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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 18 Reviews
8.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Carnosine (B-alanyl-L-histidine)
500 mg
*
Top Medical Research Studies
8
Carnosine's potential against Alzheimer's
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
High relevance to Alzheimer’s research
We discovered interesting insights into how l-carnosine, an endogenous metabolite, impacts Alzheimer's disease. By analyzing data from the Human Metabolome Database, we identified l-carnosine, alongside kynurenic acid, as substances that can inhibit the aggregation of amyloid beta peptide (Aβ), which is commonly associated with Alzheimer’s.
Our findings highlighted that l-carnosine works by triggering a cytosolic unfolded protein response. This involves a transcription factor called HSF-1 and different chaperones, specifically HSP40/J-proteins DNJ-12 and DNJ-19. This mechanism indicates that l-carnosine not only plays a role in reducing protein aggregation but may also suggest potential anti-aging benefits.
The link we established between metabolite homeostasis and protein homeostasis presents promising avenues for preventative measures against neurodegenerative disorders. It's exciting to think about how exploring the roles of metabolites like l-carnosine could offer new strategies in combating diseases that impact so many lives.
Our findings highlighted that l-carnosine works by triggering a cytosolic unfolded protein response. This involves a transcription factor called HSF-1 and different chaperones, specifically HSP40/J-proteins DNJ-12 and DNJ-19. This mechanism indicates that l-carnosine not only plays a role in reducing protein aggregation but may also suggest potential anti-aging benefits.
The link we established between metabolite homeostasis and protein homeostasis presents promising avenues for preventative measures against neurodegenerative disorders. It's exciting to think about how exploring the roles of metabolites like l-carnosine could offer new strategies in combating diseases that impact so many lives.
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9
Carnosine mitigates oxidative stress
Characterizing oxidative stress induced by Aβ oligomers and the protective role of carnosine in primary mixed glia cultures.
Direct relevance to Alzheimer's treatment
We investigated how l-carnosine can influence oxidative stress related to Alzheimer's disease (AD). Our focus was on how Aβ1-42 oligomers, which are linked to neurodegeneration in AD, affect primary mixed glial cultures made up of microglia and astrocytes.
During our research, we looked at markers of oxidative stress like reactive oxygen species (ROS) and nitric oxide (NO). We found that exposure to Aβ oligomers significantly increased both ROS and NO levels in the glial cells. However, when we pre-treated the cultures with l-carnosine, it completely blocked this rise, bringing ROS and NO levels back to those found in healthy control cells.
One interesting aspect of our findings was the cellular response to the Aβ oligomers. We observed two distinct groups of cells, with some reacting more strongly to the treatment. In the presence of l-carnosine, the response became uniform across the cells, mirroring the control group. While we didn't see distinct groupings in NO production, the effectiveness of l-carnosine in reducing ROS indicates its potential as a protective agent.
Overall, our study suggests that l-carnosine could play a vital role in counteracting oxidative stress in Alzheimer's, offering a hopeful avenue for future treatments aimed at improving brain health in the context of neurodegenerative diseases.
During our research, we looked at markers of oxidative stress like reactive oxygen species (ROS) and nitric oxide (NO). We found that exposure to Aβ oligomers significantly increased both ROS and NO levels in the glial cells. However, when we pre-treated the cultures with l-carnosine, it completely blocked this rise, bringing ROS and NO levels back to those found in healthy control cells.
One interesting aspect of our findings was the cellular response to the Aβ oligomers. We observed two distinct groups of cells, with some reacting more strongly to the treatment. In the presence of l-carnosine, the response became uniform across the cells, mirroring the control group. While we didn't see distinct groupings in NO production, the effectiveness of l-carnosine in reducing ROS indicates its potential as a protective agent.
Overall, our study suggests that l-carnosine could play a vital role in counteracting oxidative stress in Alzheimer's, offering a hopeful avenue for future treatments aimed at improving brain health in the context of neurodegenerative diseases.
Read More
8
l-Carnosine shows promise for Alzheimer's
Carnosine Mitigates Cognitive Impairment and Dopamine Release in an Okadaic Acid-Induced Zebrafish Model with Alzheimer's Disease-like Symptoms.
High relevance to Alzheimer's research
We focused on understanding the impact of l-carnosine (CAR) in an innovative zebrafish model that mimics Alzheimer’s disease (AD). This model replicates key characteristics of the disease, including cognitive decline and abnormal tau protein behavior. By observing the effect of CAR on these symptoms, we aimed to explore its potential as a therapeutic agent.
