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Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
3,000 mcg
333%
The product is found useful for the following medical conditions
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.8
9.5
No heartburn noted
Most Useful Review
Excellent! I have been taking this vitamin for about a month and my overall health and energy levels have improved. I used to feel sluggish often, but now I feel more alert and energised. I also no longer experience heartburn, which is a huge plus.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.8
9.5
Skin condition improved
Most Useful Review
My 8-year-old son took Vitamin A capsules for skin issues, as it was falling off. After taking the vitamin, his skin returned to normal balance. 👍
Migraine details
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Good
Based on 5 Reviews
8.8
4
Vitamin A's complex role in migraines
Retinol-binding protein-4 and hs-CRP levels in patients with migraine.
Most Relevant Research
We set out to explore the relationship between vitamin A, specifically through retinol-binding protein-4 (RBP4), and migraine. Our study included 48 migraine patients and 40 individuals matched by age and gender who did not suffer from migraines. By measuring the levels of RBP4 and high-sensitivity C-reactive protein (hs-CRP), we aimed to understand the inflammatory nature of migraine and how vitamin A might influence it.
Notably, we found that migraine patients had significantly lower levels of RBP4 compared to the control group, while showing elevated hs-CRP levels. This reflects an inflammatory state often associated with migraines. However, the severity, frequency, and duration of migraine attacks did not correlate with the levels of either RBP4 or hs-CRP, suggesting that simply having lower RBP4 or higher hs-CRP might not directly contribute to migraine severity or characteristics.
Overall, while our findings highlight a notable difference in the blood markers of migraine sufferers, they do not provide evidence that vitamin A treatment would directly benefit migraine management. Further research could still explore the broader implications of vitamin A's anti-inflammatory properties and their potential role in migraine.
Notably, we found that migraine patients had significantly lower levels of RBP4 compared to the control group, while showing elevated hs-CRP levels. This reflects an inflammatory state often associated with migraines. However, the severity, frequency, and duration of migraine attacks did not correlate with the levels of either RBP4 or hs-CRP, suggesting that simply having lower RBP4 or higher hs-CRP might not directly contribute to migraine severity or characteristics.
Overall, while our findings highlight a notable difference in the blood markers of migraine sufferers, they do not provide evidence that vitamin A treatment would directly benefit migraine management. Further research could still explore the broader implications of vitamin A's anti-inflammatory properties and their potential role in migraine.
9.5
Stress reduction
Most Useful Review
This vitamin has significantly reduced my stress and anxiety, making me feel like a better person. It has also helped me get rid of my migraines and acne. It works well for me, and I would certainly recommend it to my friends and family.
Yeast Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.8
9.5
Excellent quality
Most Useful Review
Vitamin A protects against flu, colds, respiratory tract infections and prevents infections of the digestive and urinary tracts. The jar size is standard. I adore this brand for its quality and affordability! It also aids with acne, my hair has stopped falling out, and my allergies have vanished. I highly recommend it!
Autoimmune Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 33 Reviews
8.7
9.5
Seizures alleviated
Most Useful Review
I took vitamins daily and noticed significant improvement after three days, achieving mostly normal mouth movement. After a week and a half, the seizures disappeared—though results can vary for others. I now take these vitamins in courses at the start of cold weather and in spring, and the issue with seizures no longer bothers me. I highly recommend purchasing these vitamins if prescribed by a doctor; you certainly won't regret it.
Bronchitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.7
7
Vitamin A supports immune response
Effect of oral vitamin A supplementation on host immune response to infectious bronchitis virus infection in specific pathogen-free chicken.
Most Relevant Research
We conducted a study to investigate how vitamin A supplementation affects the immune response in chickens infected with the infectious bronchitis virus (IBV). In our approach, we used 40 one-day-old specific pathogen-free (SPF) chickens, dividing them into two groups. One group received an oral vitamin A treatment daily, while the other group was given a placebo until they were 21 days old.
