NOW Supplements Glucosamine &amp; Chondroitin with MSM

Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15132995

Questionable

Based on 5 Researches

MSM improves mild knee pain

We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.

Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.

Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.

This suggests that MSM could be a helpful option for those dealing with mild knee pain.

Reduced knee pain

Most Useful Review

202 people found this helpful

Glucosamine, a major component of cartilage tissue, protects joints from damage and has a shock-absorbing effect. It also contributes to the synovial fluid, which lubricates and nourishes the joints. Chondroitin aids in producing joint fluid and restoring cartilage, possessing anti-inflammatory and analgesic properties. Together, glucosamine and chondroitin effectively protect and restore cartilage. Since I began taking them, I’ve noticed my knee almost never hurts, and I’ve even observed improvements in my hair and nails.

Chondromalacia Patella details

Pain considerably improved

I purchased this vitamin to alleviate the pain in my knee joint, as I was diagnosed with chondromalacia. The pain I experienced greatly improved.

Chronic Cough details

1 people found this helpful

This very good product is reputed to be capable of rebuilding joints. Since I have chronic Lyme disease and my joints are always an issue, I take these 3-6 times a day, and they are helping me immensely. I would recommend them to anyone with joint problems; they are truly amazing.

Cold Sores details

Significant improvement noted

3 people found this helpful

With the rainy cold weather, my joints often ache. After taking these glucosamine supplements for two weeks, I noticed a significant improvement. I plan to order more to complete a full course for three months.

Ear Infection details

8 people found this helpful

My mother, in her early 50s, lamented her knee pain. Unable to afford Japanese products, I searched online and purchased these instead. My mother struggles with pills, but she tolerates the large grains. Interestingly, after consuming about half a bottle, she no longer complains of knee pain! Although she only takes 2 tablets in 2 days, the desired effect is achieved. There are no side effects, and the product is very trustworthy. If you're concerned about your parents, I encourage you to try it.

Rheumatoid Arthritis details

Dai W, Qi C, Wang S. Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats. Biomed Pharmacother. 2018;105:835. doi:10.1016/j.biopha.2018.05.136

Possibly Effective

Based on 8 Researches

Glucosamine and vitamin E benefits

We investigated how glucosamine sulfate, especially in combination with vitamin E, affects rheumatoid arthritis (RA) using a neonatal rat model. Through our study, we measured various biological markers, including lipid peroxidation, antioxidant levels, and inflammatory factors to understand better how this treatment could help counteract the effects of RA.

Our findings showed that when glucosamine was paired with vitamin E, there was a notable reduction in the levels of malondialdehyde (MDA), a marker of oxidative stress. Specifically, we observed a reduction of 61.9% in MDA levels, which suggests a positive effect on oxidative stress associated with RA. Additionally, key antioxidants like superoxide dismutase (SOD), catalase, and glutathione were elevated, indicating improved antioxidant activity.

We also noted significant decreases in various inflammatory markers, including matrix metalloproteinase-3 (MMP-3) and prostaglandin E (PGE), suggesting that this combination therapy may effectively reduce inflammation related to RA. The results indicated a synergistic effect between glucosamine and vitamin E in mitigating symptoms of RA, highlighting potential benefits for those grappling with this condition.

Significant health improvement

Most Useful Review

Glucosamine chondroitin is an excellent supplement. I have back issues and joint pain. After a week of use, my health improved remarkably. My mother took this supplement for rheumatoid arthritis alongside hormones, resulting in a good outcome with pain relief. We sourced this from another manufacturer, and this one is clearly superior in quality and dosage. I highly recommend it.

Sleep Apnea details

Improved sleep quality

This is not the first time we've taken this with the girls, and all of them have shown very positive results. Those who often suffer from headaches found that the pain has ceased. I now experience vigour during the day and restful sleep at night. My dreams have become more vivid.

Back Pain details

Back pain improvement

After a year of high-dose usage, I have experienced a significant reduction in the severity of my back problems, more effective than years of strengthening and chiropractic care alone.

Bone Pain details

Significant pain relief

1052 people found this helpful

Arthrosis of the third degree was inhibited. I have arthrosis and had arthroscopy on my knee, leading to stiffness and gradual joint deformation. For six years, I received yearly hyaluron chondro injections, but stiff, aching pains and walking difficulties persisted. Despite trying Donna and other chondroprotectors with minimal improvement, I placed my hopes on this new drug, and it did not disappoint. After just a month, the aching pains and stiffness in my knee vanished. I'm genuinely delighted! I also take Neocell hyaluronic acid for moisturising. If my review is helpful, please consider me for the list.

Chest Pain details

I began taking this supplement when my wrist joint started causing me issues during training. After a prolonged period of use, the pain eventually subsided.

