' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.5
USERS' SCORE
Good
Based on 11 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Carnosine (B-alanyl-L-histidine)
500 mg
*
Top Medical Research Studies
8
Zinc l-carnosine promotes ulcer healing
Antioxidant, Anti-inflammatory, and Genomic Stability Enhancement Effects of Zinc l-carnosine: A Potential Cancer Chemopreventive Agent?
Study showcases ZnC's effectiveness
We investigated how zinc l-carnosine (ZnC) might affect ulcers, focusing on its potential as an effective treatment. The research highlighted ZnC's use in clinical settings, especially in Japan, where it is already employed to tackle gastric ulcers.
Through various studies, we learned that ZnC exhibits strong antioxidant and anti-inflammatory properties, which are key factors in healing ulcers. By working to reduce oxidative stress and inflammation, ZnC appears to create a more favorable environment for ulcer healing.
Moreover, the research points toward ZnC's ability to enhance genomic stability, which might further strengthen its role in preventing complications associated with ulcers. Overall, the findings suggest that ZnC could be a promising option for those suffering from gastric ulcers, enhancing the healing process and potentially improving patient outcomes.
Through various studies, we learned that ZnC exhibits strong antioxidant and anti-inflammatory properties, which are key factors in healing ulcers. By working to reduce oxidative stress and inflammation, ZnC appears to create a more favorable environment for ulcer healing.
Moreover, the research points toward ZnC's ability to enhance genomic stability, which might further strengthen its role in preventing complications associated with ulcers. Overall, the findings suggest that ZnC could be a promising option for those suffering from gastric ulcers, enhancing the healing process and potentially improving patient outcomes.
Read More
9
Carnosine enhances diabetic wound healing
Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes.
High relevance for diabetic ulcer treatment
We examined the effects of l-carnosine on wound healing in a model of Type 2 diabetes using db/db mice. The goal was to determine if this naturally occurring antioxidant could enhance the healing of ulcers in diabetic conditions. In our study, we created small circular wounds on the mice and treated them with daily injections of carnosine, along with local application of the substance.
Our observations indicate that treatment with l-carnosine significantly improved the healing process. Analysis of the wound tissues revealed increased levels of essential growth factors and cytokines that are crucial for repair. Furthermore, we conducted additional tests using human skin cells, confirming that l-carnosine increased cell survival under high glucose conditions, which is a common issue in diabetes.
Overall, we found that l-carnosine does not only act as an antioxidant; it also plays a role in supporting cell growth and repair during the healing process. This suggests that l-carnosine could be a promising therapeutic agent for improving wound healing in patients with diabetes.
Our observations indicate that treatment with l-carnosine significantly improved the healing process. Analysis of the wound tissues revealed increased levels of essential growth factors and cytokines that are crucial for repair. Furthermore, we conducted additional tests using human skin cells, confirming that l-carnosine increased cell survival under high glucose conditions, which is a common issue in diabetes.
Overall, we found that l-carnosine does not only act as an antioxidant; it also plays a role in supporting cell growth and repair during the healing process. This suggests that l-carnosine could be a promising therapeutic agent for improving wound healing in patients with diabetes.
Read More
8
Zinc L-Carnosine promotes ulcer healing
The role of Zinc L-Carnosine in the prevention and treatment of gastrointestinal mucosal disease in humans: a review.
Significant impact on ulcer treatment
We observed how Zinc L-carnosine functions as a unique treatment for ulcers, boasting impressive mucosal protective and anti-inflammatory effects. This pharmaceutical compound operates through various mechanisms, such as antioxidant actions and the stabilization of cell membranes, which makes it particularly effective.
Our insights indicate that Zinc L-carnosine specifically targets damaged mucosal areas, releasing zinc directly where it's needed most. This localized action can help promote healing in people suffering from peptic ulcers and other forms of mucosal injury.
In various studies, both in laboratory settings and with human patients, Zinc L-carnosine has been shown to support the repair of mucosal damage. Its potential applications have recently expanded to include conditions like ulcerative colitis and inflammation due to chemoradiotherapy, highlighting its versatility in treating gastrointestinal diseases.
