5/12/2025
Last update
5/12/2025
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Carnosine (B-alanyl-L-histidine)
500 mg
*
Top Medical Research Studies
9
Our exploration focused on the potential of N-Acetyl Carnosine (NAC) in treating cataract, a condition that occurs when proteins in the eye become insoluble and form large masses. Traditional cataract surgeries often require expensive equipment and skilled mediators, so we sought a less invasive solution through the use of solid lipid nanoparticles (SLN).
We prepared SLN-NAC using a unique method known as Mill's method, resulting in particles measuring around 75 nanometers—the ideal size for effective eye penetration. The formulation demonstrated a sustained release of the active ingredient over 24 hours, following a rapid initial release after just one hour.
Our studies also indicated that SLN-NAC penetrated the cornea more effectively than standard NAC eye drops, while corneal hydration tests showed no damage to corneal cells. This suggests that SLN-NAC may offer a promising breakthrough in cataract treatment by enhancing drug delivery and minimizing toxicity.
Overall, the compelling results lead us to believe that SLN-NAC could significantly improve the way cataracts are treated, offering a practical alternative to surgical interventions.
We prepared SLN-NAC using a unique method known as Mill's method, resulting in particles measuring around 75 nanometers—the ideal size for effective eye penetration. The formulation demonstrated a sustained release of the active ingredient over 24 hours, following a rapid initial release after just one hour.
Our studies also indicated that SLN-NAC penetrated the cornea more effectively than standard NAC eye drops, while corneal hydration tests showed no damage to corneal cells. This suggests that SLN-NAC may offer a promising breakthrough in cataract treatment by enhancing drug delivery and minimizing toxicity.
Overall, the compelling results lead us to believe that SLN-NAC could significantly improve the way cataracts are treated, offering a practical alternative to surgical interventions.
Read More
9
We aimed to understand how L-carnosine affects cataract formation, looking specifically at its potential as an anticataractogenic agent. To do this, we assessed L-carnosine through various laboratory tests that measured its ability to counteract oxidative stress and its effects on lens tissue.
Although marketed for its antioxidant properties, our findings revealed that L-carnosine is primarily a strong antiglycating agent, rather than a potent antioxidant or metal-chelating agent. In our tests using human lens cells, we found that there were no significant changes in cell survival when exposed to L-carnosine compared to controls, which suggests that it may not have a significant protective effect in these scenarios.
Interestingly, when we treated whole porcine lenses with L-carnosine in a high galactose environment—which is known to promote cataract formation—we observed a marked reduction in the formation of harmful compounds related to glycation. This indicates that L-carnosine holds promise for future treatment options for diabetic cataracts and other conditions driven by glycation, if not primarily through antioxidant mechanisms.
Although marketed for its antioxidant properties, our findings revealed that L-carnosine is primarily a strong antiglycating agent, rather than a potent antioxidant or metal-chelating agent. In our tests using human lens cells, we found that there were no significant changes in cell survival when exposed to L-carnosine compared to controls, which suggests that it may not have a significant protective effect in these scenarios.
Interestingly, when we treated whole porcine lenses with L-carnosine in a high galactose environment—which is known to promote cataract formation—we observed a marked reduction in the formation of harmful compounds related to glycation. This indicates that L-carnosine holds promise for future treatment options for diabetic cataracts and other conditions driven by glycation, if not primarily through antioxidant mechanisms.
Read More
9
Carnosine aids in cataract prevention
We explored the impact of dehydroascorbate (DHA) on the structure and functioning of lens crystallins, specifically looking at the protective role of l-carnosine against cataract formation. Our research revealed that high levels of DHA in lens tissue can lead to significant protein unfolding and aggregation, both of which are key contributors to age-related cataracts.
During the study, we observed that l-carnosine, an endogenous dipeptide, effectively preserved the natural structure of lens proteins even when faced with the challenges posed by DHA. This is crucial since maintaining the stability of these proteins could help prevent the development of cataracts as we age.
