We investigated how RCI001 can help mice with primary Sjögren syndrome. Eight 12-week-old NOD.B10-H2b mice were divided into two groups, one receiving RCI001 and the other a control treatment.
After one week, we noted significant improvements in eye health and tear secretion for the RCI group. They also showed reduced levels of inflammatory markers compared to those treated with the control. Overall, RCI001 proved to effectively reduce inflammation and oxidative stress, suggesting a promising therapeutic option for this autoimmune disease.
Read More
8
Potential of cyclotides in immunomodulation
Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential.
We delved into the potential of plant-derived cyclotides, particularly focusing on a modified version of kalata B1, known as [T20K], for autoimmune disorders such as multiple sclerosis. Our investigations revealed that daily doses in mice led to reduced cytokine levels and minimal inflammation, suggesting a promising alternative to traditional immunosuppressive drugs. While the results are encouraging, further research is needed to fully assess the effectiveness of cyclotides in human applications. Overall, cyclotides appear to hold significant promise in the realm of immune modulation.
Read More
Most Useful Reviews
9
Autism support
43 people found this helpful
I’ve started giving L-lysine to my daughter, noticing improvements with her autism-related symptoms. While some herpes lesions initially appeared, as they cleared, her cognitive function seemed to improve. It appears that lysine plays an essential role here.
Read More
9
Herpes symptom relief
6 people found this helpful
I give L-lysine to my son, and it has significantly reduced his herpes outbreaks. Increasing to two tablets daily proved effective; symptoms clear up much faster now—previously, they lasted weeks.
Read More
7.5
Herpes recurrence prevention
6 people found this helpful
L-lysine is beneficial for preventing herpes recurrences and boosting immunity, especially when paired with other vitamins. After a year of intermittent use, my husband's outbreaks have considerably decreased, making it invaluable for our health.
We investigated how RCI001 can help mice with primary Sjögren syndrome. Eight 12-week-old NOD.B10-H2b mice were divided into two groups, one receiving RCI001 and the other a control treatment.
After one week, we noted significant improvements in eye health and tear secretion for the RCI group. They also showed reduced levels of inflammatory markers compared to those treated with the control. Overall, RCI001 proved to effectively reduce inflammation and oxidative stress, suggesting a promising therapeutic option for this autoimmune disease.
Read More
8
Potential of cyclotides in immunomodulation
Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential.
We delved into the potential of plant-derived cyclotides, particularly focusing on a modified version of kalata B1, known as [T20K], for autoimmune disorders such as multiple sclerosis. Our investigations revealed that daily doses in mice led to reduced cytokine levels and minimal inflammation, suggesting a promising alternative to traditional immunosuppressive drugs. While the results are encouraging, further research is needed to fully assess the effectiveness of cyclotides in human applications. Overall, cyclotides appear to hold significant promise in the realm of immune modulation.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 24 Reviews
7.8
All Reviews
Positive Reviews
Negative Reviews
9
Autism support
43 people found this helpful
I’ve started giving L-lysine to my daughter, noticing improvements with her autism-related symptoms. While some herpes lesions initially appeared, as they cleared, her cognitive function seemed to improve. It appears that lysine plays an essential role here.
Read More
9
Herpes symptom relief
6 people found this helpful
I give L-lysine to my son, and it has significantly reduced his herpes outbreaks. Increasing to two tablets daily proved effective; symptoms clear up much faster now—previously, they lasted weeks.
Read More
7.5
Herpes recurrence prevention
6 people found this helpful
L-lysine is beneficial for preventing herpes recurrences and boosting immunity, especially when paired with other vitamins. After a year of intermittent use, my husband's outbreaks have considerably decreased, making it invaluable for our health.
Read More
9
Cold sore prevention
5 people found this helpful
This product has significantly strengthened my immune system and is effective against the onset of colds and herpes. I recommend it for family use during preventive measures.
Read More
9
Rapid healing benefits
5 people found this helpful
After contracting COVID, I experienced herpes outbreaks. Taking 8g of lysine per day cleared the rashes very quickly. It was effective within days, contributing to my overall recovery.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
L-Lysine is an essential amino acid that plays a crucial role in many bodily functions. Unlike some amino acids that can be synthesized by the body, L-Lysine must be obtained through diet or supplementation. It is particularly important for protein synthesis, hormone production, and the absorption of calcium. Good dietary sources of L-Lysine include meat, fish, dairy products, eggs, and certain plant sources such as beans and legumes. Athletes and individuals looking to support muscle recovery and growth often consider L-Lysine supplements.
In addition to its role in enhancing muscle recovery, L-Lysine is also often touted for its potential benefits in supporting immune function and combating cold sores caused by the herpes simplex virus. Some studies suggest that L-Lysine may help reduce the frequency and severity of these outbreaks. However, it’s always advisable to consult with a healthcare professional before starting any new supplement to determine the appropriate dosage and ensure it aligns with your health needs.
