We focused on the protective effects of vitamin A on stress-induced gastric lesions in piglets after experiencing hemorrhagic shock. In our study, piglets were subjected to low blood pressure and then treated with different doses of vitamin A. Remarkably, those receiving vitamin A showed no signs of gastric lesions.
This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.
Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
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We explored the effects of dietary vitamin A on preventing duodenal ulcers in rats induced by cysteamine-HCl. In our study, we compared two groups of rats—one receiving a standard diet and the other supplemented with vitamin A.
After exposing them to cysteamine-HCl, we observed that only 32% of the vitamin A group developed ulcers, compared to 74% in the control group. This shows a significant protective effect of vitamin A on ulcer formation, although it did not influence gastric acid production.
Overall, our findings suggest vitamin A supplementation could be beneficial in reducing duodenal ulcer risk in this experimental model.
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Vitamin A and beta-carotene prevent ulcersInterrelationships between the gastric cytoprotective effects of vitamin A and beta-carotene and the gastric mucosal superoxide dismutase activity in rats.
High relevance to ulcer prevention
In our investigation, we examined how vitamin A and beta-carotene impact gastric ulcers in rats. By administering these compounds before inducing gastric damage with ethanol or hydrochloric acid, we observed a notable reduction in both the number and severity of ulcers.
This suggests that both vitamin A and beta-carotene help protect the stomach lining. However, while they effectively prevent ulcers, they don't fully restore the activity of a crucial enzyme involved in gastric defense. Overall, we found that these vitamins play a key protective role, primarily due to their ability to act as antioxidants.
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We investigated whether vitamin A could shield against intestinal damage caused by ARA-C, a common leukemia treatment known for its side effects like mucosal lesions. Mice in our study were divided into several groups, some receiving vitamin A alongside ARA-C.
Our results revealed that mice treated with vitamin A showed significantly improved gut health compared to those who did not receive it. They exhibited better mucosal integrity and less tissue damage, suggesting that vitamin A can indeed play a protective role against the harmful effects of ARA-C.
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We examined how diet impacts the risk of duodenal ulcers in a large group of men, tracking their health for six years.
While we found no significant effects from fat or protein intake, we discovered that higher fruit and vegetable consumption, as well as increased dietary fiber, were linked to a reduced risk of developing ulcers.
Notably, vitamin A intake was the only nutrient that showed a strong protective effect, suggesting its potential role in ulcer prevention.
However, we also acknowledged that other dietary factors might contribute to these protective associations.
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