Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
USERS' SCORE
Good
Based on 39 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's treatment effectiveness
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
8
We conducted a study to evaluate how hyaluronic acid (HA) treatments impact osteoarthritis (OA) in a rabbit model. Specifically, we compared a novel antioxidant-conjugated form of HA, known as HA-4-aminoresorcinol (HA4AR), to a standard high molecular weight HA treatment.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
Read More
Most Useful Reviews
9
Effective for arthritis
102 people found this helpful
A worthy competitor to medicinal chondroprotectors! The order arrived in 4 days, well packed, with the product matching the description and expiry date. The capsules are medium-sized, easy to take, and have a yeasty smell. I find this medication beneficial for my arthritis; the crunch in my knee joint disappears, and any discomfort subsides during exertion. My skin feels more hydrated, and fine wrinkles are less apparent. The convenient dosage of 100mg, when combined with adequate hydration and vitamin C, proves effective.
Read More
7.5
Benefits joints noticeably
95 people found this helpful
These medium-sized capsules are straightforward to take and have a yeasty smell. I experience a positive effect on my arthritis; the crunch in my knee joint lessens, and discomfort during activity reduces. I've also noticed improved skin hydration and fewer visible wrinkles.
Read More
9
Quick knee pain relief
73 people found this helpful
I discovered that a combination of hyaluronic acid and turmeric could relieve the unbearable arthritis pain in my knee. Remarkably, within two days, my knee pain had decreased by 90%, and it has remained manageable for two weeks now. I'm unsure which supplement works best on its own, but together, they have truly been a miraculous help for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
- All Researches
9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's long-term effects unclear
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Read More
9
Hyaluronic acid's treatment effectiveness
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
9
We aimed to explore how hyaluronic acid (HA) can improve treatments for rheumatoid arthritis (RA) through a novel delivery system. The study developed a specialized liposomal drug depot that incorporates HA and delivers dexamethasone, a common anti-inflammatory medication. This formulation is designed to target the inflamed areas within the joints, minimizing off-target effects.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Read More
9
Effective combination for arthritis
We conducted a thorough analysis exploring the effectiveness of hyaluronic acid (HA) combined with platelet-rich plasma (PRP) in treating knee osteoarthritis (KOA). The aim was to determine how this combination therapy stacks up against using PRP alone.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Read More
User Reviews
USERS' SCORE
Good
Based on 39 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for arthritis
102 people found this helpful
A worthy competitor to medicinal chondroprotectors! The order arrived in 4 days, well packed, with the product matching the description and expiry date. The capsules are medium-sized, easy to take, and have a yeasty smell. I find this medication beneficial for my arthritis; the crunch in my knee joint disappears, and any discomfort subsides during exertion. My skin feels more hydrated, and fine wrinkles are less apparent. The convenient dosage of 100mg, when combined with adequate hydration and vitamin C, proves effective.
Read More
7.5
Benefits joints noticeably
95 people found this helpful
These medium-sized capsules are straightforward to take and have a yeasty smell. I experience a positive effect on my arthritis; the crunch in my knee joint lessens, and discomfort during activity reduces. I've also noticed improved skin hydration and fewer visible wrinkles.
Read More
9
Quick knee pain relief
73 people found this helpful
I discovered that a combination of hyaluronic acid and turmeric could relieve the unbearable arthritis pain in my knee. Remarkably, within two days, my knee pain had decreased by 90%, and it has remained manageable for two weeks now. I'm unsure which supplement works best on its own, but together, they have truly been a miraculous help for me.
Read More
10
Pain significantly reduced
52 people found this helpful
This product has transformed my life! Years ago, I injured my left knee and was diagnosed with severe arthritis. After two weeks of taking Now Foods Hyaluronic Acid, I've experienced a dramatic reduction in pain, allowing me to resume surfing. My doctor recommended it, and I encourage anyone with arthritis to give it a try—this truly feels like a miracle.
Read More
10
Gout flare relief
40 people found this helpful
After reading excellent reviews for Hyaluronic Acid, I had to try it. I doubled the dosage for ten days for quicker results. Within 48 hours, my gouty arthritis flare-up in my right knee (when I was on crutches) significantly improved. I will continue using 'Now Foods Hyaluronic Acid' for ongoing success against my age-related arthritis and can now enjoy many previously forbidden foods. Pain-free!