Interestingly, while DHA alters the chaperone activity of α-crystallin—a protein important for lens clarity—carnosine was found to restore its functionality. Additionally, we noted that carnosine helped combat the increased instability of lens proteins modified by DHA, thereby enhancing their resilience.
Our lens culture assessments further illustrated that DHA does cause significant lens opacity, a condition that carnosine successfully mitigated. The findings underscore carnosine's valuable properties, particularly its abilities to prevent glycation and aggregation, which may play significant roles in slowing down cataract formation, especially in oxidative stress conditions.
During the study, we observed that l-carnosine, an endogenous dipeptide, effectively preserved the natural structure of lens proteins even when faced with the challenges posed by DHA. This is crucial since maintaining the stability of these proteins could help prevent the development of cataracts as we age.
Interestingly, while DHA alters the chaperone activity of α-crystallin—a protein important for lens clarity—carnosine was found to restore its functionality. Additionally, we noted that carnosine helped combat the increased instability of lens proteins modified by DHA, thereby enhancing their resilience.
Our lens culture assessments further illustrated that DHA does cause significant lens opacity, a condition that carnosine successfully mitigated. The findings underscore carnosine's valuable properties, particularly its abilities to prevent glycation and aggregation, which may play significant roles in slowing down cataract formation, especially in oxidative stress conditions.
Read More
Most Useful Reviews
7.5
Seems effective
17 people found this helpful
This product seems to be helping with my cataract. Although it’s still a bit early to fully celebrate, it does appear to be making a difference.
Read More
9
Eyes improvement
1 people found this helpful
I'm very pleased with Carnosine! Recommended by my ophthalmologist for cataracts, I have seen a noticeable improvement in my eye health. Thank you for such quality products!
Read More
4
Vision worsened
25 people found this helpful
I attempted to reverse my cataract with CAN-C eye drops and saw measurable improvement after 3 months (from 20/50 to 20/25 in my better left eye). However, after starting L-Carnosine, my vision became blurrier, negating the benefits of the eye drops. This was alarming, so I stopped L-Carnosine and am now using only CAN-C eye drops to reverse my cataract.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
Our exploration focused on the potential of N-Acetyl Carnosine (NAC) in treating cataract, a condition that occurs when proteins in the eye become insoluble and form large masses. Traditional cataract surgeries often require expensive equipment and skilled mediators, so we sought a less invasive solution through the use of solid lipid nanoparticles (SLN).
We prepared SLN-NAC using a unique method known as Mill's method, resulting in particles measuring around 75 nanometers—the ideal size for effective eye penetration. The formulation demonstrated a sustained release of the active ingredient over 24 hours, following a rapid initial release after just one hour.
Our studies also indicated that SLN-NAC penetrated the cornea more effectively than standard NAC eye drops, while corneal hydration tests showed no damage to corneal cells. This suggests that SLN-NAC may offer a promising breakthrough in cataract treatment by enhancing drug delivery and minimizing toxicity.
Overall, the compelling results lead us to believe that SLN-NAC could significantly improve the way cataracts are treated, offering a practical alternative to surgical interventions.
We prepared SLN-NAC using a unique method known as Mill's method, resulting in particles measuring around 75 nanometers—the ideal size for effective eye penetration. The formulation demonstrated a sustained release of the active ingredient over 24 hours, following a rapid initial release after just one hour.
Our studies also indicated that SLN-NAC penetrated the cornea more effectively than standard NAC eye drops, while corneal hydration tests showed no damage to corneal cells. This suggests that SLN-NAC may offer a promising breakthrough in cataract treatment by enhancing drug delivery and minimizing toxicity.
Overall, the compelling results lead us to believe that SLN-NAC could significantly improve the way cataracts are treated, offering a practical alternative to surgical interventions.
