A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
Magnesium reduces pregnancy leg cramps
Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial.
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
Read More
7
Magnesium's potential against cramps
Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps.
We set out to investigate whether magnesium citrate could be an effective remedy for those who experience bothersome leg cramps, particularly at night. In our study, we used a randomised, double-blind, cross-over, placebo-controlled design to ensure reliable results. Participants suffering from regular leg cramps were recruited and given either magnesium citrate or a matching placebo over six weeks.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
Read More
Most Useful Reviews
9
Reduced leg cramps
449 people found this helpful
The convulsions have really ceased. It’s only been a week since I began treatment, and I can now extend my legs freely at any time without issues. I have gradually reduced my dosage from one tablet per day to 3-4 tablets weekly, allowing me to have enough for over six months. I don't take it with me on trips, yet I've not had any cramps while away. I also feel a calming effect, becoming much more composed and measured in my responses to situations at work.
Read More
9
Calm nights ahead
329 people found this helpful
This product is indispensable for my calf cramps. Every night, I take a tablet, and it ensures a peaceful night’s sleep.
We explored the effects of magnesium treatment in a unique case involving a 62-year-old woman with stage IV colon cancer undergoing oxaliplatin therapy. Shortly after her first infusion, we observed that she experienced significant neurological symptoms, including right hemibody paresthesia, muscle cramping in her right calf, and dysphonia.
To address these symptoms, she was administered intravenous magnesium sulfate along with calcium gluconate. Remarkably, within three hours, all her symptoms resolved. While this case suggests that magnesium can provide relief from cramps and other neurological side effects, it is important to note that magnesium was used in conjunction with other medications, making it challenging to assess its isolated effectiveness.
For future doses, the oxaliplatin was adjusted by reducing the dose and extending the infusion duration, which minimized her symptoms to occasional mild paresthesia. In summary, while magnesium showed promise in this case, further research is needed to determine its specific impact on leg cramps in a clearer, more controlled manner.
Read More
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
Magnesium reduces pregnancy leg cramps
Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial.
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
Read More
7
Magnesium's potential against cramps
Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps.
We set out to investigate whether magnesium citrate could be an effective remedy for those who experience bothersome leg cramps, particularly at night. In our study, we used a randomised, double-blind, cross-over, placebo-controlled design to ensure reliable results. Participants suffering from regular leg cramps were recruited and given either magnesium citrate or a matching placebo over six weeks.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
We explored the effectiveness of magnesium treatment for leg cramps during pregnancy through a review of five randomized trials involving 352 women.
The trials varied in quality, but interestingly, they included comparisons of different treatments such as calcium and sodium chloride against placebos. While the placebo-controlled trial that investigated calcium did not show any significant benefits, there were hints of promise for magnesium.
For those looking for relief from troublesome leg cramps, our analysis indicated that magnesium—specifically in the forms of magnesium lactate or citrate—might help. Taking 5mmol in the morning and 10mmol in the evening seemed to provide the best results.
However, the evidence remains mixed, and we couldn't pinpoint any strong benefits from other combinations or supplements tested. So, while magnesium might be beneficial, it’s essential to approach it as one option among many.
The convulsions have really ceased. It’s only been a week since I began treatment, and I can now extend my legs freely at any time without issues. I have gradually reduced my dosage from one tablet per day to 3-4 tablets weekly, allowing me to have enough for over six months. I don't take it with me on trips, yet I've not had any cramps while away. I also feel a calming effect, becoming much more composed and measured in my responses to situations at work.
Read More
9
Calm nights ahead
329 people found this helpful
This product is indispensable for my calf cramps. Every night, I take a tablet, and it ensures a peaceful night’s sleep.
Read More
10
Good relief
216 people found this helpful
Great magnesium! My leg cramps have disappeared!
Read More
7.5
Aiding sleep quality
207 people found this helpful
This magnesium is one of the most economical options online and a great aid for the body. It combats stress and anxiety, improves bowel function, and alleviates headaches and leg cramps. My sleep has significantly improved, and I feel much livelier and more energetic.
Read More
9
Consistent relief
200 people found this helpful
Magnesium citrate is exceptionally absorbed and helps those with constipation. I regularly take different forms and have noticed enhanced relaxation, improved sleep, and the disappearance of cramps.
Leg cramps, often referred to as "charley horses," are sudden, involuntary contractions of one or more muscles in the leg. They typically occur in the calf muscles but can also affect the thighs and feet. These cramps can be quite painful and may last from a few seconds to several minutes. While the exact cause of leg cramps is not always clear, they can be triggered by factors such as dehydration, prolonged sitting or standing, electrolyte imbalances, or physical activity, especially in those who are not used to vigorous exercise.
