NOW Supplements Glutathione

Silibinin shows toxicity via EGFR

Qi L, Singh RP, Lu Y, Agarwal R, Harrison GS, et al. Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biol Ther. 2003;2:526.

We explored how silibinin, a compound from milk thistle, impacts brain tumor cells by focusing on the epidermal growth factor receptor (EGFR). In our study, we created a specific rat glioma cell line expressing human EGFR. Our results showed that the presence of EGFR was crucial for silibinin to exert its toxic effects on cancer cells. By inhibiting the activation of EGFR, silibinin demonstrates potential as a therapeutic agent for targeting tumor growth. However, further research is needed to understand the detailed mechanisms at play.

Significant improvement

Most Useful Review

512 people found this helpful

I rated it 5. I administered it to my teenage daughter, one at a time, for a significant period. I used it to restore brain function! The results have been astonishing, literally! Numerous issues have been markedly corrected, including severe fears, impaired attention, memory, and depression. Cognitive functions have improved significantly. Now Foods offer effective and affordable products, so I highly recommend it to anyone looking to enhance brain function! Best of luck to you!

Updated: Mar 2026

Migraine details

ALA shows promise for migraines

Based on 10 Researches

Kelishadi MR, Naeini AA, Khorvash F, Askari G, Heidari Z. The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Sci Rep. 2022;12:271. doi:10.1038/s41598-021-04397-z

We evaluated how alpha-lipoic acid (ALA) supplementation impacts women suffering from episodic migraines. In a random, double-blind, placebo-controlled trial with 92 participants, those taking 300 mg of ALA daily reported significant improvements in headache severity, frequency, and impact. They also showed decreased levels of lactate and VCAM-1, suggesting enhancements in mitochondrial and endothelial functions. However, no notable changes occurred regarding nitric oxide levels and migraine duration. Overall, ALA may serve as a helpful adjunctive treatment for migraine relief.

Reduced headaches

Most Useful Review

10 people found this helpful

An excellent antioxidant! I initially bought it for my husband, but I ended up using it myself. It has made me feel lighter overall, as though it was cleansing me of something harmful. The headaches have disappeared, and it positively affects my blood and general well-being. My blood pressure has stabilised, and migraines have not returned. I liked the effect.

Updated: Apr 2025

We examined how an herbal cream containing silymarin affects patients with eczema compared to a standard treatment. In a study with 40 patients suffering from mild to moderate eczema, participants used either the herbal cream or mometasone for two weeks.

After this period, we found notable improvements in skin severity scores for both treatments. However, there wasn't a significant difference between the two groups. This suggests that while both treatments are effective, silymarin may not be superior to traditional therapies for eczema relief.

Reduced eczema significantly

Most Useful Review

2 people found this helpful

Excellent! I noticed significant improvements within two weeks of starting this product. My skin is brighter, whiter, and smoother, although the spots on my face remain. Importantly, my eczema has reduced significantly, and my skin is no longer as dry as it used to be.

Updated: Apr 2025

Indigestion details

5 people found this helpful

The effect is remarkable! After just five days of taking it, my stomach has improved significantly. Flatulence, indigestion, and discomfort after drinking have vanished, and my eyes feel less dry. Moreover, I no longer crave junk food. I'm feeling fantastic and will definitely continue taking it!

13 people found this helpful

Reflux details

This is the best glutathione I’ve ever taken. It's essential for a healthy liver, and I’ve noticed improvements in my skin, with my melasma nearly fading. I recommend it to anyone with reflux—my friend, who had seen multiple doctors without relief, tried this product and it worked wonders; she no longer suffers from reflux. I'm very grateful for the results.

Acne details

Glutathione shows potential for acne

Based on 10 Researches

Aybey B, Ergenekon G, Hekim N, Yarat A, Kurai Y, et al. Glutathione peroxidase (GSH-Px) enzyme levels of patients with acne vulgaris. J Eur Acad Dermatol Venereol. 2005;19:766.

We investigated the impact of glutathione treatment on acne vulgaris. The study particularly aimed to understand how this antioxidant affects skin health and whether it could offer relief to those struggling with acne.

The findings indicated that glutathione treatment could play a role in improving the skin condition of patients suffering from acne. This research focused on how glutathione’s properties might help reduce oxidative stress in the skin, a factor known to exacerbate acne.

While there was no mention of significant combinations with other treatments, the isolated effects of glutathione were noteworthy. Our results suggest that for those looking for alternative ways to manage acne, glutathione could be a promising option worth considering.

Transformed my skin

Most Useful Review

331 people found this helpful

Taking one tablet each night with glutathione and vitamins has truly changed my life. I used to suffer from severe acne, scars, and redness for decades without any dermatologist visits. I am thrilled to feel beautiful with just supplements, avoiding invasive treatments like lasers. The large capsule does not deter me; the positive outcomes are well worth it! My acne scars have faded, my skin tone appears improved, and the overall texture has smoothed.

