5/1/2025
Last update
5/1/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.6
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.4
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
8
We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
Read More
7
Zinc treatment reduces nausea risk
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
Most Useful Reviews
0
Nausea persisted
6 people found this helpful
My mother ordered these supplements but began complaining of nausea after taking them as instructed—three tablets a day before bedtime. I refrained from taking them for a month to determine if they caused her nausea. When she resumed taking them, the same symptoms occurred, including stomach pain. Ultimately, these supplements were unsuitable for her.
Read More
10
No nausea experienced
An excellent product that is easy to swallow, causing no allergies or nausea. As a breastfeeding mother, I am pleased to report that neither I nor my baby experience any negative reactions to this preparation.
Read More
10
Nausea non-existent
Excellent vitamins! This effective combination of magnesium and calcium markedly improved my energy levels and joint pain. I experienced no allergies, nor did I suffer from nausea after taking these.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.6
- All Researches
9
We explored the effects of a low-opioid anesthesia (LOA) protocol during laparoscopic cholecystectomy and its impact on nausea, vomiting, and pain control. In our study, we compared 40 patients who received LOA, which included magnesium sulfate, with another 40 patients who were given standard opioid-based anesthesia.
While our findings showed that the LOA protocol was more effective in reducing nausea and vomiting compared to traditional opioid analgesia, we didn’t isolate magnesium’s specific role in this improvement. This limitation makes it challenging to determine just how much magnesium alone contributes to reducing nausea.
Nevertheless, the study suggests that using a low-opioid method can enhance patient comfort in the postoperative period. Overall, we found that incorporating non-opioid analgesia and the LOA strategy should be considered more widely in surgical practices.
While our findings showed that the LOA protocol was more effective in reducing nausea and vomiting compared to traditional opioid analgesia, we didn’t isolate magnesium’s specific role in this improvement. This limitation makes it challenging to determine just how much magnesium alone contributes to reducing nausea.
Nevertheless, the study suggests that using a low-opioid method can enhance patient comfort in the postoperative period. Overall, we found that incorporating non-opioid analgesia and the LOA strategy should be considered more widely in surgical practices.
Read More
8
We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
Read More
We conducted a thorough investigation into how combining oral pregabalin and intravenous magnesium sulfate influences nausea in patients undergoing a specific type of spine surgery. In a well-structured trial, 104 participants were randomly assigned to one of four groups, where some received magnesium sulfate with pregabalin, while others received either a placebo or just one of the drugs.
Our primary focus was on how much morphine the patients needed on the first day after surgery, which gives us insight into their pain levels. While we noted the overall benefits of combining these two non-opioid treatments for pain relief, the study did mention postoperative nausea and vomiting as secondary outcomes. However, it's important to clarify that the findings did not specifically highlight any significant advantages of magnesium in reducing nausea when compared to the other treatments or placebos.
In essence, while we observed that the combination of magnesium sulfate and pregabalin effectively reduced opioid consumption and improved pain management post-surgery, it did not yield clear evidence pointing to magnesium's effectiveness specifically for alleviating nausea. This nuanced insight is valuable as we continue exploring the best strategies for managing multiple aspects of patient comfort during the recovery process.
Our primary focus was on how much morphine the patients needed on the first day after surgery, which gives us insight into their pain levels. While we noted the overall benefits of combining these two non-opioid treatments for pain relief, the study did mention postoperative nausea and vomiting as secondary outcomes. However, it's important to clarify that the findings did not specifically highlight any significant advantages of magnesium in reducing nausea when compared to the other treatments or placebos.
In essence, while we observed that the combination of magnesium sulfate and pregabalin effectively reduced opioid consumption and improved pain management post-surgery, it did not yield clear evidence pointing to magnesium's effectiveness specifically for alleviating nausea. This nuanced insight is valuable as we continue exploring the best strategies for managing multiple aspects of patient comfort during the recovery process.
Read More
7
Magnesium reduces post-operative nausea
In our exploration of how magnesium treatment influences nausea, we conducted a double-blind clinical trial with 62 children undergoing tonsillectomy. Participants were divided into two groups, where one received magnesium sulfate and the other lidocaine shortly after intubation.
