Overview
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
USERS' SCORE
Good
Based on 28 Reviews
8.8
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 2 g)
Serving Per Container: About 85
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%*
Total Sugars
2 g
†
Organic D-Mannose
2 g (2,000 mg)
†
Top Medical Research Studies
9.5
D-Mannose shows effective UTI treatment
We evaluated a D-mannose-based dietary supplement, the DAPAD complex, to see if it could effectively treat uncomplicated E. coli urinary tract infections (UTIs).
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Read More
9
We explored the effectiveness of D-mannose alongside other nonantibiotic approaches for preventing urinary tract infections (UTIs). Our analysis included 50 randomized controlled trials involving over 10,000 participants.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Read More
1
We set out to see if d-mannose could help prevent recurrent urinary tract infections (UTIs) in women. This study involved 830 participants from 99 primary care centers in the UK and followed them over six months.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
Read More
Most Useful Reviews
10
Saved my marriage
62 people found this helpful
D-Mannose has been outstanding for my chronic UTIs. For over 8 years, I suffered severe bladder infections, especially after intercourse. Despite seeing various doctors and being prescribed multiple antibiotics, nothing worked. I started taking a teaspoon daily with water and an extra one after intercourse. If I showed any symptoms, I would take one every few hours until they disappeared, typically in just one day. The addition of pure aloe vera juice and probiotics enhanced my results. My costly doctor visits and prescriptions are now a thing of the past. This combination has truly changed my life and my marriage!
Read More
10
Life-changing product
35 people found this helpful
Wish I could give it a million stars! This product has truly transformed my life. After experiencing UTI issues that antibiotics could hardly resolve post-marriage, I learned of this product and began taking it regularly. Now, I feel relief that no antibiotic has provided. My husband is thankful as well! I recommend using the powder form, as it’s much more effective.
Read More
9
Natural alternative preferred
31 people found this helpful
I would never take antibiotics for a UTI again without trying D-Mannose first. Over many years, I dealt with various treatments, but nothing worked consistently. D-Mannose has proven effective for my recurring urinary infections. I experienced significant relief with just a teaspoon three times a day. It's become my go-to solution, and it significantly reduced my infections. This simple sugar really can work wonders!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
- All Researches
9.5
D-Mannose shows effective UTI treatment
We evaluated a D-mannose-based dietary supplement, the DAPAD complex, to see if it could effectively treat uncomplicated E. coli urinary tract infections (UTIs).
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Read More
9
We explored the effectiveness of D-mannose alongside other nonantibiotic approaches for preventing urinary tract infections (UTIs). Our analysis included 50 randomized controlled trials involving over 10,000 participants.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Read More
9
We examined the strategies for diagnosing and managing recurrent urinary tract infections (rUTI). Our systematic literature search revealed that while antibiotics are highly effective for prevention, they come with significant side effects.
Interestingly, non-antibiotic options like d mannose showed promise, significantly reducing infection rates with minimal risk. This makes d mannose a potential alternative for those seeking to avoid antibiotics.
Overall, rUTI management requires a tailored approach, especially for vulnerable populations like the elderly.
Interestingly, non-antibiotic options like d mannose showed promise, significantly reducing infection rates with minimal risk. This makes d mannose a potential alternative for those seeking to avoid antibiotics.
Overall, rUTI management requires a tailored approach, especially for vulnerable populations like the elderly.
Read More
9
We explored the impact of a "care bundle" approach on recurrent urinary tract infections (rUTIs) in women, combining behavioral strategies, probiotics, D-mannose, and cranberry extract. Over six months, we observed a striking 76% reduction in urinary tract infections and over 90% less antibiotic use.
Most women reported significant improvements in their quality of life, indicating that this multi-faceted treatment is promising. However, further studies with larger groups are necessary to confirm these positive outcomes for additional safety and effectiveness.
Most women reported significant improvements in their quality of life, indicating that this multi-faceted treatment is promising. However, further studies with larger groups are necessary to confirm these positive outcomes for additional safety and effectiveness.