Afterward, both groups were infected with a pathogenic strain of IBV. Our findings showed that while vitamin A supplementation didn't significantly alter the disease's clinical course or the chickens' overall growth, it had some notable effects on their immune response. Specifically, we observed increased levels of IBV-specific antibodies and a decrease in viral load in certain tissues among the vitamin A group.
Interestingly, vitamin A appeared to also suppress some immune responses, leading to lower expression levels of certain molecules related to inflammation and immune regulation. While vitamin A helped improve specific aspects of the immune response, it did not completely cure the chickens or prevent infection.
Overall, we can conclude that while vitamin A supplementation can offer some benefits in terms of boosting immunity and managing viral replication, it doesn't drastically change the outcome of IBV infections in chickens.
Afterward, both groups were infected with a pathogenic strain of IBV. Our findings showed that while vitamin A supplementation didn't significantly alter the disease's clinical course or the chickens' overall growth, it had some notable effects on their immune response. Specifically, we observed increased levels of IBV-specific antibodies and a decrease in viral load in certain tissues among the vitamin A group.
Interestingly, vitamin A appeared to also suppress some immune responses, leading to lower expression levels of certain molecules related to inflammation and immune regulation. While vitamin A helped improve specific aspects of the immune response, it did not completely cure the chickens or prevent infection.
Overall, we can conclude that while vitamin A supplementation can offer some benefits in terms of boosting immunity and managing viral replication, it doesn't drastically change the outcome of IBV infections in chickens.
9.5
Vitamin A efficacy
Most Useful Review
Vitamin A is an excellent aid for colds, particularly beneficial for bronchitis! It's a staple in our first aid kit.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.2
USERS' SCORE
Good
Based on 16 Reviews
8.7
8
Retinoic acid enhances glioma treatment
Retinoic acid-induced alterations enhance eATP-mediated anti-cancer effects in glioma cells: Implications for P2X7 receptor variants as key players.
Most Relevant Research
We investigated how retinoic acid (RA), a derivative of vitamin A, could influence cancer treatment, particularly in glioma, a type of brain tumor. Previous attempts to use RA as a therapeutic option were inconclusive, so we aimed to explore its effects alongside extracellular ATP (eATP) to harness their combined potential.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
9.5
Aids wound healing
Most Useful Review
Vitamin A plays a vital role in maintaining the integrity of mucous membranes and skin. It promotes rapid healing of wounds and prevents keratinisation and death of skin cells. This vitamin is essential for protein synthesis in the body and is particularly effective for eye health, especially night vision. Moreover, it is a powerful antioxidant beneficial in cancer treatment and prevention. It also protects the skin from sun damage, making it advisable to take before beach holidays. It influences progesterone synthesis, impacting reproductive function and libido. Daily intake with food enhances absorption.
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 50 Reviews
8.7
9.5
Overall health improved
Most Useful Review
I’m delighted with the benefits I’ve gained from this vitamin. After struggling with a cold and other health issues for a couple of years, I tried numerous supplements without success. However, since taking this vitamin, my energy levels have risen significantly, my mood has improved, and my overall health has transformed dramatically.
Eczema details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.4
USERS' SCORE
Good
Based on 11 Reviews
8.7
9.5
Alitretinoin improves eczema treatment
The Endogenous Dual Retinoid Receptor Agonist Alitretinoin Exhibits Immunoregulatory Functions on Antigen-Presenting Cells.
Most Relevant Research
We explored the effects of alitretinoin, a form of vitamin A, on chronic hand eczema (CHE). This powerful drug is known to target specific receptors in the skin, offering insights into its method of action. Through our detailed study, we examined skin samples from patients who responded well to alitretinoin treatment.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
9.5
Dryness reduction
Most Useful Review
My wife has eczema and severe dryness in her hands. After using this vitamin A, her condition improved and the dryness disappeared, thank God.