Treatment for leg cramps often involves stretching the affected muscle gently, applying heat or cold to the area, and ensuring adequate hydration. For some, dietary adjustments to include more potassium, magnesium, and calcium may help prevent future occurrences. If cramps are frequent or severely debilitating, it may be beneficial to consult a healthcare provider for a more tailored approach. Understanding the underlying causes of leg cramps can lead to more effective management strategies, improving overall comfort and mobility.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium has been noted for its potential role in alleviating leg cramps, particularly in individuals who experience nocturnal leg cramps or muscle spasms. As an essential mineral, magnesium contributes to muscle function and helps regulate muscle contractions. Some studies suggest that supplementing with magnesium may lead to a decrease in the frequency and intensity of leg cramps, especially in populations at risk for magnesium deficiency, such as older adults or those with specific health conditions.
That said, while magnesium supplementation could be beneficial, it's always a good idea to consult with a healthcare professional before starting any new supplements. They can provide personalized advice based on your health history and dietary needs. Moreover, ensuring a balanced intake of nutrients, staying hydrated, and maintaining regular physical activity can also play significant roles in managing leg cramps effectively.
Based on user reviews, many individuals report seeing significant improvements in leg cramps within a relatively short timeframe after starting magnesium supplementation. For instance, one user noted that their cramps disappeared within just three days of taking the supplement Read Review. Others mentioned similar results, with improvements often occurring within one week to a month of consistent use Read ReviewRead Review. A user stated, "After taking it daily for a month, I noticed a significant improvement: my night cramps vanished within a week" Read Review.
Most reviews suggest that if leg cramps are a recurring issue, magnesium can serve as an effective remedy, with rapid positive effects typically reported about a week after starting treatment. Users have also highlighted additional benefits, such as improved sleep and overall well-being, further encouraging the use of magnesium as a go-to option for alleviating muscle cramps Read Review. If you're considering this supplement for leg cramps, you might expect to notice changes relatively quickly.
Magnesium supplementation has been studied for its effectiveness in treating leg cramps, particularly nocturnal leg cramps (NLC) and those experienced during pregnancy. Research indicates varying results depending on the population studied. For example, a study focusing on magnesium oxide monohydrate (MOMH) found it effective and safe for managing NLC, with participants reporting significant symptom improvement after 60 days of supplementation [1]. However, consistent results are not observed across all demographics. In pregnant women, findings are particularly mixed, with multiple analyses showing that while some women may experience slight benefits from magnesium, overall, its impact has not been statistically significant in reducing frequency or severity of leg cramps [2][3].
Overall, the evidence regarding magnesium as a go-to remedy for leg cramps remains inconclusive. While there may be instances where magnesium helps, particularly for NLC, the inconsistency in research results, especially regarding pregnant patients, highlights the need for more robust studies and a nuanced understanding of when magnesium supplementation might offer any genuine relief [1][10]. So, if you're considering magnesium for leg cramps, be prepared for some variability in its effectiveness based on different individual conditions.
Based on user reviews, many individuals have reported substantial improvements in their symptoms after starting magnesium supplementation, particularly regarding leg cramps. Users frequently mention that their cramps have vanished within a week to three weeks of beginning treatment. One reviewer noted, "I can now extend my legs freely at any time without issues" after just one week of use Read Review. Similarly, another user stated that their nocturnal leg cramps disappeared within just three days Read Review.
Moreover, users indicate additional benefits beyond muscle cramping relief, such as enhanced sleep quality and reduced anxiety. For instance, a user shared that after taking magnesium, not only did their cramps cease, but their overall calmness and sleep patterns also improved Read Review. Another remarked, “I now fall asleep effortlessly and wake up feeling refreshed,” pointing to the broader effects of magnesium on well-being and energy levels Read Review. While many report positive outcomes, it’s important to acknowledge that individual results may vary, and those considering magnesium supplements should consult with a healthcare professional, especially if they have existing health concerns.
Users reported various experiences when combining magnesium supplements with other supplements for handling leg cramps. Specifically, one reviewer noted, "Magnesium citrate with vitamin B6 really helps," pointing to the effectiveness of this combination in alleviating their leg cramps and gastrointestinal discomfort Read Review. This suggests that integrating magnesium with vitamin B6 may enhance its benefits for muscle cramps while also addressing digestive issues. Additionally, other users have mentioned that taking magnesium supports broader well-being, which implies it could complement other health supplements aimed at different concerns.
