed by my doctor for vascular and eye health, and it worked remarkably well. I also noticed improvements in my brain function and memory. I will certainly be ordering this again.
0
Ineffective product
5 people found this helpful
This product has no effects; it’s a waste of money. It doesn't offer the benefits of true niacin, which requires time-release or immediate-release forms for cholesterol and triglyceride benefits. I should have researched more before purchasing.
7.5
Calming improvement
1 people found this helpful
Regular niacin causes flushing, so I opted for this Flash Free version. I take two tablets three times daily. I’ve noticed a calming effect, and symptoms resembling an autoimmune disorder have begun to improve.
7.5
Bipolar stabilisation
6 people found this helpful
I recently noticed some stabilisation in my daughter with bipolar disorder after giving her a niacin supplement. Thus, I purchased this larger, cost-effective option to continue supporting her treatment.
4
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
8
Our exploration focused on how Myoinositol, often known as Myo, impacts autoimmune disorders, particularly autoimmune thyroiditis. We learned that Myo plays a crucial role in the body's thyroid function by aiding in the production of thyroid hormones and regulating iodine, which is essential in this process.
Interestingly, when Myo was combined with Selenium in treatment, patients with subclinical hypothyroidism showed significant decreases in thyroid-stimulating hormone (TSH) levels. Additionally, levels of antithyroid autoantibodies also dropped, which is promising for those battling autoimmune thyroid issues.
However, it is important to note that the study did not exclusively isolate the effect of Myoinositol, as the results were observed in conjunction with Selenium. Therefore, while the findings are encouraging, we cannot definitively claim that Myo alone yields the same benefits in managing autoimmune disorders.
Interestingly, when Myo was combined with Selenium in treatment, patients with subclinical hypothyroidism showed significant decreases in thyroid-stimulating hormone (TSH) levels. Additionally, levels of antithyroid autoantibodies also dropped, which is promising for those battling autoimmune thyroid issues.
However, it is important to note that the study did not exclusively isolate the effect of Myoinositol, as the results were observed in conjunction with Selenium. Therefore, while the findings are encouraging, we cannot definitively claim that Myo alone yields the same benefits in managing autoimmune disorders.
8
Myo-inositol enhances vitamin D effects
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
References
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Yavari M, Akbari M, Ramezani Ahmadi A, Siavash Dastjerdi M, Hashemi MS. Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis. Expert Rev Endocrinol Metab. 2024;19:269. doi:10.1080/17446651.2023.2295487
- Krysiak R, Kowalcze K, Szkróbka W, Okopień B. Sexual Function and Depressive Symptoms in Young Women with Euthyroid Hashimoto's Thyroiditis Receiving Vitamin D, Selenomethionine and Myo-Inositol: A Pilot Study. Nutrients. 2023;15. doi:10.3390/nu15122815
- Paparo SR, Ferrari SM, Patrizio A, Elia G, Ragusa F, et al. Myoinositol in Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756
- Krysiak R, Kowalcze K, Okopień B. The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study. J Clin Pharm Ther. 2022;47:1759. doi:10.1111/jcpt.13730
