Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 11 Reviews
8.7
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More
Most Useful Reviews
9
Surge of strength
1 people found this helpful
I take these vitamins alongside others. The convenient form and pleasant taste ensure I experience no allergies or side effects. After using them for a month, I felt a surge of energy and cheerfulness. I highly recommend them!
Read More
9
Improved metabolism
Great! Excellent quality product with perfectly chosen ingredients. I experienced no allergies or negative reactions. The large package lasts a long time, and the average capsule size has a neutral taste. Delivery was quick and undamaged. The composition includes only healthy, natural ingredients and folic acid. I've noticed improved intestinal function and metabolism, with results seen after a week. My nervous system has also improved as I'm less anxious. I trust the effectiveness of the vitamin; just ensure to check the dosage based on your age.
Read More
9
Pleasant taste
4 people found this helpful
My 1.6-year-old child was prescribed this by a neurologist to take before breakfast for three months. Although I expected lozenges, we received tablets that we easily divide with a sharp knife. The pleasant taste makes it enjoyable, and fortunately, there are no allergies.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
- All Researches
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Surge of strength
1 people found this helpful
I take these vitamins alongside others. The convenient form and pleasant taste ensure I experience no allergies or side effects. After using them for a month, I felt a surge of energy and cheerfulness. I highly recommend them!
Read More
9
Improved metabolism
Great! Excellent quality product with perfectly chosen ingredients. I experienced no allergies or negative reactions. The large package lasts a long time, and the average capsule size has a neutral taste. Delivery was quick and undamaged. The composition includes only healthy, natural ingredients and folic acid. I've noticed improved intestinal function and metabolism, with results seen after a week. My nervous system has also improved as I'm less anxious. I trust the effectiveness of the vitamin; just ensure to check the dosage based on your age.
Read More
9
Pleasant taste
4 people found this helpful
My 1.6-year-old child was prescribed this by a neurologist to take before breakfast for three months. Although I expected lozenges, we received tablets that we easily divide with a sharp knife. The pleasant taste makes it enjoyable, and fortunately, there are no allergies.
Read More
9
Lowered homocysteine
I have been taking this supplement for a long time, and it has successfully helped lower my homocysteine levels. Importantly, it does not cause allergies.
Read More
9
Easy to swallow
I find this B12 vitamins quite good. The small tablets are easy to swallow and do not cause any allergies or side effects.
Read More
Frequently Asked Questions
9
Improved metabolism
Great! Excellent quality product with perfectly chosen ingredients. I experienced no allergies or negative reactions. The large package lasts a long time, and the average capsule size has a neutral taste. Delivery was quick and undamaged. The composition includes only healthy, natural ingredients and folic acid. I've noticed improved intestinal function and metabolism, with results seen after a week. My nervous system has also improved as I'm less anxious. I trust the effectiveness of the vitamin; just ensure to check the dosage based on your age.
9
Surge of strength
1 people found this helpful
I take these vitamins alongside others. The convenient form and pleasant taste ensure I experience no allergies or side effects. After using them for a month, I felt a surge of energy and cheerfulness. I highly recommend them!
9
Lowered homocysteine
I have been taking this supplement for a long time, and it has successfully helped lower my homocysteine levels. Importantly, it does not cause allergies.
7.5
Improved symptoms
I experienced an allergy on my lips, thought to be due to a B12 deficiency. Since I started taking this vitamin, I've noticed improvement. I also do oral cleansing, but I believe the vitamin is helping. I'm satisfied!
9
No allergic reaction
These sweet, fragrant vitamins are small and did not cause any allergies during ten days of taking them. We consume them after meals.
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
References
- Guillot AJ, Martínez-Navarrete M, Giner RM, Recio MC, Santos HA, et al. Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo. J Control Release. 2024;375:537. 10.1016/j.jconrel.2024.09.032
- Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. 10.33029/0042-8833-2023-92-3-79-86
- El Rhermoul FZ, Mustafa A, Wagner A, Nakonechna A, Kayode OS, et al. Vitamin B Hypersensitivity: A Retrospective Multicenter Study. J Allergy Clin Immunol Pract. 2024;12:699. 10.1016/j.jaip.2023.10.037
