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SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: About 1/4 cup (31 g)
Amount Per Serving
%DV
Calories
180
Total Fat
13 g
17%
Saturated Fat
3 g
15%
Trans Fat
0 g
Cholesterol
0 mg
0%
Sodium
0 mg
0%
Total Carbohydrate
4 g
1%
Dietary Fiber
2 g
7%
Total Sugars
0 g
Includes 0g Added Sugars
0%
Protein
11g
Vit. D
0 mcg
0%
Calcium
8 mg
0%
Iron
4 mg
20%
Potassium
243 mg
6%
Top Medical Research Studies
9
Quercetin reduces arthritis inflammation
Quercetin, a Compound of the Total Flavonoids of Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α.
Relevant to arthritis treatment research
In our exploration of how certain natural compounds can impact rheumatoid arthritis (RA), we focused on the total flavonoids derived from Schltr., specifically identifying the effects of quercetin. Our research employed various methods, including cellular and animal models, to examine how these compounds inhibit TNF-α, a key player in inflammation and joint deterioration.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
Read More
9
Clonorchis proteins mitigate arthritis symptoms
Clonorchis sinensis excretory/secretory proteins ameliorate inflammation in rheumatoid arthritis and ankylosing spondylitis.
Direct evaluation of protein effects
We set out to investigate whether proteins from the Clonorchis sinensis parasite could help reduce inflammation in rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Our research involved analyzing blood samples from healthy individuals, as well as patients with these conditions, to assess how these proteins affected immune cells.
Through our experiments, we discovered that treatment with Clonorchis sinensis excretory/secretory proteins (CS-ESP) didn’t harm the health of the blood cells. In fact, these proteins significantly decreased the levels of certain inflammatory markers like IL-17A and GM-CSF that are associated with these types of arthritis.
We also tested these proteins in a mouse model of arthritis and found that CS-ESP notably alleviated symptoms like pain and swelling. Moreover, we isolated specific proteins, Cs-GT and Cs-Severin, which showed similar anti-inflammatory properties without affecting cell viability.
Overall, our findings suggest that these proteins may hold promise as new treatments to improve the signs and symptoms of arthritis. This study opens the door to further research on how such proteins can be used in therapeutic applications for arthritis patients.
Through our experiments, we discovered that treatment with Clonorchis sinensis excretory/secretory proteins (CS-ESP) didn’t harm the health of the blood cells. In fact, these proteins significantly decreased the levels of certain inflammatory markers like IL-17A and GM-CSF that are associated with these types of arthritis.
We also tested these proteins in a mouse model of arthritis and found that CS-ESP notably alleviated symptoms like pain and swelling. Moreover, we isolated specific proteins, Cs-GT and Cs-Severin, which showed similar anti-inflammatory properties without affecting cell viability.
Overall, our findings suggest that these proteins may hold promise as new treatments to improve the signs and symptoms of arthritis. This study opens the door to further research on how such proteins can be used in therapeutic applications for arthritis patients.
Read More
9
SDF-1 improves osteoarthritis treatment
SDF-1 alleviates osteoarthritis by resolving mitochondrial dysfunction through the activation of the Sirt3/PGC-1α signalling pathway.
Highlights mitochondrial dysfunction in OA
We explored the role of stromal cell-derived factor 1 (SDF-1) in alleviating osteoarthritis (OA), the most prevalent joint disease affecting millions. Our research delved into how SDF-1 could mitigate the progression of OA symptoms, focusing specifically on its impact on mitochondrial dysfunction within cartilage cells.
Using both OA chondrocytes and a collagen-induced osteoarthritis (CIOA) mouse model, we treated these cells and animals with SDF-1. We then assessed various markers related to mitochondrial function and cartilage health. Interestingly, we discovered that levels of important proteins like SOD2 and PGC-1α were lower in OA affected cells and tissues. Treatment with SDF-1 notably corrected these deficits, suggesting a promising pathway for restoring mitochondrial health and, consequently, improving OA symptoms.
