NOW Foods Selenium

Selenium aids Graves' orbitopathy treatment

Questionable

Based on 16 Researches

The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.

Most Relevant Research

We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.

The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.

We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.

Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.

9.5

Lowered antibodies

Most Useful Review

Selenium plays a crucial role in thyroid function, acting as a catalyst for converting inactive hormone T4 to active T3 while protecting thyroid cells from oxidative damage. I suffer from an autoimmune disorder, hypothyroidism, and my doctor recommended selenium. After taking it for over two years, my antibody levels have significantly decreased, as evidenced by my tests.

Breast Cancer details

Selenium compounds may fight breast cancer

Based on 16 Researches

Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer.

Most Relevant Research

We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.

What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.

The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.

In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.

9.5

Cancer cell disappearance

Most Useful Review

During my breast cancer treatment, I started taking one tablet of selenium daily after reading Mitsuishi Iwao's book. I continued with this dosage and a high-protein, vitamin-rich, low-carbohydrate diet throughout pre-operative chemotherapy. Remarkably, the lump shrank significantly, and post-surgery pathology indicated that cancer cells had vanished. Although navigating the chemotherapy's side effects was challenging, I believe the supplements aided my resilience while working. I intend to keep taking it diligently and would recommend it to anyone facing similar challenges during breast cancer treatment.

Cancer details

Selenium drug shows selective toxicity

Moderately Effective

Based on 14 Researches

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.

Most Relevant Research

We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.

The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.

Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.

9.5

Boosts cancer defence

Most Useful Review

This mineral supplement is vital for immunity and thyroid health. Selenium acts as a powerful antioxidant, combating atherosclerosis, cancer, infertility risk, and chronic fatigue. I recommend it for improving brain function and reducing cardiovascular disease risks.

Common Cold details

Effective cold prevention

After purchasing this product, I heard it works well with NAC to combat cold germs and prevent catching a cold. I take it every two days, and perhaps that's why I don't catch a cold even when others around me are affected!

Prostate Cancer details

Selenium nanoparticles show promise

Based on 15 Researches

Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.

Most Relevant Research

We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.

By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.

This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.

Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.

9.5

Cancer prevention

Most Useful Review

Selenium is an essential supplement for preventing cancer. To maintain my health and reduce tumour risks, I believe this supplement is crucial.

Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Most Relevant Research

We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.

Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.

Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.

However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.

9.5

Restored balance

Most Useful Review

I have congenital hypothyroidism, which only manifested severe symptoms during menopause—lethargy, drowsiness, forgetfulness, and irritability. Upon my endocrinologist's advice, I started taking selenium. My well-being has dramatically improved; my menstrual cycle is back to normal, memory has returned, and I feel calm and balanced. It's evident that bioadditives are vital for thyroid function, and completing a full course of them was crucial.

Swollen Lymph Nodes details

Notable reduction noticed

Over ten years, I've been monitored by an endocrinologist for multiple small nodes in my thyroid gland, ranging from 0.3 mm to 1 cm. Despite their stable size for years, I noticed they began to grow gently. After consulting another endocrinologist last year, she advised a regimen of selenium for 2-3 weeks followed by iodine. After the first month, I felt a surge of energy, having lost chronic fatigue and apathy. Six months later, an ultrasound showed about a two-fold reduction in the size and number of nodes on the left, with none on the right. I plan to continue this regimen and remain hopeful for further improvements.

Diabetes details

Antidiabetic effects of selenium

Based on 11 Researches

Physicochemical properties, structural characterization, and antidiabetic activity of selenylated low molecular weight apple pectin in HFD/STZ-induced type 2 diabetic mice.

Most Relevant Research

We investigated the impact of a novel selenylated low molecular weight apple pectin on diabetes management. The study focused on mice induced with type 2 diabetes through a high-fat diet and streptozotocin treatment.

Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.

Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.

9.5

Boosts immune system

Most Useful Review

Selenium is vital for cancer protection and immunity against viruses. It aids pancreatic cell growth and improves glucose absorption, essential for managing diabetes by reducing insulin resistance. This mineral is best absorbed with fat-soluble vitamins A, D, and E, and it’s crucial for synthesising thyroid hormones.

Heart Attack details

Selenium nanoparticles for heart health

Based on 14 Researches

A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.

Most Relevant Research

We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.

