Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
8
We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
Read More
8
Silibinin shows promise in arthritis
We explored the impact of silibinin, derived from silybum marianum, on immune responses related to rheumatoid arthritis. The study included both healthy individuals and patients with active arthritis to assess how silibinin affects T cell functions.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Read More
8
We explored the potential benefits of milk thistle oil, known scientifically as Silybum marianum, in managing arthritis and providing antioxidant support. The study used oil extracted from seeds at different maturity stages and measured its effects using well-established tests for both antioxidant and anti-arthritic activities.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Read More
Most Useful Reviews
9
Complete pain relief
542 people found this helpful
Surprising results. I bought this glutathione to speed my recovery from a cold, but was astonished to find that my right knee, painful for over two years due to an injury, stopped hurting completely. I hadn’t associated the pain with arthritis but assumed it was from my injury. I shopped for hours with my daughter, something that would have been painful before. I couldn't believe how effective it was, considering I must have really needed glutathione.
Read More
9
All-day relief
15 people found this helpful
Good for arthritis pain relief. Glutathione helps alleviate my arthritis pain. I take two every morning, and it provides me with all-day relief.
Read More
7.5
Knee pain relief
6 people found this helpful
I'm delighted to share my review on the 30 tablets I purchased. The results were so impressive that I ordered another 60 tablets. Initially bought to improve my skin, I noticed after about 15 days that my knee pain, shoulder pain related to osteoarthritis, and resting pain in my shoulder blades and arms from cervical spondylotic radiculopathy completely disappeared. I was astonished by the unexpected effects of the glutathione and peony mochi! While I still feel some pain when moving, the resting pain has vanished, allowing me to sleep very well. My hands have also become much fairer.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
8
Silymarin shows potential for arthritis
We explored the potential benefits of silymarin and silibinin for managing rheumatoid arthritis (RA) and osteoarthritis (OA) symptoms through a systematic review of 21 relevant studies.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
Read More
8
Silibinin shows promise in arthritis
We explored the impact of silibinin, derived from silybum marianum, on immune responses related to rheumatoid arthritis. The study included both healthy individuals and patients with active arthritis to assess how silibinin affects T cell functions.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Read More
8
We explored the potential benefits of milk thistle oil, known scientifically as Silybum marianum, in managing arthritis and providing antioxidant support. The study used oil extracted from seeds at different maturity stages and measured its effects using well-established tests for both antioxidant and anti-arthritic activities.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Read More
8
We examined the impact of silymarin, specifically the Livergol® tablet, on rheumatoid arthritis (RA) symptoms in a group of 44 stable patients over 90 days. Using the Disease Activity Score (DAS-28) to track changes, we found that adding silymarin to standard treatments led to a significant reduction in symptoms. The average scores dropped from 3.02 to 2.3, suggesting that silymarin may have anti-inflammatory and antioxidant benefits for RA patients. However, further research with larger samples and cytokine measurements is necessary to fully understand how it works.
Read More
8
We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Complete pain relief
542 people found this helpful
Surprising results. I bought this glutathione to speed my recovery from a cold, but was astonished to find that my right knee, painful for over two years due to an injury, stopped hurting completely. I hadn’t associated the pain with arthritis but assumed it was from my injury. I shopped for hours with my daughter, something that would have been painful before. I couldn't believe how effective it was, considering I must have really needed glutathione.
Read More
9
All-day relief
15 people found this helpful
Good for arthritis pain relief. Glutathione helps alleviate my arthritis pain. I take two every morning, and it provides me with all-day relief.
Read More
7.5
Knee pain relief
6 people found this helpful
I'm delighted to share my review on the 30 tablets I purchased. The results were so impressive that I ordered another 60 tablets. Initially bought to improve my skin, I noticed after about 15 days that my knee pain, shoulder pain related to osteoarthritis, and resting pain in my shoulder blades and arms from cervical spondylotic radiculopathy completely disappeared. I was astonished by the unexpected effects of the glutathione and peony mochi! While I still feel some pain when moving, the resting pain has vanished, allowing me to sleep very well. My hands have also become much fairer.