Read More
8
We aimed to uncover how D-Mannose influences the ability of drug-resistant E. coli to adhere to bladder cells. In our study, we compared clinical strains from asymptomatic bacteriuria with a standard strain. We discovered that D-Mannose significantly reduced the adhesive capacity of multidrug-resistant E. coli, similar to symptomatic strains. This suggests that D-Mannose may effectively alter the mechanisms of bacterial adhesion in urinary tract infections, providing a promising avenue for future treatment approaches.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Saved my marriage
62 people found this helpful
D-Mannose has been outstanding for my chronic UTIs. For over 8 years, I suffered severe bladder infections, especially after intercourse. Despite seeing various doctors and being prescribed multiple antibiotics, nothing worked. I started taking a teaspoon daily with water and an extra one after intercourse. If I showed any symptoms, I would take one every few hours until they disappeared, typically in just one day. The addition of pure aloe vera juice and probiotics enhanced my results. My costly doctor visits and prescriptions are now a thing of the past. This combination has truly changed my life and my marriage!
Read More
10
Life-changing product
35 people found this helpful
Wish I could give it a million stars! This product has truly transformed my life. After experiencing UTI issues that antibiotics could hardly resolve post-marriage, I learned of this product and began taking it regularly. Now, I feel relief that no antibiotic has provided. My husband is thankful as well! I recommend using the powder form, as it’s much more effective.
Read More
9
Natural alternative preferred
31 people found this helpful
I would never take antibiotics for a UTI again without trying D-Mannose first. Over many years, I dealt with various treatments, but nothing worked consistently. D-Mannose has proven effective for my recurring urinary infections. I experienced significant relief with just a teaspoon three times a day. It's become my go-to solution, and it significantly reduced my infections. This simple sugar really can work wonders!
Read More
10
Better than antibiotics
21 people found this helpful
From a frequent UTI sufferer who has been using this for years. I have had UTIs for about 10 years, averaging one infection a month. My doctor recommended ultrasounds due to the frequent incidents, but everything was functioning fine. No matter how clean I kept myself or the precautions I took, nothing helped. Tired of relying on antibiotics and their side effects, I opted for an alternative. I use D-Mannose whenever I sense a burning sensation while urinating, mixed with water, and take Cystex liquid cranberry daily. It works wonders, even for the sudden infections. I've concluded that I have a sensitive urinary tract and this method is a much better alternative to antibiotics. If you can relate, follow my advice to save money on doctor's visits and avoid the unpleasant effects of antibiotics.
Read More
9
Potent product
9 people found this helpful
I purchased this product for some friends who had urinary tract infections, and they thanked me for it. It worked for each of them, even in cases where antibiotics failed, indicating its potency. It effectively cleans the urinary tract and I highly recommend it.
Read More
Frequently Asked Questions
10
High-dose effectiveness
1 people found this helpful
D-Mannose has saved my urinary tract countless times. When my bladder feels irritated, I take mannose powder for a few days, and my urinary problems vanish without the need for antibiotics.
9
Makes a difference
3 people found this helpful
I have recurrent urinary tract problems, and D-Mannose was recommended by a group of GYN specialists in UT issues. I have been using it for at least three years, and it has made a significant difference.
2
No improvement noted
I took it several times a day and nearly finished a large bottle, but unfortunately, there was no improvement.
9
No more pyelonephritis
2 people found this helpful
My daughter suffered constantly from urinary tract infections leading to pyelonephritis. After consulting a knowledgeable nephrologist, we started D-mannose and now we no longer face pyelonephritis, which tormented us for two years. She's even managing well with cystitis. It’s important to take this in courses.
10
Effective for cystitis
1 people found this helpful
Thanks to D-Mannose, I eliminated the cystitis caused by E. coli. If you're struggling with E. coli, give D-Mannose a go, it's a true saviour. I no longer need to take antibiotics, just maintain urinary health with this powder.
7.5
Life-changing remedy
6 people found this helpful
What a blessing! I’m in my 60’s and suffer from urinary incontinence, usually accompanied by debilitating painful cystitis. I was too scared to go anywhere. A friend suggested D-Mannose powder, and it's been fantastic. I still experience some incontinence, but to a much lesser degree, and no more painful cystitis! The product dissolves easily in water or juice, has a slightly sweet flavour. I thoroughly recommend this product.
7.5
Natural solution
1 people found this helpful
It truly works! A wonderful, natural way to treat and prevent urinary tract inflammation. I now take cranberries daily and D-mannose weekly for extra precaution. I've finally stopped using antibiotics.