Osteoporosis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Improved health noted
Most Useful Review
Vitamins are well absorbed: no allergies, heartburn, or digestive issues. I firmly believe that without vitamin D3, youth and beauty are unattainable. So, I went to the pharmacy and found D3 only sold with calcium, which I didn’t need. I take the capsules as directed, ideally with fatty foods: butter, cheese, or soup works well. After two weeks, my overall health has improved, and the whole family enjoys them. I take three to five capsules daily. My skin feels supple, and my hair shines, showing these vitamins' effects even without tests. My children's academic performance has risen, and they seem more energetic. It’s vital for women to help prevent osteoporosis. I highly recommend these vitamins for anyone.
Psoriasis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Reduced plaques
Most Useful Review
It is very useful for my skin as I have psoriasis. More than two months have passed since starting treatment, and I'm very pleased that my plaques have decreased and itchiness is less frequent. The difference is quite noticeable; I only wish I had taken a photo before, as it was much worse! There is also less skin peeling on my face.
Rosacea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Rosacea in remission
Most Useful Review
I take it for rosacea. I suffer from rosacea, and when I don’t use retinol in my regimen, I take this vitamin A every evening at a dosage of 10,000 for three months. My rosacea is in remission. The size of the capsules is perfect; I don’t chew them, so they don’t cause any taste discomfort.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 9 Reviews
8.7
8
Vitamin A's impact on OSA
The role of antioxidant vitamins and selenium in patients with obstructive sleep apnea.
Most Relevant Research
We conducted a case-control study to explore the levels of essential antioxidant nutrients, particularly vitamin A, in patients with obstructive sleep apnea (OSA) who did not have any other health issues. By categorizing our 146 subjects based on their apnea-hypopnea index (AHI) scores, we examined how these nutrient levels compared between those with mild to severe OSA and healthy individuals.
Our findings revealed that patients with OSA showed increased concentrations of vitamin A as part of their antioxidant response. This suggests that vitamin A and selenium may serve as important defenses against the harmful impacts of OSA. The implication of our research highlights that supplementing with antioxidant nutrients could be a beneficial approach to enhance overall health in individuals suffering from sleep apnea.
However, while there is a positive correlation between vitamin A levels and OSA, it is important to note that the isolated effects of vitamin A were not the primary focus of our study. Therefore, more research is needed to fully unravel its specific role in treating or managing sleep apnea.
Our findings revealed that patients with OSA showed increased concentrations of vitamin A as part of their antioxidant response. This suggests that vitamin A and selenium may serve as important defenses against the harmful impacts of OSA. The implication of our research highlights that supplementing with antioxidant nutrients could be a beneficial approach to enhance overall health in individuals suffering from sleep apnea.
However, while there is a positive correlation between vitamin A levels and OSA, it is important to note that the isolated effects of vitamin A were not the primary focus of our study. Therefore, more research is needed to fully unravel its specific role in treating or managing sleep apnea.
9.5
Energy boost
Most Useful Review
Excellent! I genuinely feel like this product delivers on its promises. I've noticed a surge of energy and improved sleep quality, allowing me to enjoy more restful hours. It has also positively impacted my mood, making it a wonderful addition to my routine.
Ulcer details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Strengthened immunity
Most Useful Review
I ordered vitamin A to enhance my retina. Previously, there was a small spot in the light, but after daily intake, it diminished. My treatment lasted three months, during which I also took vitamin C. My immunity strengthened significantly, and I managed to avoid catching an ulcer during the active virus season. Quality and dosage are advantageous.
Whooping Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.7
10
Dry cough vanished
Most Useful Review
After COVID, my mother suffered from a terrible dry cough for a considerable time, which disappeared almost immediately after starting vitamin A! Nothing else worked! Vitamin A is vital for nourishing lung tissue. Please consult your doctor if you smoke. If this review helps, please click YES. I wish everyone good health!
Acne details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 92 Reviews
8.6
9.5
Vitamin A's effectiveness in acne
The role of vitamins and nutrients in rosacea.
Most Relevant Research
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
9.5
Fights acne
Most Useful Review
Excellent! A beneficial vitamin for aging, dry skin, and combating acne.
