5/9/2025
Last update
5/9/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.3
USERS' SCORE
Good
Based on 6 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 90 mg Ferrous Bisglycinate)(Ferrochel™)
18 mg
100%
Top Medical Research Studies
8
Iron's influence on cholesterol levels
We examined the relationship between essential and toxic elements in the plasma of institutionalized older adults and their cholesterol levels. Focusing on a group of 149 Brazilian seniors living in nursing homes, our goal was to understand how these elements influence lipid profiles and blood sugar levels.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Read More
2
We looked into how high doses of iron impact cholesterol levels and overall health. By adding ferrous ions to cells and testing on zebrafish over several weeks, we noticed significant increases in cholesterol and triglyceride levels. Iron not only heightened these lipids but also led to more severe aging in cells and reduced reproductive abilities in female zebrafish. Unfortunately, it seems that rather than helping, iron could make high cholesterol and blood sugar issues worse, contributing to other health complications.
Read More
9
Bovine lactoferrin reduces cholesterol levels
We aimed to evaluate the impact of bovine lactoferrin (bLF) on cholesterol levels and antioxidant activity in rats fed a high-cholesterol diet.
In our study, 44 male rats were divided into groups, including one that received bLF treatment over four weeks.
Notably, we observed that bLF led to a significant drop in harmful LDL cholesterol and triglycerides while raising beneficial HDL levels. Additionally, 8-isoprostane levels, a marker of oxidative stress, were substantially reduced.
These findings suggest that bLF may effectively combat cholesterol-associated oxidative stress.
In our study, 44 male rats were divided into groups, including one that received bLF treatment over four weeks.
Notably, we observed that bLF led to a significant drop in harmful LDL cholesterol and triglycerides while raising beneficial HDL levels. Additionally, 8-isoprostane levels, a marker of oxidative stress, were substantially reduced.
These findings suggest that bLF may effectively combat cholesterol-associated oxidative stress.
Read More
Most Useful Reviews
9
Fantastic results
17 people found this helpful
Amazing! I’ve struggled with anemia for years, feeling fatigued often. After realising I needed iron, I tried the usual store brands, which caused stomach issues. Switching to this product was transformative; I had no side effects within days and felt fantastic. The price and quality can't be beaten. Thank you, Iherb, for your excellent products!
Read More
9
Relieved anemia
2 people found this helpful
As a woman prone to severe anemia post-menstrual, I found this iron supplement effective. It alleviated my symptoms without causing constipation or the unpleasant taste associated with iron. I wholeheartedly recommend it to anyone struggling with anemia.
Read More
7.5
Helps during pregnancy
2 people found this helpful
During my pregnancy, my haemoglobin levels were low, and this remedy was the only one that helped. I needed to take a higher dosage but definitely recommend it for increasing iron levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.3
- All Researches
9
Bovine lactoferrin reduces cholesterol levels
We aimed to evaluate the impact of bovine lactoferrin (bLF) on cholesterol levels and antioxidant activity in rats fed a high-cholesterol diet.
In our study, 44 male rats were divided into groups, including one that received bLF treatment over four weeks.
Notably, we observed that bLF led to a significant drop in harmful LDL cholesterol and triglycerides while raising beneficial HDL levels. Additionally, 8-isoprostane levels, a marker of oxidative stress, were substantially reduced.
These findings suggest that bLF may effectively combat cholesterol-associated oxidative stress.
In our study, 44 male rats were divided into groups, including one that received bLF treatment over four weeks.
Notably, we observed that bLF led to a significant drop in harmful LDL cholesterol and triglycerides while raising beneficial HDL levels. Additionally, 8-isoprostane levels, a marker of oxidative stress, were substantially reduced.
These findings suggest that bLF may effectively combat cholesterol-associated oxidative stress.
Read More
8
We began by investigating how quail egg supplements enriched with marine macroalgae might influence body weight and other physiological conditions in pregnant rats. Our study involved 25 Sprague Dawley rats split into five groups, each receiving different diets, including a control group and groups that consumed quail eggs from quail fed varying percentages of macroalgae.
The results revealed that the addition of marine macroalgae, particularly at concentrations of 3%, 4%, and 5%, led to significant changes in the nutritional profile of the quail eggs. Notably, we observed an increase in iron levels, which is often considered beneficial for various physiological processes. Interestingly, these dietary changes also contributed to a decrease in cholesterol levels.
While we did see improvements in various health markers such as hemoglobin and hematocrit, which are crucial during pregnancy, it's essential to approach the findings with caution. Although iron levels went up and cholesterol levels went down in the context of this study, isolating the impact of iron alone on high cholesterol is tricky since it was part of a combined nutrient effect from the quail egg supplements.