Read More
Frequently Asked Questions
10
Pain significantly reduced
52 people found this helpful
This product has transformed my life! Years ago, I injured my left knee and was diagnosed with severe arthritis. After two weeks of taking Now Foods Hyaluronic Acid, I've experienced a dramatic reduction in pain, allowing me to resume surfing. My doctor recommended it, and I encourage anyone with arthritis to give it a try—this truly feels like a miracle.
10
Pain relief achieved
28 people found this helpful
I've struggled with knee pain for years, and my wife also suffers from arthritis. After starting Now Foods Hyaluronic Acid six weeks ago, my knee pain has completely subsided, and my wife's experience mirrors mine. This product is astonishing!
10
Miracle supplement found
7 people found this helpful
After a severe injury led to knee arthritis, I tried Now Hyaluronic Acid after some research. Within a week, I felt relief, which led me to order more bottles. I’m convinced it’s this supplement helping me, as I also noticed improvement in an older thumb injury.
7.5
Assisted with arthritis
5 people found this helpful
I experienced improvement within a week while using this hyaluronic acid, contributing to cell hydration. It has relieved my arthritis symptoms, and my skin and hair have benefitted too. I’ve used it before and will continue taking it, as it helps my joints. If you find this review helpful, let me know!
9
Effective for arthritis
102 people found this helpful
A worthy competitor to medicinal chondroprotectors! The order arrived in 4 days, well packed, with the product matching the description and expiry date. The capsules are medium-sized, easy to take, and have a yeasty smell. I find this medication beneficial for my arthritis; the crunch in my knee joint disappears, and any discomfort subsides during exertion. My skin feels more hydrated, and fine wrinkles are less apparent. The convenient dosage of 100mg, when combined with adequate hydration and vitamin C, proves effective.
7.5
Benefits joints noticeably
95 people found this helpful
These medium-sized capsules are straightforward to take and have a yeasty smell. I experience a positive effect on my arthritis; the crunch in my knee joint lessens, and discomfort during activity reduces. I've also noticed improved skin hydration and fewer visible wrinkles.
7.5
Effective for athletes
5 people found this helpful
My husband and I engage in sports, leading to joint pain. For over three years, we have used glucosamine, MSM, chondroitin, and hyaluronic acid. This combination has effectively eased arthritis symptoms and improved joint comfort.
9
Skin improvement noted
4 people found this helpful
I used this acid alongside collagen for joint support due to my rheumatoid arthritis. Within a month, my skin appeared rejuvenated with fine wrinkles reduced. While it’s too soon to judge its impact on my joints, I’m pleased with the skin improvement and had no gastrointestinal issues with this product.
7.5
Pain relief for arthritis
4 people found this helpful
My mother suffers from rheumatoid arthritis and takes one capsule twice daily with food. This supplement alleviates her pain, allowing us to discontinue her previous pain medication. I highly recommend it for managing arthritis symptoms.
7.5
Eased arthritis pain
3 people found this helpful
As I age, the depletion of hyaluronic acid affects my joints and skin elasticity. The NOW double strength product contains beneficial antioxidants and amino acids. As I experience arthritis-related pain, I plan to increase my dosage to help lubricate my joints.
9
Hyaluronic acid's long-term effects unclear
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
5
Hyaluronic acid shows mixed results
We reviewed multiple studies to see how well hyaluronic acid (HA) works for pain relief and improved function in hip osteoarthritis patients. By analyzing data from 18 randomized controlled trials with over 1,600 participants, we found that HA provided some benefits, particularly in reducing pain based on specific measures. However, there was no strong evidence to suggest that HA significantly outperformed placebo in the short, mid, or long term. The safety of HA was generally acceptable, but complications did occur in some cases.
4
Hyaluronic acid efficacy remains unclear
We examined the overall effectiveness of hyaluronic acid (HA) treatment for knee osteoarthritis (KOA) compared to platelet-rich plasma (PRP) in a series of systematic reviews and meta-analyses. The research involved an extensive review of 17 studies that aimed to clarify the benefits of HA shots for arthritis patients.
