Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 90 mg Ferrous Bisglycinate)(Ferrochel™)
18 mg
100%
Top Medical Research Studies
8
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Read More
9
Iron reduces allergenicity in milk
We explored the effects of iron-complexed hydrolyzed whey protein on cow's milk allergies. In this study, we created various treatments with different hydrolysis degrees and tested their allergenicity using specific IgE antibodies.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Read More
8
We investigated how iron oxide particles, commonly found in subway environments, affect allergic responses. By administering these particles to mice with induced allergies, we observed that they increased inflammation in the lungs.
The presence of iron enhanced the recruitment of specific immune cells and production of certain cytokines, which can worsen allergic reactions. In further laboratory tests, it was clear that iron oxide promoted harmful responses in immune cells.
Overall, while iron particles from subways may not be entirely responsible for all allergic reactions, they can certainly aggravate existing ones.
The presence of iron enhanced the recruitment of specific immune cells and production of certain cytokines, which can worsen allergic reactions. In further laboratory tests, it was clear that iron oxide promoted harmful responses in immune cells.
Overall, while iron particles from subways may not be entirely responsible for all allergic reactions, they can certainly aggravate existing ones.
Read More
Most Useful Reviews
9
Increased iron levels
1 people found this helpful
I had an iron deficiency, but since I began taking iron supplements, my levels have improved. I have not encountered any side effects or allergies, and the quality of the ingredients appears to provide significant benefits to my body. If this review has been helpful, please consider leaving a rating; I would appreciate it.
Read More
9
No side effects
12 people found this helpful
I have not experienced any side effects from taking the dosage for my allergies, which I use for prevention. My blood analysis showed a slight increase in ferritin, but I take one tablet daily to maintain my level rather than to increase it. Additionally, I take this along with Vitamin C.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
- All Researches
9
We explored the impact of ferric carboxymaltose (FCM) on individuals with hypersensitivity reactions to iron supplements. The study included patients identified through a retrospective analysis, focusing on those who displayed allergic reactions.
In our analysis, we administered different protocols to patients based on their risk profiles. For low-risk patients, a 4-step drug provocation test (DPT) was performed, while those at higher risk underwent an 11-step rapid drug desensitization (RDD) protocol.
The results were promising, showing that the majority of patients could successfully complete FCM treatments without severe allergic reactions. Out of 21 patients undergoing RDD, 95.2% completed the treatment successfully. While some experienced mild reactions, such as urticaria, serious complications were infrequent.
Additionally, 10 low-risk patients who underwent DPT also completed their iron therapy effectively, though a couple of them experienced mild symptoms afterward. Overall, we found that RDD is a reliable method for safely administering FCM and that DPT is beneficial for low-risk individuals.
In our analysis, we administered different protocols to patients based on their risk profiles. For low-risk patients, a 4-step drug provocation test (DPT) was performed, while those at higher risk underwent an 11-step rapid drug desensitization (RDD) protocol.
The results were promising, showing that the majority of patients could successfully complete FCM treatments without severe allergic reactions. Out of 21 patients undergoing RDD, 95.2% completed the treatment successfully. While some experienced mild reactions, such as urticaria, serious complications were infrequent.
Additionally, 10 low-risk patients who underwent DPT also completed their iron therapy effectively, though a couple of them experienced mild symptoms afterward. Overall, we found that RDD is a reliable method for safely administering FCM and that DPT is beneficial for low-risk individuals.
Read More
9
Iron reduces allergenicity in milk
We explored the effects of iron-complexed hydrolyzed whey protein on cow's milk allergies. In this study, we created various treatments with different hydrolysis degrees and tested their allergenicity using specific IgE antibodies.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
Read More
9
We investigated how coke oven emissions (COEs) might worsen allergic asthma, especially when combined with house dust mites. In our mouse model, exposure to both COEs and allergens led to increased airway inflammation and worsening allergic reactions compared to individual exposures.
We found that higher levels of iron were present in the combined exposure group, and when we used an iron-binding agent, it effectively reduced ferroptosis—a process damaging cells—in this context.
Our results suggest a potential new treatment avenue for asthma related to occupational COE exposure.
We found that higher levels of iron were present in the combined exposure group, and when we used an iron-binding agent, it effectively reduced ferroptosis—a process damaging cells—in this context.
Our results suggest a potential new treatment avenue for asthma related to occupational COE exposure.
Read More
8
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Read More
8
We investigated how iron oxide particles, commonly found in subway environments, affect allergic responses. By administering these particles to mice with induced allergies, we observed that they increased inflammation in the lungs.
The presence of iron enhanced the recruitment of specific immune cells and production of certain cytokines, which can worsen allergic reactions. In further laboratory tests, it was clear that iron oxide promoted harmful responses in immune cells.
Overall, while iron particles from subways may not be entirely responsible for all allergic reactions, they can certainly aggravate existing ones.
The presence of iron enhanced the recruitment of specific immune cells and production of certain cytokines, which can worsen allergic reactions. In further laboratory tests, it was clear that iron oxide promoted harmful responses in immune cells.
Overall, while iron particles from subways may not be entirely responsible for all allergic reactions, they can certainly aggravate existing ones.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased iron levels
1 people found this helpful
I had an iron deficiency, but since I began taking iron supplements, my levels have improved. I have not encountered any side effects or allergies, and the quality of the ingredients appears to provide significant benefits to my body. If this review has been helpful, please consider leaving a rating; I would appreciate it.
Read More
9
No side effects
12 people found this helpful
I have not experienced any side effects from taking the dosage for my allergies, which I use for prevention. My blood analysis showed a slight increase in ferritin, but I take one tablet daily to maintain my level rather than to increase it. Additionally, I take this along with Vitamin C.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Aslan AF, Demir S, Toprak ID, Korkmaz P, Karabacak DE, et al. From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts. Allergy Asthma Proc. 2025;46:152. doi:10.2500/aap.2025.46.240114
- Dindar Çelik F, Aksu K, Akkale Ö, Çelik Tuğlu H, Yağdıran M, et al. The experiences of ferric carboxymaltose desensitization and provocation. World Allergy Organ J. 2025;18:101025. doi:10.1016/j.waojou.2024.101025
- Lukose SJ, Divya MP, Beena AK, Rajakumar SN, Babu PS. Reduced allergenicity of hydrolysed whey protein concentrate complexed with iron: the effect of different enzymes, degree of hydrolysis and ascorbic acid. J Food Sci Technol. 2025;62:940. doi:10.1007/s13197-024-06085-y
- Afolabi BB, Babah OA, Adeyemo TA, Balogun M, Banke-Thomas A, et al. Intravenous versus oral iron for anaemia among pregnant women in Nigeria (IVON): an open-label, randomised controlled trial. Lancet Glob Health. 2024;12:e1649. doi:10.1016/S2214-109X(24)00239-0
- Chen X, Chen H, Zhang P, Ju Q, Wu Z, et al. Coke oven emissions exacerbate allergic asthma by promoting ferroptosis in airway epithelial cells. J Hazard Mater. 2024;478:135542. doi:10.1016/j.jhazmat.2024.135542
- Watanabe H, Honda A, Ichinose T, Ishikawa R, Miyasaka N, et al. Ferruginous components of particulate matters in subway environments, α-FeO or FeO, exacerbates allergies. Environ Pollut. 2024;355:124195. doi:10.1016/j.envpol.2024.124195