Acne details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 92 Reviews
8.6
9.5
Vitamin A's effectiveness in acne
The role of vitamins and nutrients in rosacea.
Most Relevant Research
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
9.5
Fights acne
Most Useful Review
Excellent! A beneficial vitamin for aging, dry skin, and combating acne.
Allergies details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 11 Reviews
8.6
9
Vitamin A and allergy management
Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.
Most Relevant Research
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
8.3
Effective for allergies
Most Useful Review
An invaluable aid for respiratory tract infections, this dosage is sufficient. Vitamin A helps protect against flu, colds, and respiratory infections, and it also works on allergies. I appreciate this brand for its quality at a reasonable price! It has improved my acne, reduced hair loss, and has helped with my allergies. Highly recommend it! Quality is excellent.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Vitamin A's role in anemia
Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances.
Most Relevant Research
We examined the connection between vitamin A deficiency (VAD) and anemia, particularly how a lack of vitamin A can impact iron metabolism in our bodies. Through reviewing existing research, we discovered that VAD doesn't just lead to general anemia but may cause a specific type known as vitamin A deficiency anemia (VADA).
Our findings reveal that vitamin A plays an essential role in the production of red blood cells. When we lack vitamin A, our bodies struggle to utilize iron effectively. Instead of being available for red blood cell production, iron accumulates in our liver and spleen, leading to reduced levels of circulating iron.
We also saw that inflammation and systemic infections could further exacerbate this issue by triggering the liver to produce more hepcidin, a protein that regulates iron levels. The excess hepcidin can create a situation where there isn’t enough iron for the production of hemoglobin, ultimately causing anemia.
Interestingly, our review highlighted that VADA happens not because of a lack of iron, but due to how iron is managed within the body. By understanding these mechanisms, we can work towards creating better strategies to tackle anemia on a global scale.
Our findings reveal that vitamin A plays an essential role in the production of red blood cells. When we lack vitamin A, our bodies struggle to utilize iron effectively. Instead of being available for red blood cell production, iron accumulates in our liver and spleen, leading to reduced levels of circulating iron.
We also saw that inflammation and systemic infections could further exacerbate this issue by triggering the liver to produce more hepcidin, a protein that regulates iron levels. The excess hepcidin can create a situation where there isn’t enough iron for the production of hemoglobin, ultimately causing anemia.
Interestingly, our review highlighted that VADA happens not because of a lack of iron, but due to how iron is managed within the body. By understanding these mechanisms, we can work towards creating better strategies to tackle anemia on a global scale.
9.5
Cured my anemia
Most Useful Review
The quality is good, with a high dose of fat-soluble vitamin A, which I administered to my child. When overdosed, it caused a severe headache, but I cured my anemia with vitamin A as it's vital for the assimilation of iron. The child's skin has improved, and it's important for immunity. I recommend it!
Angina details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
8.8
Protective against angina
Most Useful Review
The antioxidant effect of vitamin A is significant in combating heart and arterial diseases. It provides protection for individuals with angina pectoris and enhances levels of good cholesterol in the blood. Additionally, vitamin A effectively combats viruses and bacteria, strengthens nails, and accelerates wound healing.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin A's potential in arthritis treatment
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.
Most Relevant Research
We explored the potential of all-trans retinoic acid (ATRA), a form of vitamin A, in treating autoimmune arthritis. The research focused on how ATRA can help improve the body's immune response while reducing inflammation associated with arthritis.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
9.5
Disease progression halted
Most Useful Review
I take this as an adjunct to medication in treating rheumatoid arthritis, and the disease has ceased to progress.
Bloating details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Bloating disappeared
Most Useful Review
Aloe Vera juice is a wonderful addition to your health! I take 1 tablespoon in a glass of water, preferably on an empty stomach. It clears the body and helps normalise the stomach and intestines. I’ve previously tried a concentrate from Herbalife, but this organic juice is far superior! After using it for 40 days with my husband, we found our intestinal health improved significantly. Bloating and belching vanished, and I no longer felt heaviness in my stomach. My appetite has decreased. Quite pleased with the results!