Updated: Apr 2026

Bloating details

69 people found this helpful

Once sweet, it cleanses the body of toxins. I was suffering with constipation, and after using it, my excretion was regulated. I felt relaxed and relieved my colon and bloating, beginning to feel light. Every day on an empty stomach, I took a 1000 mg concentration with a vitamin C capsule from the same company. Honestly, I was surprised by the results from the first box. Don't miss it!

Depression details

Silibinin reduces depression in mice

Based on 8 Researches

Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593

We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.

Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.

Essential support

Most Useful Review

2 people found this helpful

Glutathione, a combination of cysteine, glycine, and glutamine, is effective when taken on an empty stomach, especially after covid or during episodes of spring blues and depression. It really supported me, and by the third day, I felt an extraordinary surge of energy throughout my body!

Updated: Apr 2025

Gastritis details

Effective antioxidant

36 people found this helpful

This strong antioxidant is beneficial for the body in general. It has helped me with gastritis. Please press Yes.

5 people found this helpful

Hashimoto details

I have Hashimoto disease, and my antibodies were extremely high, causing dry and pale skin. However, after I started drinking this, my condition improved significantly, and my antibodies are now lower. I am very thankful! ^_^

Inhalable silymarin shows promise

Pneumonia details

Hanafy NAN, El-Kemary MA. Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment. Int J Biol Macromol. 2022;198:101. doi:10.1016/j.ijbiomac.2021.12.073

We explored the potential of a new inhalable delivery system packed with silymarin and curcumin for treating lung inflammation caused by COVID-19. Through our research, we observed a significant reduction in key inflammatory markers in those treated with our formulated nanoparticles compared to control groups.

Furthermore, our study showed improved tissue profiles, indicating enhanced lung health. Additionally, silymarin demonstrated antiviral properties in laboratory tests against COVID-19. Overall, this innovative treatment approach could help address inflammation and improve recovery in respiratory conditions.

Significant improvement

Most Useful Review

I had never heard of glutathione until my therapist mentioned it while treating me for complications after pneumonia from the coronavirus. I struggled to breathe deeply. My doctor informed me that glutathione is often given as injections during illness to combat the cytokine storm, an inflammatory response that could be fatal. I received a prescription for glutathione for a month and did daily breathing exercises. Overall, I made great progress; not only was my breathing restored, but my energy levels significantly improved, allowing me to regain my previous productivity.

Updated: Apr 2025

Psoriasis details

Milk thistle shows anti-psoriatic effects

Kamel NM, El-Sayed SS, El-Said YAM, El-Kersh DM, Hashem MM, et al. Unlocking milk thistle's anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress. Int Immunopharmacol. 2024;139:112781. doi:10.1016/j.intimp.2024.112781

We investigated how milk thistle extract might help treat psoriasis in mice. Our study involved forty Swiss albino mice divided into four groups, including a test group treated with the milk thistle extract after inducing psoriasis with imiquimod.

The results were encouraging, showing that the extract significantly reduced skin symptoms like redness and scaling, similar to traditional cortisone treatments. It worked by inhibiting specific cellular pathways, reducing inflammation and boosting antioxidant defenses, suggesting that milk thistle could be an effective new option for psoriasis treatment.

Notable improvement

Most Useful Review

After a month of taking it, I have noticed an improvement in my psoriasis and my skin overall. Including it in my diet, particularly with my alcohol consumption, helps my liver, as I no longer feel fatigued all the time, considering my age. It is of good quality.

Updated: Apr 2025

Rash details

Glutathione may reduce skin rash

Azfar SF, Islam N. Suppression of mycobacterium tuberculosis induced reactive oxygen species and tumor necrosis factor-alpha activity in human monocytes of systemic lupus erythematosus patients by reduced glutathione. Oman Med J. 2012;27:11. doi:10.5001/omj.2012.03

We examined how reduced glutathione affects skin rashes in patients with systemic lupus erythematosus (SLE) and tuberculosis. By studying a group of 100 patients, we focused on those with SLE, tuberculosis, and the combination of both conditions.

Our findings indicated that reduced glutathione helped decrease the harmful effects caused by reactive oxygen species and tumor necrosis factor-alpha in the immune cells. This suppression may alleviate some symptoms, including skin rash, in these patients.

Rashes disappeared

Most Useful Review

344 people found this helpful

Excellent! I am very pleased with this food supplement. At 54 years old, I have suffered from chronic cholecystitis for years without gallstones, but my gallbladder inflames periodically. I have tried various anti-inflammatory and choleretic drugs. Recently, I began to take glutathione once daily on an empty stomach. The results are notable; the pain and discomfort I experienced have vanished. Furthermore, my skin has improved significantly, becoming cleaner and more hydrated, with age spots nearly gone. My 16-year-old daughter, who also took glutathione, saw her neurodermatitis improve, and her skin rashes have completely disappeared. If my review was useful, please let me know!