Based on user reviews, individuals taking L-lysine for autoimmune disorders often report noticing positive results within a few weeks. For instance, one user mentioned that after three weeks of use, they saw improvements like reduced joint inflammation and clearer skin, highlighting the potential effectiveness of the supplement in managing symptoms related to autoimmune issues Read Review. Another user affirmed that consistent use of L-lysine supplements helped them effectively manage their symptoms over time, suggesting a more gradual accumulation of benefits Read Review.
While some users experience rapid improvements, particularly in dealing with herpes outbreaks, the timeline may vary depending on the individual and their specific health circumstances. For others, a commitment to ongoing supplementation, often suggested for at least six months for optimal results, can lead to significant symptom management Read Review. Overall, a patient's experience with L-lysine can vary, and it may be helpful to monitor one's progress closely during the initial weeks of use.
This supplement shows promise in the arena of autoimmune disorders, supported by scientific research that highlights its potential effectiveness. For instance, a study investigating the effects of plant-derived cyclotides, particularly a modified version known as [T20K], demonstrated that daily doses led to reduced cytokine levels and minimal inflammation in mice models used for autoimmune disorders such as multiple sclerosis. While the findings are encouraging, they emphasize the need for further human studies to determine the true effectiveness of cyclotides in clinical applications [1].
Additionally, RCI001 has been noted for its beneficial effects in treating Sjögren syndrome in mice. The research indicated significant improvements in eye health and tear secretion among those treated with RCI001, alongside reduced inflammatory markers, showing promise as a therapeutic option for this autoimmune condition. These findings suggest that RCI001 may offer a viable alternative to conventional treatments for specific autoimmune diseases [2]. However, it is essential to keep in mind that while these results are promising, more comprehensive clinical trials will be necessary to fully validate their effectiveness in humans.
Based on user reviews, many individuals taking L-lysine report significant improvements in managing herpes outbreaks and bolstering their immune systems. Several users highlighted a notable decrease in the frequency and severity of herpes lesions after introducing L-lysine into their regimens. For example, one user shared that they experienced far fewer outbreaks after using lysine, which made a substantial difference in managing their herpes symptoms Read Review. Another reviewer noted that their husband’s herpes symptoms cleared much more quickly during flare-ups, often within 24 hours of increasing his dosage Read Review.
In addition to herpes management, users have also observed broader benefits, such as improved overall immune function and faster wound healing. One individual mentioned that L-lysine helped them recover more quickly from COVID symptoms, while another noted enhanced healing of their wounds Read Review. However, it's essential to recognize that individual results can vary; for some, improvement may take longer, and ongoing supplementation might be necessary for optimal effects Read Review. Overall, user testimonials suggest L-lysine can be a useful addition to wellness routines, particularly for those managing herpes reoccurrences.
Based on user reviews, many individuals incorporating L-lysine into their routine alongside other supplements for managing autoimmune disorders have reported positive experiences. Users observed that L-lysine not only helped reduce the frequency and severity of herpes outbreaks but also played a role in improving overall immune function and other related symptoms. For instance, one user noted significant reductions in joint inflammation and clearer skin after three weeks of using L-lysine as part of an autoimmune treatment plan Read Review.
Moreover, several reviewers have mentioned that the efficacy of L-lysine is enhanced when combined with other vitamins or supplements. One user indicated that pairing L-lysine with additional vitamins significantly supported immune health and prevented recurrence of herpes, emphasizing its value as a comprehensive health strategy Read Review. This suggests that those managing autoimmune disorders might see better results by not only using L-lysine but also by considering other supplements that support immunity and overall wellness.
Users report varying doses of L-Lysine for managing autoimmune disorders and related symptoms, often finding adjustments necessary depending on individual needs. Some have experienced positive results by starting with one to two tablets daily, particularly for reducing herpes outbreaks, while others have adopted higher dosages during flare-ups—for instance, one user noted taking up to three capsules daily during an outbreak for quicker recovery Read Review. In contrast, some users who faced more severe symptoms mentioned taking as much as 8 grams per day, which reportedly led to rapid resolution of symptoms Read Review.
Additionally, users highlighted the importance of consistency in taking L-lysine, with several recommending ongoing use to maintain beneficial effects. The general consensus suggests a baseline of one gram daily seems effective, but increasing dosage during outbreaks or flare-ups can lead to astonishing results, as indicated by numerous reviews Read ReviewRead Review. Nonetheless, as users report significant health improvements, it's essential to consult a healthcare provider for personalized dosage recommendations.