Our results highlighted that l-carnosine can significantly improve learning abilities and reduce anxiety-like behaviors in these zebrafish. Notably, we discovered that CAR helps protect against dopamine release impairments, which are often associated with AD. Furthermore, the treatment indicated varying outcomes based on the sex of the zebrafish, suggesting that responses to CAR might differ across genders.
In essence, our findings provide strong evidence for l-carnosine as a promising candidate for future research into preventive therapies for Alzheimer’s disease. We are excited about the potential implications for delaying or mitigating the onset of this challenging condition.
Our results highlighted that l-carnosine can significantly improve learning abilities and reduce anxiety-like behaviors in these zebrafish. Notably, we discovered that CAR helps protect against dopamine release impairments, which are often associated with AD. Furthermore, the treatment indicated varying outcomes based on the sex of the zebrafish, suggesting that responses to CAR might differ across genders.
In essence, our findings provide strong evidence for l-carnosine as a promising candidate for future research into preventive therapies for Alzheimer’s disease. We are excited about the potential implications for delaying or mitigating the onset of this challenging condition.
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Most Useful Reviews
9.5
Increased energy levels
My get-up-and-go had gone, but it's back! I first heard of this on Dr Oz, prompting me to research it further. Many reputable sources noted its claims and results from studies. Although a bit pricey, I decided to try it. I genuinely feel more energised after taking it, 1000mg daily. I even mix it into a tall glass of water.
I'm not a doctor, so always consult a professional before relying on online information. My energy and motivation have significantly improved, which has led to better food choices and reduced sugar cravings.
Read More
9.5
Neuroprotective effects
This is a remarkable aid for brain dysfunction and optimising neurons. My nephew with autism has shown improvement alongside lipoic acid and DHA. My wife and I take it as well to help prevent Alzheimer's disease.
Read More
9.4
Behavioural improvement
L-Carnosine is available as a supplement, marketed as a treatment for various conditions, including Alzheimer's. It has shown to help children with autism in behaviour, speech, and nervous system functioning, leading to significant improvements during studies.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
9
Carnosine mitigates oxidative stress
Characterizing oxidative stress induced by Aβ oligomers and the protective role of carnosine in primary mixed glia cultures.
Direct relevance to Alzheimer's treatment
We investigated how l-carnosine can influence oxidative stress related to Alzheimer's disease (AD). Our focus was on how Aβ1-42 oligomers, which are linked to neurodegeneration in AD, affect primary mixed glial cultures made up of microglia and astrocytes.
During our research, we looked at markers of oxidative stress like reactive oxygen species (ROS) and nitric oxide (NO). We found that exposure to Aβ oligomers significantly increased both ROS and NO levels in the glial cells. However, when we pre-treated the cultures with l-carnosine, it completely blocked this rise, bringing ROS and NO levels back to those found in healthy control cells.
One interesting aspect of our findings was the cellular response to the Aβ oligomers. We observed two distinct groups of cells, with some reacting more strongly to the treatment. In the presence of l-carnosine, the response became uniform across the cells, mirroring the control group. While we didn't see distinct groupings in NO production, the effectiveness of l-carnosine in reducing ROS indicates its potential as a protective agent.
Overall, our study suggests that l-carnosine could play a vital role in counteracting oxidative stress in Alzheimer's, offering a hopeful avenue for future treatments aimed at improving brain health in the context of neurodegenerative diseases.
During our research, we looked at markers of oxidative stress like reactive oxygen species (ROS) and nitric oxide (NO). We found that exposure to Aβ oligomers significantly increased both ROS and NO levels in the glial cells. However, when we pre-treated the cultures with l-carnosine, it completely blocked this rise, bringing ROS and NO levels back to those found in healthy control cells.
One interesting aspect of our findings was the cellular response to the Aβ oligomers. We observed two distinct groups of cells, with some reacting more strongly to the treatment. In the presence of l-carnosine, the response became uniform across the cells, mirroring the control group. While we didn't see distinct groupings in NO production, the effectiveness of l-carnosine in reducing ROS indicates its potential as a protective agent.
Overall, our study suggests that l-carnosine could play a vital role in counteracting oxidative stress in Alzheimer's, offering a hopeful avenue for future treatments aimed at improving brain health in the context of neurodegenerative diseases.
