' 
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
USERS' SCORE
Excellent
Based on 31 Reviews
9
Supplement Facts
Serving Size: Serving Size 2 Veg Capsules
Amount Per Serving
%DV
Glucosamine Sulfate (from 2,095 mg Glucosamine Potassium Sulfate Complex)
1.5 g (1,500 mg)
**
Top Medical Research Studies
9.5
N-Acetyl Glucosamine reduces arthritis
Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine.
Study closely examines arthritis treatment
We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
Read More
9
Potential OA treatment advancements
Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants.
Directly addresses N-acetylglucosamine effects
We explored the potential of N-acetyl-(D)-glucosamine, a compound often used as a dietary supplement for osteoarthritis (OA), to provide effective relief from this chronic joint condition. Our research focused on a series of newly developed prodrugs, specifically targeting ways to enhance the compound's absorption and effectiveness within the body.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
Read More
8
N-acetylglucosamine derivatives show promise
Novel biologically active series of N-acetylglucosamine derivatives for the suppressive activities on GAG release.
Highly relevant to osteoarthritis treatment
We focused our research on the potential of N-acetylglucosamine, a modified form of glucosamine, to impact osteoarthritis, a common degenerative joint disease. Our investigations revealed that N-acetylglucosamine could enhance the oral bioavailability of glucosamine and is reported to have better in vitro chondroprotective effects compared to its parent compound.
To delve deeper into this, we examined N-acetylglucosamine derivatives modified specifically at the N position, using different chemical groups such as benzenesulfonyl and isoxazole. Among the many compounds we tested, we found that the derivatives with 3-(2-chlorobenzene)-5-methyl-isoxazole formyl chloride and p-methoxybenzenesulfonyl chloride were particularly effective at promoting chondrocyte health in our laboratory studies.
Our findings suggest that these newly developed compounds may hold promise as future treatments for osteoarthritis by enhancing joint health and potentially improving the quality of life for those affected by this condition.
To delve deeper into this, we examined N-acetylglucosamine derivatives modified specifically at the N position, using different chemical groups such as benzenesulfonyl and isoxazole. Among the many compounds we tested, we found that the derivatives with 3-(2-chlorobenzene)-5-methyl-isoxazole formyl chloride and p-methoxybenzenesulfonyl chloride were particularly effective at promoting chondrocyte health in our laboratory studies.
Our findings suggest that these newly developed compounds may hold promise as future treatments for osteoarthritis by enhancing joint health and potentially improving the quality of life for those affected by this condition.
Read More
Most Useful Reviews
8.8
Slowed progression
Works for my osteoarthritis. I've used this for several years for the osteoarthritis in my hands, and it seems to have significantly slowed the progression of the bumps on my knuckles. I use it alongside SAM-e.
Read More
9.5
Significant pain relief
This is the first supplement that has truly improved my shoulder pain stemming from post-traumatic shoulder arthritis. Initially sceptical due to past failures with other products, I noticed a significant improvement after 3-4 weeks. I'm now almost pain-free and no longer need NSAIDs. I take 1.5g daily in the morning, increasing to 3g on more active days. Occasionally, I experience some reflux, which is manageable by taking the supplement with food. I highly recommend it to anyone suffering from arthritis, but patience is key as the effects take a few weeks to become apparent.
Read More
9.5
Effective arthritis control
This is the best I have found. I take this with NOW MSM and NOW Chondroitin, providing my arthritis with the best control I've ever experienced. I've tried several combination products over the last three years and found that taking individual products is much more effective. I also appreciate the absence of other ingredients like Vitamin D or Calcium, which I take in higher doses separately. The capsules are large, but I've had no trouble swallowing them. According to some articles I've read, Glucosamine Sulfate is absorbed better than other forms of Glucosamine.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
- All Researches
9.5
N-Acetyl Glucosamine reduces arthritis
Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine.
Study closely examines arthritis treatment
We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
Read More
9
N-acetylglucosamine shows promise
Partially acetylated chitooligosaccharides bind to YKL-40 and stimulate growth of human osteoarthritic chondrocytes.
