Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Medium or Average
Based on 17 Reviews
6.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
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Top Medical Research Studies
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groupsâone receiving 4 grams of MI daily and the other receiving a placeboâwhile following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some waysâlike a decrease in feelings of hunger and desire for unhealthy foodsâthe MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some waysâlike a decrease in feelings of hunger and desire for unhealthy foodsâthe MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
Read More
Most Useful Reviews
9
Helpful symptoms improvement
3 people found this helpful
Helpful for my disease symptoms. There is no flushing or itching, and as my doctor says, it significantly aids in alleviating my liver disease symptoms.
Read More
0
Unresolved liver toxicity
3 people found this helpful
My hba1c rose from 5.5 to 6.3 (pre-diabetic) and my blood sugar spiked after taking this supplement, which made me feel nauseous and fatigued. This excessive dosage poses a danger regarding liver disease and needs a clear warning.
Read More
9
Cholesterol management
Niacin without flushing or itching! It's well-established for improving cardiovascular health without adverse effects like severe itching. I find it highly beneficial, and it's helped maintain my cholesterol levels over the years.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groupsâone receiving 4 grams of MI daily and the other receiving a placeboâwhile following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some waysâlike a decrease in feelings of hunger and desire for unhealthy foodsâthe MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some waysâlike a decrease in feelings of hunger and desire for unhealthy foodsâthe MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 17 Reviews
6.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Helpful symptoms improvement
3 people found this helpful
Helpful for my disease symptoms. There is no flushing or itching, and as my doctor says, it significantly aids in alleviating my liver disease symptoms.
Read More
0
Unresolved liver toxicity
3 people found this helpful
My hba1c rose from 5.5 to 6.3 (pre-diabetic) and my blood sugar spiked after taking this supplement, which made me feel nauseous and fatigued. This excessive dosage poses a danger regarding liver disease and needs a clear warning.
Read More
9
Cholesterol management
Niacin without flushing or itching! It's well-established for improving cardiovascular health without adverse effects like severe itching. I find it highly beneficial, and it's helped maintain my cholesterol levels over the years.
Read More
0
Cholesterol caution
After about 140 pills, I was diagnosed with suspected Brugada syndrome during a health check. Upon stopping the pills, my arrhythmia improved, yet my cholesterol remains high, and I fear my attempts to lower it may have harmed my liver health.
Read More
7.5
Cholesterol management
5 people found this helpful
Excellent! Niacin reduces LDL cholesterol, enhances HDL cholesterol and lowers triglycerides. It may help prevent heart disease and treat type 1 diabetes. Niacin assists metabolism and is essential for immune function. The typical maintenance dose is between 1000-2000 mg daily.
Read More
Frequently Asked Questions
9
Helpful symptoms improvement
3 people found this helpful
Helpful for my disease symptoms. There is no flushing or itching, and as my doctor says, it significantly aids in alleviating my liver disease symptoms.
6
Positive hair growth
I took this for two months to promote hair growth, which improved, and it also helps prevent cardiovascular disease related to liver health.
8
Immune system support
ćŸć„œïŒ I take niacin to support my immune system as I have had iritis for 20 years! It's beneficial for my condition.
1
Panic attacks reduced
2 people found this helpful
Thanks to niacin, my panic attacks have eased, and Iâve been drug-free for over a year. However, my liver disease markers were high during my last checkup.
6
Liver health monitoring
4 people found this helpful
I consume niacin regularly without flushing. It calms me, but I noticed it can affect liver values with prolonged, high dosages. Regular check-ups are advisable for anyone taking high doses for extended periods.
6
Liver disease concern
31 people found this helpful
I take up to 3000 mg of niacin daily to combat liver disease. I once noted that someone using a similar amount was almost at cirrhosis stage, but I suspect they consumed excessive alcohol. A doctor informed me that niacin should not present symptoms akin to cirrhosis.
7.5
Cholesterol management
5 people found this helpful
Excellent! Niacin reduces LDL cholesterol, enhances HDL cholesterol and lowers triglycerides. It may help prevent heart disease and treat type 1 diabetes. Niacin assists metabolism and is essential for immune function. The typical maintenance dose is between 1000-2000 mg daily.
0
Unresolved liver toxicity
3 people found this helpful
My hba1c rose from 5.5 to 6.3 (pre-diabetic) and my blood sugar spiked after taking this supplement, which made me feel nauseous and fatigued. This excessive dosage poses a danger regarding liver disease and needs a clear warning.
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groupsâone receiving 4 grams of MI daily and the other receiving a placeboâwhile following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some waysâlike a decrease in feelings of hunger and desire for unhealthy foodsâthe MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some waysâlike a decrease in feelings of hunger and desire for unhealthy foodsâthe MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
References
- Aghajani T, Arefhosseini S, Ebrahimi-Mameghani M, Safaralizadeh R. The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD. Food Sci Nutr. 2024;12:7177. 10.1002/fsn3.4267
- Rostami S, Arefhosseini S, Tutunchi H, Khoshbaten M, Ebrahimi-Mameghani M. Does myo-inositol supplementation influence oxidative stress biomarkers in patients with non-alcoholic fatty liver disease?. Food Sci Nutr. 2024;12:1279. 10.1002/fsn3.3842