Our findings revealed that HA may provide some level of treatment advantage, but the methodological quality of the studies we analyzed was notably low. Many of these studies suffered from poor reporting and significant gaps in information, meaning the conclusions drawn about HA's effectiveness may not be as reliable as we would like. We found that just a small number of the outcome indicators showed medium or low-quality evidence, while the majority indicated extremely low-quality results.
Importantly, the studies highlighted considerable overlap in the research, which raises questions about the clarity of HA's isolated effects. While HA has been widely used as a treatment option for KOA, the evidence supporting its efficacy remains uncertain. As we move forward, it is clear that more robust studies are needed to firmly establish how well HA works for patients suffering from this common form of arthritis.
Our findings revealed that HA may provide some level of treatment advantage, but the methodological quality of the studies we analyzed was notably low. Many of these studies suffered from poor reporting and significant gaps in information, meaning the conclusions drawn about HA's effectiveness may not be as reliable as we would like. We found that just a small number of the outcome indicators showed medium or low-quality evidence, while the majority indicated extremely low-quality results.
Importantly, the studies highlighted considerable overlap in the research, which raises questions about the clarity of HA's isolated effects. While HA has been widely used as a treatment option for KOA, the evidence supporting its efficacy remains uncertain. As we move forward, it is clear that more robust studies are needed to firmly establish how well HA works for patients suffering from this common form of arthritis.
5
Hyaluronic Acid Shows Limited Effectiveness
We set out to explore the effects of hyaluronic acid (HA) when used alongside exosomes from adipose-derived mesenchymal stem cells (Ad-MSCs) in treating osteoarthritis (OA). Conducting the study on a group of eighteen male sheep that underwent total lateral meniscectomy, we observed the condition of their knees before and after treatment. After confirming low-grade OA six weeks post-surgery, we divided the sheep into three groups: one received repeated exosome injections, another got HA injections, and the third group benefited from both treatments together.
Our findings indicated that the combination of HA and exosomes significantly reduced lameness in the group that received both treatments, particularly noted two months in when scores were notably lower. However, while there was some improvement in radiographic scores at the three-month mark for this group, the overall clinical lameness scores did not show significant differences across the groups by that time. Notably, when we looked at macroscopic evaluations using OARSI scores, no significant differences were found.
Overall, the study suggests that the combined approach of repeated exosome and HA injections may delay the progression of OA. However, further long-term follow-up is needed to fully understand the lasting effects. This work offers hope for more effective treatments, but it also highlights the challenges in assessing the isolated benefits of HA alone.
Our findings indicated that the combination of HA and exosomes significantly reduced lameness in the group that received both treatments, particularly noted two months in when scores were notably lower. However, while there was some improvement in radiographic scores at the three-month mark for this group, the overall clinical lameness scores did not show significant differences across the groups by that time. Notably, when we looked at macroscopic evaluations using OARSI scores, no significant differences were found.
Overall, the study suggests that the combined approach of repeated exosome and HA injections may delay the progression of OA. However, further long-term follow-up is needed to fully understand the lasting effects. This work offers hope for more effective treatments, but it also highlights the challenges in assessing the isolated benefits of HA alone.
References
- Gupta N, Khatri K, Lakhani A, Dahuja A, Randhawa A, et al. Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis. J Orthop Surg Res. 2025;20:227. doi:10.1186/s13018-025-05574-w
- Powantia Pontoh LA, Fiolin J, Dilogo IH, Prasetyo M, Antarianto RD, et al. Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic, macroscopic and microscopic evaluation. F1000Res. 2024;13:494.