Highly relevant findings
We investigated how partially acetylated chitooligosaccharides, specifically the oligomers of N-acetylglucosamine, might influence the growth of chondrocytes—the cells crucial for cartilage health—in people with osteoarthritis. The study focused on the binding of these sugars to YKL-40, a protein that is often associated with inflammation in joints.
Through careful processing of chitin, we derived two forms of chitooligosaccharides: Oligomin™ and T-ChOS™. Our results unveiled that larger versions of these oligosaccharides showed a strong attraction to YKL-40. More significantly, when we exposed osteoarthritic chondrocytes to these compounds, we noted a noteworthy increase in cell growth—up to three times more under certain conditions.
Interestingly, Oligomin™ required a higher concentration compared to T-ChOS™, which demonstrated that smaller oligosaccharides could be effective at lower doses. However, more isn't always better; excessively high concentrations led to reduced benefits. When we introduced chitotriose, a smaller oligosaccharide, it hampered the positive effects seen with the larger forms, suggesting a complex interplay in oligosaccharide behavior in relation to cellular responses.
Overall, these findings indicate a promising new direction in treating joint inflammation and give us hope for developing new therapies aimed at alleviating the discomfort of arthritis.
Through careful processing of chitin, we derived two forms of chitooligosaccharides: Oligomin™ and T-ChOS™. Our results unveiled that larger versions of these oligosaccharides showed a strong attraction to YKL-40. More significantly, when we exposed osteoarthritic chondrocytes to these compounds, we noted a noteworthy increase in cell growth—up to three times more under certain conditions.
Interestingly, Oligomin™ required a higher concentration compared to T-ChOS™, which demonstrated that smaller oligosaccharides could be effective at lower doses. However, more isn't always better; excessively high concentrations led to reduced benefits. When we introduced chitotriose, a smaller oligosaccharide, it hampered the positive effects seen with the larger forms, suggesting a complex interplay in oligosaccharide behavior in relation to cellular responses.
Overall, these findings indicate a promising new direction in treating joint inflammation and give us hope for developing new therapies aimed at alleviating the discomfort of arthritis.
Read More
9
Potential OA treatment advancements
Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants.
Directly addresses N-acetylglucosamine effects
We explored the potential of N-acetyl-(D)-glucosamine, a compound often used as a dietary supplement for osteoarthritis (OA), to provide effective relief from this chronic joint condition. Our research focused on a series of newly developed prodrugs, specifically targeting ways to enhance the compound's absorption and effectiveness within the body.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
We found that some modified versions of N-acetyl-(D)-glucosamine, known as O-3 and O-4 phosphate prodrugs, demonstrated significant chondroprotective effects in vitro. In simple terms, this means they helped protect and support cartilage health, which is vital for those suffering from OA. Notably, the prodrugs that included a specific amino acid called (L)-proline were particularly effective, even outperforming earlier versions.
Overall, our findings suggest that these novel compounds hold promise as new leads in the search for more effective treatments for osteoarthritis. They signify a positive step toward improving the management of this painful and degenerative joint disease.
Read More
9
Glucosamine improves knee osteoarthritis
Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial.
Study relevance includes glucosamine-supplement
In a recent study, we aimed to find out how effective glucosamine sulfate, in combination with other nutritional supplements and supervised exercise, is in treating knee osteoarthritis. This was a well-structured trial involving 65 participants aged between 40 and 75 years, who were randomly placed into two groups—one receiving the nutritional supplements along with exercise, and the other getting a placebo with the same exercise regimen.
After six months, we observed some encouraging results. The participants taking the nutritional supplements experienced greater improvements in their joint pain and overall function compared to those who only exercised. Notably, at three months, more individuals in the supplement group reported clinically significant pain relief and better joint stiffness. This trend continued, with even larger differences seen at the six-month mark.
These findings suggest that combining glucosamine sulfate with exercise might be a more effective approach for managing knee osteoarthritis than exercise alone. This offers hope to those struggling with this painful condition, potentially leading to quicker relief and enhanced mobility.
After six months, we observed some encouraging results. The participants taking the nutritional supplements experienced greater improvements in their joint pain and overall function compared to those who only exercised. Notably, at three months, more individuals in the supplement group reported clinically significant pain relief and better joint stiffness. This trend continued, with even larger differences seen at the six-month mark.
