Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 41 Researches
7.3
USERS' SCORE
Moderately Good
Based on 59 Reviews
7.8
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%**
Sodium
150 mg
7%
Glucosamine Sulfate(from 1,500 mg Glucosamine PotassiumSulfate Complex)
1.1 g (1,100 mg)
†
Chondroitin Sodium Sulfate(from Bovine Cartilage)
1.2 g (1,200 mg)
†
MSM (Methylsulfonylmethane)
300 mg
†
Top Medical Research Studies
9.5
We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
Read More
9
We explored the potential of N-acetyl-(D)-glucosamine, a compound often used as a dietary supplement for osteoarthritis (OA), to provide effective relief from this chronic joint condition. Our research focused on a series of newly developed prodrugs, specifically targeting ways to enhance the compound's absorption and effectiveness within the body.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
Read More
8
We focused our research on the potential of N-acetylglucosamine, a modified form of glucosamine, to impact osteoarthritis, a common degenerative joint disease. Our investigations revealed that N-acetylglucosamine could enhance the oral bioavailability of glucosamine and is reported to have better in vitro chondroprotective effects compared to its parent compound.
To delve deeper into this, we examined N-acetylglucosamine derivatives modified specifically at the N position, using different chemical groups such as benzenesulfonyl and isoxazole. Among the many compounds we tested, we found that the derivatives with 3-(2-chlorobenzene)-5-methyl-isoxazole formyl chloride and p-methoxybenzenesulfonyl chloride were particularly effective at promoting chondrocyte health in our laboratory studies.
Our findings suggest that these newly developed compounds may hold promise as future treatments for osteoarthritis by enhancing joint health and potentially improving the quality of life for those affected by this condition.
To delve deeper into this, we examined N-acetylglucosamine derivatives modified specifically at the N position, using different chemical groups such as benzenesulfonyl and isoxazole. Among the many compounds we tested, we found that the derivatives with 3-(2-chlorobenzene)-5-methyl-isoxazole formyl chloride and p-methoxybenzenesulfonyl chloride were particularly effective at promoting chondrocyte health in our laboratory studies.
Our findings suggest that these newly developed compounds may hold promise as future treatments for osteoarthritis by enhancing joint health and potentially improving the quality of life for those affected by this condition.
Read More
Most Useful Reviews
9
Immediate results
100 people found this helpful
Noticed a difference the very next day! After experiencing severe pain, I was informed I have onset arthritis. I researched natural supplements and found this product. I took three capsules upon arrival and the next day, my pain reduced significantly from an 8 to a 2, with improved mobility. I am optimistic about further improvements.
Read More
9
Happy dog again
16 people found this helpful
I use this for my two-year-old Doberman who has arthritis. He no longer limps and is back to hiking the trails with us, outpacing us! I give him three pills a day—two in the morning and one in the evening, simply opening the capsule and pouring it over his dog food. He loves it and even drools while I prepare his meal. He weighs 65 pounds for reference.
Read More
9
Improved mobility
9 people found this helpful
My knees were suffering from arthritis for a long time. After ordering these tablets, I can now confidently say they work wonderfully! I can now walk up the stairs without difficulty.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 41 Researches
7.3
- All Researches
9.5
We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
Read More
9
We investigated how partially acetylated chitooligosaccharides, specifically the oligomers of N-acetylglucosamine, might influence the growth of chondrocytes—the cells crucial for cartilage health—in people with osteoarthritis. The study focused on the binding of these sugars to YKL-40, a protein that is often associated with inflammation in joints.
Through careful processing of chitin, we derived two forms of chitooligosaccharides: Oligomin™ and T-ChOS™. Our results unveiled that larger versions of these oligosaccharides showed a strong attraction to YKL-40. More significantly, when we exposed osteoarthritic chondrocytes to these compounds, we noted a noteworthy increase in cell growth—up to three times more under certain conditions.
Interestingly, Oligomin™ required a higher concentration compared to T-ChOS™, which demonstrated that smaller oligosaccharides could be effective at lower doses. However, more isn't always better; excessively high concentrations led to reduced benefits. When we introduced chitotriose, a smaller oligosaccharide, it hampered the positive effects seen with the larger forms, suggesting a complex interplay in oligosaccharide behavior in relation to cellular responses.
Overall, these findings indicate a promising new direction in treating joint inflammation and give us hope for developing new therapies aimed at alleviating the discomfort of arthritis.
Through careful processing of chitin, we derived two forms of chitooligosaccharides: Oligomin™ and T-ChOS™. Our results unveiled that larger versions of these oligosaccharides showed a strong attraction to YKL-40. More significantly, when we exposed osteoarthritic chondrocytes to these compounds, we noted a noteworthy increase in cell growth—up to three times more under certain conditions.