Updated: Apr 2025

Yeast Infection details

Silibinin induces yeast apoptosis

Yun DG, Lee DG. Silibinin triggers yeast apoptosis related to mitochondrial Ca influx in Candida albicans. Int J Biochem Cell Biol. 2016;80:1. doi:10.1016/j.biocel.2016.09.008

We explored how silibinin, derived from the milk thistle plant, affects Candida albicans, the yeast that can lead to infections. Our research demonstrated that silibinin treatment significantly increased reactive oxygen species, triggering a cascade of events that caused yeast cell death, or apoptosis. Notably, we observed that mitochondrial calcium overload plays a vital role in this process. While silibinin shows promise for combating yeast infections, our findings highlight the importance of further research to fully understand its potential and mechanisms.

Various benefits

Most Useful Review

This product offers delightful benefits as an antioxidant. It has shown anti-aging properties, reduced inflammation, alleviated depression, and may lower the risk of Alzheimer's and Parkinson's diseases. Furthermore, it fights infections and might even be effective in treating viruses!

Updated: Mar 2026

Anemia details

Questionable

Silymarin shows potential in thalassemia

Gharagozloo M, Moayedi B, Zakerinia M, Hamidi M, Karimi M, et al. Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial. Fundam Clin Pharmacol. 2009;23:359. doi:10.1111/j.1472-8206.2009.00681.x

We conducted a randomized, double-blind clinical trial to investigate the effects of silymarin on patients with beta-thalassemia major.

Over three months, 59 patients received either silymarin along with desferrioxamine or a placebo.

While silymarin showed promising benefits, particularly in liver and red blood cell health, there was no significant difference in serum ferritin levels between groups after treatment.

However, we believe that this combination can be safely integrated into therapies for iron-overloaded patients.

Improved health overall

Most Useful Review

Glutathione is a powerful antioxidant and a very effective product. It supports liver health and prevents cell oxidation. The vegetarian capsule contains glutathione, milk thistle, and alpha lipoic acid. After two months of use, I've noticed significant benefits in skin brightness, reduced pigmentation, fewer wrinkles, and a resolution of my anemia, all while following a low-carb diet and avoiding sugar.

Updated: Apr 2025

Anxiety details

Silibinin shows promise for anxiety

Based on 4 Researches

We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.

Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.

Effective for anxiety

Most Useful Review

The anti-anxiety glutathione is a lifesaver for me; it effectively reduces my anxiety and provides stress relief. I always pair it with vitamin C, and it works wonders, benefiting both my skin and mental health. I continue to buy more and recommend it to my friends. 🥰

Updated: Mar 2026

Asthma details

Promising anti-inflammatory effects observed

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

We explored the effects of silibinin, a compound from milk thistle, on asthma-related inflammation in a mouse model. By focusing on allergic airway inflammation triggered by ovalbumin, we observed that silibinin significantly decreased inflammatory cell activity and reduced levels of harmful cytokines.

Additionally, silibinin helped prevent airway hyperresponsiveness, showcasing its ability to inhibit a key inflammatory pathway known as NF-κB. These promising results position silibinin as a potential therapeutic option for managing asthma symptoms.

Less inhaler usage

Most Useful Review

16 people found this helpful

This product has notably helped with my asthma, allowing me to use my inhalers less frequently. I feel that certain asthma triggers are less prominent when I take this. My lungs feel more open and free! I’d recommend it to others with asthma.

Updated: Apr 2025

Autism details

No significant improvements found

Very Likely Ineffective

Williams PG, Sears L, Watson WH, Gunaratnam B, Feygin Y, et al. Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study. J Dev Behav Pediatr. 2025;46:e17. doi:10.1097/DBP.0000000000001334

We explored the potential of glutathione treatment as a way to improve behavioral symptoms in children with Autism Spectrum Disorder (ASD). In this study, we conducted a double-blind, placebo-controlled crossover trial involving 24 children aged 5 to 16 years who exhibited severe behavioral issues associated with ASD.

During the trial, participants received either glutathione, a combination treatment with glutathione and vitamin C plus N-acetylcysteine, or a placebo over an 8-week period. After a week off from treatment, we switched the groups to ensure an unbiased assessment of each method's effectiveness. Throughout the study, we closely monitored behavioral changes and measured plasma levels of glutathione.

Despite our thorough approach, we found that neither glutathione nor the combination treatment showed significant improvements in behavior or biological markers. Any observed positive trends seemed to stem from the placebo effect or simply the structure of being part of a study, rather than any real benefit from the treatments themselves.

7.5

Relieves symptoms

Most Useful Review

6 people found this helpful

Glutathione capsules are beneficial for children with autism, alleviating the associated symptoms. May God grant healing for all.

Updated: Apr 2025

Cold Sores details

2 people found this helpful

I use it for beauty, as it's synergistic with vitamin C; the results seem better than other supplements. Despite its high cost, I made it part of my routine for health and beauty. I can drink it on an empty stomach without any issue. After around six months, I’ve switched to Tathione but have noticed stronger immunity; I hardly catch colds even when exposed to sick children!

I buy this with confidence; it is a supplement I consistently take for constipation. The results are satisfactory.

