5/7/2025
Last update
5/7/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
3,000 mcg
333%
Top Medical Research Studies
9.5
We focused on the protective effects of vitamin A on stress-induced gastric lesions in piglets after experiencing hemorrhagic shock. In our study, piglets were subjected to low blood pressure and then treated with different doses of vitamin A. Remarkably, those receiving vitamin A showed no signs of gastric lesions.
This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.
Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.
Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
Read More
9
We explored the effects of dietary vitamin A on preventing duodenal ulcers in rats induced by cysteamine-HCl. In our study, we compared two groups of rats—one receiving a standard diet and the other supplemented with vitamin A.
After exposing them to cysteamine-HCl, we observed that only 32% of the vitamin A group developed ulcers, compared to 74% in the control group. This shows a significant protective effect of vitamin A on ulcer formation, although it did not influence gastric acid production.
Overall, our findings suggest vitamin A supplementation could be beneficial in reducing duodenal ulcer risk in this experimental model.
After exposing them to cysteamine-HCl, we observed that only 32% of the vitamin A group developed ulcers, compared to 74% in the control group. This shows a significant protective effect of vitamin A on ulcer formation, although it did not influence gastric acid production.
Overall, our findings suggest vitamin A supplementation could be beneficial in reducing duodenal ulcer risk in this experimental model.
Read More
8
Beta-carotene shows ulcer benefits
We explored the effects of daily beta-carotene treatment on patients with duodenal ulcers and erosive gastritis. After administering 18 mg of beta-carotene in an oil solution, we observed a threefold increase in its blood serum levels.
Although the concentration of retinol remained unchanged, indicating no harmful effects, the treatment showed promising results. It improved the antioxidative system, reduced pain, helped heal ulcers, and led to the healing of erosions in the gastric mucosa.
Although the concentration of retinol remained unchanged, indicating no harmful effects, the treatment showed promising results. It improved the antioxidative system, reduced pain, helped heal ulcers, and led to the healing of erosions in the gastric mucosa.
Read More
Most Useful Reviews
9
Strengthened immunity
7 people found this helpful
I ordered vitamin A to enhance my retina. Previously, there was a small spot in the light, but after daily intake, it diminished. My treatment lasted three months, during which I also took vitamin C. My immunity strengthened significantly, and I managed to avoid catching an ulcer during the active virus season. Quality and dosage are advantageous.
Read More
9
Improved mouth ulcers
5 people found this helpful
It's also effective in the early stages of a cold! I am practising nutritional therapy based on the book by Dr. Tokumi Fujikawa. When I took this, my mouth ulcers improved. I believe the ingredients and quality are commendable. Postscript: A must-read for cancer patients! Dr. Kimihiko Okazaki's book, "The Miracle Cure for Cancer Has Already Been Discovered!"
Read More
9
Effective for ulcers
1 people found this helpful
Cospa is good! It works on mucous membranes, so it is beneficial for mouth ulcers and sore throats.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
- All Researches
9.5
We focused on the protective effects of vitamin A on stress-induced gastric lesions in piglets after experiencing hemorrhagic shock. In our study, piglets were subjected to low blood pressure and then treated with different doses of vitamin A. Remarkably, those receiving vitamin A showed no signs of gastric lesions.
This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.
Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.
Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
Read More
9
We explored the effects of dietary vitamin A on preventing duodenal ulcers in rats induced by cysteamine-HCl. In our study, we compared two groups of rats—one receiving a standard diet and the other supplemented with vitamin A.
After exposing them to cysteamine-HCl, we observed that only 32% of the vitamin A group developed ulcers, compared to 74% in the control group. This shows a significant protective effect of vitamin A on ulcer formation, although it did not influence gastric acid production.
Overall, our findings suggest vitamin A supplementation could be beneficial in reducing duodenal ulcer risk in this experimental model.
After exposing them to cysteamine-HCl, we observed that only 32% of the vitamin A group developed ulcers, compared to 74% in the control group. This shows a significant protective effect of vitamin A on ulcer formation, although it did not influence gastric acid production.
Overall, our findings suggest vitamin A supplementation could be beneficial in reducing duodenal ulcer risk in this experimental model.
Read More
9
In our investigation, we examined how vitamin A and beta-carotene impact gastric ulcers in rats. By administering these compounds before inducing gastric damage with ethanol or hydrochloric acid, we observed a notable reduction in both the number and severity of ulcers.
This suggests that both vitamin A and beta-carotene help protect the stomach lining. However, while they effectively prevent ulcers, they don't fully restore the activity of a crucial enzyme involved in gastric defense. Overall, we found that these vitamins play a key protective role, primarily due to their ability to act as antioxidants.