Notably, when we inhibited Sirt3—an enzyme linked to mitochondrial function—prior to SDF-1 treatment, the benefits were diminished. This suggests that the Sirt3/PGC-1α signaling pathway is critical for the therapeutic effect of SDF-1 in OA. Thus, our findings indicate that SDF-1 stands out as a potential new treatment for OA, offering hope beyond traditional symptom management strategies.
Using both OA chondrocytes and a collagen-induced osteoarthritis (CIOA) mouse model, we treated these cells and animals with SDF-1. We then assessed various markers related to mitochondrial function and cartilage health. Interestingly, we discovered that levels of important proteins like SOD2 and PGC-1α were lower in OA affected cells and tissues. Treatment with SDF-1 notably corrected these deficits, suggesting a promising pathway for restoring mitochondrial health and, consequently, improving OA symptoms.
Notably, when we inhibited Sirt3—an enzyme linked to mitochondrial function—prior to SDF-1 treatment, the benefits were diminished. This suggests that the Sirt3/PGC-1α signaling pathway is critical for the therapeutic effect of SDF-1 in OA. Thus, our findings indicate that SDF-1 stands out as a potential new treatment for OA, offering hope beyond traditional symptom management strategies.
Read More
Most Useful Reviews
9.5
Beneficial for arthritis
The quality is excellent. I have repurchased pumpkin seeds numerous times due to their anti-inflammatory effects, which benefit my periodontal disease and arthritis. They are natural and healthy, making them a long-time staple in my diet.
Read More
8.8
Reduces arthritis inflammation
Pumpkin seeds improve with age and help reduce inflammation from arthritis while protecting bones. I enjoy adding them to salads, although they can be pricey. Their benefits are significant, particularly for arthritis treatment.
Read More
8.8
Supports arthritis treatment
I ordered pumpkin seeds for the first time, and they are of excellent quality. They are small but clean, and my family loves them, especially as they require no preparation. I incorporate them daily due to their valuable nutrients. They are believed to help combat arthritis with no side effects, strengthen blood vessels, and boost immunity. Additionally, they aid in normalising blood sugar and lowering blood pressure. Overall, the benefits, including for arthritis, are substantial. I am very pleased with my purchase and will definitely buy more.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.4
9
SDF-1 improves osteoarthritis treatment
SDF-1 alleviates osteoarthritis by resolving mitochondrial dysfunction through the activation of the Sirt3/PGC-1α signalling pathway.
Highlights mitochondrial dysfunction in OA
We explored the role of stromal cell-derived factor 1 (SDF-1) in alleviating osteoarthritis (OA), the most prevalent joint disease affecting millions. Our research delved into how SDF-1 could mitigate the progression of OA symptoms, focusing specifically on its impact on mitochondrial dysfunction within cartilage cells.
Using both OA chondrocytes and a collagen-induced osteoarthritis (CIOA) mouse model, we treated these cells and animals with SDF-1. We then assessed various markers related to mitochondrial function and cartilage health. Interestingly, we discovered that levels of important proteins like SOD2 and PGC-1α were lower in OA affected cells and tissues. Treatment with SDF-1 notably corrected these deficits, suggesting a promising pathway for restoring mitochondrial health and, consequently, improving OA symptoms.
Notably, when we inhibited Sirt3—an enzyme linked to mitochondrial function—prior to SDF-1 treatment, the benefits were diminished. This suggests that the Sirt3/PGC-1α signaling pathway is critical for the therapeutic effect of SDF-1 in OA. Thus, our findings indicate that SDF-1 stands out as a potential new treatment for OA, offering hope beyond traditional symptom management strategies.
Using both OA chondrocytes and a collagen-induced osteoarthritis (CIOA) mouse model, we treated these cells and animals with SDF-1. We then assessed various markers related to mitochondrial function and cartilage health. Interestingly, we discovered that levels of important proteins like SOD2 and PGC-1α were lower in OA affected cells and tissues. Treatment with SDF-1 notably corrected these deficits, suggesting a promising pathway for restoring mitochondrial health and, consequently, improving OA symptoms.