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 25 Reviews
8.6
9.5
Alleviates throat pain
Most Useful Review
When experiencing throat discomfort, I take 5 tablets of Vitamin A at once. After this, there is no throat pain the following day. Increasing the dosage is key when any discomfort arises; hence, I recommend it if you're suffering from throat pain.
Bruise details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
8.8
Skin condition improved
Most Useful Review
Effective! Vitamin A was prescribed by the doctor, and although I was initially sceptical, the final results were pleasing! Even those around me noticed the improvement in my skin's condition. The colour brightened, dryness disappeared, and the bruises under my eyes lightened! While everyone has their own reasons for taking vitamin A, I enjoyed an unexpected and stunning result. Highly recommend! Try it and see for yourself!
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.6
9
Improved eye fatigue
Most Useful Review
I started taking Vitamin A for eye health and immunity, and thankfully, I have not encountered any side effects. It significantly helped alleviate eye fatigue from computer use. After a two-month treatment, my skin looked beautiful and clear, which I initially didn't attribute to the vitamin. I wish everyone good health!
Constipation details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.6
10
Constipation relief
Most Useful Review
I have been using this product regularly for several months now. I'm pleased to report that both constipation and hemorrhoids have disappeared, even though alleviating these issues wasn't the primary purpose of this medication.
Heart Attack details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Eliminated heart attacks
Most Useful Review
Terrible experience; however, I noticed my nails stopped breaking after the first two weeks. My skin and hair showed changes after more than a month. Immunity seems unchanged. I was dealing with heart attacks, which prompted me to purchase Omega 3, and honestly, that issue completely vanished. I took a second pack and don't regret it at all.
Insomnia details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
8.8
Improved sleep quality
Most Useful Review
Excellent! This is a fantastic supplement! I previously experienced quite severe insomnia, but after nearly a month of usage, I realised that my sleep had improved. It also provides me with a boost of energy in the morning. It’s amusing how those who don't take it can notice the difference too.
Lung Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Vitamin A mitigates lung cancer
Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA).
Most Relevant Research
We aimed to understand how all-trans retinoic acid (ATRA), a form of vitamin A, influences lung cancer development caused by benzo(a)pyrene (B(a)P) exposure in mice. The study involved a thorough examination of the overall health of the mice, including body and organ weights, blood tests, and tissue analysis for any signs of damage or inflammation.
In our observations, B(a)P significantly harmed the mice, leading to weight loss and increased organ weight, particularly in the liver and lungs. Blood analysis revealed a concerning decrease in healthy blood cells and an increase in inflammatory markers, indicating an unhealthy state. However, we found that when these mice were treated with ATRA, their conditions improved remarkably.
The treated mice regained weight, saw improvements in their blood parameters, and exhibited lower levels of cancer-related inflammation. Notably, the expression of the COX-2 gene—an important player in inflammation and cancer—was dramatically reduced with ATRA treatment in both lung and liver tissues. This suggests that ATRA effectively counteracts the inflammatory effects and may help prevent the initial stages of cancer caused by B(a)P exposure.
Overall, our findings highlight the potential of vitamin A in mitigating some of the risks associated with lung cancer development due to environmental carcinogens, supporting further exploration of its role in cancer prevention.
In our observations, B(a)P significantly harmed the mice, leading to weight loss and increased organ weight, particularly in the liver and lungs. Blood analysis revealed a concerning decrease in healthy blood cells and an increase in inflammatory markers, indicating an unhealthy state. However, we found that when these mice were treated with ATRA, their conditions improved remarkably.
The treated mice regained weight, saw improvements in their blood parameters, and exhibited lower levels of cancer-related inflammation. Notably, the expression of the COX-2 gene—an important player in inflammation and cancer—was dramatically reduced with ATRA treatment in both lung and liver tissues. This suggests that ATRA effectively counteracts the inflammatory effects and may help prevent the initial stages of cancer caused by B(a)P exposure.