Constipation details

Hypothyroidism details

ALA reduces oxidative stress

Based on 8 Researches

Baki AM, Aydın AF, Vural P, Olgaç V, Doğru Abbasoğlu S, et al. α-Lipoic Acid Ameliorates The Changes in Prooxidant-Antioxidant Balance in Liver and Brain Tissues of Propylthiouracil-Induced Hypothyroid Rats. Cell J. 2020;22:117. doi:10.22074/cellj.2020.7049

We explored the effects of alpha-lipoic acid (ALA) on hypothyroidism, particularly focusing on oxidative stress in the body. In a controlled experiment, rats were given propylthiouracil (PTU) to induce hypothyroidism, followed by treatment with ALA and thyroxine (T4) to assess the outcomes over a 10-week period.

Our findings revealed increased oxidative stress markers, particularly in the brain, in hypothyroid rats. ALA treatment alone significantly reduced these markers, suggesting it can help counteract oxidative damage linked to hypothyroidism. Moreover, ALA also improved conditions arising from T4 therapy.

Overall, our study indicates that ALA may offer a valuable approach to manage oxidative stress in thyroid dysfunctions, both on its own and when combined with traditional hormone replacement therapies.

Reduction in indicators

Most Useful Review

I like it. This isn't my first time taking glutathione. I have hypothyroidism, and it effectively reduces my indicators.

Updated: Apr 2025

Menopause details

Effective herbal treatment for menopause

Based on 4 Researches

Saberi Z, Gorji N, Memariani Z, Moeini R, Shirafkan H, et al. Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial. Phytother Res. 2020;34:3359. doi:10.1002/ptr.6789

We evaluated the effects of Silybum marianum, a herbal remedy, on menopausal symptoms, particularly hot flashes. In a well-structured study with eighty women, half were given S. marianum extract while the other half received a placebo over 12 weeks.

Remarkably, the group taking Silybum saw a significant drop in the frequency and severity of hot flashes. Their scores on relevant scales improved notably compared to those on placebo.

This suggests that Silybum marianum could be an effective option for managing menopausal symptoms, making it a promising choice for women seeking relief.

Reduced hot flashes

Most Useful Review

Glutathione is amazing! It’s essential during menopause. I've been taking various supplements but felt something was lacking. I take one capsule daily, and I forget about everything—the hot flashes have disappeared. It's essential to have alanines, vitamin D3, Omega-3, soy lecithin, and magnesium during this time. I won’t elaborate on glutathione’s composition, but it contains three vital amino acids for our bodies. Buy it—you won't regret it. Stay healthy!

Updated: Apr 2025

Swollen Lymph Nodes details

Lowered skin sensitivities

10 people found this helpful

Excellent! Initially, I ordered this for my parents, and it suited them well; my mother's food allergies disappeared within three months. After 1.5 months of use, I've noticed a decrease in body sensitivities—previously, I reacted to almost everything—and the swelling I experienced in the mornings has alleviated. I will definitely continue with it.

Cold details

Glutathione's role in cold stress

Dong F, Li X, Liu C, Zhao B, Ma Y, et al. Exogenous 24-epibrassinolide mitigates damage in grape seedlings under low-temperature stress. Front Plant Sci. 2025;16:1487680. doi:10.3389/fpls.2025.1487680

We explored how glutathione, an important antioxidant, interacts with low temperature stress in grape seedlings treated with exogenous 24-epibrassinolide (EBR). In this study, grape seedlings were subjected to cold conditions (4°C) and then treated with EBR, alongside other substances, to evaluate their effects on growth and physiological responses over various time periods.

Notably, we observed that the seedlings treated with EBR showed an increase in glutathione levels by about 33.63%. This boost in glutathione might help in protecting the cells against oxidative damage caused by cold stress. Additionally, activities of key antioxidant enzymes, such as superoxide dismutase and peroxidase, were significantly enhanced in the EBR-treated plants.

While the treatment showed positive effects overall, it's essential to note that the study evaluated glutathione alongside other treatments, making it challenging to isolate its specific impact solely on cold stress. Despite this, the findings suggest that glutathione plays a supportive role in helping grape seedlings withstand cold temperatures.

Cold-free experience

Most Useful Review

17 people found this helpful

The rare supplement that has significantly improved my quality of life. With my job, I frequently encounter patients and usually catch an aggressive cold each year. I switched to reduced glutathione two years ago after a study about its bioavailability. During one of the worst flu seasons, I remained free of cold symptoms, despite not changing anything else. While it's not definitive evidence, it is notable to me. This product, affordable and effective, has made a significant impact on my health; I haven't had so much as a sniffle despite working long hours in stressful conditions. It has earned a permanent place in our household.

Updated: Apr 2025

Adrenal Gland Disorder details

Fatigue significantly decreased

I experienced considerable fatigue, likely due to adrenal gland disorder, but from the moment I began taking it, I noticed my fatigue reducing. I intend to keep purchasing it.

Back Pain details

Reduced discomfort felt

I was referred to this supplement by my chiropractor for unexplained physical discomfort. After over three months of use, the terrible feeling I experienced has subsided.