Read More
9
We aimed to understand how L-carnosine affects cataract formation, looking specifically at its potential as an anticataractogenic agent. To do this, we assessed L-carnosine through various laboratory tests that measured its ability to counteract oxidative stress and its effects on lens tissue.
Although marketed for its antioxidant properties, our findings revealed that L-carnosine is primarily a strong antiglycating agent, rather than a potent antioxidant or metal-chelating agent. In our tests using human lens cells, we found that there were no significant changes in cell survival when exposed to L-carnosine compared to controls, which suggests that it may not have a significant protective effect in these scenarios.
Interestingly, when we treated whole porcine lenses with L-carnosine in a high galactose environment—which is known to promote cataract formation—we observed a marked reduction in the formation of harmful compounds related to glycation. This indicates that L-carnosine holds promise for future treatment options for diabetic cataracts and other conditions driven by glycation, if not primarily through antioxidant mechanisms.
Although marketed for its antioxidant properties, our findings revealed that L-carnosine is primarily a strong antiglycating agent, rather than a potent antioxidant or metal-chelating agent. In our tests using human lens cells, we found that there were no significant changes in cell survival when exposed to L-carnosine compared to controls, which suggests that it may not have a significant protective effect in these scenarios.
Interestingly, when we treated whole porcine lenses with L-carnosine in a high galactose environment—which is known to promote cataract formation—we observed a marked reduction in the formation of harmful compounds related to glycation. This indicates that L-carnosine holds promise for future treatment options for diabetic cataracts and other conditions driven by glycation, if not primarily through antioxidant mechanisms.
Read More
9
Carnosine aids in cataract prevention
We explored the impact of dehydroascorbate (DHA) on the structure and functioning of lens crystallins, specifically looking at the protective role of l-carnosine against cataract formation. Our research revealed that high levels of DHA in lens tissue can lead to significant protein unfolding and aggregation, both of which are key contributors to age-related cataracts.
During the study, we observed that l-carnosine, an endogenous dipeptide, effectively preserved the natural structure of lens proteins even when faced with the challenges posed by DHA. This is crucial since maintaining the stability of these proteins could help prevent the development of cataracts as we age.
Interestingly, while DHA alters the chaperone activity of α-crystallin—a protein important for lens clarity—carnosine was found to restore its functionality. Additionally, we noted that carnosine helped combat the increased instability of lens proteins modified by DHA, thereby enhancing their resilience.
Our lens culture assessments further illustrated that DHA does cause significant lens opacity, a condition that carnosine successfully mitigated. The findings underscore carnosine's valuable properties, particularly its abilities to prevent glycation and aggregation, which may play significant roles in slowing down cataract formation, especially in oxidative stress conditions.
During the study, we observed that l-carnosine, an endogenous dipeptide, effectively preserved the natural structure of lens proteins even when faced with the challenges posed by DHA. This is crucial since maintaining the stability of these proteins could help prevent the development of cataracts as we age.
Interestingly, while DHA alters the chaperone activity of α-crystallin—a protein important for lens clarity—carnosine was found to restore its functionality. Additionally, we noted that carnosine helped combat the increased instability of lens proteins modified by DHA, thereby enhancing their resilience.
Our lens culture assessments further illustrated that DHA does cause significant lens opacity, a condition that carnosine successfully mitigated. The findings underscore carnosine's valuable properties, particularly its abilities to prevent glycation and aggregation, which may play significant roles in slowing down cataract formation, especially in oxidative stress conditions.
Read More
We explored the effects of L-carnosine on cataract treatment, specifically through the use of 1% N-acetylcarnosine eye drops. This innovative approach was designed to address lens opacity, a significant factor contributing to vision impairment and potentially associated with aging processes.
Our study aimed to analyze how oxidative stress affects lens epithelial cells, particularly regarding telomere attrition, which can lead to cataract formation. Through our research, we discovered that L-carnosine can reduce the rate of telomere shortening, suggesting a protective role for the lens cells exposed to oxidative damage.