Moreover, several users have highlighted their positive experiences with supplemental magnesium alone, but specific interactions with other products beyond vitamin B6 remain less frequently mentioned. For instance, one user stated that magnesium “combats stress and anxiety, improves bowel function, and alleviates headaches and leg cramps” without specifying other supplements in their regimen Read Review. This indicates that many find magnesium effective on its own for muscle relaxation and stress relief, even if combinations with other supplements were not explicitly detailed in the reviews.
Users report varied dosages for magnesium when it comes to treating leg cramps, highlighting both effectiveness and personal preference. Many users find success with lower daily doses, noting that one or two capsules can significantly alleviate symptoms. For example, one user mentioned taking just one capsule daily after dinner over five years, leading to a considerable reduction in cramps and an overall increase in mobility Read Review. Other users have noted taking magnesium about half an hour before bedtime, finding it effective in preventing nocturnal cramps and enhancing sleep quality Read Review.
Additionally, some reviews emphasize the importance of maintaining consistent dosages to avoid the return of cramps. A user mentioned that their cramps returned after a month without taking magnesium citrate, indicating that a steady routine is crucial for long-term benefits Read Review. Overall, while the optimal dosage appears to vary among individuals, many users suggest that regular intake of magnesium in reasonable amounts can lead to significant relief from leg cramps.
9
Nocturnal improvement
99 people found this helpful
I struggled with severe nocturnal calf cramps, which were dreadful to wake up to. However, this magnesium worked quickly; by the third day, my cramps had vanished, and my sleep improved significantly. I take it 30 minutes before bedtime and trust this brand's quality.
9
Reduced leg cramps
449 people found this helpful
The convulsions have really ceased. It’s only been a week since I began treatment, and I can now extend my legs freely at any time without issues. I have gradually reduced my dosage from one tablet per day to 3-4 tablets weekly, allowing me to have enough for over six months. I don't take it with me on trips, yet I've not had any cramps while away. I also feel a calming effect, becoming much more composed and measured in my responses to situations at work.
7.5
Calmer mornings
108 people found this helpful
This is my first magnesium supplement, recommended by a trusted nutritionist. After three weeks, my night leg cramps have significantly decreased, and I've felt more calm and less irritable. I take it 30 minutes before bed and have observed improvements in my morning energy levels.
9
Effective muscle relaxation
13 people found this helpful
Magnesium citrate is excellent in an easily digestible form. The large package contains many tablets at a lower cost than similar products in pharmacies. After taking it daily for a month, I noticed a significant improvement: my night cramps vanished within a week, and my nervous tick disappeared after two weeks. While it’s not recommended for long-term use, I believe several courses a year can be beneficial. Overall, this product is not the best, but it’s quite good and worth trying.
9
Positive effects noted
61 people found this helpful
I sought magnesium during a stressful time due to my son’s graduation. Since starting, my leg cramps have vanished, and I feel calmer overall. The dosage I follow has significantly aided both my son and me, with noticeable changes in our sleep quality and mood.
9
Sleep improved significantly
23 people found this helpful
After struggling with poor sleep and fatigue, I began taking magnesium at my doctor’s suggestion. The results have been remarkable; I now fall asleep effortlessly and wake up feeling refreshed. It’s particularly effective for muscle cramps!
9
Effective for cramps
21 people found this helpful
Just superb for me! Magnesium citrate with vitamin B6 really helps. The main issue for me was leg cramps; I struggled to sleep at night due to the pain. Now, everything is fine. I learned it’s essential to avoid skipping magnesium citrate B6, as my cramps returned after a month without it. Additionally, this magnesium alleviates gastrointestinal discomfort and negates the need for laxatives.
7.5
Aiding sleep quality
207 people found this helpful
This magnesium is one of the most economical options online and a great aid for the body. It combats stress and anxiety, improves bowel function, and alleviates headaches and leg cramps. My sleep has significantly improved, and I feel much livelier and more energetic.
9
Highly recommended product
14 people found this helpful
I am 80 years old and suffered from muscle cramps daily all over my body, unable to walk more than 5 minutes for the last 16 years. Since taking just one capsule daily after dinner for the past five years, I can now walk for 60 minutes and swim 1000 meters on alternate days. I have recommended this product to many, including a 92-year-old retired doctor and an 85-year-old retired bishop. Highly recommended for anyone with body cramps.
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
2
Magnesium ineffective for leg cramps
Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials.