Interestingly, Oligomin™ required a higher concentration compared to T-ChOS™, which demonstrated that smaller oligosaccharides could be effective at lower doses. However, more isn't always better; excessively high concentrations led to reduced benefits. When we introduced chitotriose, a smaller oligosaccharide, it hampered the positive effects seen with the larger forms, suggesting a complex interplay in oligosaccharide behavior in relation to cellular responses.
Overall, these findings indicate a promising new direction in treating joint inflammation and give us hope for developing new therapies aimed at alleviating the discomfort of arthritis.
Read More
9
We explored the potential of N-acetyl-(D)-glucosamine, a compound often used as a dietary supplement for osteoarthritis (OA), to provide effective relief from this chronic joint condition. Our research focused on a series of newly developed prodrugs, specifically targeting ways to enhance the compound's absorption and effectiveness within the body.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
Read More
9
MSM and mobilee support cartilage health
We investigated how methylsulfonylmethane (MSM) and a herbal extract called mobilee influence arthritis in human chondrocytes, the cells found in cartilage. By exposing these cells to interleukin (IL)-1β—a protein that can cause joint inflammation—we aimed to understand if these treatments could mitigate the damage commonly associated with osteoarthritis (OA).
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
Read More
9
We conducted a thoughtful investigation into how Methylsulfonylmethane (MSM) impacts the treatment of knee osteoarthritis (OA) when paired with glucosamine and chondroitin sulfate. In our study, 147 patients diagnosed with Kellgren-Lawrence grade I-II knee OA were randomly divided into three groups. One group received a combination of glucosamine and chondroitin sulfate, the second group received the same combination with MSM, and the third group was given a placebo.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 59 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immediate results
100 people found this helpful
Noticed a difference the very next day! After experiencing severe pain, I was informed I have onset arthritis. I researched natural supplements and found this product. I took three capsules upon arrival and the next day, my pain reduced significantly from an 8 to a 2, with improved mobility. I am optimistic about further improvements.
Read More
9
Happy dog again
16 people found this helpful
I use this for my two-year-old Doberman who has arthritis. He no longer limps and is back to hiking the trails with us, outpacing us! I give him three pills a day—two in the morning and one in the evening, simply opening the capsule and pouring it over his dog food. He loves it and even drools while I prepare his meal. He weighs 65 pounds for reference.
Read More
9
Improved mobility
9 people found this helpful
My knees were suffering from arthritis for a long time. After ordering these tablets, I can now confidently say they work wonderfully! I can now walk up the stairs without difficulty.
Read More
10
Reduced knee pain
7 people found this helpful
This product helped my mother with her knee pain. It supports cartilage regeneration and reduces inflammation. After just a month, her pain has significantly decreased.
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9
No more complaints
6 people found this helpful
I have been giving this product to my 91-year-old father for a year. He takes two a day and no longer complains about arthritis pain in his hands or hips.
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Frequently Asked Questions
7.5
Joint pain relief
4 people found this helpful
I bought this for my father, who suffers from arthritis and foot pain. After just a few days of taking it, he felt improvement and could trust its safety.
10
Reduced knee pain
7 people found this helpful
This product helped my mother with her knee pain. It supports cartilage regeneration and reduces inflammation. After just a month, her pain has significantly decreased.
9
Pain reduction
3 people found this helpful
It works! I combine it with Now Foods hyaluronic acid, and my arthritis has become almost unnoticed. I can now sit and stand without pain, but consistency is key; I recommend at least six months.
7.5
Stiffness relief
2 people found this helpful
I’ve been taking this supplement for over six months for my arthritis, and it’s definitely helped with pain and stiffness.
7.5
Less discomfort
6 people found this helpful
I've been dealing with polyosteoarthritis and arthritis. After starting this product, I've noticed a difference in my symptoms. The crunching in my joints has decreased, and it’s much easier to descend stairs.
9
No more complaints
6 people found this helpful
I have been giving this product to my 91-year-old father for a year. He takes two a day and no longer complains about arthritis pain in his hands or hips.
6
Cumulative effect noted
33 people found this helpful
These supplements have a cumulative effect, so instant results shouldn't be expected. I take chondroitin and glucosamine for my arthritis as prescribed. While I appreciate the ingredients and price, I don't expect miracles. I found another similarly composed product that offers better value.
9
Reduced joint pain
My mother has rheumatoid arthritis and gout. After taking chondroitin along with vitamin D3 and calcium citrate, the pain in her joints decreased considerably. She regained her mobility. I will certainly reorder as soon as it becomes available.
7.5
Supports joint health
This product maintains joint health, particularly during physical activity. It reduces inflammation and promotes cartilage restoration, making it an excellent choice for athletes and those with arthritis.