Notably, when we inhibited Sirt3—an enzyme linked to mitochondrial function—prior to SDF-1 treatment, the benefits were diminished. This suggests that the Sirt3/PGC-1α signaling pathway is critical for the therapeutic effect of SDF-1 in OA. Thus, our findings indicate that SDF-1 stands out as a potential new treatment for OA, offering hope beyond traditional symptom management strategies.
Read More
9
Hydrogen sulfide improves arthritis treatment
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.
Study effectively addresses protein therapy
We explored the impact of hydrogen sulfide (HS) on rheumatoid arthritis (RA) through a specially designed delivery system. Our research focused on a new type of nanoparticle called NaHS@Cy5@MS@SP, which allows for a controlled and targeted release of HS directly to the affected synovium. This innovative approach aims to address the limitations of traditional HS treatments, like sodium hydrosulfide, known for their short effectiveness.
By targeting fibroblast-like synoviocytes (FLSs), which play a major role in the inflammation and proliferation associated with RA, we observed that our nanoparticles not only delivered HS more effectively but also encouraged the production of enzymes that help regulate inflammation. This response was a game-changer: we found that the upregulation of these enzymes led to a decrease in the harmful overactivity of FLSs.
In tests conducted on arthritic mice, NaHS@Cy5@MS@SP showed significant reductions in symptoms compared to free sodium hydrosulfide. Notably, it worked by inactivating the Hedgehog signaling pathway, a key contributor to RA’s progression. As a result, we noted improvements in joint health, including decreased synovial hyperplasia and less damage to bone and cartilage.
Overall, this study highlights a promising approach to managing RA through targeted delivery of HS, positioning NaHS@Cy5@MS@SP as a potential therapeutic strategy.
By targeting fibroblast-like synoviocytes (FLSs), which play a major role in the inflammation and proliferation associated with RA, we observed that our nanoparticles not only delivered HS more effectively but also encouraged the production of enzymes that help regulate inflammation. This response was a game-changer: we found that the upregulation of these enzymes led to a decrease in the harmful overactivity of FLSs.
In tests conducted on arthritic mice, NaHS@Cy5@MS@SP showed significant reductions in symptoms compared to free sodium hydrosulfide. Notably, it worked by inactivating the Hedgehog signaling pathway, a key contributor to RA’s progression. As a result, we noted improvements in joint health, including decreased synovial hyperplasia and less damage to bone and cartilage.
Overall, this study highlights a promising approach to managing RA through targeted delivery of HS, positioning NaHS@Cy5@MS@SP as a potential therapeutic strategy.
Read More
9
Quercetin reduces arthritis inflammation
Quercetin, a Compound of the Total Flavonoids of Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α.
Relevant to arthritis treatment research
In our exploration of how certain natural compounds can impact rheumatoid arthritis (RA), we focused on the total flavonoids derived from Schltr., specifically identifying the effects of quercetin. Our research employed various methods, including cellular and animal models, to examine how these compounds inhibit TNF-α, a key player in inflammation and joint deterioration.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
Read More
9
Clonorchis proteins mitigate arthritis symptoms
Clonorchis sinensis excretory/secretory proteins ameliorate inflammation in rheumatoid arthritis and ankylosing spondylitis.
Direct evaluation of protein effects
We set out to investigate whether proteins from the Clonorchis sinensis parasite could help reduce inflammation in rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Our research involved analyzing blood samples from healthy individuals, as well as patients with these conditions, to assess how these proteins affected immune cells.
Through our experiments, we discovered that treatment with Clonorchis sinensis excretory/secretory proteins (CS-ESP) didn’t harm the health of the blood cells. In fact, these proteins significantly decreased the levels of certain inflammatory markers like IL-17A and GM-CSF that are associated with these types of arthritis.
We also tested these proteins in a mouse model of arthritis and found that CS-ESP notably alleviated symptoms like pain and swelling. Moreover, we isolated specific proteins, Cs-GT and Cs-Severin, which showed similar anti-inflammatory properties without affecting cell viability.
