We examined how Zhigancao Decoction (ZGCD) affects diabetic cardiomyopathy (DCM), aiming to uncover its clinical benefits and underlying mechanisms. After analyzing numerous studies, we found that ZGCD significantly improves cardiac function and reduces blood pressure more effectively than conventional treatments. Additionally, it appears to have fewer side effects. The positive effects are likely linked to its ability to influence the AGEs-RAGE signaling pathway, boost lipid metabolism, and reduce atherosclerosis. However, it's important to note that more research is needed to fully understand these mechanisms.
Read More
7
KSP shows potential heart health benefits
Plasma and fecal bioactive mediators in relation to the prevention of atherogenesis in LDL-r-KO mice: insights from an African staple food.
We investigated how Kgengwe seed powder (KSP) impacts cardiovascular health by examining its effects on low-density lipoprotein receptor knockout (LDL-r-KO) mice. Over 20 weeks, we fed one group of mice an atherogenic diet with 10% KSP, while the control group received no supplement.
The treatment led to higher levels of beneficial metabolites like amino acids and various fatty acids in the blood of the KSP group. Notably, there was a significant decrease in atherosclerotic lesions in those mice, implying a potential protective effect of KSP against heart disease. However, for a fuller understanding, more research is necessary to detail the mechanisms behind these findings.
Read More
Most Useful Reviews
9
Strong antiviral effect
542 people found this helpful
Excellent antiviral and immunomodulating agent. L-Lysine boasts a more than 95% effectiveness in treating viral diseases compared to 50-80% for antiviral drugs, regardless of the disease stage. Even in cases where it’s less effective, it prevents disease progression and enhances overall well-being. Additionally, it improves brain function and increases stress resilience.
Read More
9
Boosts immunity
6 people found this helpful
Very strong antiviral effect. L-Lysine outperforms many antiviral medications. It halts disease progression and enhances overall well-being. It also improves brain function and may support cardiovascular health. Easy to take without an unpleasant taste and increases appetite.
Read More
9
Strong immuno-strengthening effect
1 people found this helpful
L-lysine exhibits an impressive antiviral effect, surpassing many antiviral medications. It enhances the immune system and contributes positively to my cardiovascular condition, promoting overall well-being.
We examined how Zhigancao Decoction (ZGCD) affects diabetic cardiomyopathy (DCM), aiming to uncover its clinical benefits and underlying mechanisms. After analyzing numerous studies, we found that ZGCD significantly improves cardiac function and reduces blood pressure more effectively than conventional treatments. Additionally, it appears to have fewer side effects. The positive effects are likely linked to its ability to influence the AGEs-RAGE signaling pathway, boost lipid metabolism, and reduce atherosclerosis. However, it's important to note that more research is needed to fully understand these mechanisms.
Read More
7
KSP shows potential heart health benefits
Plasma and fecal bioactive mediators in relation to the prevention of atherogenesis in LDL-r-KO mice: insights from an African staple food.
We investigated how Kgengwe seed powder (KSP) impacts cardiovascular health by examining its effects on low-density lipoprotein receptor knockout (LDL-r-KO) mice. Over 20 weeks, we fed one group of mice an atherogenic diet with 10% KSP, while the control group received no supplement.
The treatment led to higher levels of beneficial metabolites like amino acids and various fatty acids in the blood of the KSP group. Notably, there was a significant decrease in atherosclerotic lesions in those mice, implying a potential protective effect of KSP against heart disease. However, for a fuller understanding, more research is necessary to detail the mechanisms behind these findings.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Strong antiviral effect
542 people found this helpful
Excellent antiviral and immunomodulating agent. L-Lysine boasts a more than 95% effectiveness in treating viral diseases compared to 50-80% for antiviral drugs, regardless of the disease stage. Even in cases where it’s less effective, it prevents disease progression and enhances overall well-being. Additionally, it improves brain function and increases stress resilience.
Read More
9
Boosts immunity
6 people found this helpful
Very strong antiviral effect. L-Lysine outperforms many antiviral medications. It halts disease progression and enhances overall well-being. It also improves brain function and may support cardiovascular health. Easy to take without an unpleasant taste and increases appetite.
Read More
9
Strong immuno-strengthening effect
1 people found this helpful
L-lysine exhibits an impressive antiviral effect, surpassing many antiviral medications. It enhances the immune system and contributes positively to my cardiovascular condition, promoting overall well-being.
Read More
7.5
Supports heart health
347 people found this helpful
Great product! The quality is excellent and the tablets are easy to swallow. L-Lysine is not only an effective antiviral agent but also promotes hair growth and can help prevent blood clots and cholesterol plaques, which are linked to cardiovascular disease. I will certainly continue to use it.