14 people found this helpful

Blurred Vision details

I really like it! It gives my skin a certain glow, clears up acne, and seems to help improve my vision. This is my third bottle, and I am very pleased with this product. I've heard it contains milk thistle, which is good for the liver. Thanks for the speedy and affordable shipping, iHerb! I also appreciate your excellent customer service.

Bone Pain details

Best glutathione; excellent quality and ingredients. It comes with good dosage instructions and is beneficial for body immunity. The taste is pleasant, and the packaging is attractive. It greatly supports bone health. I find this product very helpful and safe.

Diabetes details

Silibinin shows potential for diabetes

Based on 19 Researches

Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x

We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.

It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.

Enhances exercise performance

Most Useful Review

This product is very helpful in managing diabetes. If taken before exercising, it significantly enhances athletic performance.

Updated: Apr 2025

Heart Disease details

2,3-dehydrosilybin shows heart protection

Based on 8 Researches

Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028

We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.

The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.

7.5

Positive heart health

Most Useful Review

Vitamin D3 is essential for regulating calcium and phosphorus levels, which helps maintain healthy bones and teeth. It plays a crucial role in bone health, with deficiencies leading to osteoporosis in adults and rickets in children. Vitamin D3 supports the immune system, crucial for fighting infections; a lack of it can diminish disease resistance. Additionally, studies suggest it may positively influence cardiovascular health, reducing the risk of heart disease. Furthermore, it can affect serotonin levels in the brain, impacting mood regulation. Deficiency in this vitamin has been associated with an increased risk of depression and anxiety disorders.

Updated: Mar 2026

Influenza details

Silymarin shows strong antiviral potential

Based on 3 Researches

Song JH, Choi HJ. Silymarin efficacy against influenza A virus replication. Phytomedicine. 2011;18:832. doi:10.1016/j.phymed.2011.01.026

We investigated the antiviral properties of silymarin against the influenza A virus in cultured cells. The study found that silymarin reduced viral activity by 98% without any cytotoxic effects, compared to oseltamivir, which showed only a 52% reduction.

Additionally, we analyzed how silymarin inhibits viral mRNA synthesis. Our results suggest that silymarin affects late-stage viral RNA production more effectively than oseltamivir. This promising outcome indicates that silymarin could be a valuable option for treating influenza infections.

7.5

Strong immune support

Most Useful Review

Excellent! I highly recommend consuming glutathione to strengthen one's immune system against viruses and influenza.

Updated: Apr 2025

Lung Cancer details

Potential NSCLC treatment candidate

Based on 14 Researches

Rugamba A, Kang DY, Sp N, Jo ES, Lee JM, et al. Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells. Cells. 2021;10. doi:10.3390/cells10071632

We investigated the potential of silibinin, a natural compound from milk thistle, in treating non-small cell lung cancer (NSCLC). Our study employed various assays to analyze how silibinin impacts cancer cell growth and migration.

We found that silibinin effectively inhibited the growth of NSCLC cells and suppressed important pathways linked to tumor progression. It worked by preventing tumor cells' ability to form new tumors and inhibited the expression of proteins associated with cancer growth.

Overall, silibinin shows promise as a candidate for both tumor immunotherapy and targeting cancer stem cells.

7.5

Immunity restoration

Most Useful Review

I purchased this for my mother to aid her recovery following a Covid-related hospital stay where 40% of her lungs were impacted. The product helps in boosting immunity and detoxification, especially after antibiotic treatments. While it’s from a reputable brand, the cost is quite high. I am uncertain of the long-term effects and may update my review later.

Updated: Apr 2025

Mild Cognitive Impairment details

Brain function preserved

It keeps my elderly parent's brains functioning well, helping to stave off dementia!

277 people found this helpful

Pelvic Pain details

Excellent! I'm currently experimenting and will share my evaluation after completing a month’s course. Initially, I took one pill, then increased to two after a week. Its effects are noticeable, though they may vary between individuals. I experienced a significant reduction in pelvic pain, which had been troubling me for over six years. Thankfully, all discomfort in my body has disappeared. I’m eager to purchase a second box, despite my limited budget. I hope my experience helps others.

Visible improvement noted

Rosacea details

22 people found this helpful

Visible effect on rosacea. After a course of liver cleansing with a local remedy, I noticed its impact on my rosacea. The product also contained glutathione, which I decided to take separately. The blood vessels at the wings of my nose are less prominent than before, even though summer is challenging for vessels. Additionally, the redness of my skin in the rosacea area is less pronounced, making it easier to cover with powder. For those with slightly thinner and smaller veins, glutathione may have an even more significant visual effect.

Cancer details

Investigating silibinin's cancer treatment role

Based on 19 Researches

Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901

We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.

Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.

Aid after chemotherapy

Most Useful Review

This powerful antioxidant is found naturally in fruits and vegetables and produced by the body. As a cancer patient, I use this product following my chemotherapy and radiation treatments to facilitate quicker recovery and detox.

Updated: Apr 2025

Chronic Cough details

NOW Foods Glutathione has worked miracles in my life. I suffered from chronic fatigue for years, but now, thanks to daily use, my energy levels have transformed. I feel energised throughout the day, and I no longer experience lethargy. It's also helped detox my body.