These findings suggest that combining glucosamine sulfate with exercise might be a more effective approach for managing knee osteoarthritis than exercise alone. This offers hope to those struggling with this painful condition, potentially leading to quicker relief and enhanced mobility.
Read More
8
Glucosamine derivatives aid cartilage health
The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model.
Moderate relevance to cartilage therapy
We examined how glucosamine derivatives, particularly n-acetylglucosamine (GlcNAc), impact chondrocyte behavior following cartilage trauma. In our study, human cartilage samples were subjected to trauma and then treated with GlcNAc, glucosamine sulfate, or an O-GlcNAcase inhibitor called PUGNAc, alongside a GFAT-1 inhibitor named azaserine. Over the course of the experiment, we looked at factors such as cell viability, the expression of key genes related to cartilage health, and the content of important cartilage components like type II collagen.
Our findings revealed that exposing cartilage to trauma disrupted the balance of enzymes involved in the hexosamine biosynthetic pathway (HBP), mimicking the conditions seen in advanced osteoarthritis. Both GlcNAc and PUGNAc showed encouraging results by protecting cells after trauma. However, while PUGNAc led to an increase in type II collagen production, GlcNAc did not demonstrate this same enhancement, indicating that it may not be as effective on its own.
Importantly, PUGNAc, along with the glucosamine derivatives, demonstrated anti-catabolic effects, helping counteract degrading processes in the cartilage. Conversely, the use of azaserine raised catabolic activity, which wasn't beneficial. Overall, we found that supporting the HBP through glucosamine derivatives or O-GlcNAcase inhibition can help protect cartilage cells following trauma, presenting a promising area for future arthritis therapies despite the variable effects of GlcNAc alone.
Our findings revealed that exposing cartilage to trauma disrupted the balance of enzymes involved in the hexosamine biosynthetic pathway (HBP), mimicking the conditions seen in advanced osteoarthritis. Both GlcNAc and PUGNAc showed encouraging results by protecting cells after trauma. However, while PUGNAc led to an increase in type II collagen production, GlcNAc did not demonstrate this same enhancement, indicating that it may not be as effective on its own.
Importantly, PUGNAc, along with the glucosamine derivatives, demonstrated anti-catabolic effects, helping counteract degrading processes in the cartilage. Conversely, the use of azaserine raised catabolic activity, which wasn't beneficial. Overall, we found that supporting the HBP through glucosamine derivatives or O-GlcNAcase inhibition can help protect cartilage cells following trauma, presenting a promising area for future arthritis therapies despite the variable effects of GlcNAc alone.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 31 Reviews
9
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Slowed progression
Works for my osteoarthritis. I've used this for several years for the osteoarthritis in my hands, and it seems to have significantly slowed the progression of the bumps on my knuckles. I use it alongside SAM-e.
9.5
Significant pain relief
This is the first supplement that has truly improved my shoulder pain stemming from post-traumatic shoulder arthritis. Initially sceptical due to past failures with other products, I noticed a significant improvement after 3-4 weeks. I'm now almost pain-free and no longer need NSAIDs. I take 1.5g daily in the morning, increasing to 3g on more active days. Occasionally, I experience some reflux, which is manageable by taking the supplement with food. I highly recommend it to anyone suffering from arthritis, but patience is key as the effects take a few weeks to become apparent.
Read More
9.5
Effective arthritis control
This is the best I have found. I take this with NOW MSM and NOW Chondroitin, providing my arthritis with the best control I've ever experienced. I've tried several combination products over the last three years and found that taking individual products is much more effective. I also appreciate the absence of other ingredients like Vitamin D or Calcium, which I take in higher doses separately. The capsules are large, but I've had no trouble swallowing them. According to some articles I've read, Glucosamine Sulfate is absorbed better than other forms of Glucosamine.
Read More
9
Eliminated pain
Osteo-arthritis help. I have used this product for the past 25 years. While it doesn't aid my Rheumatoid Arthritis, it has effectively eliminated the issues I had with osteo-arthritis, especially in my hands. Jan P.
10
Quick pain relief
Buy the best, forget the rest. My arthritis pain in my hip completely vanished within the first week of using this product. For maintenance, it only needs to be taken three times a week. If you have simple osteoarthritis, this is all you need. It’s 100% effective and thoroughly reliable.
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