Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Selenium (elemental)(from 40 mg L-Selenomethionine)
200 mcg
364%
Top Medical Research Studies
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
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8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
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9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
Most Useful Reviews
9
Heart health improvement
7 people found this helpful
I started taking selenium for my relatives, initially loading for two weeks before adding iodine. My mother-in-law has experienced better heart function and improved mental clarity, prompting her to ask when she can start taking selenium again.
Read More
6
Essential mineral
2 people found this helpful
Selenium is vital for heart health and the absorption of iodine for the thyroid. Its deficiency is prevalent in Australia and NZ, making it essential to take in adequate dosages for optimal health.
Read More
9
Visible health effects
I love this selenium with all my heart, as the effects are noticeable from the first tablets.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
Read More
9
Selenium compound shows heart protection
We investigated the effects of a new selenium-containing compound, Se-SAHA, on heart failure caused by isoproterenol. Our study found that Se-SAHA helped protect heart cells from damage, reducing cardiac hypertrophy and fibrosis in lab models.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
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9
We investigated the use of a new selenium delivery system to combat radiation-induced heart disease, which is a serious concern for cancer patients undergoing thoracic radiation. Our innovative oral microcarriers showed remarkable effects in protecting heart cells from radiation damage by reducing harmful reactive oxygen species.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
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User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Heart health improvement
7 people found this helpful
I started taking selenium for my relatives, initially loading for two weeks before adding iodine. My mother-in-law has experienced better heart function and improved mental clarity, prompting her to ask when she can start taking selenium again.
Read More
6
Essential mineral
2 people found this helpful
Selenium is vital for heart health and the absorption of iodine for the thyroid. Its deficiency is prevalent in Australia and NZ, making it essential to take in adequate dosages for optimal health.
Read More
9
Visible health effects
I love this selenium with all my heart, as the effects are noticeable from the first tablets.
Read More
7.5
Reduced heart disease
Good Selenium is a strong antioxidant, lowers cancer risk, and diminishes the incidence of heart disease while enhancing the immune system. I highly recommend it!
Read More
6
Maintains heart health
77 people found this helpful
Previously, I tried gelatin capsules, but I found this supplement effective for maintaining heart health. I attempted to increase my dosage, but it made my heart race. Online reviews have aided my supplement choices, considering medical professionals may not always be knowledgeable on such matters.
Read More
Frequently Asked Questions
9
Heart health improvement
7 people found this helpful
I started taking selenium for my relatives, initially loading for two weeks before adding iodine. My mother-in-law has experienced better heart function and improved mental clarity, prompting her to ask when she can start taking selenium again.
9
Visible health effects
I love this selenium with all my heart, as the effects are noticeable from the first tablets.
7.5
Reduced heart disease
Good Selenium is a strong antioxidant, lowers cancer risk, and diminishes the incidence of heart disease while enhancing the immune system. I highly recommend it!
7.5
Heart and immune support
Selenium is a fantastic antioxidant and trace mineral. Its primary benefit is heart support, in addition to aiding the immune system and thyroid function. It helps alleviate symptoms like tiredness and weakness. The taste is acceptable.
6
Maintains heart health
77 people found this helpful
Previously, I tried gelatin capsules, but I found this supplement effective for maintaining heart health. I attempted to increase my dosage, but it made my heart race. Online reviews have aided my supplement choices, considering medical professionals may not always be knowledgeable on such matters.
6
Essential mineral
2 people found this helpful
Selenium is vital for heart health and the absorption of iodine for the thyroid. Its deficiency is prevalent in Australia and NZ, making it essential to take in adequate dosages for optimal health.
References
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. 10.1016/j.freeradbiomed.2025.03.004
- He X, Sun H, Zhao Y, Fu X, Wang M, et al. Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses. Eur J Prev Cardiol. 2025. 10.1093/eurjpc/zwaf118
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. 10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. 10.1016/j.biomaterials.2025.123119
- Chen Q, Wang WY, Xu QY, Dai YF, Zhu XY, et al. The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism. J Cell Mol Med. 2024;28:e70124. 10.1111/jcmm.70124
- Heuer RM, Falagan-Lotsch P, Okutsu J, Deperalto M, Koop RR, et al. Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio). Cardiovasc Toxicol. 2024;24:1287. 10.1007/s12012-024-09910-0
- Bhattarai U, Xu R, He X, Pan L, Niu Z, et al. High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox Biol. 2024;76:103325. 10.1016/j.redox.2024.103325
- Sun Y, Mao Q, Zhou D, Tian J, Du H, et al. Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population. Environ Pollut. 2024;360:124718. 10.1016/j.envpol.2024.124718
- Marhamati S, Younesian O, Mir SM, Hosseinzadeh S, Joshaghani HR, et al. The effects of high doses of selenium supplementation on mRNA and protein levels of cMLCK levels and total antioxidant capacity in rat heart tissue. Food Chem Toxicol. 2024;191:114886. 10.1016/j.fct.2024.114886
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Cheng T, Liu C, Wang Y, Li G, Feng L, et al. A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition. Toxicol Appl Pharmacol. 2024;487:116957. 10.1016/j.taap.2024.116957
- Liu C, Wang W, Lai H, Chen Y, Li L, et al. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease. Bioact Mater. 2024;37:393. 10.1016/j.bioactmat.2024.03.034
- Aryafar M, Mahdavi M, Shahzadi H, Ranjbar YR, Sohouli MH, et al. Association between dietary selenium and zinc intake and risk of dilated cardiomyopathy in children: a case-control study. BMC Pediatr. 2024;24:251. 10.1186/s12887-024-04706-1
- Karaye KM, Sa'idu H, Ishaq NA, Balarabe SA, Ahmed BG, et al. Selenium Deficiency as a Risk Factor for Peripartum Cardiomyopathy. West Afr J Med. 2024;41:209.
- Li SJ, Wang AW, Huang KL, Yang Y. Recent Advances on Selenium Nutrition and Keshan Disease. Int Heart J. 2024;65:173. 10.1536/ihj.23-628
- Al-Mubarak AA, Markousis Mavrogenis G, Guo X, De Bruyn M, Nath M, et al. Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes. Redox Biol. 2024;70:103046. 10.1016/j.redox.2024.103046