Overall, our findings highlight the potential of vitamin A in mitigating some of the risks associated with lung cancer development due to environmental carcinogens, supporting further exploration of its role in cancer prevention.
8.8
Significant Improvements
Most Useful Review
For the eyes, skin, and lungs, vitamin A is excellent when combined with fish oil, especially during and after Covid. Following the optimal dosage of one per day ensures no excess. I've seen clear benefits for my family's health during illness; our sense of smell returned rapidly, and my skin glows without flakiness. I've failed to achieve similar results from pharmacy forms of vitamin A. Always consume with fatty foods and avoid mixing with vitamin D for maximum effect. Thank you for reading!
Pneumonia details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Excellent recovery aid
Most Useful Review
An excellent vitamin! Prescribed by a pulmonologist after my viral pneumonia, I find that drinking it regularly is essential.
Sinusitis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.6
9.5
Reduces nasal dryness
Most Useful Review
Very useful for sinusitis. It reduces dryness in the nose and aids the mucous membrane in forming and eliminating bacteria. This is particularly beneficial for those experiencing issues with their nasal sinuses and allergic rhinitis, taking a capsule every two days.
Urinary Tract Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Digestive health improvement
Most Useful Review
Vitamin A is crucial for forming mucous tissue in the respiratory, gastrointestinal, and urinary systems. My child was given it to enhance the digestive system, and it worked effectively, reducing issues significantly.
Cardiovascular Disease details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.5
8.8
Dry eye relief
Most Useful Review
Since I started taking vitamin A, my dry eyes no longer bother me. I previously relied on eye drops, but now I've found relief, disputing previous medical advice regarding my condition.
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Reduced dry eyes
Most Useful Review
Effective for eyestrain. Dry eye and eyestrain have been alleviated! Dr Fujikawa is administering mechavitamin therapy. I began taking one tablet at night, and by the third day, my dry eyes and stiff shoulders from the eyestrain improved. Concerned about an overdose, I take one tablet every three days at my own discretion.
Influenza details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
8.8
Improved immunity
Most Useful Review
I take vitamin A as a doctor recommended, using one tablet for a month. During this period, the condition of my skin, hair, and nails has improved. My eyes feel less strained when using the computer, and I have become more resistant to influenza viruses, enhancing my overall immunity. I highly recommend it!
Kidney Stones details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.5
9.5
Restored appetite
Most Useful Review
This supplement aids recovery from long-term loss of appetite! Following my surgery, I lost 8 kg in six months due to a lack of hunger, feeling as if I had a stone lodged in my throat. The hospital's medication proved ineffective. I took a mega dose of vitamin A, which surprisingly relieved my throat discomfort and returned my appetite. I took 100,000 IU, but do so at your own risk, as excessive vitamin A can lead to itchy skin and headaches. I experienced severe itching on my feet from overdoing it. This vitamin truly saved my life, and I will continue to take it appropriately.
Menopause details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
Excellent supplement
Most Useful Review
Amazing! Under trial, this wonderful nutritional supplement for women during menopause.
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8.4
8
Vitamin A's role in anxiety management
Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression.
Most Relevant Research
We explored how vitamin A, more specifically its active form retinoic acid (RA), impacts anxiety levels. In this study, researchers discovered that a specific protein, cellular RA binding protein 1 (Crabp1), plays a crucial role in regulating responses to stress. Mice lacking Crabp1 showed significantly lower levels of anxiety and less stress-induced hormone release, indicating that Crabp1 dampens the body's stress response.
By examining the interactions between Crabp1 and another protein called FKBP5, we observed that reducing Crabp1 levels led to decreased FKBP5 expression. This is important because lower FKBP5 levels lessened feedback inhibition in the hypothalamic-pituitary-adrenal (HPA) axis, which in turn helped reduce anxiety-like behaviors. It was noted that stress and RA can actually increase Crabp1 levels, which may heighten FKBP5 expression and possibly raise the risk of anxiety disorders.
