Last update
3/20/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
We explored how glutathione, an important antioxidant, interacts with low temperature stress in grape seedlings treated with exogenous 24-epibrassinolide (EBR). In this study, grape seedlings were subjected to cold conditions (4°C) and then treated with EBR, alongside other substances, to evaluate their effects on growth and physiological responses over various time periods.
Notably, we observed that the seedlings treated with EBR showed an increase in glutathione levels by about 33.63%. This boost in glutathione might help in protecting the cells against oxidative damage caused by cold stress. Additionally, activities of key antioxidant enzymes, such as superoxide dismutase and peroxidase, were significantly enhanced in the EBR-treated plants.
While the treatment showed positive effects overall, it's essential to note that the study evaluated glutathione alongside other treatments, making it challenging to isolate its specific impact solely on cold stress. Despite this, the findings suggest that glutathione plays a supportive role in helping grape seedlings withstand cold temperatures.
Notably, we observed that the seedlings treated with EBR showed an increase in glutathione levels by about 33.63%. This boost in glutathione might help in protecting the cells against oxidative damage caused by cold stress. Additionally, activities of key antioxidant enzymes, such as superoxide dismutase and peroxidase, were significantly enhanced in the EBR-treated plants.
While the treatment showed positive effects overall, it's essential to note that the study evaluated glutathione alongside other treatments, making it challenging to isolate its specific impact solely on cold stress. Despite this, the findings suggest that glutathione plays a supportive role in helping grape seedlings withstand cold temperatures.
Read More
Most Useful Reviews
8
Cold-free experience
17 people found this helpful
The rare supplement that has significantly improved my quality of life. With my job, I frequently encounter patients and usually catch an aggressive cold each year. I switched to reduced glutathione two years ago after a study about its bioavailability. During one of the worst flu seasons, I remained free of cold symptoms, despite not changing anything else. While it's not definitive evidence, it is notable to me. This product, affordable and effective, has made a significant impact on my health; I haven't had so much as a sniffle despite working long hours in stressful conditions. It has earned a permanent place in our household.
Read More
9
Effective for colds
6 people found this helpful
GREAT ANTIOXIDANT TO HELP FIGHT OFF COLDS. This is a wonderful product with empirical evidence supporting its ability to support the immune system and combat colds and bacteria. I highly recommend it as a daily supplement.
Read More
8
Cold combat support
6 people found this helpful
It really works! It's a good resource to combat colds.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We explored how glutathione, an important antioxidant, interacts with low temperature stress in grape seedlings treated with exogenous 24-epibrassinolide (EBR). In this study, grape seedlings were subjected to cold conditions (4°C) and then treated with EBR, alongside other substances, to evaluate their effects on growth and physiological responses over various time periods.
Notably, we observed that the seedlings treated with EBR showed an increase in glutathione levels by about 33.63%. This boost in glutathione might help in protecting the cells against oxidative damage caused by cold stress. Additionally, activities of key antioxidant enzymes, such as superoxide dismutase and peroxidase, were significantly enhanced in the EBR-treated plants.
While the treatment showed positive effects overall, it's essential to note that the study evaluated glutathione alongside other treatments, making it challenging to isolate its specific impact solely on cold stress. Despite this, the findings suggest that glutathione plays a supportive role in helping grape seedlings withstand cold temperatures.
Notably, we observed that the seedlings treated with EBR showed an increase in glutathione levels by about 33.63%. This boost in glutathione might help in protecting the cells against oxidative damage caused by cold stress. Additionally, activities of key antioxidant enzymes, such as superoxide dismutase and peroxidase, were significantly enhanced in the EBR-treated plants.
While the treatment showed positive effects overall, it's essential to note that the study evaluated glutathione alongside other treatments, making it challenging to isolate its specific impact solely on cold stress. Despite this, the findings suggest that glutathione plays a supportive role in helping grape seedlings withstand cold temperatures.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8
Cold-free experience
17 people found this helpful
The rare supplement that has significantly improved my quality of life. With my job, I frequently encounter patients and usually catch an aggressive cold each year. I switched to reduced glutathione two years ago after a study about its bioavailability. During one of the worst flu seasons, I remained free of cold symptoms, despite not changing anything else. While it's not definitive evidence, it is notable to me. This product, affordable and effective, has made a significant impact on my health; I haven't had so much as a sniffle despite working long hours in stressful conditions. It has earned a permanent place in our household.
Read More
9
Effective for colds
6 people found this helpful
GREAT ANTIOXIDANT TO HELP FIGHT OFF COLDS. This is a wonderful product with empirical evidence supporting its ability to support the immune system and combat colds and bacteria. I highly recommend it as a daily supplement.
Read More
8
Cold combat support
6 people found this helpful
It really works! It's a good resource to combat colds.
Read More
8.5
Immune boost
2 people found this helpful
Boost immune system! I haven't caught a cold since I began taking this.
Read More
8
Knee pain relief
542 people found this helpful
Surprising results! I purchased this glutathione to see if it would help me recover more quickly from a nasty cold bug since it's the mother antioxidant. To my amazement, my right knee, which had been in great pain for over two years, is no longer hurting at all! I had to research glutathione and knee pain to see if there was a connection, as it's the only thing I changed. It seems to aid arthritis, which I never considered for my knee pain; I thought it was just from my injury. I even went shopping for hours with my daughter on her birthday, something that would have once been very painful. I'm still in shock and grateful to NOW for this incredible product!
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Frequently Asked Questions
References
- Dong F, Li X, Liu C, Zhao B, Ma Y, et al. Exogenous 24-epibrassinolide mitigates damage in grape seedlings under low-temperature stress. Front Plant Sci. 2025;16:1487680. 10.3389/fpls.2025.1487680
Data last updated:
