' 
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 36 Reviews
8.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 90 mg Ferrous Bisglycinate)(Ferrochel™)
18 mg
100%
Top Medical Research Studies
8
CUR-PDT triggers ferroptosis in RA
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
High relevance for RA treatment
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
Iron links to MS lesion recovery
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI.
High relevance for MS therapy
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9.5
Reduced hair loss
Suffering from iron deficiency anaemia, I take iron supplements when I notice more hair than usual on my comb. This product has been effective, so I rate it five stars. It has no harsh effects on my digestive system, and next time, I plan to order an iron complex with vitamin C from the same manufacturer.
Read More
9.5
Effective for panic disorder
I discovered that iron supplements alleviate my panic disorder. Since starting the treatment, my seizures have nearly vanished. Previously, I was anaemic and often felt light-headed, but that has improved. I initially took 36mg for six months and have since reduced the dosage to 18mg daily after dinner. I believe it's a worthwhile option for anyone suffering from panic disorder.
Read More
9.5
Improved sleep
After using this supplement previously, I noticed my hair and nails looked healthier and younger. I hadn't used it for a while, but upon resuming, my sleep disorder improved immediately, and my day-night routine became normal. Iron deficiency had been the surprising cause all along!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
8
CUR-PDT triggers ferroptosis in RA
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
High relevance for RA treatment
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
Iron links to MS lesion recovery
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI.
High relevance for MS therapy
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduced hair loss
Suffering from iron deficiency anaemia, I take iron supplements when I notice more hair than usual on my comb. This product has been effective, so I rate it five stars. It has no harsh effects on my digestive system, and next time, I plan to order an iron complex with vitamin C from the same manufacturer.
Read More
9.5
Effective for panic disorder
I discovered that iron supplements alleviate my panic disorder. Since starting the treatment, my seizures have nearly vanished. Previously, I was anaemic and often felt light-headed, but that has improved. I initially took 36mg for six months and have since reduced the dosage to 18mg daily after dinner. I believe it's a worthwhile option for anyone suffering from panic disorder.
Read More
9.5
Improved sleep
After using this supplement previously, I noticed my hair and nails looked healthier and younger. I hadn't used it for a while, but upon resuming, my sleep disorder improved immediately, and my day-night routine became normal. Iron deficiency had been the surprising cause all along!
Read More
9.5
Improved iron levels
I have had anaemia since 2014, and I managed to raise my iron index from 62 to 128, which I'm immensely happy about. Previously, I took another type of Solgar iron, which only raised it to 118. When I wanted to reorder that, it was out of stock, so I opted for Now Foods. To my delight, my iron levels increased again! It's a great supplement.
Read More
9.5
Quality absorption
If there are gastrointestinal issues, iron won't be absorbed properly, but if all is well and you need to replenish iron, these capsules are an excellent option. They absorb well without negative reactions, and there are no issues with stools or staining of teeth, unlike liquid iron supplements.
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