In summary, while iron from the enriched quail eggs appears to contribute positively to the rats' physiological health, the direct relationship between iron supplementation and lower cholesterol levels requires further investigation.
The results revealed that the addition of marine macroalgae, particularly at concentrations of 3%, 4%, and 5%, led to significant changes in the nutritional profile of the quail eggs. Notably, we observed an increase in iron levels, which is often considered beneficial for various physiological processes. Interestingly, these dietary changes also contributed to a decrease in cholesterol levels.
While we did see improvements in various health markers such as hemoglobin and hematocrit, which are crucial during pregnancy, it's essential to approach the findings with caution. Although iron levels went up and cholesterol levels went down in the context of this study, isolating the impact of iron alone on high cholesterol is tricky since it was part of a combined nutrient effect from the quail egg supplements.
In summary, while iron from the enriched quail eggs appears to contribute positively to the rats' physiological health, the direct relationship between iron supplementation and lower cholesterol levels requires further investigation.
Read More
8
Iron's influence on cholesterol levels
We examined the relationship between essential and toxic elements in the plasma of institutionalized older adults and their cholesterol levels. Focusing on a group of 149 Brazilian seniors living in nursing homes, our goal was to understand how these elements influence lipid profiles and blood sugar levels.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Read More
7
Our study explored the relationship between whole blood iron levels and cholesterol in a community in Taizhou, China, involving 1,917 participants. We looked specifically at how iron levels might connect with various lipid profile parameters, including total cholesterol and triglycerides.
We found that whole blood iron concentration was positively correlated with total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol for both men and women. The most significant association was observed with triglycerides. However, we did not see a correlation between iron levels and high-density lipoprotein (HDL) cholesterol.
Interestingly, the positive correlations were stronger in men compared to women. While our findings suggest that managing iron levels could be a potential strategy for controlling cholesterol levels, the study does not indicate that iron treatment directly lowers high cholesterol. Therefore, any potential dietary or therapeutic strategies involving iron need to be considered carefully.
Our results might help inform healthcare providers about managing cholesterol and dyslipidemia in the population, especially among males.
We found that whole blood iron concentration was positively correlated with total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol for both men and women. The most significant association was observed with triglycerides. However, we did not see a correlation between iron levels and high-density lipoprotein (HDL) cholesterol.
Interestingly, the positive correlations were stronger in men compared to women. While our findings suggest that managing iron levels could be a potential strategy for controlling cholesterol levels, the study does not indicate that iron treatment directly lowers high cholesterol. Therefore, any potential dietary or therapeutic strategies involving iron need to be considered carefully.
Our results might help inform healthcare providers about managing cholesterol and dyslipidemia in the population, especially among males.
Read More
4
We investigated how dietary iron impacts cholesterol metabolism and the role of copper in this process. Using a rat model, we conducted experiments with varying iron and copper amounts to see how these elements interact in the body.
Our findings revealed that a high intake of iron, especially when copper levels were low, led to an increase in cholesterol levels—a condition known as hypercholesterolemia. This shift in cholesterol metabolism also resulted in changes to gene expression linked to lipids, increasing risks for cardiovascular diseases.
Interestingly, when we supplemented copper in the diet, we noticed positive changes that helped reduce these negative effects associated with high iron intake. The data showed that significant gene activity related to cholesterol synthesis increased with high iron consumption, while pathways responsible for cholesterol elimination decreased.
Ultimately, our study highlights the crucial balance needed between iron and copper in maintaining healthy cholesterol levels. It shows that while iron can be beneficial in addressing deficiencies, its excess can cause complications, emphasizing the importance of a balanced diet.
Our findings revealed that a high intake of iron, especially when copper levels were low, led to an increase in cholesterol levels—a condition known as hypercholesterolemia. This shift in cholesterol metabolism also resulted in changes to gene expression linked to lipids, increasing risks for cardiovascular diseases.
Interestingly, when we supplemented copper in the diet, we noticed positive changes that helped reduce these negative effects associated with high iron intake. The data showed that significant gene activity related to cholesterol synthesis increased with high iron consumption, while pathways responsible for cholesterol elimination decreased.
Ultimately, our study highlights the crucial balance needed between iron and copper in maintaining healthy cholesterol levels. It shows that while iron can be beneficial in addressing deficiencies, its excess can cause complications, emphasizing the importance of a balanced diet.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Fantastic results
17 people found this helpful
Amazing! I’ve struggled with anemia for years, feeling fatigued often. After realising I needed iron, I tried the usual store brands, which caused stomach issues. Switching to this product was transformative; I had no side effects within days and felt fantastic. The price and quality can't be beaten. Thank you, Iherb, for your excellent products!
