We investigated the antiviral properties of silymarin against the influenza A virus in cultured cells. The study found that silymarin reduced viral activity by 98% without any cytotoxic effects, compared to oseltamivir, which showed only a 52% reduction.
Additionally, we analyzed how silymarin inhibits viral mRNA synthesis. Our results suggest that silymarin affects late-stage viral RNA production more effectively than oseltamivir. This promising outcome indicates that silymarin could be a valuable option for treating influenza infections.
Read More
9.5
Silybum marianum effective against influenza
Identification of 23-(s)-2-amino-3-phenylpropanoyl-silybin as an antiviral agent for influenza A virus infection in vitro and in vivo.
We explored the antiviral effects of Silybum marianum, specifically its active compound silybin, against the influenza A virus. Through initial screenings of 89 medicinal plants, we found that silybin effectively inhibits flu infections. Further research led us to synthesize compounds, with 23-(S)-2-amino-3-phenylpropanoyl-silybin showing the most promise. Both silybin and its derivative reduced virus replication in infected mice and targeted factors involved in viral replication. These findings suggest that Silybum marianum could be a valuable option in the fight against influenza A.
We examined the effects of compounds isolated from Silybum marianum seeds on influenza A(H5N1). Using hot water extraction followed by resin and chromatography methods, we identified seven bioactive compounds. Notably, some of these compounds showed promising antiviral activity, with ICâ‚…â‚€ values indicating effective action against the virus. However, concerns arose regarding cytotoxicity against liver cells. Overall, while certain compounds exhibited potential benefits against influenza, their safety and effectiveness warrant further investigation.
Read More
Most Useful Reviews
7.5
Strong immune support
Excellent! I highly recommend consuming glutathione to strengthen one's immune system against viruses and influenza.
Read More
6
Healthy during illness
I've been drinking it since last year, and my husband experienced two colds (influenza and corona) at the end of last year and the beginning of this year, but I remained in good health. I believe this is due to the glutathione.
We explored the antiviral effects of Silybum marianum, specifically its active compound silybin, against the influenza A virus. Through initial screenings of 89 medicinal plants, we found that silybin effectively inhibits flu infections. Further research led us to synthesize compounds, with 23-(S)-2-amino-3-phenylpropanoyl-silybin showing the most promise. Both silybin and its derivative reduced virus replication in infected mice and targeted factors involved in viral replication. These findings suggest that Silybum marianum could be a valuable option in the fight against influenza A.
Read More
9.5
Silymarin shows strong antiviral potential
Silymarin efficacy against influenza A virus replication.
We investigated the antiviral properties of silymarin against the influenza A virus in cultured cells. The study found that silymarin reduced viral activity by 98% without any cytotoxic effects, compared to oseltamivir, which showed only a 52% reduction.
Additionally, we analyzed how silymarin inhibits viral mRNA synthesis. Our results suggest that silymarin affects late-stage viral RNA production more effectively than oseltamivir. This promising outcome indicates that silymarin could be a valuable option for treating influenza infections.
We examined the effects of compounds isolated from Silybum marianum seeds on influenza A(H5N1). Using hot water extraction followed by resin and chromatography methods, we identified seven bioactive compounds. Notably, some of these compounds showed promising antiviral activity, with ICâ‚…â‚€ values indicating effective action against the virus. However, concerns arose regarding cytotoxicity against liver cells. Overall, while certain compounds exhibited potential benefits against influenza, their safety and effectiveness warrant further investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
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7.5
Strong immune support
Excellent! I highly recommend consuming glutathione to strengthen one's immune system against viruses and influenza.
Read More
6
Healthy during illness
I've been drinking it since last year, and my husband experienced two colds (influenza and corona) at the end of last year and the beginning of this year, but I remained in good health. I believe this is due to the glutathione.
Read More
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References
Zhang Y, Peng YB, Chen XZ, Song LY. [Bioactive lignans from Silybum marianum]. Zhongguo Zhong Yao Za Zhi. 2016;41:1654. 10.4268/cjcmm20160915
Dai JP, Wu LQ, Li R, Zhao XF, Wan QY, et al. Identification of 23-(s)-2-amino-3-phenylpropanoyl-silybin as an antiviral agent for influenza A virus infection in vitro and in vivo. Antimicrob Agents Chemother. 2013;57:4433. 10.1128/AAC.00759-13
Song JH, Choi HJ. Silymarin efficacy against influenza A virus replication. Phytomedicine. 2011;18:832. 10.1016/j.phymed.2011.01.026