Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Read More
9
Magnesium aids postoperative pain relief
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
Magnesium reduces postoperative knee pain
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
Most Useful Reviews
9
Pill difficulty
1 people found this helpful
It was challenging to take these large pills, but after finishing the course, I noticed I felt calmer, and my knee pain has stopped.
Read More
6
Short-term relief
This supplement has a high dosage of magnesium and calcium, which relieved my knee pain effectively, but it shouldn't be taken long-term.
Read More
6
Nail and joint strength
With a good dosage of calcium and magnesium, my nails are growing quickly, and the crunch in my knees during squats has almost vanished. I suggest taking them after meals for best results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.8
- All Researches
9
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Read More
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Read More
9
Magnesium aids postoperative pain relief
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
We evaluated how effective magnesium, especially when combined with bupivacaine, is for managing knee pain after arthroscopy. Our study looked at data from 78 randomized trials involving 4,425 participants.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
Read More
9
Magnesium reduces postoperative knee pain
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pill difficulty
1 people found this helpful
It was challenging to take these large pills, but after finishing the course, I noticed I felt calmer, and my knee pain has stopped.
Read More
6
Short-term relief
This supplement has a high dosage of magnesium and calcium, which relieved my knee pain effectively, but it shouldn't be taken long-term.
Read More
6
Nail and joint strength
With a good dosage of calcium and magnesium, my nails are growing quickly, and the crunch in my knees during squats has almost vanished. I suggest taking them after meals for best results.
Read More
6
Stronger knees
1 people found this helpful
I felt my knees getting stronger after just a few days, especially when going up the stairs.
Read More
7.5
Back pain diminished
It helped me with my back pain and headaches.
Read More
Frequently Asked Questions
6
Stronger knees
1 people found this helpful
I felt my knees getting stronger after just a few days, especially when going up the stairs.
9
Pill difficulty
1 people found this helpful
It was challenging to take these large pills, but after finishing the course, I noticed I felt calmer, and my knee pain has stopped.
6
Short-term relief
This supplement has a high dosage of magnesium and calcium, which relieved my knee pain effectively, but it shouldn't be taken long-term.
6
Nail and joint strength
With a good dosage of calcium and magnesium, my nails are growing quickly, and the crunch in my knees during squats has almost vanished. I suggest taking them after meals for best results.
7.5
Back pain diminished
It helped me with my back pain and headaches.
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
8
Magnesium reduces knee surgery pain
We assessed whether adding magnesium sulfate to a conventional pain relief cocktail could enhance comfort for those undergoing total knee arthroplasty. In a carefully designed study involving 100 participants, half received the modified approach while the other half got the standard mix.
Notably, results showed that the modified cocktail significantly eased postoperative pain, leading to a reduction in opioid use. This suggests a promising advancement in pain management strategies for knee surgeries.
Notably, results showed that the modified cocktail significantly eased postoperative pain, leading to a reduction in opioid use. This suggests a promising advancement in pain management strategies for knee surgeries.
4
We explored the role of calcium gluconate as an activator alongside platelet-rich plasma (PRP) injections for patients dealing with early knee osteoarthritis. In this study, participants were split into two groups: one received PRP alone, while the other got PRP mixed with calcium gluconate.
Both groups were evaluated over six months for pain relief and overall satisfaction. Interestingly, despite a noticeable decrease in pain and improvement in overall function in both groups, we found no significant differences when comparing the effectiveness of the two treatments.
This led us to conclude that adding calcium gluconate might not provide any extra benefit to PRP injections in managing knee pain for early-stage osteoarthritis, which is quite important for patients considering their treatment options.
Both groups were evaluated over six months for pain relief and overall satisfaction. Interestingly, despite a noticeable decrease in pain and improvement in overall function in both groups, we found no significant differences when comparing the effectiveness of the two treatments.
This led us to conclude that adding calcium gluconate might not provide any extra benefit to PRP injections in managing knee pain for early-stage osteoarthritis, which is quite important for patients considering their treatment options.
9
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
References
- Rai S, Patel S, Chouhan DK, Jain A, Thami T, et al. Is There a Need for an Exogenous Activator Along with PRP for Early Knee Osteoarthritis? A Triple-Blinded Randomized Control Trial. Indian J Orthop. 2024;58:905. 10.1007/s43465-024-01159-7
- Stratton A, Wanless M, Abidi N. Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee. J Knee Surg. 2024;37:341. 10.1055/a-2094-5724
- Zhu Y, Shen S, Cui L, Wu L, Zhang B. Magnesium sulphate and sodium bicarbonate as additives for periarticular local infiltration analgesia improve pain management after unicompartmental knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2024;19:764. 10.1186/s13018-024-05233-6
- Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. 10.2147/DDDT.S444896
- Zhao C, Wang L, Chen L, Wang Q, Kang P. Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2023;18:301. 10.1186/s13018-023-03790-w
- Wang Q, Zhao C, Hu J, Ma T, Yang J, et al. Efficacy of a Modified Cocktail for Periarticular Local Infiltration Analgesia in Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Controlled Trial. J Bone Joint Surg Am. 2023;105:354. 10.2106/JBJS.22.00614
- Choi JW, Lahori A, Merlo JA, Gill O, Ghoddoussi F, et al. Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial. Clin J Pain. 2022;38:388. 10.1097/AJP.0000000000001036
- He Y, He H, Li X, Lei G, Xie D, et al. Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis. Arthroscopy. 2022;38:2897. 10.1016/j.arthro.2022.03.013
- Shi L, Zhu H, Ma J, Shi LL, Gao F, et al. Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:111. 10.1186/s13018-021-02264-1
- Zhao Z, Zhang X, Peng H, Li W, Liu H, et al. Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period after Total Knee Arthroplasty. J Knee Surg. 2021;34:1463. 10.1055/s-0040-1710364
- Condello V, Filardo G, Madonna V, Andriolo L, Screpis D, et al. Use of a Biomimetic Scaffold for the Treatment of Osteochondral Lesions in Early Osteoarthritis. Biomed Res Int. 2018;2018:7937089. 10.1155/2018/7937089
- Shmagel A, Onizuka N, Langsetmo L, Vo T, Foley R, et al. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018;26:651. 10.1016/j.joca.2018.02.002
- Shin HJ, Kim EY, Na HS, Kim TK, Kim MH, et al. Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial. Br J Anaesth. 2016;117:497. 10.1093/bja/aew227
- Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2012;40:2032.
- Ekmekci P, Bengisun ZK, Akan B, Kazbek BK, Ozkan KS, et al. The effect of magnesium added to levobupivacaine for femoral nerve block on postoperative analgesia in patients undergoing ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2013;21:1119. 10.1007/s00167-012-2093-4
- Koltka K, Koknel-Talu G, Asik M, Ozyalcin S. Comparison of efficacy of intraarticular application of magnesium, levobupivacaine and lornoxicam with placebo in arthroscopic surgery. Knee Surg Sports Traumatol Arthrosc. 2011;19:1884. 10.1007/s00167-011-1497-x
- Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2009;37:1733.
- Farouk S, Aly A. A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery. J Anesth. 2009;23:508. 10.1007/s00540-009-0822-8