Essentially, this study sheds light on the complex relationship between vitamin A, Crabp1, and anxiety, suggesting that while Crabp1 modulates stress responses beneficially, an overabundance can potentially increase anxiety risks.
By examining the interactions between Crabp1 and another protein called FKBP5, we observed that reducing Crabp1 levels led to decreased FKBP5 expression. This is important because lower FKBP5 levels lessened feedback inhibition in the hypothalamic-pituitary-adrenal (HPA) axis, which in turn helped reduce anxiety-like behaviors. It was noted that stress and RA can actually increase Crabp1 levels, which may heighten FKBP5 expression and possibly raise the risk of anxiety disorders.
Essentially, this study sheds light on the complex relationship between vitamin A, Crabp1, and anxiety, suggesting that while Crabp1 modulates stress responses beneficially, an overabundance can potentially increase anxiety risks.
9.5
Natural anti-stress
Most Useful Review
Magnesium helps reduce stress and anxiety, improving sleep quality. It acts as a natural anti-stress component by inhibiting excitation processes in the central nervous system and reducing sensitivity to external stimuli.
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Vitamin A benefits thyroid function
The effect of vitamin A supplementation on thyroid function in premenopausal women.
Most Relevant Research
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
8.8
Vision improved
Most Useful Review
A good vitamin. I have hypothyroidism, and vitamin A is not absorbed from food. After completing the course, I noticed an improvement in my night vision. For better absorption, it's advisable to consume protein and fat during breakfast alongside zinc. Those who smoke or have recently quit should avoid it for up to three years. Pregnant women should consult a doctor, and the dosage might need to be halved. If you enjoyed the review, please show some love! 💓
Blood Clot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.3
9.5
Eliminated nosebleeds
Most Useful Review
Very effective in strengthening mucous membranes! Before I began taking this, I frequently had blood in my nose when blowing it and experienced stomach upset after consuming oily foods. I also suffered from a sore throat and struggled to sleep in a dry air-conditioned room due to weak mucous membranes. Discovering this product was a godsend! The aforementioned symptoms vanished completely. I find this product exceptionally effective!
Back Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.1
9.5
Acne improved
Most Useful Review
My husband had acne all over his back, and while Roaccutane was initially prescribed, it became too expensive. We opted for vitamin A, which was surprisingly affordable. After just two months of taking it, his acne disappeared completely, leaving us both astonished and pleased.
Liver Disease details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.1
9.5
Boosted skin vitality
Most Useful Review
This vitamin remarkably aids liver health, resulting in youthful, smooth skin. I noticed changes within a week and a half after starting. For better absorption, it's ideal to take vitamin A with a meal containing healthy fats. Here's to health and beauty!
Headache details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.7
8
Vitamin A toxicity's impact on headaches
A Rare Case Report of Benign Intracranial Hypertension Caused by Hypervitaminosis A.
Most Relevant Research
We examined a rare case involving a 13-year-old girl who experienced symptoms of headache and visual disturbances due to benign intracranial hypertension (BIH) related to vitamin A toxicity. This condition was characterized by elevated pressure inside her skull, which led to her experiencing severe headaches, photophobia, and vomiting.
After conducting various tests, including magnetic resonance imaging and a lumbar puncture, we confirmed the diagnosis of BIH. Treatment was initiated with acetazolamide, a medication commonly used to reduce intracranial pressure. Although the study primarily focuses on the condition resulting from vitamin A excess, the use of acetazolamide makes it challenging to isolate the effect of vitamin A on headache relief specifically.
What's particularly noteworthy in this case is the significant elevation of serum vitamin A levels, which aligned with her symptoms. Following treatment, this patient showed a remarkable clinical improvement, including a reduction in papilledema during regular eye check-ups. Within just two weeks after starting treatment, she was discharged symptom-free, highlighting how important it is to consider vitamin A levels in children presenting with similar symptoms.