Notably, patients who used the 1% N-acetylcarnosine drops showed significant improvements in visual functions, such as visual acuity and glare sensitivity. In contrast, those in the control group experienced no meaningful changes.
Ultimately, the findings indicate that L-carnosine may offer a promising therapeutic option for preventing and treating cataracts, enhancing visual health, and addressing aging-related eye issues. As we look towards clinical applications, this research provides an exciting foundation for personalized cataract care.
Our study aimed to analyze how oxidative stress affects lens epithelial cells, particularly regarding telomere attrition, which can lead to cataract formation. Through our research, we discovered that L-carnosine can reduce the rate of telomere shortening, suggesting a protective role for the lens cells exposed to oxidative damage.
Notably, patients who used the 1% N-acetylcarnosine drops showed significant improvements in visual functions, such as visual acuity and glare sensitivity. In contrast, those in the control group experienced no meaningful changes.
Ultimately, the findings indicate that L-carnosine may offer a promising therapeutic option for preventing and treating cataracts, enhancing visual health, and addressing aging-related eye issues. As we look towards clinical applications, this research provides an exciting foundation for personalized cataract care.
Read More
9
We explored the impact of a mixture of N-acetylcarnosine and D-pantethine on cataract development in rats induced by UV-A light. The study utilized instillation of a 5% mixture into the eyes or intraperitoneal injections of varying doses, aiming to observe the mixture's protective effects starting from the 82nd day of the experiment. Notably, we observed that the combination significantly inhibited cataract formation, especially as the study progressed.
UV-A exposure increased the content of water-insoluble proteins in the lens, which is commonly associated with cataract development. However, the use of the mixture effectively prevented this rise, showcasing its potential in cataract treatment. Interestingly, we also noted that the proteins were categorized into three fractions and that UV-A reduced one fraction while increasing others. The combined treatment not only mitigated these changes but demonstrated properties similar to chaperones, which help in maintaining protein structure.
Overall, while the study indicates a positive effect of this specific mixture on cataract development, it doesn't allow us to evaluate the effects of l-carnosine alone given the presence of D-pantethine in the mixture. Thus, while promising, further research is needed to establish the effectiveness of l-carnosine by itself in preventing cataracts.
UV-A exposure increased the content of water-insoluble proteins in the lens, which is commonly associated with cataract development. However, the use of the mixture effectively prevented this rise, showcasing its potential in cataract treatment. Interestingly, we also noted that the proteins were categorized into three fractions and that UV-A reduced one fraction while increasing others. The combined treatment not only mitigated these changes but demonstrated properties similar to chaperones, which help in maintaining protein structure.
Overall, while the study indicates a positive effect of this specific mixture on cataract development, it doesn't allow us to evaluate the effects of l-carnosine alone given the presence of D-pantethine in the mixture. Thus, while promising, further research is needed to establish the effectiveness of l-carnosine by itself in preventing cataracts.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Seems effective
17 people found this helpful
This product seems to be helping with my cataract. Although it’s still a bit early to fully celebrate, it does appear to be making a difference.
Read More
9
Eyes improvement
1 people found this helpful
I'm very pleased with Carnosine! Recommended by my ophthalmologist for cataracts, I have seen a noticeable improvement in my eye health. Thank you for such quality products!
Read More
4
Vision worsened
25 people found this helpful
I attempted to reverse my cataract with CAN-C eye drops and saw measurable improvement after 3 months (from 20/50 to 20/25 in my better left eye). However, after starting L-Carnosine, my vision became blurrier, negating the benefits of the eye drops. This was alarming, so I stopped L-Carnosine and am now using only CAN-C eye drops to reverse my cataract.
Read More
2
Ineffective for me
11 people found this helpful
I have been taking this for a long time to combat glycation due to my cataract, but it hasn't worked thus far. I’m still taking it in the hopes that it will eventually be effective.