9
Effective treatment
5 people found this helpful
Forget antibiotics; D-Mannose works wonders for treating cystitis without harming your digestive system. It has been a saviour for me, especially when taken alongside enzymes that eliminate biofilms.
6
Supports urinary wellness
1 people found this helpful
Good organic quality! I’ve been using Organic D-mannose powder for a while now, and it’s been transformative for my urinary tract health. I mix a scoop of this powder into my water daily, and I’ve noticed it helps maintain a healthy urinary tract. I value its purity and quality; being organic offers peace of mind regarding the ingredients I’m consuming. It’s critical to my daily routine for urinary wellness, with a dosage of 3-5 grams.
9
Immediate relief
1 people found this helpful
I wouldn't be without D-Mannose. For any urinary tract upset, I've used D-Mannose for years. As soon as symptoms appear, I mix it into my water or juice. It works effectively every time!
9
We explored the effectiveness of D-mannose alongside other nonantibiotic approaches for preventing urinary tract infections (UTIs). Our analysis included 50 randomized controlled trials involving over 10,000 participants.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
7
We explored the potential of d-mannose and cranberry in preventing urinary tract infections (UTIs). The review highlights that both of these natural products may help by blocking harmful bacteria from attaching to the bladder walls.
Some studies, however, reported limited effects, primarily due to small sample sizes and design flaws. While there is promise in using d-mannose as a preventive strategy for UTIs, more robust research is needed to confirm its effectiveness and determine the best usage.
Some studies, however, reported limited effects, primarily due to small sample sizes and design flaws. While there is promise in using d-mannose as a preventive strategy for UTIs, more robust research is needed to confirm its effectiveness and determine the best usage.
1
We set out to see if d-mannose could help prevent recurrent urinary tract infections (UTIs) in women. This study involved 830 participants from 99 primary care centers in the UK and followed them over six months.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
4
d-Mannose shows limited UTI benefit
We aimed to investigate whether d-mannose could help prevent recurrent urinary tract infections (UTIs) in postmenopausal women already using vaginal estrogen therapy (VET).
In our randomized controlled trial involving 57 participants, we found that d-mannose was well tolerated, but the results suggested it didn’t significantly improve UTI prevention compared to VET alone.
The cumulative UTI incidence was 41.1% in the d-mannose group versus 50.4% in the control, but this difference wasn't powerful enough to support a strong conclusion.
More research is definitely needed to fully assess d-mannose's benefits.
In our randomized controlled trial involving 57 participants, we found that d-mannose was well tolerated, but the results suggested it didn’t significantly improve UTI prevention compared to VET alone.
The cumulative UTI incidence was 41.1% in the d-mannose group versus 50.4% in the control, but this difference wasn't powerful enough to support a strong conclusion.
More research is definitely needed to fully assess d-mannose's benefits.
8
Cystenium II aids pyelonephritis treatment
We explored the effectiveness of the dietary supplement Cystenium II, containing D-mannose and cranberry extract, in treating children aged 7 to 14 with acute and recurrent pyelonephritis. In our study, 60 children were divided into a clinical group receiving both antibiotics and Cystenium II, and a control group receiving antibiotics alone.
After six months, the combination therapy showed significant improvement, with only one relapse in the clinical group compared to six in the control group. This suggests Cystenium II could be beneficial in reducing recurrent infections and reliance on antibiotics.
After six months, the combination therapy showed significant improvement, with only one relapse in the clinical group compared to six in the control group. This suggests Cystenium II could be beneficial in reducing recurrent infections and reliance on antibiotics.
4
We explored the effectiveness of D-mannose as a non-antibiotic treatment for urinary tract infections (UTIs) in women. Our systematic review gathered data from 21 studies, which also included cranberry and NSAIDs.
While we found some low-level evidence suggesting D-mannose may help prevent UTIs without significant side effects, the results are based on a limited number of studies. Larger and well-structured trials are necessary for more definitive conclusions. In comparison, research on cranberry and NSAIDs showed mixed results regarding their effectiveness.
While we found some low-level evidence suggesting D-mannose may help prevent UTIs without significant side effects, the results are based on a limited number of studies. Larger and well-structured trials are necessary for more definitive conclusions. In comparison, research on cranberry and NSAIDs showed mixed results regarding their effectiveness.
