Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
Most Useful Reviews
9
Headache improvement
13 people found this helpful
After 30 days of taking Now Foods Vitamin B12 + Folic Acid, I noticed a significant improvement. Initially prescribed for a deficiency revealed during thyroid treatment, I took one delicious tablet daily. Over the month, my constant drowsiness and fatigue vanished, I felt more active, and my headaches significantly diminished.
Read More
9
Effective remedy
1 people found this helpful
I really like this complex. Since starting it, my headaches have decreased and my overall well-being has improved. It's effective, and I'm buying it again.
Read More
9
Stress relief
1 people found this helpful
The cherry-flavoured tablet dissolves well under the tongue. I've taken it daily, as advised, and noticed a significant decrease in fatigue and headaches, improving my productivity during these stressful times.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
- All Researches
9
We investigated a unique case where a 14-year-old girl experienced prolonged headaches and nausea due to cerebral venous thrombosis linked to a rare genetic mutation. Elevated homocysteine levels were discovered during examinations, leading to anticoagulation therapy.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Read More
9
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
Read More
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Headache improvement
13 people found this helpful
After 30 days of taking Now Foods Vitamin B12 + Folic Acid, I noticed a significant improvement. Initially prescribed for a deficiency revealed during thyroid treatment, I took one delicious tablet daily. Over the month, my constant drowsiness and fatigue vanished, I felt more active, and my headaches significantly diminished.
Read More
9
Effective remedy
1 people found this helpful
I really like this complex. Since starting it, my headaches have decreased and my overall well-being has improved. It's effective, and I'm buying it again.
Read More
9
Stress relief
1 people found this helpful
The cherry-flavoured tablet dissolves well under the tongue. I've taken it daily, as advised, and noticed a significant decrease in fatigue and headaches, improving my productivity during these stressful times.
Read More
9
Enhanced calmness
1 people found this helpful
The cherry-flavoured tablets dissolve under the tongue very well. I've been taking one daily with meals and noticed reduced fatigue and fewer headaches. They help ease my stress in these trying times.
Read More
9
Energy boost
1 people found this helpful
Good quality! After a week of use, my constant drowsiness and fatigue disappeared. I'm more active now, and the headaches have noticeably lessened.
Read More
Frequently Asked Questions
6
Reduced headache
1 people found this helpful
Excellent product. I used it because I heard that its deficiency could lead to chronic headaches, which I was experiencing. After about a week of use, I have only felt a slight headache, a mild pain compared to before. Thank God for His grace.
9
Energy boost
1 people found this helpful
Good quality! After a week of use, my constant drowsiness and fatigue disappeared. I'm more active now, and the headaches have noticeably lessened.
0
Fatigue reduction
4 people found this helpful
Prescribed by my neurologist for headaches and fatigue, I've felt a considerable improvement after two months of taking this vitamin. My energy levels have increased, I've been sleeping better, and I plan to continue taking it.
9
Headache improvement
13 people found this helpful
After 30 days of taking Now Foods Vitamin B12 + Folic Acid, I noticed a significant improvement. Initially prescribed for a deficiency revealed during thyroid treatment, I took one delicious tablet daily. Over the month, my constant drowsiness and fatigue vanished, I felt more active, and my headaches significantly diminished.
9
Stress relief
1 people found this helpful
The cherry-flavoured tablet dissolves well under the tongue. I've taken it daily, as advised, and noticed a significant decrease in fatigue and headaches, improving my productivity during these stressful times.
9
Headaches relieved
Great vitamin; my headaches have disappeared. It is advisable to also consume calcium, so I will continue taking more.
7.5
Cold relief
I was experiencing headaches, and the Vitamin B complex helped. It also combats colds and increases blood flow.
6
Good for headaches
Sometimes, B12 has been effective for my headaches, and I have used it previously with good results.
9
Enhanced calmness
1 people found this helpful
The cherry-flavoured tablets dissolve under the tongue very well. I've been taking one daily with meals and noticed reduced fatigue and fewer headaches. They help ease my stress in these trying times.
9
Effective remedy
1 people found this helpful
I really like this complex. Since starting it, my headaches have decreased and my overall well-being has improved. It's effective, and I'm buying it again.
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
7
Cerebral venous thrombosis and treatment
We explored the case of a 25-year-old man who came to the hospital with severe headaches and dizziness. Following a diagnosis of cerebral venous thrombosis, linked to his vitamin B12 deficiency from nitrous oxide use, he received treatment that included vitamin B12 supplements.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
9
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
References
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Singh J, Dinkar A, Gupta P, Atam V. Vitamin B12 deficiency in northern India tertiary care: Prevalence, risk factors and clinical characteristics. J Family Med Prim Care. 2022;11:2381. 10.4103/jfmpc.jfmpc_650_21
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. 10.18502/cjn.v21i2.10494
- Arıcan P, Bozkurt O, Cavusoglu D, Gencpınar P, Haspolat S, et al. Various Neurological Symptoms with Vitamin B12 Deficiency and Posttreatment Evaluation. J Pediatr Neurosci. 2020;15:365. 10.4103/jpn.JPN_130_19
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. 10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. 10.3389/fnut.2024.1456502
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. 10.1097/MD.0000000000040458
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. 10.1016/j.nutres.2023.11.008
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. 10.1017/S000711452300137X
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. 10.1007/s13760-020-01491-3
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