Through our review, we discovered that the therapeutic benefits of this compound could prove to be a game changer for gastroenterologists and patients alike, providing promising options for managing ulcer-related conditions effectively.
Our insights indicate that Zinc L-carnosine specifically targets damaged mucosal areas, releasing zinc directly where it's needed most. This localized action can help promote healing in people suffering from peptic ulcers and other forms of mucosal injury.
In various studies, both in laboratory settings and with human patients, Zinc L-carnosine has been shown to support the repair of mucosal damage. Its potential applications have recently expanded to include conditions like ulcerative colitis and inflammation due to chemoradiotherapy, highlighting its versatility in treating gastrointestinal diseases.
Through our review, we discovered that the therapeutic benefits of this compound could prove to be a game changer for gastroenterologists and patients alike, providing promising options for managing ulcer-related conditions effectively.
Read More
Most Useful Reviews
9.5
Improved ulcers significantly
I've suffered from gastric ulcers for years, but since taking this with traditional Chinese medicine, my symptoms have notably improved.
Read More
9.5
Effective for ulcers
Carnosine is an excellent antioxidant that protects against a variety of ailments, including ulcers. It's easy to take as small white capsules, and I recommend it for gastrointestinal and cognitive health.
Read More
9.5
Ulcers pain relief
A friend of mine had stomach ulcers, and after taking L-Carnosine, their stomach pain disappeared. This product has been very effective for them.
Read More
Most Recommended Products for Ulcer
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.5
9.5
Salicyl-carnosine shows ulcer benefits
A new derivative of acetylsalicylic acid and carnosine: synthesis, physical and chemical properties, biological activity.
Addresses effects on ulcers
We explored the effects of a novel compound called salicyl-carnosine (SC), created from l-carnosine and acetylsalicylic acid (ASA), on ulcer prevention and its overall biological activity. Our research sought to assess whether SC could deliver the antioxidant benefits of l-carnosine while minimizing the gastrointestinal side effects often associated with ASA.
To gather our insights, we synthesized SC through the condensation of these two compounds. We employed various methods, including spectrophotometric and chemiluminescent assessments, to evaluate the antioxidant properties of SC. We also tested its antiplatelet activity using a light transmission-aggregometry method.
The results were promising; SC showed antioxidant capabilities similar to, or even better than, traditional l-carnosine. Additionally, we found SC's ability to inhibit platelet aggregation comparable to or exceeding that of ASA. Most notably, SC protected the gastric mucosa from ulcer formation and aided in healing existing lesions.
Overall, SC seems to retain the beneficial properties of both parent molecules, offering a dual advantage of antioxidant protection and reduced risk of gastric damage. This discovery opens exciting new avenues for developing drugs aimed at reducing inflammation and preventing blood clots without the traditional side effects of ASA.
To gather our insights, we synthesized SC through the condensation of these two compounds. We employed various methods, including spectrophotometric and chemiluminescent assessments, to evaluate the antioxidant properties of SC. We also tested its antiplatelet activity using a light transmission-aggregometry method.
The results were promising; SC showed antioxidant capabilities similar to, or even better than, traditional l-carnosine. Additionally, we found SC's ability to inhibit platelet aggregation comparable to or exceeding that of ASA. Most notably, SC protected the gastric mucosa from ulcer formation and aided in healing existing lesions.
Overall, SC seems to retain the beneficial properties of both parent molecules, offering a dual advantage of antioxidant protection and reduced risk of gastric damage. This discovery opens exciting new avenues for developing drugs aimed at reducing inflammation and preventing blood clots without the traditional side effects of ASA.
Read More
9.5
Polaprezinc aids pressure ulcer healing
Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial.
Study shows potential benefits
We aimed to understand how l-carnosine, as part of polaprezinc, affects the healing of chronic pressure ulcers. In our open-label trial, we treated 14 patients suffering from various stages of pressure ulcers with 150 mg of polaprezinc daily for eight weeks.
Throughout the study, we monitored the severity of the ulcers weekly using the Pressure Ulcer Scale for Healing (PUSH) score. Remarkably, the PUSH score showed significant improvement, going from 8.1 at the start to -1.4 after eight weeks, indicating marked healing.