We examined the effectiveness of magnesium supplements in reducing leg cramps during pregnancy, a common issue that affects up to half of pregnant women. Four randomized controlled trials were included in our analysis, with a total of 332 participants, which compared magnesium treatment to a placebo.
Our findings showed that magnesium supplementation did not significantly decrease the frequency of leg cramps compared to the control group. The weighted mean difference was -0.47, which indicates that while there may be a slight improvement, it was not considered statistically meaningful.
Moreover, magnesium did not help women recover from leg cramps more effectively than the placebo, and there were no significant side effects reported. Overall, we found that oral magnesium supplementation is not effective in treating leg cramps during pregnancy.
We observed the effectiveness of magnesium as a treatment for leg cramps during pregnancy, using data from several studies that included over 500 women. The research aimed to understand whether magnesium could help reduce the frequency and intensity of leg cramps, a common complaint among expectant mothers.
While some studies indicated that magnesium might help reduce the occurrence of leg cramps for some women, the results were inconsistent and did not show a clear benefit. In fact, for various outcomes measured, such as pain intensity and the total number of cramps, the evidence was not strong enough to draw firm conclusions. The studies varied in how they reported their findings, making it challenging for us to compile and compare the data effectively.
Additionally, the certainty of the evidence we found was rated as low to very low, largely due to the small size of the trials and some design limitations. Importantly, there were not enough data to assess the safety of magnesium or compare it adequately with other treatments. Overall, it appears that magnesium may not be the magic bullet for dealing with leg cramps in pregnancy, but more research could help clarify its role in the future.
We examined the effectiveness of magnesium supplementation for preventing skeletal muscle cramps through a systematic review of several studies. Seven trials involving a total of 406 participants were included, with some studies focusing on women experiencing leg cramps during pregnancy and others on adults with idiopathic cramps.
Overall, we found that magnesium supplementation did not offer a significant benefit in reducing the frequency or intensity of cramps for older adults. The data on idiopathic cramps showed only minor changes that weren’t statistically significant. Specifically, the difference in the number of cramps per week between magnesium and placebo groups was negligible, suggesting that it may not provide any clinically meaningful relief.
For pregnant women experiencing leg cramps, the results were mixed, indicating a need for further research. It’s clear from the trials that magnesium might not be the miracle solution that many hope for when it comes to leg cramps. We also noted that any side effects reported were similar to those seen with placebo, reinforcing the idea that magnesium poses little risk.
References
Barna O, Lohoida P, Holovchenko Y, Bazylevych A, Velychko V, et al. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps. Nutr J. 2021;20:90. doi:10.1186/s12937-021-00747-9
Liu J, Song G, Zhao G, Meng T. Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials. Taiwan J Obstet Gynecol. 2021;60:609. doi:10.1016/j.tjog.2021.05.006
Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. doi:10.1002/14651858.CD010655.pub3
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, et al. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2020;9:CD009402. doi:10.1002/14651858.CD009402.pub3
Araújo CAL, Lorena SB, Cavalcanti GCS, Leão GLS, Tenório GP, et al. Oral magnesium supplementation for leg cramps in pregnancy-An observational controlled trial. PLoS One. 2020;15:e0227497. doi:10.1371/journal.pone.0227497
Sebo P, Haller D, Cerutti B, Maisonneuve H. A prospective observational study of the main features of nocturnal leg cramps in primary care. Swiss Med Wkly. 2019;149:w20048. doi:10.4414/smw.2019.20048
Roguin Maor N, Alperin M, Shturman E, Khairaldeen H, Friedman M, et al. Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2017;177:617. doi:10.1001/jamainternmed.2016.9261
Zhou K, West HM, Zhang J, Xu L, Li W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD010655.pub2
Sebo P, Cerutti B, Haller DM. Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations. Fam Pract. 2014;31:7. doi:10.1093/fampra/cmt065
Garrison SR, Allan GM, Sekhon RK, Musini VM, Khan KM. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2012;2012:CD009402. doi:10.1002/14651858.CD009402.pub2
Supakatisant C, Phupong V. Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Matern Child Nutr. 2015;11:139. doi:10.1111/j.1740-8709.2012.00440.x
Garrison SR, Birmingham CL, Koehler BE, McCollom RA, Khan KM. The effect of magnesium infusion on rest cramps: randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2011;66:661. doi:10.1093/gerona/glq232
Uña E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280. doi:10.1177/1078155209355849
Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 2002;8:CR326.
Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2002.
Frusso R, Zárate M, Augustovski F, Rubinstein A. Magnesium for the treatment of nocturnal leg cramps: a crossover randomized trial. J Fam Pract. 1999;48:868.
Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 1995;173:175.