This suggests that both vitamin A and beta-carotene help protect the stomach lining. However, while they effectively prevent ulcers, they don't fully restore the activity of a crucial enzyme involved in gastric defense. Overall, we found that these vitamins play a key protective role, primarily due to their ability to act as antioxidants.
Read More
9
We examined a unique case of lip ulcers linked to the intravenous use of zoledronic acid (ZA) in a patient undergoing treatment for metastatic breast cancer. Despite managing the patient's anemia and an E. coli infection, the ulcers persisted until ZA was discontinued.
After halting the medication, the ulcers healed within three months with a treatment plan that included systemic antibiotics and vitamins A and E. However, upon resuming ZA, recurrence occurred, but follow-up treatment kept the patient clear of lesions for 18 months.
This case highlights how vitamin A can aid in the healing of severe oral mucosal ulcers related to bisphosphonate therapy.
After halting the medication, the ulcers healed within three months with a treatment plan that included systemic antibiotics and vitamins A and E. However, upon resuming ZA, recurrence occurred, but follow-up treatment kept the patient clear of lesions for 18 months.
This case highlights how vitamin A can aid in the healing of severe oral mucosal ulcers related to bisphosphonate therapy.
Read More
8
Vitamin A protects against ARA-C damage
We investigated whether vitamin A could shield against intestinal damage caused by ARA-C, a common leukemia treatment known for its side effects like mucosal lesions. Mice in our study were divided into several groups, some receiving vitamin A alongside ARA-C.
Our results revealed that mice treated with vitamin A showed significantly improved gut health compared to those who did not receive it. They exhibited better mucosal integrity and less tissue damage, suggesting that vitamin A can indeed play a protective role against the harmful effects of ARA-C.
Our results revealed that mice treated with vitamin A showed significantly improved gut health compared to those who did not receive it. They exhibited better mucosal integrity and less tissue damage, suggesting that vitamin A can indeed play a protective role against the harmful effects of ARA-C.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strengthened immunity
7 people found this helpful
I ordered vitamin A to enhance my retina. Previously, there was a small spot in the light, but after daily intake, it diminished. My treatment lasted three months, during which I also took vitamin C. My immunity strengthened significantly, and I managed to avoid catching an ulcer during the active virus season. Quality and dosage are advantageous.
Read More
9
Improved mouth ulcers
5 people found this helpful
It's also effective in the early stages of a cold! I am practising nutritional therapy based on the book by Dr. Tokumi Fujikawa. When I took this, my mouth ulcers improved. I believe the ingredients and quality are commendable. Postscript: A must-read for cancer patients! Dr. Kimihiko Okazaki's book, "The Miracle Cure for Cancer Has Already Been Discovered!"
Read More
9
Effective for ulcers
1 people found this helpful
Cospa is good! It works on mucous membranes, so it is beneficial for mouth ulcers and sore throats.
Read More
9
Prevented mouth ulcers
My husband has become very adept at preventing mouth ulcers and can no longer suffer from them; his hay fever has improved too.
Read More
9
No more nosebleeds
Be cautious not to take too much! I was battling itching and a runny nose due to hay fever, along with nosebleeds. After learning that vitamin A is beneficial for mucous membranes, I began this supplement. Since then, I have hardly had any nosebleeds, and mouth ulcers are a thing of the past. I plan to keep taking it.
Read More
Frequently Asked Questions
9
Strengthened immunity
7 people found this helpful
I ordered vitamin A to enhance my retina. Previously, there was a small spot in the light, but after daily intake, it diminished. My treatment lasted three months, during which I also took vitamin C. My immunity strengthened significantly, and I managed to avoid catching an ulcer during the active virus season. Quality and dosage are advantageous.
9
Improved mouth ulcers
5 people found this helpful
It's also effective in the early stages of a cold! I am practising nutritional therapy based on the book by Dr. Tokumi Fujikawa. When I took this, my mouth ulcers improved. I believe the ingredients and quality are commendable. Postscript: A must-read for cancer patients! Dr. Kimihiko Okazaki's book, "The Miracle Cure for Cancer Has Already Been Discovered!"
9
Prevented mouth ulcers
My husband has become very adept at preventing mouth ulcers and can no longer suffer from them; his hay fever has improved too.
9
No more nosebleeds
Be cautious not to take too much! I was battling itching and a runny nose due to hay fever, along with nosebleeds. After learning that vitamin A is beneficial for mucous membranes, I began this supplement. Since then, I have hardly had any nosebleeds, and mouth ulcers are a thing of the past. I plan to keep taking it.