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7.5
Effective prevention
24 people found this helpful
Affordable and effective, I find L-Lysine has no equal in quality. My family takes it as a preventative for low immunity and respiratory diseases. I appreciate its quick relief for herpes symptoms and regret not choosing L-Lysine over expensive gels sooner. Highly recommended!
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
L-Lysine is an essential amino acid that plays a crucial role in many bodily functions. Unlike some amino acids that can be synthesized by the body, L-Lysine must be obtained through diet or supplementation. It is particularly important for protein synthesis, hormone production, and the absorption of calcium. Good dietary sources of L-Lysine include meat, fish, dairy products, eggs, and certain plant sources such as beans and legumes. Athletes and individuals looking to support muscle recovery and growth often consider L-Lysine supplements.
In addition to its role in enhancing muscle recovery, L-Lysine is also often touted for its potential benefits in supporting immune function and combating cold sores caused by the herpes simplex virus. Some studies suggest that L-Lysine may help reduce the frequency and severity of these outbreaks. However, it’s always advisable to consult with a healthcare professional before starting any new supplement to determine the appropriate dosage and ensure it aligns with your health needs.
Based on user reviews, the time frame to see results from taking L-Lysine for cardiovascular health varies, but many users report experiencing noticeable benefits relatively quickly. For instance, some users mention improvements in overall well-being and cardiovascular conditions soon after starting the supplement Read Review. Interestingly, a few individuals emphasize the importance of consistent use over time, indicating that while initial benefits may appear swiftly, sustained improvements and optimal health outcomes unfold with longer-term usage Read Review.
Moreover, several reviews underscore L-Lysine’s ability to combat blood clots and improve heart health, which could imply that its cardiovascular effects may be cumulative and become more pronounced the longer you take it Read Review. Overall, while many users report feeling positive changes within the first couple of weeks, consistent and long-term supplementation appears to be key for maximizing cardiovascular benefits.
Based on recent scientific investigations, certain supplements show promising potential for supporting cardiovascular health. For instance, research on the Zhigancao Decoction (ZGCD) indicates that it not only improves cardiac function and reduces blood pressure more effectively than conventional treatments but also has fewer side effects. Its positive effects may be attributed to its influence on the AGEs-RAGE signaling pathway, enhanced lipid metabolism, and reduced atherosclerosis, though further studies are necessary to fully delineate these mechanisms [1].
Additionally, Kgengwe seed powder (KSP) has been studied in LDL-receptor knockout mice, indicating a significant reduction in atherosclerotic lesions. This suggests a protective role against heart disease, as KSP supplementation was associated with enhanced levels of beneficial metabolites. However, as with ZGCD, more research is needed to clarify the underlying mechanisms of KSP's cardiovascular benefits [2]. While these findings are promising, relying on any supplement for cardiovascular disease management should be done with caution until further research is conducted.
Users have reported a variety of improvements in symptoms after using L-Lysine, particularly highlighting its antiviral properties and overall well-being. Many reviewers express satisfaction with its effectiveness in treating viral diseases, suggesting it performs significantly better than conventional antiviral medications, particularly in halting disease progression and enhancing general wellness Read Review. Additionally, individuals have noted improvements in brain function and immune resilience, with one user stating it effectively combats early cold symptoms Read Review.
Moreover, L-Lysine users have shared observations regarding its support for cardiovascular health, with benefits including reduced bad cholesterol and improved heart function Read Review. Several reviewers mention its synergistic effect when taken alongside other supplements, like vitamin C Read Review, and its role in promoting collagen synthesis vital for connective tissue Read Review. Overall, users report positive changes including enhanced immunity and cardiovascular support, demonstrating L-Lysine's potential as a beneficial supplement, though individual results can vary.
Users report that combining L-Lysine with other supplements can enhance its cardiovascular benefits, particularly when paired with vitamin C. Many individuals have noted a synergistic effect that not only bolsters immune health but also supports heart function Read Review. Additionally, users have highlighted L-Lysine's role in reducing bad cholesterol and preventing blood clots, which are crucial factors in managing cardiovascular disease Read Review.
The general consensus among users is that L-Lysine’s effectiveness in promoting heart health may be amplified when taken in conjunction with other nutrients that support protein synthesis and overall well-being Read Review. For instance, several reviews emphasize its critical function in collagen production, necessary for maintaining the structural integrity of blood vessels Read Review. Overall, while users appreciate L-Lysine’s standalone benefits, the potential for increased efficacy through combination with other supplements appears to be a common theme in product feedback.
Users report that L-Lysine is a notable supporter of cardiovascular health, highlighting its role in collagen production, fat metabolism, and cholesterol management. Indeed, many reviewers indicate its potential to prevent blood clots and cholesterol plaques, both of which are linked to cardiovascular diseases. For example, one user mentioned that L-Lysine can help prevent blood clots and is beneficial due to its cardiovascular advantages Read Review. Another user noted its impact on reducing bad cholesterol, which they found advantageous for their cardiovascular health Read Review.
