5/22/2025
Last update
5/22/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 6 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
Read More
9
We explored the effects of silibinin on allergies by studying its impact on antibody production and T-cell responses in mice sensitized to ovalbumin. The mice received either no treatment or different doses of silibinin before being exposed to the allergen.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Read More
8
Silybine shows potential against allergies
We observed the effects of silybine, a key component derived from Silybum marianum seeds, on allergic reactions in rats. The study revealed that silybine can lower blood pressure and inhibit the severe responses associated with anaphylactic shock.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Read More
Most Useful Reviews
9
Hay fever relief
5 people found this helpful
Since I started taking this supplement, my skin has become firmer and noticeably brighter! Despite my alcohol consumption, I've found hangovers much easier to manage. Additionally, my severe hay fever symptoms have significantly improved. I highly recommend this supplement!
Read More
9
Skin clearing
Amazing for liver. I had a skin allergy due to my liver, and this helped clear my skin, improved my liver health, and reduced my breakouts. I totally recommend it.
Read More
7.5
Seasonal allergy relief
After a month on this supplement, I've noticed remarkable improvements, particularly regarding my skin. Despite consuming joint-friendly foods, my immunity seems robust. Having severe rhinitis and allergies, I’m grateful that my symptoms have not worsened—possibly due to my diet. Given its diverse benefits, I plan to incorporate it regularly, especially for women in their 50s.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
- All Researches
9
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
Read More
9
We explored the effects of silibinin on allergies by studying its impact on antibody production and T-cell responses in mice sensitized to ovalbumin. The mice received either no treatment or different doses of silibinin before being exposed to the allergen.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Read More
9
We explored how silymarin, a natural compound from milk thistle, impacts UV light-induced immune suppression and oxidative stress. Testing on mice showed that silymarin treatment significantly enhanced the skin's immune response, reducing harmful leukocyte infiltration and lowering levels of immunosuppressive cytokines.
Notably, silymarin also decreased the production of reactive oxygen species and nitric oxide linked to skin damage. Our findings suggest that silymarin could be a promising candidate for developing skincare products or sunscreens aimed at preventing skin cancer.
Notably, silymarin also decreased the production of reactive oxygen species and nitric oxide linked to skin damage. Our findings suggest that silymarin could be a promising candidate for developing skincare products or sunscreens aimed at preventing skin cancer.
Read More
8
Silybine shows potential against allergies
We observed the effects of silybine, a key component derived from Silybum marianum seeds, on allergic reactions in rats. The study revealed that silybine can lower blood pressure and inhibit the severe responses associated with anaphylactic shock.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Hay fever relief
5 people found this helpful
Since I started taking this supplement, my skin has become firmer and noticeably brighter! Despite my alcohol consumption, I've found hangovers much easier to manage. Additionally, my severe hay fever symptoms have significantly improved. I highly recommend this supplement!
Read More
9
Skin clearing
Amazing for liver. I had a skin allergy due to my liver, and this helped clear my skin, improved my liver health, and reduced my breakouts. I totally recommend it.
Read More
7.5
Seasonal allergy relief
After a month on this supplement, I've noticed remarkable improvements, particularly regarding my skin. Despite consuming joint-friendly foods, my immunity seems robust. Having severe rhinitis and allergies, I’m grateful that my symptoms have not worsened—possibly due to my diet. Given its diverse benefits, I plan to incorporate it regularly, especially for women in their 50s.
Read More
7.5
Skin improvement
One month review. It's already been a month since I took it on an empty stomach. If there's anything that stands out, it's my skin. My immunity seems to be good, even though I have severe rhinitis and am sensitive to allergies. I'm grateful that I've not experienced worse, perhaps due to my diet. They say it's beneficial for health, so I'll continue taking it regularly. It has a variety of effects, so it's recommended to women in their 50s.
Read More
2
No effects noted
Would not order again. I purchased this for a potential mould allergy, but this product did not seem to make any difference.
Read More
Frequently Asked Questions
7.5
Seasonal allergy relief
After a month on this supplement, I've noticed remarkable improvements, particularly regarding my skin. Despite consuming joint-friendly foods, my immunity seems robust. Having severe rhinitis and allergies, I’m grateful that my symptoms have not worsened—possibly due to my diet. Given its diverse benefits, I plan to incorporate it regularly, especially for women in their 50s.
7.5
Skin improvement
One month review. It's already been a month since I took it on an empty stomach. If there's anything that stands out, it's my skin. My immunity seems to be good, even though I have severe rhinitis and am sensitive to allergies. I'm grateful that I've not experienced worse, perhaps due to my diet. They say it's beneficial for health, so I'll continue taking it regularly. It has a variety of effects, so it's recommended to women in their 50s.
2
No effects noted
Would not order again. I purchased this for a potential mould allergy, but this product did not seem to make any difference.
9
Hay fever relief
5 people found this helpful
Since I started taking this supplement, my skin has become firmer and noticeably brighter! Despite my alcohol consumption, I've found hangovers much easier to manage. Additionally, my severe hay fever symptoms have significantly improved. I highly recommend this supplement!
9
Skin clearing
Amazing for liver. I had a skin allergy due to my liver, and this helped clear my skin, improved my liver health, and reduced my breakouts. I totally recommend it.
9
We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.
9
We explored the effects of silibinin on allergies by studying its impact on antibody production and T-cell responses in mice sensitized to ovalbumin. The mice received either no treatment or different doses of silibinin before being exposed to the allergen.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
Our findings revealed that silibinin significantly reduced the levels of IgE antibodies, which are responsible for allergic reactions. Conversely, it boosted levels of IgG(2a), an antibody that can help fight off allergens.
Silibinin also shifted the immune response towards a balance that favors Th1 cells, which may provide a beneficial effect against allergies.
8
Silybine shows potential against allergies
We observed the effects of silybine, a key component derived from Silybum marianum seeds, on allergic reactions in rats. The study revealed that silybine can lower blood pressure and inhibit the severe responses associated with anaphylactic shock.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
Notably, it appears to stabilize mast cell membranes, preventing the release of histamine—a major player in allergic reactions. However, while these findings are promising, it remains unclear how these effects translate to humans suffering from allergies.
References
- Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. 10.1016/j.bbrc.2012.07.112
- Kuo FH, Jan TR. Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice. Phytomedicine. 2009;16:271. 10.1016/j.phymed.2008.07.006
- Katiyar SK. Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol. 2002;21:1213.
- Lecomte J. [General pharmacologic properties of silybine and silymarine in the rat]. Arch Int Pharmacodyn Ther. 1975;214:165.