Read More
9
Glycation prevention
5 people found this helpful
This powerful antioxidant combats protein glycation, which accelerates ageing. I take it in two-month courses multiple times a year and use it in eye drops and lens injections to slow cataract progression. It pairs well with Taurine and Alpha Lipoic Acid for vision support.
Read More
Frequently Asked Questions
6
Satisfying results
5 people found this helpful
This product works effectively alongside proper eye medication for cataracts. Although the results take time, persistence over six months yields satisfying outcomes.
9
Glycation prevention
5 people found this helpful
This powerful antioxidant combats protein glycation, which accelerates ageing. I take it in two-month courses multiple times a year and use it in eye drops and lens injections to slow cataract progression. It pairs well with Taurine and Alpha Lipoic Acid for vision support.
9
Eyes improvement
1 people found this helpful
I'm very pleased with Carnosine! Recommended by my ophthalmologist for cataracts, I have seen a noticeable improvement in my eye health. Thank you for such quality products!
7.5
Vision improvement
My vision has noticeably improved since I began taking this product for my cataracts.
9
Our exploration focused on the potential of N-Acetyl Carnosine (NAC) in treating cataract, a condition that occurs when proteins in the eye become insoluble and form large masses. Traditional cataract surgeries often require expensive equipment and skilled mediators, so we sought a less invasive solution through the use of solid lipid nanoparticles (SLN).
We prepared SLN-NAC using a unique method known as Mill's method, resulting in particles measuring around 75 nanometers—the ideal size for effective eye penetration. The formulation demonstrated a sustained release of the active ingredient over 24 hours, following a rapid initial release after just one hour.
Our studies also indicated that SLN-NAC penetrated the cornea more effectively than standard NAC eye drops, while corneal hydration tests showed no damage to corneal cells. This suggests that SLN-NAC may offer a promising breakthrough in cataract treatment by enhancing drug delivery and minimizing toxicity.
Overall, the compelling results lead us to believe that SLN-NAC could significantly improve the way cataracts are treated, offering a practical alternative to surgical interventions.
We prepared SLN-NAC using a unique method known as Mill's method, resulting in particles measuring around 75 nanometers—the ideal size for effective eye penetration. The formulation demonstrated a sustained release of the active ingredient over 24 hours, following a rapid initial release after just one hour.
Our studies also indicated that SLN-NAC penetrated the cornea more effectively than standard NAC eye drops, while corneal hydration tests showed no damage to corneal cells. This suggests that SLN-NAC may offer a promising breakthrough in cataract treatment by enhancing drug delivery and minimizing toxicity.
Overall, the compelling results lead us to believe that SLN-NAC could significantly improve the way cataracts are treated, offering a practical alternative to surgical interventions.
8
l-Carnosine shows potential for cataracts
Our investigation delved into the beneficial effects of l-carnosine in treating cataracts, focusing on its delivery through specially formulated lubricant eye drops. We utilized a meta-analysis from phase 2 randomized double-blind placebo-controlled clinical trials to gather comprehensive data on how well this treatment works.
The drops contained 1% N-acetylcarnosine, which is a prodrug of l-carnosine, designed to enhance corneal absorption. We discovered that the l-carnosine absorbed in the eye showcased various pharmacological benefits, particularly in preventing and even reversing cataract formation.
Furthermore, we noted that systemic absorption of l-carnosine activated key brain areas involved in vision, improving sensory pathways related to sight. In addition, the treatment displayed a good safety profile, minimizing inflammation in the eyes post-treatment without any toxicity to surrounding structures.
Overall, our findings support the potential of l-carnosine not only for managing cataracts but also as a neuroprotective agent that safeguards vision under stress conditions.
The drops contained 1% N-acetylcarnosine, which is a prodrug of l-carnosine, designed to enhance corneal absorption. We discovered that the l-carnosine absorbed in the eye showcased various pharmacological benefits, particularly in preventing and even reversing cataract formation.