Read More
9
Relieved anemia
2 people found this helpful
As a woman prone to severe anemia post-menstrual, I found this iron supplement effective. It alleviated my symptoms without causing constipation or the unpleasant taste associated with iron. I wholeheartedly recommend it to anyone struggling with anemia.
Read More
7.5
Helps during pregnancy
2 people found this helpful
During my pregnancy, my haemoglobin levels were low, and this remedy was the only one that helped. I needed to take a higher dosage but definitely recommend it for increasing iron levels.
Read More
7.5
Effective for circulation
1 people found this helpful
We purchased this for preventing anaemia, and it seems effective against poor circulation and depression. This iron is easily absorbable and gentle on the stomach, which is beneficial. It is a recommended source of iron because it is less likely to cause constipation.
Read More
7.5
PMS relief
2 people found this helpful
I bought this iron supplement primarily for PMS symptoms. Concerned about potential constipation, I opted for a lower concentration. There were no issues, and this 18mg dose is sufficient for daily needs. After using it, my PMS feelings have notably lessened; I'm much less frustrated before my period. I believe it’s beneficial for PMS relief based on my personal experience, and I plan to keep purchasing it.
Read More
Frequently Asked Questions
9
Fantastic results
17 people found this helpful
Amazing! I’ve struggled with anemia for years, feeling fatigued often. After realising I needed iron, I tried the usual store brands, which caused stomach issues. Switching to this product was transformative; I had no side effects within days and felt fantastic. The price and quality can't be beaten. Thank you, Iherb, for your excellent products!
9
Relieved anemia
2 people found this helpful
As a woman prone to severe anemia post-menstrual, I found this iron supplement effective. It alleviated my symptoms without causing constipation or the unpleasant taste associated with iron. I wholeheartedly recommend it to anyone struggling with anemia.
7.5
Helps during pregnancy
2 people found this helpful
During my pregnancy, my haemoglobin levels were low, and this remedy was the only one that helped. I needed to take a higher dosage but definitely recommend it for increasing iron levels.
7.5
Effective for circulation
1 people found this helpful
We purchased this for preventing anaemia, and it seems effective against poor circulation and depression. This iron is easily absorbable and gentle on the stomach, which is beneficial. It is a recommended source of iron because it is less likely to cause constipation.
7.5
PMS relief
2 people found this helpful
I bought this iron supplement primarily for PMS symptoms. Concerned about potential constipation, I opted for a lower concentration. There were no issues, and this 18mg dose is sufficient for daily needs. After using it, my PMS feelings have notably lessened; I'm much less frustrated before my period. I believe it’s beneficial for PMS relief based on my personal experience, and I plan to keep purchasing it.
7
Our study explored the relationship between whole blood iron levels and cholesterol in a community in Taizhou, China, involving 1,917 participants. We looked specifically at how iron levels might connect with various lipid profile parameters, including total cholesterol and triglycerides.
We found that whole blood iron concentration was positively correlated with total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol for both men and women. The most significant association was observed with triglycerides. However, we did not see a correlation between iron levels and high-density lipoprotein (HDL) cholesterol.
Interestingly, the positive correlations were stronger in men compared to women. While our findings suggest that managing iron levels could be a potential strategy for controlling cholesterol levels, the study does not indicate that iron treatment directly lowers high cholesterol. Therefore, any potential dietary or therapeutic strategies involving iron need to be considered carefully.
Our results might help inform healthcare providers about managing cholesterol and dyslipidemia in the population, especially among males.
We found that whole blood iron concentration was positively correlated with total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol for both men and women. The most significant association was observed with triglycerides. However, we did not see a correlation between iron levels and high-density lipoprotein (HDL) cholesterol.
Interestingly, the positive correlations were stronger in men compared to women. While our findings suggest that managing iron levels could be a potential strategy for controlling cholesterol levels, the study does not indicate that iron treatment directly lowers high cholesterol. Therefore, any potential dietary or therapeutic strategies involving iron need to be considered carefully.
Our results might help inform healthcare providers about managing cholesterol and dyslipidemia in the population, especially among males.
2
We looked into how high doses of iron impact cholesterol levels and overall health. By adding ferrous ions to cells and testing on zebrafish over several weeks, we noticed significant increases in cholesterol and triglyceride levels. Iron not only heightened these lipids but also led to more severe aging in cells and reduced reproductive abilities in female zebrafish. Unfortunately, it seems that rather than helping, iron could make high cholesterol and blood sugar issues worse, contributing to other health complications.