8.8

Boosted immunity

Most Useful Review

Selenium is essential for health! I've been taking it for autoimmune thyroiditis as prescribed by my doctor. It strengthens my immunity and overall well-being. One capsule daily prepares me for any challenge. I trust NOW products, and this specific selenium supplement has been effective. It serves various functions including antioxidant action, support for the immune system, and heart health, which is vital given the risk of heart attack.

Hyperthyroidism details

I have been using selenium for two years following a disruption in my body post-Covid, which caused thyroid problems. Taking it with Euthyrox, I value the all-natural ingredients and small size for easy swallowing. It aids in addressing deficiencies and has no significant symptoms of hyperthyroidism. I recommend this supplement!

This was my first experience with selenium due to facial skin issues. I committed to one tablet daily for six months, with fantastic results—the rash disappeared. Now, I’ve ordered another jar for my sister, who the doctor advised to take for a year for thyroid regulation. Her first analysis confirmed selenium’s effectiveness, so I recommend following a doctor’s prescription when using this product.

Allergies details

Selenium nanoparticles reduce allergies

Moderately Effective

Based on 6 Researches

Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins.

Most Relevant Research

We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.

9.5

Significant allergy relief

Most Useful Review

Can help with allergy relief. Take only if you have had blood tests taken! It's easy to overdose on this. I owe this (not solely) huge relief for my mite allergy symptoms. Currently, I follow a specific diet and supplement plan to support my thyroid functions. I added an optimal dose of vitamin D3, vitamin C, selenium, magnesium, and vitamin B complex in a well-absorbing form. To my surprise, this combination of healthy foods and these supplements made a substantial impact on reducing the swelling and clearing my nose (my allergy pill did not alleviate all the symptoms). I'm considering pausing my allergy medicine to assess improvements in my immune system's efficiency.

Anemia details

Prevents anemia effectively

Excellent! Selenium is crucial for human health and plays a role in various physiological processes. It is particularly beneficial as it helps to increase compromised immunity, stimulates metabolism, and prevents the onset of anemia by participating in hematopoiesis. Selenium also protects cells from free radical damage, aids in iodine absorption by the thyroid, and is necessary for producing various enzymes. Additionally, it helps slow down aging, positively influences male fertility, and lowers the risk of miscarriage.

Anxiety details

After taking the capsule at noon, I experienced a sedative effect. My mind feels clear but inclined towards sleep. Anxiety has dissipated and my pupils appear normal. This medication is not compatible with other drugs. I plan to take it tonight to aid my sleep, using half a dosage every two days.

Blood Clot details

Combats deficiency issues

Selenium is vital for thyroid hormone functionality and a staggering 80% of people suffer from its deficiency, leading to various health issues. Personally, I struggled with lethargy, high blood pressure, and weight gain due to hypothyroidism. After taking selenium combined with natural iodine and L-tyrosine for six months, my metabolism normalised, energy levels surged, and I lost significant weight. This experience has convinced me of selenium's importance in combating health problems associated with deficiencies.

Selenium is one of the best supplements I've ever used. It significantly contributes to my health, particularly in managing chronic cough and other persistent health issues. I've been taking selenium for a long time, and it's essential for absorption when in a chelated form. This particular brand meets all my needs, being suitable for vegetarians and having small, easy-to-swallow capsules. The improvements in my overall health are noticeable; I get fewer colds, my hair loss has stopped, and my skin condition has improved. Although I like another brand as well, this one offers great value. Remember to take it in courses for best results.

Dizziness details

The results appear quickly. The supplement contains selenium in an active form and has no yeast in the composition. The pills have a peculiar smell, which I quite like. I read nearly all the reviews before purchasing, and some women mentioned an increased heart rate and dizziness after taking a whole pill; I experienced this too. Whilst I felt a boost of cheerfulness and energy, dizziness set in after a while but faded later. I opted to take half the dosage, as each tablet contains 286%. Overall, the supplement is effective and reasonably priced, though I recommend trying 1/3 or 1/2 of the daily dosage.

Ear Infection details

Prevents infections effectively

Selenium is an essential mineral and powerful antioxidant. It plays a vital role in cellular health by neutralising free radicals and reducing oxidative stress, while also being crucial for thyroid hormone production. Personally, I take it for immune support as it enhances my defense against infections. This product effectively boosts my immune system, and though I have no thyroid issues, I see it as preventative for potential problems. The vegetarian capsules are a boon for those avoiding animal products.

Eczema details