Furthermore, we noted that systemic absorption of l-carnosine activated key brain areas involved in vision, improving sensory pathways related to sight. In addition, the treatment displayed a good safety profile, minimizing inflammation in the eyes post-treatment without any toxicity to surrounding structures.
Overall, our findings support the potential of l-carnosine not only for managing cataracts but also as a neuroprotective agent that safeguards vision under stress conditions.
9
Carnosine aids in cataract prevention
We explored the impact of dehydroascorbate (DHA) on the structure and functioning of lens crystallins, specifically looking at the protective role of l-carnosine against cataract formation. Our research revealed that high levels of DHA in lens tissue can lead to significant protein unfolding and aggregation, both of which are key contributors to age-related cataracts.
During the study, we observed that l-carnosine, an endogenous dipeptide, effectively preserved the natural structure of lens proteins even when faced with the challenges posed by DHA. This is crucial since maintaining the stability of these proteins could help prevent the development of cataracts as we age.
Interestingly, while DHA alters the chaperone activity of α-crystallin—a protein important for lens clarity—carnosine was found to restore its functionality. Additionally, we noted that carnosine helped combat the increased instability of lens proteins modified by DHA, thereby enhancing their resilience.
Our lens culture assessments further illustrated that DHA does cause significant lens opacity, a condition that carnosine successfully mitigated. The findings underscore carnosine's valuable properties, particularly its abilities to prevent glycation and aggregation, which may play significant roles in slowing down cataract formation, especially in oxidative stress conditions.
During the study, we observed that l-carnosine, an endogenous dipeptide, effectively preserved the natural structure of lens proteins even when faced with the challenges posed by DHA. This is crucial since maintaining the stability of these proteins could help prevent the development of cataracts as we age.
Interestingly, while DHA alters the chaperone activity of α-crystallin—a protein important for lens clarity—carnosine was found to restore its functionality. Additionally, we noted that carnosine helped combat the increased instability of lens proteins modified by DHA, thereby enhancing their resilience.
Our lens culture assessments further illustrated that DHA does cause significant lens opacity, a condition that carnosine successfully mitigated. The findings underscore carnosine's valuable properties, particularly its abilities to prevent glycation and aggregation, which may play significant roles in slowing down cataract formation, especially in oxidative stress conditions.
9
We explored the role of carnosine, an endogenous peptide found in our lenses, in mitigating cataract formation. Through several in vitro models, we investigated how carnosine protects lens proteins from damage caused by calpain-induced proteolysis and from ultraviolet (UV) light exposure.
In our experiments, we measured turbidity, a cloudiness representative of cataract formation, by assessing the optical density of lens proteins. We found that increasing concentrations of carnosine significantly reduced turbidity in samples after exposure to heat and UV-B light, suggesting its protective qualities against these stressors.
Specifically, carnosine showed strong inhibitory effects on calpain activity, which is known to break down lens proteins. Furthermore, it reduced aggregation of γ-crystallin, a key protein in the lens, upon exposure to UV-C radiation. Overall, our findings indicate that carnosine stands out as a potential treatment for cataracts by enhancing lens protein stability and reducing degradation, especially in UV-C conditions.
These results suggest an exciting avenue for further research into carnosine as a natural protective agent against cataracts, potentially paving the way for effective treatments in the future.
In our experiments, we measured turbidity, a cloudiness representative of cataract formation, by assessing the optical density of lens proteins. We found that increasing concentrations of carnosine significantly reduced turbidity in samples after exposure to heat and UV-B light, suggesting its protective qualities against these stressors.
Specifically, carnosine showed strong inhibitory effects on calpain activity, which is known to break down lens proteins. Furthermore, it reduced aggregation of γ-crystallin, a key protein in the lens, upon exposure to UV-C radiation. Overall, our findings indicate that carnosine stands out as a potential treatment for cataracts by enhancing lens protein stability and reducing degradation, especially in UV-C conditions.
These results suggest an exciting avenue for further research into carnosine as a natural protective agent against cataracts, potentially paving the way for effective treatments in the future.