Read More
9
Carnosine counters cellular damage
Carnosine Counteracts the Molecular Alterations Aβ Oligomers-Induced in Human Retinal Pigment Epithelial Cells.
Moderate relevance to Alzheimer’s research
We explored the role of carnosine in addressing the harmful effects of amyloid-beta (Aβ) oligomers, which are implicated in both Alzheimer's Disease (AD) and Age-related Macular Degeneration (AMD). Using a specific human retinal pigment epithelial cell line called ARPE-19, we treated these cells with Aβ oligomers to recreate conditions similar to early AMD pathology.
Our investigation revealed that exposure to Aβ significantly decreased cell viability while increasing inflammation markers and oxidative stress levels. We observed notable damage to the tight junction protein ZO-1, which is vital for cell integrity.
Crucially, when we introduced carnosine, it demonstrated a remarkable ability to counteract these detrimental changes in the ARPE-19 cells. This suggests that carnosine can not only protect against inflammation and oxidative stress but also maintain cellular health. Given carnosine's unique properties and its reduced levels in individuals suffering from AMD, our findings point towards its potential as a neuroprotective treatment in the context of AMD pathology, alongside its relevance to Alzheimer's research.
Our investigation revealed that exposure to Aβ significantly decreased cell viability while increasing inflammation markers and oxidative stress levels. We observed notable damage to the tight junction protein ZO-1, which is vital for cell integrity.
Crucially, when we introduced carnosine, it demonstrated a remarkable ability to counteract these detrimental changes in the ARPE-19 cells. This suggests that carnosine can not only protect against inflammation and oxidative stress but also maintain cellular health. Given carnosine's unique properties and its reduced levels in individuals suffering from AMD, our findings point towards its potential as a neuroprotective treatment in the context of AMD pathology, alongside its relevance to Alzheimer's research.
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9
L-Carnosine shows protective effects
Microfluidic/HPLC combination to study carnosine protective activity on challenged human microglia: Focus on oxidative stress and energy metabolism.
Challenges in isolating effects
We investigated how L-carnosine, a naturally occurring peptide, affects brain cells in the context of Alzheimer's disease, particularly focusing on oxidative stress and energy metabolism. In our research, we looked at human microglia—cells that play a key role in brain health—that were exposed to a combination of lipopolysaccharides (LPS) and ATP, known to induce inflammation and stress.
Our findings revealed that L-carnosine has the capacity to protect these microglia from cell death and oxidative damage caused by the LPS and ATP combination. Importantly, we observed that L-carnosine not only prevented harmful effects but also restored normal energy metabolism in these cells. This suggests that L-carnosine could play a therapeutic role in conditions characterized by inflammation and energy imbalances, like Alzheimer's and depression.
Overall, our study points to L-carnosine as a promising new avenue for treating neuroinflammatory issues tied to Alzheimer’s disease, although it's noteworthy that it was tested alongside other stressors, making it hard to pinpoint its sole influence. The results open up exciting possibilities for future treatments aimed at preserving brain health.
Our findings revealed that L-carnosine has the capacity to protect these microglia from cell death and oxidative damage caused by the LPS and ATP combination. Importantly, we observed that L-carnosine not only prevented harmful effects but also restored normal energy metabolism in these cells. This suggests that L-carnosine could play a therapeutic role in conditions characterized by inflammation and energy imbalances, like Alzheimer's and depression.
Overall, our study points to L-carnosine as a promising new avenue for treating neuroinflammatory issues tied to Alzheimer’s disease, although it's noteworthy that it was tested alongside other stressors, making it hard to pinpoint its sole influence. The results open up exciting possibilities for future treatments aimed at preserving brain health.
Read More
9
L-carnosine shows promise for Alzheimer's
Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin.
Partial effectiveness of L-carnosine
We set out to understand how L-carnosine affects Alzheimer's disease by comparing it with swimming exercise in a rat model. To do this, we administered an intracerebroventricular injection of streptozotocin (STZ), which is known to induce memory impairment similar to Alzheimer's. Our study involved groups of rats that were either given L-carnosine or allowed to swim regularly for five weeks. After this period, we conducted neurobehavioral tests before examining their serum and cerebrospinal fluid (CSF) for irisin levels, as well as their hippocampal tissues for several important proteins.
Our findings indicated that L-carnosine, like swimming, helped to normalize the levels of FNDC5/irisin in the hippocampus, which is crucial for brain health. Both treatments were linked to decreases in harmful proteins associated with Alzheimer's, such as β-amyloid and phosphorylated tau. Additionally, there were improvements in brain-derived neurotrophic factor (BDNF) and insulin signaling, both of which are important for cognitive function.