This case serves as a reminder for clinicians regarding the potential consequences of vitamin A toxicity, especially when evaluating children with headaches correlated to papilledema.
After conducting various tests, including magnetic resonance imaging and a lumbar puncture, we confirmed the diagnosis of BIH. Treatment was initiated with acetazolamide, a medication commonly used to reduce intracranial pressure. Although the study primarily focuses on the condition resulting from vitamin A excess, the use of acetazolamide makes it challenging to isolate the effect of vitamin A on headache relief specifically.
What's particularly noteworthy in this case is the significant elevation of serum vitamin A levels, which aligned with her symptoms. Following treatment, this patient showed a remarkable clinical improvement, including a reduction in papilledema during regular eye check-ups. Within just two weeks after starting treatment, she was discharged symptom-free, highlighting how important it is to consider vitamin A levels in children presenting with similar symptoms.
This case serves as a reminder for clinicians regarding the potential consequences of vitamin A toxicity, especially when evaluating children with headaches correlated to papilledema.
8.8
Effective for headaches
Most Useful Review
I purchased this supplement for my eyes and skin, and it also appears effective for my daily headaches. I find it alleviates headaches stemming from neck stiffness and eye strain. I take one tablet a day and have experienced no side effects, so I plan to continue my regimen.
Dizziness details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.6
7
Dizziness relief
Most Useful Review
This product is excellent; it alleviated my dizziness in the eyes after a month of use. I recommend taking it with vitamin C and a hearty meal for the best results, as I've noticed improvements in my skin and hair since beginning the supplement.
Diarrhea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
8
Vitamin A reduces diarrhea risk
Multilevel analysis of prevalence and determinants of diarrhea among under-five children in Somalia: insights from the Somalia demographic and health survey 2020.
Most Relevant Research
We explored the significant health concern of diarrhea among children under five in Somalia, with a particular focus on how vitamin A supplementation influences this issue. The analysis we conducted utilized data from the 2020 Somalia Demographic and Health Survey, which provided insights into various factors affecting child health.
Our findings revealed that children who received vitamin A were less likely to suffer from diarrhea, showcasing the importance of this nutrient in boosting young immune systems. We observed that alongside vitamin A, factors such as household wealth and maternal education also played crucial roles in determining the risk of diarrhea.
It’s clear that enhancing regular vitamin A supplementation could lead to a notable decrease in diarrhea cases among these young children. The study emphasizes the need for targeted public health initiatives to improve access to vitamin A and other health resources, ultimately protecting our vulnerable children from preventable diseases.
Our findings revealed that children who received vitamin A were less likely to suffer from diarrhea, showcasing the importance of this nutrient in boosting young immune systems. We observed that alongside vitamin A, factors such as household wealth and maternal education also played crucial roles in determining the risk of diarrhea.
It’s clear that enhancing regular vitamin A supplementation could lead to a notable decrease in diarrhea cases among these young children. The study emphasizes the need for targeted public health initiatives to improve access to vitamin A and other health resources, ultimately protecting our vulnerable children from preventable diseases.
3.8
Prefer vitamin A
Most Useful Review
This American supplement is good; the pills are small and tasteless. However, daily intake of high doses of ingredients can lead to problems, so adjusting the amount is wise. I find that beta-carotene causes me diarrhea, which is why I prefer vitamin A instead.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Medium or Average
Based on 12 Reviews
6.8
8
Vitamin A reduces pregnancy nausea
Vitamin A or beta-carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali women.
Most Relevant Research
We conducted a double-masked, placebo-controlled trial involving 15,832 Nepali women to explore how vitamin A and beta-carotene supplementation affects pregnancy-related nausea and overall illness symptoms. Our observations showed that while there was no noticeable impact during the early stages of pregnancy, vitamin A supplementation made a significant difference in late pregnancy.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
9.5
No side effects
Most Useful Review
This light, tasteless vitamin does not cause nausea and helps alleviate a deficiency of Vitamin A in the body. The box contains a large quantity of 100 tablets, making it convenient to use.