9
Bovine lactoferrin reduces cholesterol levels
We aimed to evaluate the impact of bovine lactoferrin (bLF) on cholesterol levels and antioxidant activity in rats fed a high-cholesterol diet.
In our study, 44 male rats were divided into groups, including one that received bLF treatment over four weeks.
Notably, we observed that bLF led to a significant drop in harmful LDL cholesterol and triglycerides while raising beneficial HDL levels. Additionally, 8-isoprostane levels, a marker of oxidative stress, were substantially reduced.
These findings suggest that bLF may effectively combat cholesterol-associated oxidative stress.
In our study, 44 male rats were divided into groups, including one that received bLF treatment over four weeks.
Notably, we observed that bLF led to a significant drop in harmful LDL cholesterol and triglycerides while raising beneficial HDL levels. Additionally, 8-isoprostane levels, a marker of oxidative stress, were substantially reduced.
These findings suggest that bLF may effectively combat cholesterol-associated oxidative stress.
4
We investigated how dietary iron impacts cholesterol metabolism and the role of copper in this process. Using a rat model, we conducted experiments with varying iron and copper amounts to see how these elements interact in the body.
Our findings revealed that a high intake of iron, especially when copper levels were low, led to an increase in cholesterol levels—a condition known as hypercholesterolemia. This shift in cholesterol metabolism also resulted in changes to gene expression linked to lipids, increasing risks for cardiovascular diseases.
Interestingly, when we supplemented copper in the diet, we noticed positive changes that helped reduce these negative effects associated with high iron intake. The data showed that significant gene activity related to cholesterol synthesis increased with high iron consumption, while pathways responsible for cholesterol elimination decreased.
Ultimately, our study highlights the crucial balance needed between iron and copper in maintaining healthy cholesterol levels. It shows that while iron can be beneficial in addressing deficiencies, its excess can cause complications, emphasizing the importance of a balanced diet.
Our findings revealed that a high intake of iron, especially when copper levels were low, led to an increase in cholesterol levels—a condition known as hypercholesterolemia. This shift in cholesterol metabolism also resulted in changes to gene expression linked to lipids, increasing risks for cardiovascular diseases.
Interestingly, when we supplemented copper in the diet, we noticed positive changes that helped reduce these negative effects associated with high iron intake. The data showed that significant gene activity related to cholesterol synthesis increased with high iron consumption, while pathways responsible for cholesterol elimination decreased.
Ultimately, our study highlights the crucial balance needed between iron and copper in maintaining healthy cholesterol levels. It shows that while iron can be beneficial in addressing deficiencies, its excess can cause complications, emphasizing the importance of a balanced diet.
References
- Basri H, Widiyanto S, Saragih HTS, Zuprizal Z. The effect of quail egg supplements enriched with marine macroalgae spinosum on the physiological condition of Sprague Dawley rats during pregnancy. J Adv Vet Anim Res. 2024;11:1114. 10.5455/javar.2024.k862
- Pan RJ, Luo Z, You YS, Wang JD, Chen YQ, et al. Relationship Between Whole Blood Iron Levels and Lipid Profile Parameters in the General Population: Findings from Routine Physical Examination Report. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04459-z
- Pacheco DA, de Sousa Campêlo AL, de Sousa SES, Sales MC, Sena-Evangelista KCM, et al. Association between exposure to plasma mixture of essential and toxic elements and the lipid profile in institutionalized older adults. J Trace Elem Med Biol. 2024;85:127490. 10.1016/j.jtemb.2024.127490
- Lee J, Jang H, Doo M, Kim BH, Ha JH. High Iron Consumption Modifies the Hepatic Transcriptome Related to Cholesterol Metabolism. J Med Food. 2024;27:895. 10.1089/jmf.2024.k.0139
- Faridvand Y, Nozari S, Asoudeh-Fard A, Karimi MA, Pezeshkian M, et al. Bovine lactoferrin ameliorates antioxidant esterase activity and 8-isoprostane levels in high-cholesterol-diet fed rats. Int J Vitam Nutr Res. 2017;87:201. 10.1024/0300-9831/a000516
- Kim SH, Yadav D, Kim SJ, Kim JR, Cho KH. High Consumption of Iron Exacerbates Hyperlipidemia, Atherosclerosis, and Female Sterility in Zebrafish via Acceleration of Glycation and Degradation of Serum Lipoproteins. Nutrients. 2017;9. 10.3390/nu9070690