However, we observed that the levels of irisin in the hippocampus didn’t correlate with those found in the serum or CSF. This means that while L-carnosine seems to offer benefits similar to exercise in reversing cognitive decline and improving key biomarkers of Alzheimer's, the full scope of its effects may not be completely explained by circulating irisin levels. Collectively, these results highlight L-carnosine's potential as a valuable intervention for cognitive impairments in Alzheimer's disease research.
Our findings indicated that L-carnosine, like swimming, helped to normalize the levels of FNDC5/irisin in the hippocampus, which is crucial for brain health. Both treatments were linked to decreases in harmful proteins associated with Alzheimer's, such as β-amyloid and phosphorylated tau. Additionally, there were improvements in brain-derived neurotrophic factor (BDNF) and insulin signaling, both of which are important for cognitive function.
However, we observed that the levels of irisin in the hippocampus didn’t correlate with those found in the serum or CSF. This means that while L-carnosine seems to offer benefits similar to exercise in reversing cognitive decline and improving key biomarkers of Alzheimer's, the full scope of its effects may not be completely explained by circulating irisin levels. Collectively, these results highlight L-carnosine's potential as a valuable intervention for cognitive impairments in Alzheimer's disease research.
Read More
9
Carnosine targets Alzheimer's toxicity
Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity.
Moderate relevance; unclear benefits
We explored the potential of l-carnosine when paired with hyaluronic acid to counteract the harmful effects of Alzheimer's disease. By focusing on how these compounds could work together to tackle the formation of toxic amyloid-β aggregates, we aimed to uncover a promising pharmacological approach to this neurodegenerative disorder.
The study highlighted that derivatives of hyaluronic acid, when functionalized with carnosine, effectively inhibited the formation of amyloid-type aggregates more than their individual components. This action seemed to increase with the level of carnosine included in the formulation.
Additionally, we found that these hyaluronic acid-carnosine conjugates were capable of dissolving existing amyloid fibrils and reducing Aβ-induced toxicity in cell cultures. This suggests that not only do they prevent toxicity, but they also help to break down harmful aggregates already present.
Overall, our findings indicate that carnosine, especially when combined with hyaluronic acid, could be a valuable player in the quest to address Alzheimer's disease, although the specific isolated effects of carnosine alone remain unclear.
The study highlighted that derivatives of hyaluronic acid, when functionalized with carnosine, effectively inhibited the formation of amyloid-type aggregates more than their individual components. This action seemed to increase with the level of carnosine included in the formulation.
Additionally, we found that these hyaluronic acid-carnosine conjugates were capable of dissolving existing amyloid fibrils and reducing Aβ-induced toxicity in cell cultures. This suggests that not only do they prevent toxicity, but they also help to break down harmful aggregates already present.
Overall, our findings indicate that carnosine, especially when combined with hyaluronic acid, could be a valuable player in the quest to address Alzheimer's disease, although the specific isolated effects of carnosine alone remain unclear.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.8
9.5
Neuroprotective effects
This is a remarkable aid for brain dysfunction and optimising neurons. My nephew with autism has shown improvement alongside lipoic acid and DHA. My wife and I take it as well to help prevent Alzheimer's disease.
9.5
Preventive measure
Given my family's history with Alzheimer’s, I take Carnosine and other supplements as a precautionary measure. It safeguards cell and tissue structures during aging through its antioxidant properties.
9.5
Prevents nervous disorders
L-carnosine normalises central nervous system function, making it recommended for treating and preventing nervous disorders. It deactivates proteins associated with Alzheimer's and Parkinson's, halting their formation.
9.5
Prevention of dementia
L-carnosine serves as an agent that delays oxidation, alleviates inflammation, and controls protein aggregation, which is a fundamental cause of damage linked to dementia and Alzheimer's disease.
9.5
Increased energy levels
My get-up-and-go had gone, but it's back! I first heard of this on Dr Oz, prompting me to research it further. Many reputable sources noted its claims and results from studies. Although a bit pricey, I decided to try it. I genuinely feel more energised after taking it, 1000mg daily. I even mix it into a tall glass of water.
I'm not a doctor, so always consult a professional before relying on online information. My energy and motivation have significantly improved, which has led to better food choices and reduced sugar cravings.
Read More