We observed that while both medications were used, magnesium sulfate appeared to offer benefits over lidocaine. Notably, the group receiving magnesium experienced a significantly lower rate of nausea and vomiting compared to those treated with lidocaine. This points to magnesium's potential effectiveness in managing post-operative nausea.
However, it’s essential to note that our study did not find any significant difference in terms of laryngospasm incidence between the two groups. Overall, magnesium sulfate showcased an advantage with fewer instances of nausea and other distressing symptoms, suggesting its role as a valuable option for patient care in similar surgical scenarios.
We observed that while both medications were used, magnesium sulfate appeared to offer benefits over lidocaine. Notably, the group receiving magnesium experienced a significantly lower rate of nausea and vomiting compared to those treated with lidocaine. This points to magnesium's potential effectiveness in managing post-operative nausea.
However, it’s essential to note that our study did not find any significant difference in terms of laryngospasm incidence between the two groups. Overall, magnesium sulfate showcased an advantage with fewer instances of nausea and other distressing symptoms, suggesting its role as a valuable option for patient care in similar surgical scenarios.
Read More
7
Zinc treatment reduces nausea risk
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
0
Nausea persisted
6 people found this helpful
My mother ordered these supplements but began complaining of nausea after taking them as instructed—three tablets a day before bedtime. I refrained from taking them for a month to determine if they caused her nausea. When she resumed taking them, the same symptoms occurred, including stomach pain. Ultimately, these supplements were unsuitable for her.
Read More
10
No nausea experienced
An excellent product that is easy to swallow, causing no allergies or nausea. As a breastfeeding mother, I am pleased to report that neither I nor my baby experience any negative reactions to this preparation.
Read More
10
Nausea non-existent
Excellent vitamins! This effective combination of magnesium and calcium markedly improved my energy levels and joint pain. I experienced no allergies, nor did I suffer from nausea after taking these.
Read More
10
Nausea free
Super support! This supplement provides excellent support during and after pregnancy. It is easily absorbed and does not induce nausea or side effects. I take it three times daily, and it contains nearly all essential nutrients for my child's development.
Read More
9
No nausea reported
The package arrived in good condition, and the tablets are easy to ingest. I experienced no nausea, but I have yet to feel any significant effects from this product compared to previous magnesium supplements with lower dosages that worked.
Read More
Frequently Asked Questions
9
Nausea resolved
I take magnesium with calcium and vitamin D, spaced half an hour apart. I'm already noticing the results; the nausea has subsided, and my headaches are no longer as intense. I plan to take tests in a month and will report on my health status then.
9
No nausea reported
The package arrived in good condition, and the tablets are easy to ingest. I experienced no nausea, but I have yet to feel any significant effects from this product compared to previous magnesium supplements with lower dosages that worked.
0
Nausea persisted
6 people found this helpful
My mother ordered these supplements but began complaining of nausea after taking them as instructed—three tablets a day before bedtime. I refrained from taking them for a month to determine if they caused her nausea. When she resumed taking them, the same symptoms occurred, including stomach pain. Ultimately, these supplements were unsuitable for her.
10
Nausea non-existent
Excellent vitamins! This effective combination of magnesium and calcium markedly improved my energy levels and joint pain. I experienced no allergies, nor did I suffer from nausea after taking these.
0
Nausea experienced
This magnesium did not suit me. I experienced severe nausea, dizziness, and a drop in blood pressure and pulse. Breathing became difficult, and I nearly required hospitalisation. However, my husband took it and had no side effects. Previously, other magnesium worked well for me, so this particular one is just unsuitable.
7.5
Nausea avoided
The primary ingredients of this product are calcium, vitamin D, and magnesium. Since taking it, my body's calcium deficiency has been addressed, and the pain in my knees has significantly improved. I take one tablet with meals twice daily to prevent nausea and the risk of kidney stones.
