Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 51 Reviews
8
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Magnesium (elemental) (from 2,667 mg Magnesium Citrate)
400 mg
95%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Read More
Most Useful Reviews
9
Improved sleep quality
251 people found this helpful
I had wanted to order magnesium for a long time and this is the first company I've tried. I started taking it before bed and was pleasantly surprised to find I began to sleep well. I used to wake up feeling tired, but now I wake up before my alarm, full of energy. Additionally, it has helped with my constipation. I recommend it!
Read More
9
Fatigue relief
207 people found this helpful
This magnesium is one of the most affordable online and is a great aid to my health. Stress and anxiety deplete magnesium, leading to deficiency. It improves bowel function and I noticed a significant reduction in headaches and cramps. My sleep quality has improved immensely; I now fall asleep quickly and wake up refreshed.
Read More
9
Insomnia alleviated
74 people found this helpful
This magnesium in citrate form has greatly improved my sleep! After many years of insomnia, I now take it at night and sleep soundly until 6 am. I’ve ordered twice now and will continue. The convulsions I experienced have also disappeared.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Read More
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 51 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved sleep quality
251 people found this helpful
I had wanted to order magnesium for a long time and this is the first company I've tried. I started taking it before bed and was pleasantly surprised to find I began to sleep well. I used to wake up feeling tired, but now I wake up before my alarm, full of energy. Additionally, it has helped with my constipation. I recommend it!
Read More
9
Fatigue relief
207 people found this helpful
This magnesium is one of the most affordable online and is a great aid to my health. Stress and anxiety deplete magnesium, leading to deficiency. It improves bowel function and I noticed a significant reduction in headaches and cramps. My sleep quality has improved immensely; I now fall asleep quickly and wake up refreshed.
Read More
9
Insomnia alleviated
74 people found this helpful
This magnesium in citrate form has greatly improved my sleep! After many years of insomnia, I now take it at night and sleep soundly until 6 am. I’ve ordered twice now and will continue. The convulsions I experienced have also disappeared.
Read More
9
Stress relief
61 people found this helpful
I wanted to buy magnesium for a long time due to stress and sleep issues related to my child's graduation. After research, I purchased magnesium citrate, which is well absorbed. Initially, I took one capsule to assess my reaction. Gradually increasing the dose led to calm and improved sleep, leaving me rejuvenated each morning.
Read More
9
Constipation relief
39 people found this helpful
This magnesium has been my salvation after suffering from intestinal issues and constipation for years, despite various diets and treatments. Taking four capsules a day, two in the morning and two at night, I now have regular bowel movements. These small, easy-to-swallow capsules work wonders. I will order more!
Read More
Frequently Asked Questions
7.5
Restores sleep
11 people found this helpful
I ordered magnesium citrate for my husband to help restore his sleep. After a week of taking it, his sleep improved significantly, and his joint and muscle pains lessened. He now takes one capsule three times a day, and it's a very beneficial supplement.
9
Enhances calmness
10 people found this helpful
This is my second magnesium order from iHerb. After using it for two months, I have noticed significant calmness. I'm a mother and sometimes lose my patience, but this magnesium helps me maintain composure. It relaxes my muscles and restores my energy, leading to a more enjoyable life.
9
Headache relief
1 people found this helpful
My endocrinologist prescribed magnesium, and it’s worked miracles. After a month, I’ve had no headaches and restful sleep without racing thoughts. I no longer suffer from leg cramps either. I am definitely going to keep ordering this.
9
Insomnia alleviated
74 people found this helpful
This magnesium in citrate form has greatly improved my sleep! After many years of insomnia, I now take it at night and sleep soundly until 6 am. I’ve ordered twice now and will continue. The convulsions I experienced have also disappeared.
9
Improved sleep quality
251 people found this helpful
I had wanted to order magnesium for a long time and this is the first company I've tried. I started taking it before bed and was pleasantly surprised to find I began to sleep well. I used to wake up feeling tired, but now I wake up before my alarm, full of energy. Additionally, it has helped with my constipation. I recommend it!
9
Lessens cramps
7 people found this helpful
My menstrual cramps have improved immensely since I started taking magnesium. Initially, I avoided medication but found that magnesium effectively alleviated my pain, which was surprising. It also shortened the duration of my period significantly. This has become an essential item for me!
9
Eliminated cramps
1 people found this helpful
I’ve been taking magnesium from this company for a while, and it’s resolved my leg cramps completely. I used to wake up from them often. Plus, it has really improved the quality of my sleep, which has had a calming effect.
8.5
Enhanced relaxation
1 people found this helpful
Magnesium citrate is superb due to its bioavailability. I recommend it for anyone engaged in strenuous mental or physical tasks. It alleviates irritability and muscle cramps, supports joint health, and enhances relaxation, especially when taken alongside vitamin B6.
9
Calming effects
3 people found this helpful
Initially, I had a negative experience with tachycardia and tremors due to chelated vitamins. After realising the issue was with those, I found that taking magnesium alone left me feeling 99% calmer. It’s excellent for those dealing with autoimmune disorders and anxiety. I recommend it!
0
Negative side effects
20 people found this helpful
It's surprising how positive the reviews are! I took these capsules for 5 days but experienced severe abdominal pain and felt nauseous, reminiscent of an autoimmune disorder flare-up. I stopped taking them and don't recommend this product.
7.5
Tic alleviated
211 people found this helpful
This form of magnesium citrate is well absorbed. I ordered it to address a nervous tic that had developed as my eye twitched, which was very unsettling. I suggest starting with one capsule daily to avoid nausea. After gradually increasing my dose, the twitching stopped, and I am very happy with the results.
9
Constipation relief
39 people found this helpful
This magnesium has been my salvation after suffering from intestinal issues and constipation for years, despite various diets and treatments. Taking four capsules a day, two in the morning and two at night, I now have regular bowel movements. These small, easy-to-swallow capsules work wonders. I will order more!
9
Reduced anxiety
1 people found this helpful
Magnesium has been a huge benefit for my mother’s hypertension. She takes two capsules at night, which has really improved her sleep and reduced her anxiety. Her bowel movements are more regular now as well. It seems to positively impact her nervous system.
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. doi:10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. doi:10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. doi:10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. doi:10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