- Bernetti A, Agostini F, Finamore N, Dal Borgo M, Mangone M, et al. Effectiveness of ultrasound-guided hip injections on pain and functioning in patients with hip osteoarthritis: A systematic review. J Back Musculoskelet Rehabil. 2025;38:19. doi:10.1177/10538127241296338
- Migliorini F, Maffulli N, Pipino G, Jeyaraman M, Ramasubramanian S, et al. Intra-articular injections of hyaluronic acid versus plasma rich in growth factors (PRGF) for knee osteoarthritis: a meta-analysis of randomised controlled trials : A meta-analysis. Orthopadie (Heidelb). 2025;54:218. doi:10.1007/s00132-025-04615-w
- Zhang C, Lu Y, Huang Y. Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid. J Orthop Surg Res. 2025;20:153. doi:10.1186/s13018-025-05543-3
- Nisha M, Adnan M, Sakure K, Jain P. Innovations in Glycosaminoglycan Delivery: Transforming Joint Health Therapies. Pharm Nanotechnol. 2025. doi:10.2174/0122117385329819241212040246
- Zhang Z, Wang G, Zhang Z, Liang X, Wang G, et al. Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair. J Nanobiotechnology. 2025;23:69. doi:10.1186/s12951-025-03110-w
- Heller S, Seemann RJ, Burgkart R, Obermeier A, Locher H. Lidocaine Shows Significant Antimicrobial Effects Against Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injectables, like Steroids and Hyaluronan, in the Context of Arthritis Management. Biomedicines. 2025;13. doi:10.3390/biomedicines13010106
- Kumaran K, Vasudevan AK, Jayakumar R, Biswas R. Injectable vancomycin loaded hyaluronic acid-chitosan hydrogel for the treatment of Staphylococcus aureus septic arthritis. Carbohydr Res. 2025;550:109384. doi:10.1016/j.carres.2025.109384
- Du D, Liang Y. A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA). J Orthop Surg Res. 2025;20:57. doi:10.1186/s13018-024-05429-w
- Zhou Q, Chen J, Yu W, Cao D, Ye Y, et al. A critical overview of systematic reviews and meta-analyses of intra-articular injection of platelet rich plasma versus hyaluronic acid for knee osteoarthritis. Clin Rheumatol. 2025;44:547. doi:10.1007/s10067-024-07264-0
- Rieger R, Kaderli S, Boulocher C. In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate. BMC Musculoskelet Disord. 2024;25:1018. doi:10.1186/s12891-024-07921-0
- Migliorini F, Schäfer L, Pilone M, Bell A, Simeone F, et al. Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Arch Orthop Trauma Surg. 2024;145:68. doi:10.1007/s00402-024-05614-w
- Monti L, Franchi E, Verde F, Sgherzi S, Anghilieri FM. Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis. Reumatismo. 2025;77. doi:10.4081/reumatismo.2024.1699
- Oon SF, Lazarakis S, Mallawa G, Nguyen C. Intra-articular hyaluronic acid and platelet-rich plasma as monotherapy or combination therapy in knee osteoarthritis?. Regen Med. 2024;19:637. doi:10.1080/17460751.2024.2439221
- Zhou C, Hao W, Yao J, Zhu T, Sun M, et al. Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis treatment. Int J Biol Macromol. 2025;287:138610. doi:10.1016/j.ijbiomac.2024.138610
- Said M, Tavakoli C, Dumot C, Toupet K, Olivier C, et al. A self-healing radiopaque hyaluronic acid hydrogel as a new injectable biomaterial for precision medicine in osteoarthritis. Theranostics. 2025;15:4054. doi:10.7150/thno.104551
- Liu Q, Ye H, Yang Y, Chen H. The efficacy and safety of intra-articular platelet-rich plasma versus sodium hyaluronate for the treatment of osteoarthritis: Meta-analysis. PLoS One. 2025;20:e0314878. doi:10.1371/journal.pone.0314878
- Woo I, Park JJ, Park CH. Dual intra-articular injections of corticosteroid and hyaluronic acid versus single corticosteroid injection for ankle osteoarthritis: a randomized comparative trial. BMC Musculoskelet Disord. 2025;26:239. doi:10.1186/s12891-025-08488-0
- Bensa A, Bianco Prevot L, Moraca G, Sangiorgio A, Boffa A, et al. Corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based therapies for knee osteoarthritis - literature trends are shifting in the injectable treatments' evidence: a systematic review and expert opinion. Expert Opin Biol Ther. 2025;25:309. doi:10.1080/14712598.2025.2465833
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