8
We explored the protective effects of l-carnosine on lens proteins when faced with methylglyoxal (MGO), a compound that increases in concentration in the eyes of diabetic patients and is known to contribute to cataract formation. By treating eye lens proteins with MGO while introducing carnosine, we actively sought to determine whether carnosine could mitigate the structural damage that MGO causes.
Our experiments, which included sodium dodecyl sulfate polyacrylamide gel electrophoresis and fluorescence assessments, revealed that MGO significantly alters the structure of lens proteins. We observed that this damage leads to the formation of new chromophores, which are indicative of structural changes. However, when carnosine was present, we noted a marked reduction in these protein changes, suggesting a significant protective role for carnosine against MGO-induced damage.
Consequently, our findings propose that carnosine could be a valuable preventive measure against diabetic cataracts in humans, highlighting its potential as a dietary supplement in eye health.
Our experiments, which included sodium dodecyl sulfate polyacrylamide gel electrophoresis and fluorescence assessments, revealed that MGO significantly alters the structure of lens proteins. We observed that this damage leads to the formation of new chromophores, which are indicative of structural changes. However, when carnosine was present, we noted a marked reduction in these protein changes, suggesting a significant protective role for carnosine against MGO-induced damage.
Consequently, our findings propose that carnosine could be a valuable preventive measure against diabetic cataracts in humans, highlighting its potential as a dietary supplement in eye health.
We explored the effects of L-carnosine on cataract treatment, specifically through the use of 1% N-acetylcarnosine eye drops. This innovative approach was designed to address lens opacity, a significant factor contributing to vision impairment and potentially associated with aging processes.
Our study aimed to analyze how oxidative stress affects lens epithelial cells, particularly regarding telomere attrition, which can lead to cataract formation. Through our research, we discovered that L-carnosine can reduce the rate of telomere shortening, suggesting a protective role for the lens cells exposed to oxidative damage.
Notably, patients who used the 1% N-acetylcarnosine drops showed significant improvements in visual functions, such as visual acuity and glare sensitivity. In contrast, those in the control group experienced no meaningful changes.
Ultimately, the findings indicate that L-carnosine may offer a promising therapeutic option for preventing and treating cataracts, enhancing visual health, and addressing aging-related eye issues. As we look towards clinical applications, this research provides an exciting foundation for personalized cataract care.
Our study aimed to analyze how oxidative stress affects lens epithelial cells, particularly regarding telomere attrition, which can lead to cataract formation. Through our research, we discovered that L-carnosine can reduce the rate of telomere shortening, suggesting a protective role for the lens cells exposed to oxidative damage.
Notably, patients who used the 1% N-acetylcarnosine drops showed significant improvements in visual functions, such as visual acuity and glare sensitivity. In contrast, those in the control group experienced no meaningful changes.
Ultimately, the findings indicate that L-carnosine may offer a promising therapeutic option for preventing and treating cataracts, enhancing visual health, and addressing aging-related eye issues. As we look towards clinical applications, this research provides an exciting foundation for personalized cataract care.
We examined the potential of N-acetylcarnosine, a prodrug that converts to L-carnosine, as a new treatment for cataracts. This study delved into how N-acetylcarnosine enhances ocular drug delivery through its activation via enzymatic processes in the eye. According to our findings, N-acetylcarnosine acts as a powerful antioxidant while also promoting the removal of damaging sugar molecules linked to cataract formation.
Through various clinical methods, including visual acuity tests and photography, we aimed to assess the effectiveness of N-acetylcarnosine eye drops in preventing and treating cataracts and other eye diseases. Importantly, our research highlighted that the effectiveness of this treatment relates closely to the specific formulation of the eye drops used.
The results documented in our study suggest that the therapeutic benefits observed might largely stem from the antioxidant and transglycating properties of N-acetylcarnosine, promoting better eye health among individuals coping with cataracts. Overall, while the initial results show promise, we noted that the treatment's success greatly depends on the proper formulation, rather than isolating L-carnosine's effects alone.