Common Cold details

Positive skin turnover

I began taking this for beauty about a week ago, so I can’t assess the full effect yet. I'm taking it with vitamin C and cysteine. It seems to have positively influenced my skin's turnover as the healed pimples cleared quicker. The capsules are easy to swallow, and there’s no distinct taste. I'm eager to see how my skin evolves!

3 people found this helpful

Food Poisoning details

I’ve taken this drug twice to combat post-Covid symptoms, and I highly recommend it. It helps relieve constant fatigue and apathy caused by the virus. After two weeks, I felt significant relief. It also seems to alleviate hangover symptoms, which is an added bonus!

Allergies details

Silibinin shows promise for asthma

Based on 4 Researches

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.

Hay fever relief

Most Useful Review

5 people found this helpful

Since I started taking this supplement, my skin has become firmer and noticeably brighter! Despite my alcohol consumption, I've found hangovers much easier to manage. Additionally, my severe hay fever symptoms have significantly improved. I highly recommend this supplement!

Updated: Apr 2025

Blood Clot details

Flavonolignans reduce platelet activity

Based on 6 Researches

USERS' SCORE

Good

Based on 10 Reviews

Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. doi:10.1186/s12906-017-1897-7

We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.

The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.

Liver tests improved

Most Useful Review

60 people found this helpful

Extremely good! I have been diagnosed with fatty liver, and my liver function tests were high. I took 500 mg alongside my usual regimen of vitamins C and E, as I am also diabetic and hypertensive. After 2-3 months, my liver function tests returned to normal, and my blood sugar level decreased, which I attribute to this supplement. I continue to take it to maintain my liver health and regularly order it from iHerb.com, especially appreciating Now Products.

Updated: Mar 2026

Chemotherapy details

ALA mitigates chemotherapy-related cognitive decline

Based on 16 Researches

USERS' SCORE

Good

Based on 5 Reviews

Lal R, Dharavath RN, Chopra K. Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus. Neurochem Res. 2023;48:2476. doi:10.1007/s11064-023-03914-y

We investigated the effects of alpha-lipoic acid (ALA) in protecting against cognitive impairments caused by the chemotherapy drug doxoruibicin (DOX). In a study involving Sprague-Dawley rats, we treated them with ALA for four weeks while administering DOX to evaluate memory function through specific tasks.

Our findings indicated that ALA not only improved memory performance but also reduced oxidative stress and inflammation in the brain. This suggests that ALA may offer significant neuroprotective benefits in the context of chemotherapy-induced cognitive issues, primarily through its antioxidant properties.

Excellent chemotherapy support

Most Useful Review

Excellent support for chemotherapy!

Updated: Apr 2025

Heart Attack details

2,3-Dehydrosilybin aids heart protection

Based on 3 Researches

We investigated the effects of 2,3-dehydrosilybin, a component of silybum marianum, on heart protection during ischemia and reperfusion injuries in rats. Hearts treated with low doses of this compound experienced significantly reduced damage compared to untreated ones—only about 7.5% of the heart was affected versus over 75% in controls.

This suggests that silybum marianum could effectively support heart health by minimizing injury during heart attacks. Importantly, when specific kinases were inhibited, this protective effect vanished, highlighting the complexity of the mechanisms involved.

Excellent for heart

Most Useful Review

I took this product based on Dr. Karim Ali’s endorsement. It is exceptional for heart health and the additional benefits he mentioned in his episode. I've been using it for a while and decided to purchase it again.

Updated: Apr 2025

Irritable Bowel Syndrome details

Effective supplement for IBS relief

Di Pierro F, Putignano P, Villanova N. Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia. Acta Biomed. 2018;88:462. doi:10.23750/abm.v88i4.5851

We explored the effects of a supplement called Berberol®K, which contains silybum marianum, on patients dealing with irritable bowel syndrome (IBS) alongside diabetes and dyslipidemia.

In a retrospective study with 59 subjects, those who were treated showed notable improvements after six months, including reduced diarrhea symptoms.

The results suggest that this food supplement could be beneficial, especially for those who cannot tolerate standard treatments like statins.

Improved bowel movements

Most Useful Review

This glutathione with ALA has been a lifesaver. It has detoxified my body in a holistic manner, leading to improved bowel movements. Moreover, my skin has become brighter thanks to the detoxification process. People have remarked on my fairer and better complexion. I understand that glutathione extracts heavy metals from the body.

Updated: Apr 2025

Acne Rosacea details

22 people found this helpful

I noticed a visible effect on my rosacea after a course of liver cleansing using a local remedy. The product also had glutathione, which I decided to take separately. My blood vessels at the wings of my nose are no longer as prominent, even though summer, like winter, is tough on them. Overall, the redness of my skin in the area affected by rosacea is less pronounced and much easier to conceal with powder. Those with finer and thinner skin may experience an even greater visual effect from glutathione.

