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We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.
Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
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Interestingly, when Myo was combined with Selenium in treatment, patients with subclinical hypothyroidism showed significant decreases in thyroid-stimulating hormone (TSH) levels. Additionally, levels of antithyroid autoantibodies also dropped, which is promising for those battling autoimmune thyroid issues.
However, it is important to note that the study did not exclusively isolate the effect of Myoinositol, as the results were observed in conjunction with Selenium. Therefore, while the findings are encouraging, we cannot definitively claim that Myo alone yields the same benefits in managing autoimmune disorders.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.
Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
While all treatment groups showed improved sexual functioning and well-being compared to the untreated women, we observed that the greatest benefits came from those receiving vitamin D. Additionally, there were no significant differences in sexual functioning and depressive symptoms between the myo-inositol and selenomethionine treatment groups.
As a result, we must note that myo-inositol's isolated effect was not clearly determined in this study due to its combination with other treatments. Therefore, while myo-inositol is seen as part of a broader therapy, its specific influence on autoimmune disorders warrants further investigation.
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Frequently Asked Questions
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
B3, also known as niacin or nicotinic acid, is a water-soluble vitamin that is part of the B-vitamin complex. It plays a crucial role in converting food into energy by helping to transform carbohydrates, fats, and proteins into usable energy. Additionally, niacin is essential for maintaining healthy skin, nerves, and digestion. It assists in the production of certain hormones and cholesterol in the body, which can contribute to overall cardiovascular health.
Niacin can be found in a variety of foods, including meat, fish, poultry, whole grains, and legumes. The body can also synthesize niacin from the amino acid tryptophan, which can be found in high-protein foods. While most people get enough niacin through their diet, some individuals, particularly those with specific health conditions, may require supplements. However, it is essential to consult a healthcare professional before starting any supplementation, as excessive intake can lead to side effects such as skin flushing, itching, and gastrointestinal issues.
Based on user reviews, the time frame for seeing results from this supplement can vary significantly from person to person. Some users, like one who has been practicing the Fujikawa method for panic disorder, reported significant improvements after about six months of consistent use ((Read Review)). Others have seen noticeable effects, such as improved anxiety and mental stability, within a few weeks to months ((Read Review)), while some were still waiting for results after one bottle, suggesting that it might take longer for the intended effects to manifest ((Read Review)).
In general, users emphasize the importance of consistency in taking the supplement. One user noted that their son experienced a decrease in symptoms only when he maintained a regular intake, indicating that continuity may play a crucial role in effectiveness ((Read Review)). Overall, while results can be varied, many users recommend giving it at least a few weeks to a couple of months to gauge its full impact on conditions such as autoimmune disorders.
Myo-inositol has been studied for its potential role in managing autoimmune disorders, particularly in conditions like Hashimoto's thyroiditis. However, the evidence supporting its efficacy as a standalone treatment appears to be limited. Research shows that while selenium supplementation significantly benefits thyroid health by reducing thyroid autoantibody levels, the effects of myo-inositol alone have not been as promising. In a study that evaluated the impact of inositol on thyroid autoantibodies, it was found that myo-inositol did not lead to significant reductions in levels of thyroid peroxidase or thyroglobulin autoantibodies, which suggests it may not be effective in lowering autoantibody levels associated with autoimmune disorders ([1]).
Moreover, while combining myo-inositol with selenium has shown some mixed results—particularly in improving thyroid function markers—these effects were not robust enough to establish a clear benefit for managing autoimmune disorders. Additional studies indicated that while myo-inositol might enhance the impact of other treatments like vitamin D, the isolated benefits of myo-inositol remain unclear ([4], [5]). In conclusion, if you're considering myo-inositol for autoimmune conditions, it may be wise to consult with healthcare professionals, as current research emphasizes a greater role for selenium in effective treatment.