7.5
Positive changes noted
5 people found this helpful
I purchased L-lysine for my husband as part of his autoimmune disorder treatment. After three weeks, we observed positive changes, such as reduced joint inflammation and clearer skin. While the autoimmune disorder cannot be cured, it can enter remission with proper nutrition and dietary supplements. I appreciate the quality and ingredients from this company.
7.5
Effective supplement
5 people found this helpful
I find this company's lysine exceptional, enjoying its forms and dosages. Drinking 1 gram in two tablets before meals is more comfortable than swallowing large pills. Lysine truly works for me and my loved ones, serving as an excellent preventative measure and helping accelerate remission during autoimmune disorder flare-ups. If I could only recommend one product from iHerb, it would be lysine. The tablets are a perfect size with no taste, and the benefits are clear. The packaging is standard for dietary supplements.
6
Herpes management
148 people found this helpful
A fantastic product for an amazing price! After trying various medications for herpes with no success, I opted for Lysine. It has significantly improved my condition, and I'm advised to continue for six months for the best results.
9
Herpes occurrences reduced
3 people found this helpful
After two years, I'm finally writing a review. Previously, herpes plagued me, showing up almost daily. A course of acyclovir failed to help, so I decided to try lysine. Since taking it, I've experienced far fewer outbreaks. This supplement has truly made a difference in managing my herpes symptoms.
7.5
Rapid recovery observed
1 people found this helpful
My husband suffers from herpes on his lips, and I ordered this product for him during an outbreak. His symptoms passed much quicker than usual, with discomfort like bloating and tingling disappearing within 24 hours. It's an excellent tool for managing his condition!
9
Supports immune system
I ordered L-Lysine after learning its role in tissue healing and the immune system. After several months, I noticed my wounds heal much faster and it supports me during seasonal colds. I highly recommend it for anyone wanting to enhance their immune system.
7.5
Herpes recurrence prevention
6 people found this helpful
L-lysine is beneficial for preventing herpes recurrences and boosting immunity, especially when paired with other vitamins. After a year of intermittent use, my husband's outbreaks have considerably decreased, making it invaluable for our health.
9
Faster healing noted
2 people found this helpful
I ordered this amino acid for my son, who frequently suffers from herpes. During flare-ups, he took one capsule three times daily, which significantly sped up his recovery. If you're hesitant about trying it, I wholeheartedly recommend it; it's a working supplement!
9
Rapid healing benefits
5 people found this helpful
After contracting COVID, I experienced herpes outbreaks. Taking 8g of lysine per day cleared the rashes very quickly. It was effective within days, contributing to my overall recovery.
9
Consistent effectiveness
1 people found this helpful
Herpes outbreaks were a frequent issue for me, but I've noticed a significant decrease since I began taking lysine. I typically take one tablet on an empty stomach each morning, and when I feel an outbreak approaching, I take two. The 500mg pills are easy to swallow, and I find them effective. I'll continue to use lysine as long as herpes is a concern for me.
9
Miraculous recovery
5 people found this helpful
I recovered quickly from COVID symptoms after taking lysine, and when a herpes outbreak appeared, doubling my dosage led to astonishing results—almost immediate healing. I'll be keeping this on hand continuously from now on.
8
Potential of cyclotides in immunomodulation
Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential.
We delved into the potential of plant-derived cyclotides, particularly focusing on a modified version of kalata B1, known as [T20K], for autoimmune disorders such as multiple sclerosis. Our investigations revealed that daily doses in mice led to reduced cytokine levels and minimal inflammation, suggesting a promising alternative to traditional immunosuppressive drugs. While the results are encouraging, further research is needed to fully assess the effectiveness of cyclotides in human applications. Overall, cyclotides appear to hold significant promise in the realm of immune modulation.
9
RCI001 shows promise for Sjögren syndrome
Efficacy of RCI001 as a Therapeutic Candidate in a Primary Sjögren Syndrome Mouse Model.
We investigated how RCI001 can help mice with primary Sjögren syndrome. Eight 12-week-old NOD.B10-H2b mice were divided into two groups, one receiving RCI001 and the other a control treatment.
After one week, we noted significant improvements in eye health and tear secretion for the RCI group. They also showed reduced levels of inflammatory markers compared to those treated with the control. Overall, RCI001 proved to effectively reduce inflammation and oxidative stress, suggesting a promising therapeutic option for this autoimmune disease.
References
Mishra R, Agarwal P, Sharma A, Mittal M, Gulati P, et al. Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential. Protein Pept Lett. 2025. doi:10.2174/0109298665364479250214101422
Kang H, Jung YH, Moon J, Ryu JS, Yoon CH, et al. Efficacy of RCI001 as a Therapeutic Candidate in a Primary Sjögren Syndrome Mouse Model. Cornea. 2025;44:226. doi:10.1097/ICO.0000000000003696