SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
8
Calcium's role in gastritis therapy
A Dual-Biomineralized Yeast Micro-/Nanorobot with Self-Driving Penetration for Gastritis Therapy and Motility Recovery.
Moderate relevance to calcium effects
We explored the potential of calcium treatment for alleviating gastritis through innovative yeast micro-/nanorobots. In this study, a self-driving Cur@CaY-robot was devised using a dual biomineralization process to incorporate calcium carbonate. These robots are designed to navigate the harsh gastric environment, effectively delivering curcumin, a natural anti-inflammatory compound.
What we found particularly interesting is how these robots can penetrate deep into thick gastric mucus. This ability not only improves the concentration of curcumin in gastric wall tissues but also releases calcium cations, which seem to play a dual role in both enhancing drug delivery and aiding the recovery of gastric motility in mice suffering from gastritis.
While leveraging the biocompatibility and biodegradability of the yeast-based robots, our findings suggest that calcium can indeed have a notable effect in the context of gastritis treatment. However, it’s important to note that the interplay between calcium and curcumin might complicate our understanding of their individual impacts on gastritis. The study points to promising avenues for future research, emphasizing the need for deeper exploration into how these elements work together.
What we found particularly interesting is how these robots can penetrate deep into thick gastric mucus. This ability not only improves the concentration of curcumin in gastric wall tissues but also releases calcium cations, which seem to play a dual role in both enhancing drug delivery and aiding the recovery of gastric motility in mice suffering from gastritis.
While leveraging the biocompatibility and biodegradability of the yeast-based robots, our findings suggest that calcium can indeed have a notable effect in the context of gastritis treatment. However, it’s important to note that the interplay between calcium and curcumin might complicate our understanding of their individual impacts on gastritis. The study points to promising avenues for future research, emphasizing the need for deeper exploration into how these elements work together.
Read More
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
Study highlights zinc's effectiveness
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Zinc shows effectiveness against H. pylori
Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori.
Significant but not isolated findings
We explored the effectiveness of zinc chloride (ZnCl) in treating Helicobacter pylori (H. pylori) infections, particularly concerning various gastritis conditions. Our study involved testing 116 clinical isolates of H. pylori to see how they responded to ZnCl, bismuth subsalicylate (BSS), and clarithromycin (CLR).
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
Read More
Most Useful Reviews
8
Helps relieve spasms
Magnesium gives me energy and appears to soften stool, yet is not recommended for ulcers, gastritis, or high acidity. If you’re unsure which magnesium form to choose, it’s advisable to alternate to prevent dependency; another variant may suit you better. I’ve tried many types, and I can attest that they generally seem effective. When I experience pain during menstruation, I prefer taking magnesium over painkillers, and it’s genuinely helpful as it alleviates spasms.
Read More
7.5
Relieves postpartum discomfort
I appreciate the composition, as I sought a calcium to magnesium ratio of 2:1, but this product has double the magnesium compared to calcium, which is in highly digestible forms. Being a breastfeeding mother, I began experiencing leg pain and dental issues, but I feel better now. After childbirth, I struggled with sleep and persistent fatigue. Although I was advised to take a B complex or magnesium citrate, I found I could not due to gastritis, yet this product has suited me perfectly. Thank you!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9.5
Calcium's role in alleviating gastritis
Alleviation of calcium hydroxide nanoparticles induced genotoxicity and gastritis by coadministration of calcium titanate and yttrium oxide nanoparticles in mice.
Moderate relevance to calcium effects
We observed that various nanoparticles, particularly calcium hydroxide (Ca(OH)), can significantly impact gastritis and DNA integrity in mice. In our study, we administered a dose of 50 mg/kg of Ca(OH) nanoparticles orally three times a week for two weeks. This led to increased DNA damage and reactive oxygen species (ROS) generation, indicating a heightened inflammatory response.
Surprisingly, when we combined Ca(OH) with calcium titanate (CaTiO) and yttrium oxide (YO) nanoparticles, the harmful effects were remarkably reduced. The observed inflammation and DNA damage levels returned to a range similar to the negative control group, demonstrating that CaTiO and YO nanoparticles effectively mitigated the adverse effects induced by Ca(OH).
Importantly, the combination treatment altered the expression levels of key genes involved in inflammation. While Ca(OH) alone raised the levels of inflammatory markers, the coadministration with CaTiO and YO resulted in significant recovery, underscoring a protective effect.
Overall, this suggests a potential pathway for managing inflammation and DNA damage linked to calcium hydroxide exposure. However, we recommend further investigations to explore the full implications of these findings and the toxicological effects of these nanoparticles.
Surprisingly, when we combined Ca(OH) with calcium titanate (CaTiO) and yttrium oxide (YO) nanoparticles, the harmful effects were remarkably reduced. The observed inflammation and DNA damage levels returned to a range similar to the negative control group, demonstrating that CaTiO and YO nanoparticles effectively mitigated the adverse effects induced by Ca(OH).