While specific dosage recommendations for treating cardiovascular disease weren't prominently discussed in the reviews, users consistently emphasize the overall health benefits of maintaining adequate L-Lysine levels. Many suggest daily use supports both immune function and cardiovascular health, although individual responses may vary. As with any supplement, consulting a healthcare professional for a tailored dosage, especially for specific health conditions, remains essential.
9
Strong immuno-strengthening effect
1 people found this helpful
L-lysine exhibits an impressive antiviral effect, surpassing many antiviral medications. It enhances the immune system and contributes positively to my cardiovascular condition, promoting overall well-being.
6
Essential for cardiovascular health
1 people found this helpful
L-lysine is critical for protein production and the maintenance of collagen and elastin in connective tissues. It also acts as a precursor to L-carnitine, promoting fat metabolism and energy, thereby supporting cardiovascular health.
6
Hair growth aid
3 people found this helpful
L-Lysine not only fights viruses effectively but also promotes hair growth and prevents blood clots, which is beneficial in reducing the risk of cardiovascular disease. If you find this review helpful, please click 👍!
9
Strong antiviral effect
542 people found this helpful
Excellent antiviral and immunomodulating agent. L-Lysine boasts a more than 95% effectiveness in treating viral diseases compared to 50-80% for antiviral drugs, regardless of the disease stage. Even in cases where it’s less effective, it prevents disease progression and enhances overall well-being. Additionally, it improves brain function and increases stress resilience.
7.5
Family immunity boost
5 people found this helpful
This is my go-to product for strengthening the immune system. It effectively combats early cold symptoms, especially when combined with vitamin C. My family uses it for prevention, and it has consistently proven effective.
6
Beneficial for cardiovascular disease
2 people found this helpful
L-lysine is vital for normal bone formation, supports calcium absorption, and aids in producing collagen, antibodies, hormones, and enzymes. It helps reduce bad cholesterol and is advantageous for my cardiovascular health.
7
Supports cardiovascular health
1 people found this helpful
L-Lysine is an essential amino acid that I must obtain from food or supplements. It plays a vital role in protein production and supports the structural proteins collagen and elastin, crucial for connective tissue such as skin and bones. Furthermore, L-Lysine is a precursor to L-carnitine, which is necessary for fat metabolism and energy production. I have found that it also aids my immune system and helps in maintaining cardiovascular health.
7.5
Supports heart health
347 people found this helpful
Great product! The quality is excellent and the tablets are easy to swallow. L-Lysine is not only an effective antiviral agent but also promotes hair growth and can help prevent blood clots and cholesterol plaques, which are linked to cardiovascular disease. I will certainly continue to use it.
9
ZGCD improves diabetic cardiomyopathy
Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy.
We examined how Zhigancao Decoction (ZGCD) affects diabetic cardiomyopathy (DCM), aiming to uncover its clinical benefits and underlying mechanisms. After analyzing numerous studies, we found that ZGCD significantly improves cardiac function and reduces blood pressure more effectively than conventional treatments. Additionally, it appears to have fewer side effects. The positive effects are likely linked to its ability to influence the AGEs-RAGE signaling pathway, boost lipid metabolism, and reduce atherosclerosis. However, it's important to note that more research is needed to fully understand these mechanisms.
7
KSP shows potential heart health benefits
Plasma and fecal bioactive mediators in relation to the prevention of atherogenesis in LDL-r-KO mice: insights from an African staple food.
We investigated how Kgengwe seed powder (KSP) impacts cardiovascular health by examining its effects on low-density lipoprotein receptor knockout (LDL-r-KO) mice. Over 20 weeks, we fed one group of mice an atherogenic diet with 10% KSP, while the control group received no supplement.
The treatment led to higher levels of beneficial metabolites like amino acids and various fatty acids in the blood of the KSP group. Notably, there was a significant decrease in atherosclerotic lesions in those mice, implying a potential protective effect of KSP against heart disease. However, for a fuller understanding, more research is necessary to detail the mechanisms behind these findings.
References
Ji K, Han M, Yang M, Xu Q, Zhang Y. Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy. Front Cardiovasc Med. 2025;12:1454647. 10.3389/fcvm.2025.1454647
Kaur R, Kobue-Lekalake R, Masisi K, Aukema H, Moghadasian MH. Plasma and fecal bioactive mediators in relation to the prevention of atherogenesis in LDL-r-KO mice: insights from an African staple food. Appl Physiol Nutr Metab. 2025;50:1. 10.1139/apnm-2024-0328