8
Glucosamine and exercise enhance arthritis treatment
We sought to determine whether a combination of a nutrition supplement, including glucosamine and chondroitin, along with supervised exercise, is more effective for knee osteoarthritis than exercise alone.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
4
We explored how n-acetylglucosamine, a compound closely related to glucosamine, affects arthritis. Despite the mixed results in clinical trials concerning glucosamine, studies in rodent models show its potential to prevent joint destruction and reduce inflammation.
Our findings indicate that the effectiveness of glucosamine is significantly influenced by dosage. In particular, higher doses in animal studies appear to enhance its benefits on inflammatory conditions. Interestingly, the minimum effective dose of glucosamine we observed in studies achieves plasma levels similar to those produced when taking standard daily doses.
We noted that every clinical trial so far has utilized the same dose of 1.5 grams, a figure recommended decades ago. However, there has been no solid evidence supporting that this dose is the most effective. With varying patient populations and study designs, it's easy to see why some trials have reported null results.
We believe it is essential to investigate higher dosages and their effects on osteoarthritis rigorously. By doing so, we can provide clearer insights into the potential benefits of n-acetylglucosamine for individuals suffering from this debilitating condition.
Our findings indicate that the effectiveness of glucosamine is significantly influenced by dosage. In particular, higher doses in animal studies appear to enhance its benefits on inflammatory conditions. Interestingly, the minimum effective dose of glucosamine we observed in studies achieves plasma levels similar to those produced when taking standard daily doses.
We noted that every clinical trial so far has utilized the same dose of 1.5 grams, a figure recommended decades ago. However, there has been no solid evidence supporting that this dose is the most effective. With varying patient populations and study designs, it's easy to see why some trials have reported null results.
We believe it is essential to investigate higher dosages and their effects on osteoarthritis rigorously. By doing so, we can provide clearer insights into the potential benefits of n-acetylglucosamine for individuals suffering from this debilitating condition.
7
Glucosamine sulfate effective for KOA
We investigated the effectiveness and safety of glucosamine sulfate in managing knee osteoarthritis, commonly referred to as KOA. This systematic review collected data from various studies published between 1994 and 2022, evaluating how glucosamine sulfate, chondroitin sulfate, and their combinations affect knee joint health.
The findings showed that glucosamine sulfate does offer significant benefits, particularly in reducing joint space narrowing, which is a key concern in arthritis treatment. Moreover, chondroitin sulfate was noted for its ability to decrease pain intensity and enhance physical function. However, when we looked at the combination of these two treatments, the results were less encouraging. It turned out that this combination didn’t provide any additional effectiveness in symptom relief or disease modification.
This discrepancy highlights the need for further research to understand the potential enhanced benefits of using glucosamine sulfate and chondroitin sulfate together. Conducting more multicentric randomized controlled trials could help clarify if there’s a therapeutic advantage when these two drugs are combined in treating KOA.
The findings showed that glucosamine sulfate does offer significant benefits, particularly in reducing joint space narrowing, which is a key concern in arthritis treatment. Moreover, chondroitin sulfate was noted for its ability to decrease pain intensity and enhance physical function. However, when we looked at the combination of these two treatments, the results were less encouraging. It turned out that this combination didn’t provide any additional effectiveness in symptom relief or disease modification.
This discrepancy highlights the need for further research to understand the potential enhanced benefits of using glucosamine sulfate and chondroitin sulfate together. Conducting more multicentric randomized controlled trials could help clarify if there’s a therapeutic advantage when these two drugs are combined in treating KOA.
7
We explored the effectiveness of glucosamine sulfate in managing knee osteoarthritis (OA), a condition that can significantly impact quality of life. This position statement from the Italian Orthopaedic and Traumatology Society gathered expert opinions and examined a range of available evidence, although it noted the absence of robust, evidence-based guidelines for non-surgical treatments.
Among various non-surgical management strategies, glucosamine and chondroitin were suggested as part of chronic treatment. While we recognize the market prevalence of glucosamine sulfate for arthritis, the exact benefits were discussed in the context of overall symptom management, rather than being highlighted as a standalone miracle solution.
Together with lifestyle changes, weight management, and physical activity, glucosamine sulfate may serve as a helpful aspect of an individual's comprehensive treatment plan. However, we must acknowledge that further research is needed to firmly establish its effectiveness compared to other therapies available for knee OA.
Among various non-surgical management strategies, glucosamine and chondroitin were suggested as part of chronic treatment. While we recognize the market prevalence of glucosamine sulfate for arthritis, the exact benefits were discussed in the context of overall symptom management, rather than being highlighted as a standalone miracle solution.
Together with lifestyle changes, weight management, and physical activity, glucosamine sulfate may serve as a helpful aspect of an individual's comprehensive treatment plan. However, we must acknowledge that further research is needed to firmly establish its effectiveness compared to other therapies available for knee OA.