Of the 14 patients, 11 completely healed within the treatment period, and importantly, all patients completed the study without dropping out. We also noted increases in serum zinc levels, alongside decreases in serum copper levels and copper/zinc ratios, suggesting a well-tolerated treatment without serious complications.
These findings indicate that l-carnosine, when taken orally as part of polaprezinc, can potentially aid in healing pressure ulcers, providing a new avenue for treatment. Our results suggest l-carnosine’s safety and efficacy, inviting further exploration in larger studies to confirm these benefits.
Throughout the study, we monitored the severity of the ulcers weekly using the Pressure Ulcer Scale for Healing (PUSH) score. Remarkably, the PUSH score showed significant improvement, going from 8.1 at the start to -1.4 after eight weeks, indicating marked healing.
Of the 14 patients, 11 completely healed within the treatment period, and importantly, all patients completed the study without dropping out. We also noted increases in serum zinc levels, alongside decreases in serum copper levels and copper/zinc ratios, suggesting a well-tolerated treatment without serious complications.
These findings indicate that l-carnosine, when taken orally as part of polaprezinc, can potentially aid in healing pressure ulcers, providing a new avenue for treatment. Our results suggest l-carnosine’s safety and efficacy, inviting further exploration in larger studies to confirm these benefits.
Read More
9
Polaprezinc reduces ulcer inflammation
Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study.
Moderate relevance to ulcer treatment
We focused on the effects of polaprezinc (Pol), a compound that includes l-carnosine, and its ability to reduce inflammation in cells associated with neurodegenerative diseases. Through experiments involving LPS-induced BV-2 microglia, we observed that Pol successfully lowered the levels of nitric oxide (NO) and reactive oxygen species (ROS), which are often elevated during inflammatory responses.
Notably, Pol also suppressed the expression of key inflammatory markers, including iNOS, COX-2, IL-6, TNF-α, and IL-1β. These promising findings indicate that Pol could contribute beneficially to managing inflammation linked to ulcers.
Additionally, we investigated whether combining Pol with aspergillusidone G (Asp G) could further enhance its anti-inflammatory effects. What we found was quite remarkable: low doses of Asp G boosted Pol's ability to inhibit NO production from about 30% to an impressive 80%. Our analyses pointed toward the involvement of several molecular targets in this synergistic effect, further supporting Pol's potential role in addressing neuroinflammation.
Overall, while the study does suggest that l-carnosine, as part of Pol, plays a functional role concerning ulcers, it doesn’t isolate its specific contribution. Thus, more targeted research would be necessary to directly link l-carnosine's effectiveness to ulcer treatment.
Notably, Pol also suppressed the expression of key inflammatory markers, including iNOS, COX-2, IL-6, TNF-α, and IL-1β. These promising findings indicate that Pol could contribute beneficially to managing inflammation linked to ulcers.
Additionally, we investigated whether combining Pol with aspergillusidone G (Asp G) could further enhance its anti-inflammatory effects. What we found was quite remarkable: low doses of Asp G boosted Pol's ability to inhibit NO production from about 30% to an impressive 80%. Our analyses pointed toward the involvement of several molecular targets in this synergistic effect, further supporting Pol's potential role in addressing neuroinflammation.
Overall, while the study does suggest that l-carnosine, as part of Pol, plays a functional role concerning ulcers, it doesn’t isolate its specific contribution. Thus, more targeted research would be necessary to directly link l-carnosine's effectiveness to ulcer treatment.
Read More
9
L-carnosine enhances corneal healing
Hybrid thermosensitive-mucoadhesive forming gels for enhanced corneal wound healing effect of L-carnosine.
Study highlights treatment effectiveness
We set out to explore how L-carnosine, a natural dipeptide, can effectively aid in the healing of corneal ulcers. Our study involved creating innovative thermosensitive gels using a combination of poloxamer 407 and mucoadhesive polymers, specifically chitosan and methyl cellulose. These gels are designed to provide a long-lasting delivery system for the treatment.
