Last update
3/20/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
8
Silybum marianum may reduce diarrhea
We analyzed how the food supplement Berberol®K, which includes silybin and berberine, affects diarrhea in diabetic patients struggling with dyslipidemia. In our study of 59 patients dealing with irritable bowel syndrome or diarrhea caused by metformin, we found that those taking Berberol®K experienced a notable reduction in diarrhea symptoms.
After six months, only five participants on the supplement reported diarrhea compared to 22 in the untreated group. This suggests that Silybum marianum may help alleviate diarrhea, making it a promising option for patients who are statin intolerant or struggling with gastrointestinal discomfort.
After six months, only five participants on the supplement reported diarrhea compared to 22 in the untreated group. This suggests that Silybum marianum may help alleviate diarrhea, making it a promising option for patients who are statin intolerant or struggling with gastrointestinal discomfort.
Read More
4
Silymarin shows limited effect on diarrhea
We examined the potential of silymarin in reducing chemotherapy-related diarrhea among other adverse reactions. Our review included 64 studies, which indicated that silymarin is generally safe and well-tolerated. While it demonstrates benefits for several conditions related to cancer treatment, its specific effect on diarrhea was less prominent, with only one study addressing this issue. Overall, we found that silymarin holds promise as a supportive treatment option, but more research is necessary to identify the best usage guidelines.
Read More
Most Useful Reviews
9
No diarrhoea now
13 people found this helpful
This product is very cost-effective and boasts a rapid anti-inflammatory effect. The mix of milk thistle and glutathione is good value for money. Initially, I combined it with another high dose of glutathione. Over time, I’ve noticed that I now suffer from no diarrhoea at all, which is a significant improvement for me as I had experienced it for a long time.
Read More
0
Severe side effects
41 people found this helpful
I wouldn't recommend this to anyone. It caused terrible acne and persistent diarrhoea. Despite initially believing I was detoxing, symptoms worsened. I now question the integrity of the product I received. Beware of taking these types of supplements, as reactions can vary widely.
Read More
7.5
Improved condition
1 people found this helpful
After a year of taking this for detoxification, I noticed significant improvements. When I wasn't using it, I would suffer severe diarrhoea, but since I started taking it, my condition has improved remarkably, and I can feel the positive effects now.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
- All Researches
8
Silybum marianum may reduce diarrhea
We analyzed how the food supplement Berberol®K, which includes silybin and berberine, affects diarrhea in diabetic patients struggling with dyslipidemia. In our study of 59 patients dealing with irritable bowel syndrome or diarrhea caused by metformin, we found that those taking Berberol®K experienced a notable reduction in diarrhea symptoms.
After six months, only five participants on the supplement reported diarrhea compared to 22 in the untreated group. This suggests that Silybum marianum may help alleviate diarrhea, making it a promising option for patients who are statin intolerant or struggling with gastrointestinal discomfort.
After six months, only five participants on the supplement reported diarrhea compared to 22 in the untreated group. This suggests that Silybum marianum may help alleviate diarrhea, making it a promising option for patients who are statin intolerant or struggling with gastrointestinal discomfort.
Read More
4
Silymarin shows limited effect on diarrhea
We examined the potential of silymarin in reducing chemotherapy-related diarrhea among other adverse reactions. Our review included 64 studies, which indicated that silymarin is generally safe and well-tolerated. While it demonstrates benefits for several conditions related to cancer treatment, its specific effect on diarrhea was less prominent, with only one study addressing this issue. Overall, we found that silymarin holds promise as a supportive treatment option, but more research is necessary to identify the best usage guidelines.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
No diarrhoea now
13 people found this helpful
This product is very cost-effective and boasts a rapid anti-inflammatory effect. The mix of milk thistle and glutathione is good value for money. Initially, I combined it with another high dose of glutathione. Over time, I’ve noticed that I now suffer from no diarrhoea at all, which is a significant improvement for me as I had experienced it for a long time.
Read More
0
Severe side effects
41 people found this helpful
I wouldn't recommend this to anyone. It caused terrible acne and persistent diarrhoea. Despite initially believing I was detoxing, symptoms worsened. I now question the integrity of the product I received. Beware of taking these types of supplements, as reactions can vary widely.
Read More
7.5
Improved condition
1 people found this helpful
After a year of taking this for detoxification, I noticed significant improvements. When I wasn't using it, I would suffer severe diarrhoea, but since I started taking it, my condition has improved remarkably, and I can feel the positive effects now.
Read More
2
Rejects Glutathione
This supplement caused my diarrhoea, and I noticed that stopping it alleviated the diarrhoea. There's research indicating Glutathione helps, but my body seems to reject it every time. I prefer taking NAC instead, which is a precursor to Glutathione.
Read More
2
Wrong usage?
I am unsure if I'm using this incorrectly, but it consistently gives me diarrhoea, which is a major concern for me.
Read More
Frequently Asked Questions
9
No diarrhoea now
13 people found this helpful
This product is very cost-effective and boasts a rapid anti-inflammatory effect. The mix of milk thistle and glutathione is good value for money. Initially, I combined it with another high dose of glutathione. Over time, I’ve noticed that I now suffer from no diarrhoea at all, which is a significant improvement for me as I had experienced it for a long time.
2
Rejects Glutathione
This supplement caused my diarrhoea, and I noticed that stopping it alleviated the diarrhoea. There's research indicating Glutathione helps, but my body seems to reject it every time. I prefer taking NAC instead, which is a precursor to Glutathione.
0
Daily consumption causes diarrhea
Consuming this product daily leads to diarrhoea and acts as a diuretic, cleansing toxins from the body. However, I am still uncertain about the actual absorption levels of this supplement.
7.5
Improved condition
1 people found this helpful
After a year of taking this for detoxification, I noticed significant improvements. When I wasn't using it, I would suffer severe diarrhoea, but since I started taking it, my condition has improved remarkably, and I can feel the positive effects now.
2
Wrong usage?
I am unsure if I'm using this incorrectly, but it consistently gives me diarrhoea, which is a major concern for me.
4
Silymarin shows limited effect on diarrhea
We examined the potential of silymarin in reducing chemotherapy-related diarrhea among other adverse reactions. Our review included 64 studies, which indicated that silymarin is generally safe and well-tolerated. While it demonstrates benefits for several conditions related to cancer treatment, its specific effect on diarrhea was less prominent, with only one study addressing this issue. Overall, we found that silymarin holds promise as a supportive treatment option, but more research is necessary to identify the best usage guidelines.
8
Silybum marianum may reduce diarrhea
We analyzed how the food supplement Berberol®K, which includes silybin and berberine, affects diarrhea in diabetic patients struggling with dyslipidemia. In our study of 59 patients dealing with irritable bowel syndrome or diarrhea caused by metformin, we found that those taking Berberol®K experienced a notable reduction in diarrhea symptoms.
After six months, only five participants on the supplement reported diarrhea compared to 22 in the untreated group. This suggests that Silybum marianum may help alleviate diarrhea, making it a promising option for patients who are statin intolerant or struggling with gastrointestinal discomfort.
After six months, only five participants on the supplement reported diarrhea compared to 22 in the untreated group. This suggests that Silybum marianum may help alleviate diarrhea, making it a promising option for patients who are statin intolerant or struggling with gastrointestinal discomfort.
References
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. 10.1007/s00228-022-03434-8
- Di Pierro F, Putignano P, Villanova N. Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia. Acta Biomed. 2018;88:462. 10.23750/abm.v88i4.5851
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