9
Effective for ulcers
1 people found this helpful
Cospa is good! It works on mucous membranes, so it is beneficial for mouth ulcers and sore throats.
8
We investigated the effectiveness of various treatments, including Vitamin A, for healing chronic gastric and duodenal ulcers in a multiclinical study with 441 patients. Each patient was randomized to receive different drug combinations, including cytoprotective options like Vitamin A.
After six weeks of treatment, we observed significant improvements in ulcer size and a reduction in pain scores across all treatment groups. However, the results didn’t indicate that Vitamin A uniquely contributed to ulcer healing compared to other treatments. Overall, while many therapies showed promise, the specific impact of Vitamin A remains unclear.
After six weeks of treatment, we observed significant improvements in ulcer size and a reduction in pain scores across all treatment groups. However, the results didn’t indicate that Vitamin A uniquely contributed to ulcer healing compared to other treatments. Overall, while many therapies showed promise, the specific impact of Vitamin A remains unclear.
9.5
We focused on the protective effects of vitamin A on stress-induced gastric lesions in piglets after experiencing hemorrhagic shock. In our study, piglets were subjected to low blood pressure and then treated with different doses of vitamin A. Remarkably, those receiving vitamin A showed no signs of gastric lesions.
This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.
Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.
Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
5
We reviewed the evidence on how diet influences duodenal ulcers (DU), focusing on a high-fibre diet as a potential protective factor.
Our findings suggest that increasing dietary fibre—especially from fruits and vegetables—can significantly reduce the risk of developing DU.
Furthermore, vitamin A intake may also lower the risk. However, there’s limited evidence that other factors like fat, protein, or alcohol consumption affect DU risk.
Our findings suggest that increasing dietary fibre—especially from fruits and vegetables—can significantly reduce the risk of developing DU.
Furthermore, vitamin A intake may also lower the risk. However, there’s limited evidence that other factors like fat, protein, or alcohol consumption affect DU risk.
8
Vitamin A shows modest ulcer benefits
We compared the healing effects of vitamin A, De-Nol, and sucralfate with pirenzepine in patients suffering from chronic gastric ulcers. Over four weeks, 100 patients received different treatments and we monitored their progress through endoscopy.
While ulcer size decreased across all groups, De-Nol showed the most significant reduction. Interestingly, vitamin A demonstrated notably positive effects on ulcer healing during the second week, although its overall impact was less pronounced than that of De-Nol.
Thus, while vitamin A has some benefits, De-Nol appears to be the most effective for healing chronic gastric ulcers.
While ulcer size decreased across all groups, De-Nol showed the most significant reduction. Interestingly, vitamin A demonstrated notably positive effects on ulcer healing during the second week, although its overall impact was less pronounced than that of De-Nol.
Thus, while vitamin A has some benefits, De-Nol appears to be the most effective for healing chronic gastric ulcers.
7
Vitamin A reduces stress ulcer severity
We investigated how vitamin A could protect against stress-induced ulcers in rats. The study involved administering intramuscular injections of 1000 or 2000 IU of vitamin A every 6 hours after 19 hours of immobilization.
The results showed that rats receiving vitamin A had significantly fewer and smaller ulcers compared to the control group. However, it’s important to note that, despite the apparent benefits, the protection was not absolute, as some rats still developed gastric ulcers.
This shines a light on the potential therapeutic role of vitamin A in preventing ulcers, although further exploration is necessary for conclusive recommendations.
The results showed that rats receiving vitamin A had significantly fewer and smaller ulcers compared to the control group. However, it’s important to note that, despite the apparent benefits, the protection was not absolute, as some rats still developed gastric ulcers.
This shines a light on the potential therapeutic role of vitamin A in preventing ulcers, although further exploration is necessary for conclusive recommendations.
8
We examined how diet impacts the risk of duodenal ulcers in a large group of men, tracking their health for six years.
While we found no significant effects from fat or protein intake, we discovered that higher fruit and vegetable consumption, as well as increased dietary fiber, were linked to a reduced risk of developing ulcers.
Notably, vitamin A intake was the only nutrient that showed a strong protective effect, suggesting its potential role in ulcer prevention.
However, we also acknowledged that other dietary factors might contribute to these protective associations.
While we found no significant effects from fat or protein intake, we discovered that higher fruit and vegetable consumption, as well as increased dietary fiber, were linked to a reduced risk of developing ulcers.