Based on user reviews, many individuals have reported notable improvements in their symptoms after using the niacin supplement. For instance, a user experiencing panic disorder mentioned that taking niacin helped them to stop almost all their medications after ten years of struggling, showcasing a significant shift in their mental health ((Read Review)). Another reviewer noted an impressive enhancement in their sleep quality after dealing with a sleep disorder for nearly 20 years, which also contributed to reduced irritability and anxiety levels ((Read Review)).
Moreover, users seeking relief from tic disorders have reported a noticeable decrease in symptoms when using this supplement, highlighting the potential positive effects of consistency in supplement intake ((Read Review)). A significant number of users have commented on improvements in vascular health, brain function, and overall energy levels, further supporting the supplement's beneficial impact ((Read Review)). While these anecdotal experiences suggest that niacin can be effective for various conditions, it's important to remember that individual results can vary. Not all users experienced positive effects; for some, the product did not meet their expectations ((Read Review)).
Based on user reviews, there appears to be a positive trend among individuals combining this niacin supplement with other vitamins and minerals to manage symptoms related to autoimmune disorders and other conditions. One user reported experiencing improvements in symptoms resembling an autoimmune disorder after taking the Flash Free version of niacin alongside proteins, vitamins, and minerals, noting a calming effect that helped them manage daily stressors more effectively ((Read Review)). Additionally, another user with bipolar disorder mentioned that taking niacin, in conjunction with other supplements, has led to a more stable mental state, demonstrating that synergy may exist between these supplements when used together ((Read Review)).
Moreover, users emphasize the importance of consistency in supplement intake. For instance, one parent observed that their son’s symptoms of tics improved significantly with regular use, indicating that maintaining a routine with various supplements, including niacin, can play a crucial role in enhancing their effectiveness ((Read Review)). While results may vary among individuals, many report satisfactory outcomes when combining niacin with other nutritional therapies, thus offering a holistic approach for those addressing conditions such as autoimmune disorders.
Based on user reviews, there seems to be a range of experiences and opinions regarding the appropriate dosage of B3 Niacin for treating autoimmune disorders. Some users have reported positive effects with specific dosages, such as taking two tablets three times daily of a flash-free version, which led to improvements in symptoms resembling an autoimmune disorder (Read Review). Others have shared that they achieved significant stabilization in mental conditions, such as bipolar disorder, after including niacin in their regimen, often accompanied by other supplements (Read Review).
It’s crucial to note that while some users achieved beneficial effects with regular doses, others reported discomfort with higher doses causing flushing (Read Review). As a result, individuals considering niacin should carefully monitor their reactions, possibly opting for lower doses or avoiding flush-inducing forms to find their ideal balance. Consulting with a healthcare professional for tailored advice could also enhance treatment efficacy and comfort levels.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Interestingly, when Myo was combined with Selenium in treatment, patients with subclinical hypothyroidism showed significant decreases in thyroid-stimulating hormone (TSH) levels. Additionally, levels of antithyroid autoantibodies also dropped, which is promising for those battling autoimmune thyroid issues.
However, it is important to note that the study did not exclusively isolate the effect of Myoinositol, as the results were observed in conjunction with Selenium. Therefore, while the findings are encouraging, we cannot definitively claim that Myo alone yields the same benefits in managing autoimmune disorders.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
References
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Yavari M, Akbari M, Ramezani Ahmadi A, Siavash Dastjerdi M, Hashemi MS. Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis. Expert Rev Endocrinol Metab. 2024;19:269. doi:10.1080/17446651.2023.2295487
- Krysiak R, Kowalcze K, Szkróbka W, Okopień B. Sexual Function and Depressive Symptoms in Young Women with Euthyroid Hashimoto's Thyroiditis Receiving Vitamin D, Selenomethionine and Myo-Inositol: A Pilot Study. Nutrients. 2023;15. doi:10.3390/nu15122815
- Paparo SR, Ferrari SM, Patrizio A, Elia G, Ragusa F, et al. Myoinositol in Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756
- Krysiak R, Kowalcze K, Okopień B. The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study. J Clin Pharm Ther. 2022;47:1759. doi:10.1111/jcpt.13730