Through various clinical methods, including visual acuity tests and photography, we aimed to assess the effectiveness of N-acetylcarnosine eye drops in preventing and treating cataracts and other eye diseases. Importantly, our research highlighted that the effectiveness of this treatment relates closely to the specific formulation of the eye drops used.
The results documented in our study suggest that the therapeutic benefits observed might largely stem from the antioxidant and transglycating properties of N-acetylcarnosine, promoting better eye health among individuals coping with cataracts. Overall, while the initial results show promise, we noted that the treatment's success greatly depends on the proper formulation, rather than isolating L-carnosine's effects alone.
References
- Kianpour M, Yousefi R. Carnosine Prevents Different Structural Damages Induced by Methylglyoxal in Lens Crystallins. Cell Biochem Biophys. 2019;77:343. 10.1007/s12013-019-00884-3
- Wang L, Liu W, Huang X. An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line. Libyan J Med. 2018;13:1500347. 10.1080/19932820.2018.1500347
- Abdelkader H, Longman M, Alany RG, Pierscionek B. On the Anticataractogenic Effects of L-Carnosine: Is It Best Described as an Antioxidant, Metal-Chelating Agent or Glycation Inhibitor?. Oxid Med Cell Longev. 2016;2016:3240261.
- Javadi S, Yousefi R, Hosseinkhani S, Tamaddon AM, Uversky VN. Protective effects of carnosine on dehydroascorbate-induced structural alteration and opacity of lens crystallins: important implications of carnosine pleiotropic functions to combat cataractogenesis. J Biomol Struct Dyn. 2017;35:1766. 10.1080/07391102.2016.1194230
- Abdelkader H, Longman MR, Alany RG, Pierscionek B. Phytosome-hyaluronic acid systems for ocular delivery of L-carnosine. Int J Nanomedicine. 2016;11:2815. 10.2147/IJN.S104774
- Babizhayev MA, Yegorov YE. Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique. Recent Pat Drug Deliv Formul. 2016;10:82.
- Avetisov SÉ, Sheremet NL, Muranov KO, Polianskiĭ NB, Polunin GS, et al. [Deceleration of cataract development in rats under the action of N-acetylcarnosine and D-pantethine mixture]. Eksp Klin Farmakol. 2014;77:11.
- Villari V, Attanasio F, Micali N. Control of the structural stability of α-crystallin under thermal and chemical stress: the role of carnosine. J Phys Chem B. 2014;118:13770. 10.1021/jp5092009
- Liao JH, Lin IL, Huang KF, Kuo PT, Wu SH, et al. Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C-induced degradation. J Agric Food Chem. 2014;62:5932. 10.1021/jf5017708
- Babizhayev MA, Yegorov YE. Biomarkers of oxidative stress and cataract. Novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: anti-cataract which helps to prevent and treat cataracts in the eyes of dogs and other animals. Curr Drug Deliv. 2014;11:24.
- Dizhevskaya AK, Muranov KO, Boldyrev AA, Ostrovsky MA. Natural dipeptides as mini-chaperones: molecular mechanism of inhibition of lens βL-crystallin aggregation. Curr Aging Sci. 2012;5:236.
- Babizhayev MA. Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents. Recent Pat Drug Deliv Formul. 2012;6:107.
- Babizhayev MA. Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine. Fundam Clin Pharmacol. 2012;26:86. 10.1111/j.1472-8206.2011.00969.x
- Babizhayev MA, Khoroshilova-Maslova IP, Kasus-Jacobi A. Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care. Fundam Clin Pharmacol. 2012;26:644. 10.1111/j.1472-8206.2011.00963.x
- Babizhayev MA. Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform. Drug Test Anal. 2012;4:468. 10.1002/dta.265
- Babizhayev MA, Yegorov YE. Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy. Front Biosci (Landmark Ed). 2010;15:934.