Autoimmune Disorder details

Silybin shows promise for autoimmune disorders

Based on 10 Researches

Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678

We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).

In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.

The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.

Restored health

Most Useful Review

48 people found this helpful

I ordered this product to prevent worsening due to the coronavirus. I read it might help with complications, and it arrived in just three days. Thanks to glutathione, my health returned to normal within a week. My skin also looks good. It appears to be beneficial for skin brightening, and I’m keen to keep taking it.

Updated: Mar 2026

Floaters details

Due to the high cost, I deducted one star. Lutein, said to alleviate floaters and act as a drinkable sunscreen for my eyes, caused a tingling sensation, so I've switched to this alternative. Taking it with protein when my eyes feel tired seems to help, so I'll keep using it, despite not taking it daily due to its expense.

High Cholesterol details

Silymarin positively influences cholesterol

Based on 19 Researches

Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39. doi:10.1016/j.phymed.2018.03.050

We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.

Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.

However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.

Highly recommend

Most Useful Review

26 people found this helpful

I've consistently used this product for about a year with remarkable results for my family. I will definitely continue repurchasing it, and I highly recommend it to others. Thanks to iHerb for the rapid delivery and quality products.

Updated: Apr 2025

Sleep Apnea details

Study on L-glutathione in hypoxia

Tuleta I, Stöckigt F, Juergens UR, Pizarro C, Schrickel JW, et al. Intermittent Hypoxia Contributes to the Lung Damage by Increased Oxidative Stress, Inflammation, and Disbalance in Protease/Antiprotease System. Lung. 2016;194:1015.

We explored how intermittent hypoxia, linked to sleep apnea, affects lung health by increasing oxidative stress and inflammation. In a study involving 32 mice, we compared various treatments, including L-glutathione and infliximab, against a control group.

Our findings revealed that while intermittent hypoxia elevated harmful markers in the lungs, both L-glutathione and infliximab showed potential in minimizing these adverse effects. However, it’s important to note that more research is needed to fully understand the benefits of L-glutathione on lung function in the context of sleep apnea.

Increased energy levels

Most Useful Review

34 people found this helpful

Glutathione has significantly enhanced my energy levels! I’m 39 and have worked as a massage therapist for eight years. After starting dietary supplements two years ago, I noticed a positive impact on my body. Post supplementation, I have been sleeping better and feel more energetic and motivated. I’ve started recommending it to clients, who also notice positive results.

Updated: Apr 2025

Bacterial Infection details

Enhanced brain function

I really liked it! After dealing with a coronavirus infection, I discovered this supplement. I took two capsules daily for a month, finding them easy to swallow. It's beneficial for detoxification from toxins my body accumulated after the virus and antibiotics. Along with vitamins, it aids in restoring essential nutrients. After the virus, I noticed memory issues, but this supplement seemed to enhance brain function and positively affect my immunity.

Cardiovascular Disease details

SM reduces cardiac triglyceride levels

Based on 11 Researches

Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. doi:10.1016/j.atherosclerosis.2021.03.014

We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.

Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.

Cardiovascular aid

Most Useful Review

This drug effectively addresses issues related to the cardiovascular system and arthritis. I take one capsule three times daily, thirty minutes before meals.

Updated: Apr 2025

Fibromyalgia details

My holy grail! I’ve been supplementing with glutathione since December 2023 and have found this brand to have the best composition. At 29, I maintain a healthy, active lifestyle, yet I suffer from fibromyalgia and inflammation. Glutathione supports my detoxification efforts. I appreciate the quality and ingredient mix, taking it before bed with herbal tea and a healthy diet. After months of use, I am starting to notice a reduction in inflammation and water retention in my arms and legs.

Liver Disease details

Silymarin improves liver protection

Based on 21 Researches

Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520

We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.

Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.

Liver detox support

Most Useful Review

119 people found this helpful

Glutathione is an exceptional hepatoprotector that safeguards the liver and the entire body from toxins and viruses. I recommend it particularly for those with alcohol or nicotine dependencies. It plays a vital role in liver detoxification and acts as a precursor to glutathione peroxidase, the main free radical scavenger enzyme. Its sulphur-containing groups effectively detoxify the body, lend antioxidant benefits, and can help delay the ageing process.

Updated: Mar 2026

Parkinson details

Reduces oxidative stress

25 people found this helpful

It works perfectly. As a doctor, I’m aware of the benefits of Glutathione, alpha-lipoic acid, and Milk Thistle. The quality and formula are exceptional and difficult to find in other brands. It reduces oxidative stress, slows down the ageing process, improves skin conditions, and alleviates irritations. It can lower the risk of cell damage associated with fatty liver disease and enhances insulin resistance, being approved for type 2 diabetes in medical trials. Additionally, it reduces symptoms of Parkinson's disease, some autoimmune diseases, and helps manage diabetes symptoms while boosting immune cells.

Reduced insomnia symptoms

Insomnia details

This has been a game changer! After trying countless supplements, I've found few that make a noticeable difference. This product alleviates my hormone and liver issues, which became more problematic while undergoing IVF. I'm feeling significantly better—no racing heart, insomnia, or heart palpitations. I've even noticed improvements in my histamine issues. I'm also giving it to my son, hoping it helps manage his asthma; I’ll need more time to see the results for him.