Importantly, the combination treatment altered the expression levels of key genes involved in inflammation. While Ca(OH) alone raised the levels of inflammatory markers, the coadministration with CaTiO and YO resulted in significant recovery, underscoring a protective effect.
Overall, this suggests a potential pathway for managing inflammation and DNA damage linked to calcium hydroxide exposure. However, we recommend further investigations to explore the full implications of these findings and the toxicological effects of these nanoparticles.
Read More
9.5
Zinc Carnosine Enhances Eradication
Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study.
Relevant to gastritis treatment
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
9.5
Zinc supports recovery in CCS
Case of Cronkhite Canada syndrome shows improvement with enteral supplements.
Multi-component treatment assessed
Our examination focuses on the intriguing case of a 33-year-old man diagnosed with Cronkhite-Canada syndrome (CCS), a rare condition affecting the gastrointestinal tract and skin. During his hospital stay, he presented with severe gastrointestinal symptoms alongside notable skin changes.
To address his condition, the treatment regime included high protein supplements, proton pump inhibitors, and zinc-vitamin supplements. Over the course of five months, we observed a complete improvement in his symptoms. While this particular case emphasizes the role of zinc within a comprehensive treatment plan, it’s important to note that zinc was part of a multi-component strategy that makes it difficult to isolate its individual effects on gastritis directly.
Nonetheless, this case illustrates how early diagnosis and a well-structured treatment approach—integrating nutritional support—can lead to significant recovery in rare syndromes like CCS.
To address his condition, the treatment regime included high protein supplements, proton pump inhibitors, and zinc-vitamin supplements. Over the course of five months, we observed a complete improvement in his symptoms. While this particular case emphasizes the role of zinc within a comprehensive treatment plan, it’s important to note that zinc was part of a multi-component strategy that makes it difficult to isolate its individual effects on gastritis directly.
Nonetheless, this case illustrates how early diagnosis and a well-structured treatment approach—integrating nutritional support—can lead to significant recovery in rare syndromes like CCS.
Read More
8
Calcium's role in gastritis therapy
A Dual-Biomineralized Yeast Micro-/Nanorobot with Self-Driving Penetration for Gastritis Therapy and Motility Recovery.
Moderate relevance to calcium effects
We explored the potential of calcium treatment for alleviating gastritis through innovative yeast micro-/nanorobots. In this study, a self-driving Cur@CaY-robot was devised using a dual biomineralization process to incorporate calcium carbonate. These robots are designed to navigate the harsh gastric environment, effectively delivering curcumin, a natural anti-inflammatory compound.
What we found particularly interesting is how these robots can penetrate deep into thick gastric mucus. This ability not only improves the concentration of curcumin in gastric wall tissues but also releases calcium cations, which seem to play a dual role in both enhancing drug delivery and aiding the recovery of gastric motility in mice suffering from gastritis.
While leveraging the biocompatibility and biodegradability of the yeast-based robots, our findings suggest that calcium can indeed have a notable effect in the context of gastritis treatment. However, it’s important to note that the interplay between calcium and curcumin might complicate our understanding of their individual impacts on gastritis. The study points to promising avenues for future research, emphasizing the need for deeper exploration into how these elements work together.
What we found particularly interesting is how these robots can penetrate deep into thick gastric mucus. This ability not only improves the concentration of curcumin in gastric wall tissues but also releases calcium cations, which seem to play a dual role in both enhancing drug delivery and aiding the recovery of gastric motility in mice suffering from gastritis.
While leveraging the biocompatibility and biodegradability of the yeast-based robots, our findings suggest that calcium can indeed have a notable effect in the context of gastritis treatment. However, it’s important to note that the interplay between calcium and curcumin might complicate our understanding of their individual impacts on gastritis. The study points to promising avenues for future research, emphasizing the need for deeper exploration into how these elements work together.
Read More
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
Study highlights zinc's effectiveness
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Helps relieve spasms
Magnesium gives me energy and appears to soften stool, yet is not recommended for ulcers, gastritis, or high acidity. If you’re unsure which magnesium form to choose, it’s advisable to alternate to prevent dependency; another variant may suit you better. I’ve tried many types, and I can attest that they generally seem effective. When I experience pain during menstruation, I prefer taking magnesium over painkillers, and it’s genuinely helpful as it alleviates spasms.
Read More
7.5
Relieves postpartum discomfort
I appreciate the composition, as I sought a calcium to magnesium ratio of 2:1, but this product has double the magnesium compared to calcium, which is in highly digestible forms. Being a breastfeeding mother, I began experiencing leg pain and dental issues, but I feel better now. After childbirth, I struggled with sleep and persistent fatigue. Although I was advised to take a B complex or magnesium citrate, I found I could not due to gastritis, yet this product has suited me perfectly. Thank you!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