Common Cold details

9 people found this helpful

Helped to cope with knee pain. I acquired this medication on recommendation. In winter, I experienced knee difficulties, unable to bend or straighten, leading to considerable discomfort while walking. The exacerbation period lasted two weeks, but the pain does return occasionally. After a month’s course, I've noticed significant improvement; now, the knee only aches in the cold. Doctors found no issues and prescribed nothing. When I inquired about taking chondroitin, they unanimously deemed it unnecessary. However, I do not regret taking it. In the autumn, I intend to complete the full course, needing three jars. At its initial, non-neglected stage, it proves very effective.

Heart Disease details

Preventative joint support

100% WORKS, effective both in treatment and prevention! I've encountered much contradictory information regarding Glucosamine & Chondroitin. I, too, have experienced age-related changes whilst participating in sports. After a month on Glucosamine & Chondroitin with MSM, I saw remarkable results; the crunch in my knees diminished, and my joints felt stronger. Additionally, I enjoyed better sleep quality, and it even helped with hemorrhoids. I always aim to provide honest reviews to assist others.

Osteoporosis details

MSM enhances bone cell differentiation

Kim DN, Joung YH, Darvin P, Kang DY, Sp N, et al. Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. Mol Med Rep. 2016;14:460. doi:10.3892/mmr.2016.5274

We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.

Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.

Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.

Improved flexibility

Most Useful Review

This amazing product is for elderly people suffering from Osteoporosis. I purchased it for my mother, and it enhances cartilage and bone strength while reducing discomfort related to Osteoporosis.

Swollen Lymph Nodes details

Joint swelling reduced

Great results! My family takes it on the recommendation of our chiropractor. We make sure to take it for at least four weeks, and after eight days of use, my mother noticed her joint swelling had diminished.

Tendonitis details

I occasionally take this supplement. During sports activities, I notice the effects within a few days of use. It’s an essential supplement for tendon health!

Athlete’s Foot details

Significant pain reduction

I’ve dealt with foot pain for four years with no help from doctors. After taking this supplement for a month, I have drastically reduced my reliance on painkillers. My leg complains much less frequently now, and I will definitely continue purchasing this product in the future.

Blood Clot details

Joint crunching alleviated

1 people found this helpful

Glucosamine and chondroitin positively influence joint health, particularly in alleviating knee crunching. I took one capsule twice daily after meals for several months annually. The process improved, as glucosamine helps cartilage recover. I combined this regimen with collagen and vitamin D, while also moderating salt intake to prevent blood pressure issues. There were no side effects noted, and I saw improvements in my joint health. I highly recommend this supplement for its effectiveness.

Chronic Fatigue Syndrome details

The quality is superb. The ingredients in one capsule have an excellent effect on my health. I take courses in the autumn and spring, and as a result, I have stopped suffering from chronic fatigue syndrome. The size of the capsule is standard, and it has no smell. The benefits are noticeable after completing the intake.

Food Poisoning details

Joint relief experienced

8 people found this helpful

I prefer the liquid form from NOW Foods! The results on my daughter's joints were immediate. Her crunching joints decreased after taking it, and it noticeably lifted her mood. Moreover, it aids in restoring damage caused by metabolic issues, supporting cartilage integrity and resilience under pressure. It's an effective health solution!

High Cholesterol details

Positive joint support

Great Product! I’ve been using this for about a year, and I feel it has positively impacted my joints. When I miss doses for about two months, my joints become stiff and slow to move. I highly recommend this product.

Leg Cramps details

17 people found this helpful

On my vet's advice, I give my Bichon one capsule daily. He had leg and knee issues, but since incorporating this powder into his diet, he has faced no problems whatsoever.

Arthritis details

N-Acetyl Glucosamine reduces arthritis

Possibly Effective

Based on 41 Researches

Richter J, Capková K, Hříbalová V, Vannucci L, Danyi I, et al. Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine. Clin Exp Immunol. 2014;177:121. doi:10.1111/cei.12313

We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.

The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.

Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.

Immediate results

Most Useful Review

100 people found this helpful

Noticed a difference the very next day! After experiencing severe pain, I was informed I have onset arthritis. I researched natural supplements and found this product. I took three capsules upon arrival and the next day, my pain reduced significantly from an 8 to a 2, with improved mobility. I am optimistic about further improvements.

Pelvic Pain details

231 people found this helpful

Long-lasting effect, no pain, and improved joint mobility.

Rash details

2 people found this helpful

First, I purchased it for my father, who suffers from arthritis, and he subsequently requested it for a friend. There is indeed an effect, but it's noticeable after approximately three weeks. The formulation has a good composition and appropriate dosage of its key ingredients. The inclusion of sulphur (MCM) provided a pleasant side effect; after a week of usage, my face cleared up as I had been experiencing rashes. We’ve concluded that the sulphur is beneficial for this issue, so we continue to buy this supplement during flare-ups.

Adenoiditis details

1 people found this helpful

Although there was no immediate effect, I found I could ascend the stairs without relying on the handrail. It appears to be essential as it improves within a week once cut. Even with prolonged use for years, it sometimes blocks my throat, yet I deem it a safe product if stored in the refrigerator.

Allergies details