Notably, vitamin A intake was the only nutrient that showed a strong protective effect, suggesting its potential role in ulcer prevention.
However, we also acknowledged that other dietary factors might contribute to these protective associations.
References
- Elli M, Aydin O, Bilge S, Bozkurt A, Dagdemir A, et al. Protective effect of vitamin A on ARA-C induced intestinal damage in mice. Tumori. 2009;95:87.
- Ryan-Harshman M, Aldoori W. How diet and lifestyle affect duodenal ulcers. Review of the evidence. Can Fam Physician. 2004;50:727.
- Pimenov LT, Balobanov VIu, Pushina LN, Shemiakina TV. [The clinico-endoscopic, psychological and physical characteristics of duodenal peptic ulcer patients using piracetam and aevit]. Ter Arkh. 1997;69:10.
- Aldoori WH, Giovannucci EL, Stampfer MJ, Rimm EB, Wing AL, et al. Prospective study of diet and the risk of duodenal ulcer in men. Am J Epidemiol. 1997;145:42.
- Stanislavchuk NA, Pentiuk AA, Vovk OG, Ostapchuk EI. [The influence of retinol, tocopherol and cimetidine on the ulcerogenic effect of Orthofen, indomethacin and naproxen]. Eksp Klin Farmakol. 1995;58:33.
- Mózsik G, Hunyady B, Garamszegi M, Németh A, Pakodi F, et al. Dynamism of cytoprotective and antisecretory drugs in patients with unhealed gastric and duodenal ulcers. J Gastroenterol Hepatol. 1994;9 Suppl 1:S88.
- Spirichev VB, Levachev MM, Rymarenko TV, Iakushina LM, Kharitonchik LA, et al. [The effect of administration of beta-carotene in an oil solution on its blood serum level and antioxidant status of patients with duodenal ulcer and erosive gastritis]. Vopr Med Khim. 1992;38:44.
- Király A, Sütö G, Vincze A, Tóth G, Matus Z, et al. Correlation between the cytoprotective effect of beta-carotene and its gastric mucosal level in indomethacin (IND) treated rats with or without acute surgical vagotomy. Acta Physiol Hung. 1992;80:213.
- Granov AM, Aiskhanov SK, Nikolaev LI, Smirnova NA. [Clinico-endoscopic evaluation of the effectiveness of the treatment of uncomplicated gastroduodenal ulcers after local administration of solcoseryl and aevit]. Vestn Khir Im I I Grek. 1989;144:12.
- Mahmood T, Tenenbaum S, Niu XT, Levenson SM, Seifter E, et al. Prevention of duodenal ulcer formation in the rat by dietary vitamin A supplementation. JPEN J Parenter Enteral Nutr. 1986;10:74.
- Mózsik G, Jávor T, Tóth G, Zsoldos T, Tigyi A. Interrelationships between the gastric cytoprotective effects of vitamin A and beta-carotene and the gastric mucosal superoxide dismutase activity in rats. Acta Physiol Hung. 1984;64:315.
- Patty I, Tárnok F, Simon L, Jávor T, Deák G, et al. A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). Acta Physiol Hung. 1984;64:379.
- Patty I, Benedek S, Deák G, Jávor T, Kenéz P, et al. Cytoprotective effect of vitamin A and its clinical importance in the treatment of patients with chronic gastric ulcer. Int J Tissue React. 1983;5:301.
- von Gerstenbergk L, Büsing M, Seufert RM, Doertenbach J, Hottenrott C. [Lose-dose treatment with vitamin A in prevention of stress ulcer in swine]. Langenbecks Arch Chir. 1976;Suppl:224.
- Schumpelick V, Farthmann E. [Study on the protective effect of vitamin A on stress ulcer of the rat (author's transl)]. Arzneimittelforschung. 1976;26:386.
- Kivilaakso E, Kalima TV, Lempinen M. Modification of procine stress ulceration by methylprednisolone, vitaminA and methysergide treatment. Eur Surg Res. 1976;8:281.
- Andreadis D, Mauroudis S, Poulopoulos A, Markopoulos A, Epivatianos A. Lip ulceration associated with intravenous administration of zoledronic acid: report of a case. Head Neck Pathol. 2012;6:275. 10.1007/s12105-011-0313-8
- Lischer CJ, Dietrich-Hunkeler A, Geyer H, Schulze J, Ossent P. [Healing process of uncomplicated sole ulcers in dairy cows kept in tie stalls: clinical description and blood chemical investigations]. Schweiz Arch Tierheilkd. 2001;143:125.