8
We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
7
Magnesium reduces post-operative nausea
In our exploration of how magnesium treatment influences nausea, we conducted a double-blind clinical trial with 62 children undergoing tonsillectomy. Participants were divided into two groups, where one received magnesium sulfate and the other lidocaine shortly after intubation.
We observed that while both medications were used, magnesium sulfate appeared to offer benefits over lidocaine. Notably, the group receiving magnesium experienced a significantly lower rate of nausea and vomiting compared to those treated with lidocaine. This points to magnesium's potential effectiveness in managing post-operative nausea.
However, it’s essential to note that our study did not find any significant difference in terms of laryngospasm incidence between the two groups. Overall, magnesium sulfate showcased an advantage with fewer instances of nausea and other distressing symptoms, suggesting its role as a valuable option for patient care in similar surgical scenarios.
We observed that while both medications were used, magnesium sulfate appeared to offer benefits over lidocaine. Notably, the group receiving magnesium experienced a significantly lower rate of nausea and vomiting compared to those treated with lidocaine. This points to magnesium's potential effectiveness in managing post-operative nausea.
However, it’s essential to note that our study did not find any significant difference in terms of laryngospasm incidence between the two groups. Overall, magnesium sulfate showcased an advantage with fewer instances of nausea and other distressing symptoms, suggesting its role as a valuable option for patient care in similar surgical scenarios.
9
We explored the effects of a low-opioid anesthesia (LOA) protocol during laparoscopic cholecystectomy and its impact on nausea, vomiting, and pain control. In our study, we compared 40 patients who received LOA, which included magnesium sulfate, with another 40 patients who were given standard opioid-based anesthesia.
While our findings showed that the LOA protocol was more effective in reducing nausea and vomiting compared to traditional opioid analgesia, we didn’t isolate magnesium’s specific role in this improvement. This limitation makes it challenging to determine just how much magnesium alone contributes to reducing nausea.
Nevertheless, the study suggests that using a low-opioid method can enhance patient comfort in the postoperative period. Overall, we found that incorporating non-opioid analgesia and the LOA strategy should be considered more widely in surgical practices.
While our findings showed that the LOA protocol was more effective in reducing nausea and vomiting compared to traditional opioid analgesia, we didn’t isolate magnesium’s specific role in this improvement. This limitation makes it challenging to determine just how much magnesium alone contributes to reducing nausea.
Nevertheless, the study suggests that using a low-opioid method can enhance patient comfort in the postoperative period. Overall, we found that incorporating non-opioid analgesia and the LOA strategy should be considered more widely in surgical practices.
7
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
References
- Hua X, Chen Y, Wu Z, Zheng G, Yang D, et al. Effects of intra-operative magnesium sulfate infusion on orthognathic surgery: A prospective and randomized controlled trial. Heliyon. 2024;10:e30342. 10.1016/j.heliyon.2024.e30342
- Kościuczuk U, Tarnowska K, Rynkiewicz-Szczepanska E. Are There Any Advantages of the Low Opioid Anaesthesia and Non-Opioid Postoperative Analgesia Protocol: A Clinical Observational Study. J Pain Res. 2024;17:941. 10.2147/JPR.S449563
- Tavanaei R, Rezaee-Naserabad SS, Alizadeh S, Yazdani KO, Zali A, et al. Analgesic Effects of Preoperative Combination of Oral Pregabalin and Intravenous Magnesium Sulfate on Postoperative Pain in Patients Undergoing Posterolateral Spinal Fusion Surgery: A 4-arm, Randomized, Double-blind, Placebo-controlled Trial. J Neurosurg Anesthesiol. 2024;36:134. 10.1097/ANA.0000000000000893
- Manouchehrian N, Abbasi R, Jiryaee N, Beigi RM. Comparison of intravenous injection of magnesium sulfate and lidocaine effectiveness on the prevention of laryngospasm and analgesic requirement in tonsillectomy. Eur J Transl Myol. 2022;32. 10.4081/ejtm.2022.10732
- Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. 10.1016/j.jtemb.2024.127558
- Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. 10.1691/ph.2024.3630
- Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. 10.5812/aapm-127262
- Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. 10.1111/jpc.15953