Overall, our findings suggest that these proteins may hold promise as new treatments to improve the signs and symptoms of arthritis. This study opens the door to further research on how such proteins can be used in therapeutic applications for arthritis patients.
Through our experiments, we discovered that treatment with Clonorchis sinensis excretory/secretory proteins (CS-ESP) didn’t harm the health of the blood cells. In fact, these proteins significantly decreased the levels of certain inflammatory markers like IL-17A and GM-CSF that are associated with these types of arthritis.
We also tested these proteins in a mouse model of arthritis and found that CS-ESP notably alleviated symptoms like pain and swelling. Moreover, we isolated specific proteins, Cs-GT and Cs-Severin, which showed similar anti-inflammatory properties without affecting cell viability.
Overall, our findings suggest that these proteins may hold promise as new treatments to improve the signs and symptoms of arthritis. This study opens the door to further research on how such proteins can be used in therapeutic applications for arthritis patients.
Read More
9
Nanoparticles enhance arthritis treatment
Biomimetic Nanoparticles Inhibit the HIF-1α/iNOS/NLRP3 Pathway to Alleviate Rheumatoid Arthritis.
Innovative approach with biomimetic targeting
We examined how a biomimetic nanocarrier can enhance the delivery of chrysin, a natural compound known for its anti-inflammatory properties, specifically geared toward treating rheumatoid arthritis (RA). RA is characterized by chronic inflammation in the joints, leading to pain and disability.
In our approach, we utilized fibroblast-like synoviocyte (FLS) membrane proteins to create FMPlipo@C, a unique chrysin-loaded liposome. This method takes advantage of the natural affinity these proteins have for inflamed joints, effectively targeting the affected areas and facilitating the release of chrysin exactly where it's needed most.
Our findings showed that FMPlipo@C significantly reduced inflammation in collagen-induced rheumatoid arthritis model mice. It works by suppressing the HIF-1α/iNOS/NLRP3 pathway, which is crucial in the inflammatory response. By doing this, we observed that it not only protects the cartilage but also prevents bone erosion, leading to reduced swelling and stiffness in the joints.
This innovative strategy highlights the potential of targeting treatments more precisely, paving the way for improved therapeutic options for those struggling with rheumatoid arthritis.
In our approach, we utilized fibroblast-like synoviocyte (FLS) membrane proteins to create FMPlipo@C, a unique chrysin-loaded liposome. This method takes advantage of the natural affinity these proteins have for inflamed joints, effectively targeting the affected areas and facilitating the release of chrysin exactly where it's needed most.
Our findings showed that FMPlipo@C significantly reduced inflammation in collagen-induced rheumatoid arthritis model mice. It works by suppressing the HIF-1α/iNOS/NLRP3 pathway, which is crucial in the inflammatory response. By doing this, we observed that it not only protects the cartilage but also prevents bone erosion, leading to reduced swelling and stiffness in the joints.
This innovative strategy highlights the potential of targeting treatments more precisely, paving the way for improved therapeutic options for those struggling with rheumatoid arthritis.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Beneficial for arthritis
The quality is excellent. I have repurchased pumpkin seeds numerous times due to their anti-inflammatory effects, which benefit my periodontal disease and arthritis. They are natural and healthy, making them a long-time staple in my diet.
8.8
Supports arthritis treatment
I ordered pumpkin seeds for the first time, and they are of excellent quality. They are small but clean, and my family loves them, especially as they require no preparation. I incorporate them daily due to their valuable nutrients. They are believed to help combat arthritis with no side effects, strengthen blood vessels, and boost immunity. Additionally, they aid in normalising blood sugar and lowering blood pressure. Overall, the benefits, including for arthritis, are substantial. I am very pleased with my purchase and will definitely buy more.
Read More
8.8
Reduces arthritis inflammation
Pumpkin seeds improve with age and help reduce inflammation from arthritis while protecting bones. I enjoy adding them to salads, although they can be pricey. Their benefits are significant, particularly for arthritis treatment.