By examining various combinations of these polymers, we measured their impact on several important factors, such as how quickly they gel, their texture, mucoadhesion, and the ability to permeate through the cornea. The results were promising; we found that the poloxamer 407 and chitosan combinations not only gelled effectively but also showed good spreading properties and encouraged the healing of corneal epithelial wounds in a rabbit model.
Importantly, we observed that the formulations were well-tolerated by the ocular surface, presenting an ideal option for delivering L-carnosine for corneal healing. This suggests that with the right formulation, L-carnosine can play a significant role in treating corneal ulcers, thanks to the properties of these advanced gels.
By examining various combinations of these polymers, we measured their impact on several important factors, such as how quickly they gel, their texture, mucoadhesion, and the ability to permeate through the cornea. The results were promising; we found that the poloxamer 407 and chitosan combinations not only gelled effectively but also showed good spreading properties and encouraged the healing of corneal epithelial wounds in a rabbit model.
Importantly, we observed that the formulations were well-tolerated by the ocular surface, presenting an ideal option for delivering L-carnosine for corneal healing. This suggests that with the right formulation, L-carnosine can play a significant role in treating corneal ulcers, thanks to the properties of these advanced gels.
Read More
9
L-Carnosine aids diabetic ulcer healing
MMP-9 responsive dipeptide-tempted natural protein hydrogel-based wound dressings for accelerated healing action of infected diabetic wound.
Study effects are somewhat complex
We explored how l-carnosine, a metal-chelating dipeptide, impacts the healing of diabetic ulcers, particularly those complicated by infections. Our focus was on using l-carnosine in combination with curcumin and a silk protein hydrogel to enhance healing in infected diabetic wounds.
The study indicated that l-carnosine helps to deactivate matrix metalloproteinase-9 (MMP-9), an enzyme that can slow down the healing process by degrading essential components of the wound. By chelating zinc ions in the active center of MMP-9, l-carnosine showed a promising ability to accelerate healing.
We found that the hydrogel designed with l-carnosine and curcumin was not only biocompatible but also effective in the laboratory, promoting cell survival and reducing inflammation. Following tests on diabetic mice, we observed that this treatment significantly improved healing at wound sites, demonstrating the effectiveness of l-carnosine in this context.
Overall, while the combination treatment is effective, it challenges the isolation of l-carnosine's individual effects. Nonetheless, our findings present a hopeful avenue for improving healing in challenging diabetic wounds.
The study indicated that l-carnosine helps to deactivate matrix metalloproteinase-9 (MMP-9), an enzyme that can slow down the healing process by degrading essential components of the wound. By chelating zinc ions in the active center of MMP-9, l-carnosine showed a promising ability to accelerate healing.
We found that the hydrogel designed with l-carnosine and curcumin was not only biocompatible but also effective in the laboratory, promoting cell survival and reducing inflammation. Following tests on diabetic mice, we observed that this treatment significantly improved healing at wound sites, demonstrating the effectiveness of l-carnosine in this context.
Overall, while the combination treatment is effective, it challenges the isolation of l-carnosine's individual effects. Nonetheless, our findings present a hopeful avenue for improving healing in challenging diabetic wounds.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.6
9.5
Improved ulcers significantly
I've suffered from gastric ulcers for years, but since taking this with traditional Chinese medicine, my symptoms have notably improved.
9.5
Effective for ulcers
Carnosine is an excellent antioxidant that protects against a variety of ailments, including ulcers. It's easy to take as small white capsules, and I recommend it for gastrointestinal and cognitive health.
9.5
Ulcers pain relief
A friend of mine had stomach ulcers, and after taking L-Carnosine, their stomach pain disappeared. This product has been very effective for them.
8.8
Protects from ulcers
Carnosine is a powerful antioxidant that protects against the oxidation of lipids, proteins, and nucleic acids. I've found it improves muscle performance and recovery after exercise, enhances mental state and behaviour in children with autism, protects the brain from cognitive decline, and aids in healing ulcers when combined with zinc.
Read More
8.8
Improves stomach issues
L-Carnosine is a great product that has positively affected my overall well-being and stomach issues, especially when taken with zinc for ulcers. I appreciate that the capsules are in powder form.