References
- Han Z, Yi X, Li J, Liao D, Ai J. Nonantibiotic prophylaxis for urinary tract infections: a network meta-analysis of randomized controlled trials. Infection. 2024. doi:10.1007/s15010-024-02357-z
- Ioannou P, Baliou S. The Molecular Mechanisms and Therapeutic Potential of Cranberry, D-Mannose, and Flavonoids against Infectious Diseases: The Example of Urinary Tract Infections. Antibiotics (Basel). 2024;13. doi:10.3390/antibiotics13070593
- Boeri L, De Lorenzis E, Lucignani G, Turetti M, Silvani C, et al. Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial. J Sex Med. 2024;21:627. doi:10.1093/jsxmed/qdae052
- Schmiemann G, Kranz J, Mandraka F, Schubert S, Wagenlehner F, et al. The Diagnosis, Treatment, and Prevention of Recurrent Urinary Tract Infection. Dtsch Arztebl Int. 2024;121:373. doi:10.3238/arztebl.m2024.0068
- Rau M, Santelli A, Martí S, Díaz MI, Sabé N, et al. Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study. Nefrologia (Engl Ed). 2024;44:408. doi:10.1016/j.nefroe.2024.02.011
- Hayward G, Mort S, Hay AD, Moore M, Thomas NPB, et al. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial. JAMA Intern Med. 2024;184:619. doi:10.1001/jamainternmed.2024.0264
- Ghosh A, Mukherjee M. Type 1 fimbrial phase variation in multidrug-resistant asymptomatic uropathogenic Escherichia coli clinical isolates upon adherence to HTB-4 cells. Folia Microbiol (Praha). 2024;69:1185. doi:10.1007/s12223-024-01159-y
- Joshi CS, Salazar AM, Wang C, Ligon MM, Chappidi RR, et al. D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024;59:33. doi:10.1016/j.devcel.2023.11.017
- Venturini S, Reffo I, Avolio M, Basaglia G, Del Fabro G, et al. The Management of Recurrent Urinary Tract Infection: Non-Antibiotic Bundle Treatment. Probiotics Antimicrob Proteins. 2024;16:1857. doi:10.1007/s12602-023-10141-y
- Faustino M, Silva S, Costa EM, Pereira AM, Pereira JO, et al. Effect of Mannan Oligosaccharides Extracts in Uropathogenic Adhesion in Human Bladder Cells. Pathogens. 2023;12. doi:10.3390/pathogens12070885
- Al-Shukri AS, Maksimova AV, Dub NI, Kostyukov SV, Manchenko AA, et al. [Prevention of the development of catheter-associated urinary system infections in the early postoperative period]. Urologiia. 2023.
- Quattrone C, Manfredi C, Napolitano L, Ferraro A, Distefano C, et al. D-Mannose Plus to Prevent Urinary Tract Infections and Discomfort after Cystoscopy: A Single-Center Prospective Randomized Pilot Study. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59061165
- Lenger SM, Chu CM, Ghetti C, Durkin MJ, Jennings Z, et al. d-Mannose for Recurrent Urinary Tract Infection Prevention in Postmenopausal Women Using Vaginal Estrogen: A Randomized Controlled Trial. Urogynecology (Phila). 2023;29:367. doi:10.1097/SPV.0000000000001270
- Nashivochnikova NA, Leanovich VE. [Clinical and pathogenetic aspects of the treatment and prevention of pyelonephritis in children]. Urologiia. 2022.
- Salvatore S, Ruffolo AF, Stabile G, Casiraghi A, Zito G, et al. A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections. Eur Urol Focus. 2023;9:654. doi:10.1016/j.euf.2022.12.013
- Gu R, Liu H, Hu M, Zhu Y, Liu X, et al. D-Mannose prevents bone loss under weightlessness. J Transl Med. 2023;21:8. doi:10.1186/s12967-022-03870-1
- Konesan J, Liu L, Mansfield KJ. The Clinical Trial Outcomes of Cranberry, D-Mannose and NSAIDs in the Prevention or Management of Uncomplicated Urinary Tract Infections in Women: A Systematic Review. Pathogens. 2022;11. doi:10.3390/pathogens11121471