Read More
9
Inflammation reduced
I bought this Glutathione for my neighbour who suffers from arthritis and often experiences painful flare-ups. After using it for a month, he reported that his pain had improved significantly and the inflammation had subsided. Overall, his health appears to have enhanced, and he continues to take it daily.
Read More
7.5
Resting pain vanished
I initially bought this for better skin, but after roughly 15 days, my knee pain, shoulder pain due to osteoarthritis, and resting pain in my shoulder blades and arms diminished significantly. I was amazed to find glutathione on the shelf and at the unexpected benefits of peony mochi. Although I still experience pain when I move, the resting pain has disappeared, allowing for much better sleep. My hands have become noticeably whiter, and I'm planning to purchase an additional 60-count variant for further benefits.
Read More
Frequently Asked Questions
7.5
Knee pain relief
6 people found this helpful
I'm delighted to share my review on the 30 tablets I purchased. The results were so impressive that I ordered another 60 tablets. Initially bought to improve my skin, I noticed after about 15 days that my knee pain, shoulder pain related to osteoarthritis, and resting pain in my shoulder blades and arms from cervical spondylotic radiculopathy completely disappeared. I was astonished by the unexpected effects of the glutathione and peony mochi! While I still feel some pain when moving, the resting pain has vanished, allowing me to sleep very well. My hands have also become much fairer.
9
Inflammation reduced
I bought this Glutathione for my neighbour who suffers from arthritis and often experiences painful flare-ups. After using it for a month, he reported that his pain had improved significantly and the inflammation had subsided. Overall, his health appears to have enhanced, and he continues to take it daily.
7.5
Resting pain vanished
I initially bought this for better skin, but after roughly 15 days, my knee pain, shoulder pain due to osteoarthritis, and resting pain in my shoulder blades and arms diminished significantly. I was amazed to find glutathione on the shelf and at the unexpected benefits of peony mochi. Although I still experience pain when I move, the resting pain has disappeared, allowing for much better sleep. My hands have become noticeably whiter, and I'm planning to purchase an additional 60-count variant for further benefits.
8
Silymarin shows potential for arthritis
We explored the potential benefits of silymarin and silibinin for managing rheumatoid arthritis (RA) and osteoarthritis (OA) symptoms through a systematic review of 21 relevant studies.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
8
We examined the impact of silymarin, specifically the Livergol® tablet, on rheumatoid arthritis (RA) symptoms in a group of 44 stable patients over 90 days. Using the Disease Activity Score (DAS-28) to track changes, we found that adding silymarin to standard treatments led to a significant reduction in symptoms. The average scores dropped from 3.02 to 2.3, suggesting that silymarin may have anti-inflammatory and antioxidant benefits for RA patients. However, further research with larger samples and cytokine measurements is necessary to fully understand how it works.
8
Silibinin shows promise in arthritis
We explored the impact of silibinin, derived from silybum marianum, on immune responses related to rheumatoid arthritis. The study included both healthy individuals and patients with active arthritis to assess how silibinin affects T cell functions.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
8
We explored the potential benefits of milk thistle oil, known scientifically as Silybum marianum, in managing arthritis and providing antioxidant support. The study used oil extracted from seeds at different maturity stages and measured its effects using well-established tests for both antioxidant and anti-arthritic activities.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
References
- Ghahfarrokhi SH, Heidari-Soureshjani S, Sherwin CMT, Azadegan-Dehkordi Z. Efficacy and Mechanisms of , Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review. Curr Rheumatol Rev. 2024;20:414. doi:10.2174/0115733971266397231122080247
- Dupuis ML, Conti F, Maselli A, Pagano MT, Ruggieri A, et al. The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis. Front Immunol. 2018;9:1903. doi:10.3389/fimmu.2018.01903
- Harrabi S, Ferchichi A, Bacheli A, Fellah H. Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages. Lipids Health Dis. 2018;17:82. doi:10.1186/s12944-018-0682-z
- Shavandi M, Moini A, Shakiba Y, Mashkorinia A, Dehghani M, et al. Silymarin (Livergol®) Decreases Disease Activity Score in Patients with Rheumatoid Arthritis: A Non-randomized Single-arm Clinical Trial. Iran J Allergy Asthma Immunol. 2017;16:99.
- Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000;7:21.