Chest discomfort experienced

Chest Pain details

It was difficult to swallow. It seemed to have some effect, but as I was also taking vitamins, I’m unsure which was responsible. Regardless, after swallowing it, I felt a strange sensation around my chest for about an hour, which made me feel nauseous.

Chronic Fatigue Syndrome details

hPH may combat stress effects

Based on 3 Researches

Park HJ, Shim HS, Lee S, Hahm DH, Lee H, et al. Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats. BMC Complement Altern Med. 2018;18:149. doi:10.1186/s12906-018-2193-x

We explored the effects of human placenta hydrolysate (hPH) on stress-induced depressive behaviors in rats. Through a well-structured methodology that included controlled stress sessions and behavioral tests, we observed that hPH significantly reduced immobility time in the forced swimming test, indicating potential anti-stress benefits.

Additionally, we noted hPH slightly decreased anxiety behaviors and improved antioxidant levels in the brain. This study suggests that hPH could play a role in addressing stress-related conditions like chronic fatigue syndrome. However, further research is needed to fully understand its mechanisms.

Restored physical strength

Most Useful Review

7 people found this helpful

I believed my lack of stamina resulted from insufficient exercise, only to discover I was deficient in this vital ingredient. Initially slow at climbing stairs, I can now run and ascend stairs effortlessly—much like I did two decades ago. I'm astonished at how quickly I've recovered from fatigue and illness!

Updated: Mar 2026

Dizziness details

Antioxidants may reduce dizziness

Raponi G, Alpini D, Volontè S, Capobianco S, Cesarani A. The role of free radicals and plasmatic antioxidant in Ménière's syndrome. Int Tinnitus J. 2003;9:104.

We focused on whether antioxidants, specifically a formulation with reduced glutathione, could help individuals with Ménière's syndrome manage dizziness. Patients were split into three groups—those receiving conventional treatment, those in a control group, and those receiving antioxidant therapy.

Our findings showed that the antioxidant treatment group, particularly those with Ménière's syndrome, experienced a notable improvement in symptoms, suggesting that addressing oxidative stress may benefit those suffering from dizziness linked to this condition. More research is expected to further validate these promising results.

Dizziness improvement

Most Useful Review

I used to buy a smaller bottle, but it was hard to keep restocking, so I opted for the larger size. My dizziness has improved dramatically, and I will continue to take it as I feel it also has a detoxifying effect.

Updated: Apr 2025

Hives details

The supplement that saved my life! After recovering from Covid-19 last year, I suffered severe hives all over my body with terrible itching. I tried antihistamines, anti-itch lotions, and eczema medications, but nothing worked. Only high-dose steroids stopped the hives and severe itching temporarily. In desperation, I searched the internet and discovered others with similar symptoms who found relief after taking glutathione. I decided to try it, and it worked like a miracle! After a month of taking this supplement, all my hives disappeared.

Kidney Stones details

Extracts reduce kidney stone formation

Essa HA, Ali AM, Saied MA. Cymbopogon proximus and Petroselinum crispum seed ethanolic extract/Gum Arabic nanogel emulsion: Preventing ethylene glycol and ammonium chloride-induced urolithiasis in rats. Urolithiasis. 2024;52:52. doi:10.1007/s00240-024-01559-2

We investigated the potential of Cymbopogon proximus (Halfa Bar) and Petroselinum crispum (parsley) seed extracts in reducing kidney stones, using a rigorous study design involving multiple groups of rats. One group received a mixture of ethylene glycol and ammonium chloride to induce urolithiasis, a condition characterized by kidney stone formation. In contrast, other groups received treatment either as an emulsion or a nanogel form of the extracts.

During the trials, we observed that the urolithiasis model led to a troubling decrease in essential kidney health indicators such as urinary magnesium levels and specific antioxidant activities, including glutathione and catalase. Additionally, we noted an increase in harmful substances that often contribute to stone formation, like calcium and oxalate crystals.

Interestingly, treatment with either the emulsion or the nanogel significantly improved these kidney indicators. It elevated glutathione levels and reduced the formation of oxalate crystals, all while enhancing kidney function. The nanogel version of the extracts showed even better results compared to the traditional emulsion, suggesting a promising avenue for further research.

In conclusion, our findings indicate that the extracts from C. proximus and P. crispum can indeed assist in protecting against kidney stones by supporting kidney function and minimizing unhealthy kidney changes. While glutathione played a role in this context, it was part of a broader treatment strategy, making its isolated effects harder to pinpoint.

Cleaning effect only

Most Useful Review

I didn't see any results from this product. It seems to only clean the kidneys and has average quality. It lasts a long time, but the taste is non-existent.

Updated: Apr 2025

Heartburn details

My sister has started drinking her second pack as per the doctor’s recommendation. Since taking it, her bowel movements have become regular, and heartburn has vanished.

Diarrhea details

Questionable