SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
USERS' SCORE
Excellent
Based on 76 Reviews
9
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%**
Sodium
150 mg
7%
Glucosamine Sulfate(from 1,500 mg Glucosamine PotassiumSulfate Complex)
1.1 g (1,100 mg)
†
Chondroitin Sodium Sulfate(from Bovine Cartilage)
1.2 g (1,200 mg)
†
MSM (Methylsulfonylmethane)
300 mg
†
Top Medical Research Studies
8
MSM improves mild knee pain
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Good relevance score
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
4
MSM shows minor knee OA improvements
Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study.
Evaluates MSM's practical effects
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
MSM ineffective for knee pain
A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees.
No significant improvement observed
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
Most Useful Reviews
9.5
Reduced knee pain
Glucosamine, a major component of cartilage tissue, protects joints from damage and has a shock-absorbing effect. It also contributes to the synovial fluid, which lubricates and nourishes the joints. Chondroitin aids in producing joint fluid and restoring cartilage, possessing anti-inflammatory and analgesic properties. Together, glucosamine and chondroitin effectively protect and restore cartilage. Since I began taking them, I’ve noticed my knee almost never hurts, and I’ve even observed improvements in my hair and nails.
Read More
9.5
Weak joints helped
It helps with weak knee joints; I recommend it!
Read More
9.5
Knee pain relief
I bought this a year ago based on my trainer's recommendation for physical exercise. Initially, I didn't notice much and didn't repurchase it. Then, after a period of running and cycling, one knee was in agony for a month. I ordered it again and, after a month of consistent use, my knee no longer bothered me. Now, I take this supplement periodically, as it helps replenish joint functions. I wasn't sure about these supplements initially, but I’ve grown to trust them.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
- All Researches
8
MSM improves mild knee pain
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Good relevance score
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
8
Instaflex™ alleviates knee pain
A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.
Highly relevant for joint pain.
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Read More
7
MSM shows promise for knee pain
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
Promising, needs further investigation.
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
Read More
4
MSM shows minor knee OA improvements
Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study.
Evaluates MSM's practical effects
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
MSM ineffective for knee pain
A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees.
No significant improvement observed
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 76 Reviews
9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduced knee pain
Glucosamine, a major component of cartilage tissue, protects joints from damage and has a shock-absorbing effect. It also contributes to the synovial fluid, which lubricates and nourishes the joints. Chondroitin aids in producing joint fluid and restoring cartilage, possessing anti-inflammatory and analgesic properties. Together, glucosamine and chondroitin effectively protect and restore cartilage. Since I began taking them, I’ve noticed my knee almost never hurts, and I’ve even observed improvements in my hair and nails.
Read More
9.5
Weak joints helped
It helps with weak knee joints; I recommend it!
9.5
Knee pain relief
I bought this a year ago based on my trainer's recommendation for physical exercise. Initially, I didn't notice much and didn't repurchase it. Then, after a period of running and cycling, one knee was in agony for a month. I ordered it again and, after a month of consistent use, my knee no longer bothered me. Now, I take this supplement periodically, as it helps replenish joint functions. I wasn't sure about these supplements initially, but I’ve grown to trust them.
Read More
9.5
Reduced knee pain
Working! After heavy squats and improper running on asphalt destroyed my knees two years ago, this product has truly helped alleviate the morning stiffness and crunching in my knees. I also no longer experience sore feet. I continue taking it as a preventive measure, although there's not much to worry about!
Read More
10
No knee issues
This stuff works! Upon my vet's recommendation, I use one capsule daily for my Bichon. He had leg and knee problems, and since adding this powder, he's experienced no difficulties whatsoever.
Frequently Asked Questions
No FAQs are available for this product and symptom.