References
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- McCarty MF, O'Keefe JH, DiNicolantonio JJ. Glucosamine for the Treatment of Osteoarthritis: The Time Has Come for Higher-Dose Trials. J Diet Suppl. 2019;16:179. 10.1080/19390211.2018.1448920
- Kubomura D, Ueno T, Yamada M, Tomonaga A, Nagaoka I. Effect of N-acetylglucosamine administration on cartilage metabolism and safety in healthy subjects without symptoms of arthritis: A case report. Exp Ther Med. 2017;13:1614. 10.3892/etm.2017.4140
- Bolognesi G, Belcaro G, Feragalli B, Cornelli U, Cotellese R, et al. Movardol® (N-acetylglucosamine, Boswellia serrata, ginger) supplementation in the management of knee osteoarthritis: preliminary results from a 6-month registry study. Eur Rev Med Pharmacol Sci. 2016;20:5198.
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- Şükür E, Talu C, Akman YE, Çirci E, Öztürkmen Y, et al. Comparison of the chondroprotective effect of a novel hydrogel compound and traditional hyaluronate on rat cartilage in a papain-induced osteoarthritis model. Acta Orthop Traumatol Turc. 2016;50:458. 10.1016/j.aott.2016.07.008
- Kim HB, Lee SW, Mun CH, Yoon JY, Pai J, et al. O-linked N-acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast-like synoviocytes stimulated by tumor necrosis factor-α and mice with collagen induced arthritis. Arthritis Res Ther. 2015;17:248. 10.1186/s13075-015-0762-7
- Tsuji T, Yoon J, Kitano N, Okura T, Tanaka K. Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial. Aging Clin Exp Res. 2016;28:197. 10.1007/s40520-015-0412-6
- Richter J, Capková K, Hříbalová V, Vannucci L, Danyi I, et al. Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine. Clin Exp Immunol. 2014;177:121. 10.1111/cei.12313
- Frisbie DD, McIlwraith CW, Kawcak CE, Werpy NM. Evaluation of intra-articular hyaluronan, sodium chondroitin sulfate and N-acetyl-D-glucosamine combination versus saline (0.9% NaCl) for osteoarthritis using an equine model. Vet J. 2013;197:824. 10.1016/j.tvjl.2013.05.033
- Coburn JM, Wo L, Bernstein N, Bhattacharya R, Aich U, et al. Short-chain fatty acid-modified hexosamine for tissue-engineering osteoarthritic cartilage. Tissue Eng Part A. 2013;19:2035. 10.1089/ten.TEA.2012.0317
- Einarsson JM, Bahrke S, Sigurdsson BT, Ng CH, Petersen PH, et al. Partially acetylated chitooligosaccharides bind to YKL-40 and stimulate growth of human osteoarthritic chondrocytes. Biochem Biophys Res Commun. 2013;434:298. 10.1016/j.bbrc.2013.02.122
- Serpi M, Bibbo R, Rat S, Roberts H, Hughes C, et al. Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants. J Med Chem. 2012;55:4629. 10.1021/jm300074y
- Akpınar K, Şimşek EK, Özen ÖI, Haberal B. The effect of MSM in the treatment of ankle arthrosis: Is MSM as effective as methylprednisolone or hyaluronic acid?. J Orthop Res. 2024;42:1527. 10.1002/jor.25795
- Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15132995
- Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, et al. Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway. J Ethnopharmacol. 2024;318:116906. 10.1016/j.jep.2023.116906
- Cheleschi S, Fioravanti A, De Palma A, Corallo C, Franci D, et al. Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway. Int Immunopharmacol. 2018;65:129. 10.1016/j.intimp.2018.10.004
- Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial. Acta Med Indones. 2017;49:105.
- Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, et al. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. Int J Immunopathol Pharmacol. 2016;29:140. 10.1177/0394632015622215
- Panuccio E, Memeo A, Richetta S. [Evaluation of the combined treatment of oral viscosupplementation with hyaluronic acid intra-articular injection on symptomatic knee osteoarthritis]. Clin Ter. 2015;166:e321. 10.7417/T.2015.1886
- Alekseeva LI, Sharapova EP, Kashevarova NG, Taskina EA, Anikin SG, et al. [Use of ARTRA MSM FORTE in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug]. Ter Arkh. 2015;87:49. 10.17116/terarkh2015871249-54
- Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013;31:16. 10.1007/s00774-012-0378-9
- Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, et al. The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011;28:894. 10.1007/s12325-011-0068-3
- Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. 10.1186/1472-6882-11-50
- Brien S, Prescott P, Bashir N, Lewith H, Lewith G. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2008;16:1277. 10.1016/j.joca.2008.03.002
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.
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